Structural studies, homology modeling and molecular docking of novel non-competitive antagonists of GluK1/GluK2 receptors

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 2, 2014, Pages 787-795

  Kaczor, Agnieszka A ^a,b   Karczmarzyk, Zbigniew ^c   Fruziński, Andrzej ^d   Pihlaja, Kalevi ^e   Sinkkonen, Jari ^e   Wiinämaki, Kirsti ^e   Kronbach, Christiane ^f   Unverferth, Klaus ^f   Poso, Antti ^b   Matosiuk, Dariusz ^a  

^a Dept of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Lab Faculty of Pharmacy with Division of Medical Analytics   (Poland)

^b UNIVERSITY OF EASTERN FINLAND   (Finland)

^c SIEDLCE UNIVERSITY OF NATURAL SCIENCES AND HUMANITIES   (Poland)

^d LODZ UNIVERSITY OF TECHNOLOGY   (Poland)

^e UNIVERSITY OF TURKU   (Finland)

^f Biotie Therapie GmbH   (Germany)

Author keywords

Homology modeling; Indole derivatives; Kainate receptors; Molecular docking; X ray structure determination

Indexed keywords

AMPA RECEPTOR; GLUK1 RECEPTOR; GLUK1 RECEPTOR BLOCKING AGENT; GLUK2 RECEPTOR; GLUK2 RECEPTOR BLOCKING AGENT; KAINIC ACID RECEPTOR; LIGAND; NS 3763; RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG; GLUK1 KAINATE RECEPTOR; GLUK2 KAINATE RECEPTOR; INDOLE DERIVATIVE;

ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DRUG STRUCTURE; MASS SPECTROMETRY; MOLECULAR DOCKING; MOLECULAR MODEL; NUCLEAR MAGNETIC RESONANCE; RECEPTOR BINDING; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS; ANTAGONISTS AND INHIBITORS; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; HUMAN; STRUCTURE ACTIVITY RELATION; SYNTHESIS; X RAY CRYSTALLOGRAPHY;

CRYSTALLOGRAPHY, X-RAY; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INDOLES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; RECEPTORS, KAINIC ACID; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84892368749     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.013     Document Type: Article

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