Synthesis and biological evaluation of 6H-pyrido[2′,1′:2,3] imidazo[4,5-c]isoquinolin-5(6H)-ones as antimitotic agents and inhibitors of tubulin polymerization

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 2, 2014, Pages 848-855

  Meng, Tao ^a   Wang, Wei ^a   Zhang, Zhixiang ^a   Ma, Lanping ^a   Zhang, Yongliang ^a   Miao, Zehong ^a   Shen, Jingkang ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

6H Pyrido 2 ,1 :2,3 imidazo 4,5 c isoquinolin 5(6H) ones; Antitumor agents; Colchicine binding site; Inhibitors of tubulin polymerization

Indexed keywords

6 (1,3 BENZODIOXOL 5 YLMETHYL)PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 (2 FURYLMETHYL)PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 (2,4 DIMETHOXYBENZYL)PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 (3,4 DIMETHOXYBENZYL)PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 (4 METHOXYBENZYL) 11 METHYLPYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 (4 METHOXYBENZYL) 8 METHYLPYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [2 (4 HYDROXYPHENYL)ETHYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [2 (4 METHOXYPHENYL)ETHYL] 9 [(2 MORPHOLIN 4 YLETHYL)AMINO]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [2 (4 METHOXYPHENYL)ETHYL] 9 [(PYRIDIN 2 YLMETHYL) AMINO]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [2 (4 METHOXYPHENYL)ETHYL] 9 [(PYRIDIN 3 YLMETHYL) AMINO]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [2 (4 METHOXYPHENYL)ETHYL] 9 [(PYRIDIN 4 YLMETHYL) AMINO]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [2 (4 METHOXYPHENYL)ETHYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [3 (4 METHOXYPHENYL)PROPYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6 [4 (TRIFLUOROMETHOXY)BENZYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 6H PYRIDO[2',1':2,3] IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE DERIVATIVE; 9 (1H IMIDAZOL 1 YL) 6 [2 (4 METHOXYPHENYL)ETHYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 9 BROMO 6 (4 METHOXYBENZYL) 10 METHYLPYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 9 BROMO 6 (4 METHOXYBENZYL) 8 METHYLPYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 9 [[2 (DIETHYLAMINO)ETHYL]AMINO] 6 [2 (4 METHOXYPHENYL)ETHYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; 9 [[3 (1H IMIDAZOL 1 YL)PROPYL]AMINO] 6 [2 (4 METHOXYPHENYL)ETHYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; ANTIMITOTIC AGENT; COLCHICINE; METHYL 3 (5 OXOPYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 6(5H) YL)PROPANOATE; UNCLASSIFIED DRUG; VINCRISTINE; [(2 HYDROXYETHYL)AMINO] 6 [2 (4 METHOXYPHENYL)ETHYL]PYRIDO[2',1':2,3]IMIDAZO[4,5 C]ISOQUINOLIN 5(6H) ONE; IMIDAZOLE DERIVATIVE; ISOQUINOLINE DERIVATIVE; PYRIDINE DERIVATIVE; TUBULIN;

ANTIPROLIFERATIVE ACTIVITY; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOTOXICITY; DRUG STRUCTURE; DRUG SYNTHESIS; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; IC 50; IMMUNOFLUORESCENCE; IN VITRO STUDY; M PHASE CELL CYCLE CHECKPOINT; MICROTUBULE ASSEMBLY; STRUCTURE ACTIVITY RELATION; CELL CYCLE; CELL PROLIFERATION; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; HELA CELL LINE; METABOLISM; POLYMERIZATION; SYNTHESIS;

ANTIMITOTIC AGENTS; CELL CYCLE; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HELA CELLS; HUMANS; IMIDAZOLES; ISOQUINOLINES; MOLECULAR STRUCTURE; POLYMERIZATION; PYRIDINES; STRUCTURE-ACTIVITY RELATIONSHIP; TUBULIN;

EID: 84892368345     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.12.004     Document Type: Article

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