Ruthenium (II) polypyridyl complexes stabilize the bcl-2 promoter quadruplex and induce apoptosis of Hela tumor cells

BioMetals

Volumn 26, Issue 3, 2013, Pages 387-402

  Wang, Chuan ^a   Yu, Qianqian ^a   Yang, Licong ^a   Liu, Yanyu ^a   Sun, Dongdong ^a   Huang, Yongchao ^a   Zhou, Yanhui ^a   Zhang, Qianling ^b   Liu, Jie ^a  

^a JINAN UNIVERSITY   (China)

^b SHENZHEN UNIVERSITY   (China)

Author keywords

Anticancer; Apoptosis; Bcl 2 gene; Cellular uptake; G quadruplex; Ru(II) complexes

Indexed keywords

PROTEIN BCL 2; RUTHENIUM (II) POLYPYRIDYL COMPLEX; RUTHENIUM COMPLEX; SURAMIN; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; GUANINE QUADRUPLEX; ORGANOMETALLIC COMPOUND; PYRIDINE DERIVATIVE; RUTHENIUM;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; BCL 2 GENE; BINDING AFFINITY; CANCER INHIBITION; CELL MIGRATION; CELL PROLIFERATION; CIRCULAR DICHROISM; CONTROLLED STUDY; CYTOTOXICITY; DRUG POTENCY; FLUORESCENCE RESONANCE ENERGY TRANSFER; FLUORESCENCE SPECTROSCOPY; G1 PHASE CELL CYCLE CHECKPOINT; G2 PHASE CELL CYCLE CHECKPOINT; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; METASTASIS; POLYMERASE CHAIN REACTION; PROMOTER REGION; S PHASE CELL CYCLE CHECKPOINT; ULTRAVIOLET SPECTROSCOPY; CHEMICAL STRUCTURE; CHEMISTRY; DOSE RESPONSE; DRUG EFFECTS; DRUG SCREENING; GENETICS; HELA CELL LINE; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

ANTINEOPLASTIC AGENTS; APOPTOSIS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; G-QUADRUPLEXES; HELA CELLS; HUMANS; MODELS, MOLECULAR; ORGANOMETALLIC COMPOUNDS; PROMOTER REGIONS, GENETIC; PROTO-ONCOGENE PROTEINS C-BCL-2; PYRIDINES; RUTHENIUM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879205998     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-013-9622-6     Document Type: Article

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