Cytotoxicity, apoptosis, cell cycle arrest, reactive oxygen species, mitochondrial membrane potential, and Western blotting analysis of ruthenium(II) complexes

Journal of Biological Inorganic Chemistry

Volumn 18, Issue 8, 2013, Pages 873-882

  Lin, Gan Jian ^a   Jiang, Guang Bin ^a   Xie, Yang Yin ^a   Huang, Hong Liang ^a   Liang, Zhen Hua ^a   Liu, Yun Jun ^a  

^a GUANGDONG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

Cell cycle arrest; Cytotoxicity; Mitochondrial membrane potential; Ru(II) complexes; Western blotting analysis

Indexed keywords

CASPASE 3; CASPASE 7; CISPLATIN; PROCASPASE 7; REACTIVE OXYGEN METABOLITE; RUTHENIUM DERIVATIVE; UNCLASSIFIED DRUG; [RUTHENIUM (2,2' BIPYRIDINE)(7 AMINODIPYRIDO[3,2-A:20,30 C]PHENAZINE)](PERCHLORATE); [RUTHENIUM (2,9 DIMETHYL 1,10 PHENANTHROLINE )(7 AMINODIPYRIDO[3,2-A:20,30 C]PHENAZINE)](PERCHLORATE); [RUTHENIUM (4,4' DIMETHYL 2,2' BIPYRIDINE)(7 AMINODIPYRIDO[3,2-A:20,30 C]PHENAZINE)](PERCHLORATE);

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CELL CYCLE ARREST; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CYTOTOXICITY; DRUG SYNTHESIS; ENZYME ACTIVITY; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; WESTERN BLOTTING;

2,2'-DIPYRIDYL; ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; CELL CYCLE CHECKPOINTS; CELL LINE, TUMOR; COORDINATION COMPLEXES; HUMANS; MEMBRANE POTENTIAL, MITOCHONDRIAL; NEOPLASMS; PHENANTHROLINES; PHENAZINES; PYRIDINES; REACTIVE OXYGEN SPECIES; RUTHENIUM;

EID: 84892365137     PISSN: 09498257     EISSN: 14321327     Source Type: Journal    
DOI: 10.1007/s00775-013-1032-2     Document Type: Article

References (35)

1. Markman M (2003) Expert Opin Drug Saf 2:597-607
2. Bruijnincx PC, Sadler PJ (2008) Curr Opin Chem Biol 12:197-206
3. Bratsos I, Jedner S, Gianferrara T, Alessio E (2007) Chimia 61:692-697
4. Meng X, Leyva ML, Jenny M, Gross I, Benosman S, Frocker B, Harlepp S, Hébraud P, Boos A, Wlosik P, Bischoff P, Sirlin C, Pfeffer M, Loeffler JP, Gaiddon C (2009) Cancer Res 69:5458-5466
5. Yan YK, Melchart M, Habtemariam A, Sadler PJ (2005) Chem Commun 4764-4776
6. Mendoza-Ferri MG, Hartinger CG, Eichinger RE, Stolyarova N, Severin K, Jakupec MA, Nazarov AA, Keppler BK (2008) Organometallics 27:2405-2407
7. Nazarov AA, Risse J, Ang WH, Schmitt F, Zava O, Ruggi A, Groessl M, Scopelitti R, Juillerat-Jeanneret L, Hartinger CG, Dyson PJ (2012) Inorg Chem 51:3633-3639
8. Filak LK, Mühlgassner G, Bacher F, Roller A, Galanski M, Jakupec MA, Keppler BK, Arion VB (2011) Organometallics 30:273-283
9. Bratsos I, Mitri E, Ravalico F, Zangrando E, Gianferrara T, Bergamo A, Alessio E (2012) Dalton Trans 41:7358-7371
10. Betanzos-Lara S, Novakova O, Deeth RJ, Pizarro AM, Clarkson GJ, Liskova B, Brabec V, Sadler PJ, Habtemariam A (2012) J Biol Inorg Chem 17:1033-1051
11. Wang C, Yu QQ, Yang LC, Liu YY, Sun DD, Zhou YH, Zhang QL, Liu J (2013) J Biol Inorg Chem 26:387-402
12. Kou JF, Qian C, Wang JQ, Cheng X, Wang LL, Chao H, Ji LN (2012) J Biol Inorg Chem 17:81-96
13. Tan LF, Shen JL, Liu J, Zeng LL, Jin LH, Weng C (2012) Dalton Trans 41:4575-4587
14. Tan CP, Lai SS, Wu SH, Hu S, Zhou LJ, Chen Y, Wang MX, Zhu YP, Lian W, Peng WL, Ji LN, Xu AL (2010) J Med Chem 53:7613-7624
15. Chen TF, Liu YN, Zhen WJ, Liu J, Wong YS (2010) Inorg Chem 49:6366-6368
16. Schatzschneider U, Niesel J, Ott I, Gust R, Alborzinia H, Wolfl S (2008) ChemMedChem 3:1104-1109
17. Huang HL, Li ZZ, Liang ZH, Liu YJ (2011) Eur J Inorg Chem 2011:5538-5547
18. Paw W, Eisenberg R (1997) Inorg Chem 36:2287-2293
19. Reddy KL, Reddy YHK, Satyanarayana S (2009) Nucleosides Nucleotides Nucleic Acids 28:953-968
20. Sullivan BP, Salmon DJ, Meyer TJ (1978) Inorg Chem 17:3334-3341
21. Collin JP, Sauvage JP (1986) Inorg Chem 25:135-141
22. Mosmann T (1983) J Immunol Methods 65:55-63
23. Lo KK, Lee TK, Lau JS, Poon WL, Cheng SH (2008) Inorg Chem 47:200-208
24. Gao F, Chen X, Wang JQ, Chen Y, Chao H, Ji LN (2009) Inorg Chem 48:5599-5601
25. Liu YJ, Liang ZH, Li ZZ, Yao JH, Huang HL (2011) J Organomet Chem 696:2728-2735
26. Huang HL, Li ZZ, Liang ZH, Yao JH, Liu YJ (2011) Eur J Med Chem 46:3282-3290
27. Pierroz V, Joshi T, Leonidova A, Mari C, Schur J, Ott I, Spiccia L, Ferrari S, Gasser G (2012) J Am Soc Chem 134:20376-20387
28. Puckett CA, Barton JK (2008) Biochemistry 47:11711-11716
29. Bugarcic T, Nováková O, Hálámiková A, Zerzánková L, Vrána O, Kaspárková J, Hebtemariam A, Parsons S, Sadler PJ, Brabec V (2008) J Med Chem 51:5310-5319
30. Xie YY, Huang HL, Yao JH, Lin GJ, Jiang GB, Liu YJ (2013) Eur J Med Chem 63:603-610
31. Kalaivani P, Prabhakaran R, Poornima P, Dallemer F, Vijalayakshmi K, Padma VV, Natarajan K (2012) Organometallics 31:8323-8332
32. Junn E, Lee KN, Ju HR, Han SH, Im JY, Kang HS, Lee TH, Bae YS, Ha KS, Lee ZW, Rhee SG, Choi I (2000) J Immunol 165:2190-2197
33. Salvesen GS, Dixit VM (1997) Cell 91:443-446
34. Thornberry NA, Lazebnik Y (1998) Science 281:1312-1316
35. Cory S, Huang DC, Adams JM (2003) Oncogene 22:8590-8607