Moderators of treatment response in adults with ADHD treated with a vitamin-mineral supplement

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 50, Issue , 2014, Pages 163-171

  Rucklidge, Julia J ^a   Johnstone, Jeanette ^a   Gorman, Brigette ^a   Boggis, Anna ^b   Frampton, Christopher M ^c  

^a UNIVERSITY OF CANTERBURY   (New Zealand)

^b CANTERBURY DISTRICT HEALTH BOARD   (New Zealand)

^c UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

ADHD; Micronutrients; Minerals; Predictors; Treatment; Vitamins

Indexed keywords

COPPER; CYANOCOBALAMIN; EMPOWERPLUS; FERRITIN; FOLIC ACID; IRON; MINERAL; PLACEBO; TRACE ELEMENT; UNCLASSIFIED DRUG; VITAMIN; VITAMIN D; ZINC;

ADOLESCENT; ADULT; AGED; ARTICLE; ATTENTION DEFICIT DISORDER; DEPRESSION; DRUG DOSE INCREASE; FEMALE; HEADACHE; HUMAN; MAJOR CLINICAL STUDY; MALE; NAUSEA; NUTRIENT; OUTCOME ASSESSMENT; RANDOMIZED CONTROLLED TRIAL (TOPIC); RISK ASSESSMENT; RISK FACTOR; SLEEP DISORDER; TREATMENT OUTCOME; TREATMENT RESPONSE; UNSPECIFIED SIDE EFFECT; VITAMIN D DEFICIENCY; XEROSTOMIA; AFFECT; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFECTS; MIDDLE AGED; PSYCHOLOGICAL RATING SCALE; RANDOMIZED CONTROLLED TRIAL; YOUNG ADULT;

ADOLESCENT; ADULT; AFFECT; AGED; ATTENTION DEFICIT DISORDER WITH HYPERACTIVITY; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MICRONUTRIENTS; MIDDLE AGED; PSYCHIATRIC STATUS RATING SCALES; RISK FACTORS; TREATMENT OUTCOME; YOUNG ADULT;

EID: 84892185053     PISSN: 02785846     EISSN: 18784216     Source Type: Journal    
DOI: 10.1016/j.pnpbp.2013.12.014     Document Type: Article

References (68)

1. Akhondzadeh S., Mohammadi M.-R., Khademi M. Zinc sulfate as an adjunct to methylphenidate for the treatment of attention deficit hyperactivity disorder in children: a double blind and randomized trial. BMC Psychiatry 2004, 4:08.
2. American Psychiatric Association Diagnostic and statistical manual of mental disorders: DSM-IV-TR 2000, APA, Washington, DC. Text revision: 4th ed.
3. Ames B.N., Elson-Schwab I., Silver E. High-dose vitamin therapy stimulates variant enzymes with decreased coenzyme binding affinity (increased Km): relevance to genetic disease and polymorphisms. Am J Clin Nutr 2002, 75:616-658.
4. Arnold L.E., Bozzolo H., Hollway J., Cook A., DiSilvestro R.A., Bozzolo D.R., et al. Serum zinc correlates with parent- and teacher-rated inattention in children with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2005, 15:628-636.
5. Arnold L.E., Disilvestro R.A., Bozzolo D., Bozzolo H., Crowl L., Fernandez S., et al. Zinc for attention-deficit/hyperactivity disorder: placebo-controlled double-blind pilot trial alone and combined with amphetamine. J Child Adolesc Psychopharmacol 2011, 21:1-19.
6. Baker C.W., Little T.D., Brownell K.D. Predicting adolescent eating and activity behaviors. The role of social norms and personal agency. Health Psychol 2003, 22:189-198.
7. Bilici M., Yildirim F., Kandil S., Bekaroglu M., Yildirmis S., Deger O., et al. Double-blind, placebo-controlled study of zinc sulfate in the treatment of attention deficit hyperactivity disorder. Prog Neuropsychopharmacol Biol Psychiatry 2004, 28:181-190.
8. Bottiglieri T., Laundy M., Crellin R., Toone B.K., Carney M.W.P., Reynolds E.H. Homocysteine, folate, methylation, and monoamine metabolism in depression. J Neurol Neurosurg Psychiatry 2000, 69:228-232.
9. Buitelaar J.K., Kooij J.J.S., Ramos-Quiroga J.A., Dejonckheere J., Casas M., van Oene J.C., et al. Predictors of treatment outcome in adults with ADHD treated with OROS® methylphenidate. Prog Neuropsychopharmacol Biol Psychiatry 2011, 35:554-560.
10. Buske-Kirschbaum A., Schmitt J., Plessow F., Romanos M., Weidinger S., Roessner V. Psychoendocrine and psychoneuroimmunological mechanisms in the comorbidity of atopic eczema and attention deficit/hyperactivity disorder. Psychoneuroendocrinology 2013, 38:12-23.
11. Calarge C., Farmer C., DiSilvestro R., Arnold L.E. Serum ferritin and amphetamine response in youth with attention-deficit/hyperactivity disorder. J Child Adolesc Psychopharmacol 2010, 20:495-502.
12. Chen M.-H., Su T.-P., Chen Y.-S., Hsu J.-W., Huang K.-L., Chang W.-H., et al. Asthma and attention-deficit/hyperactivity disorder: a nationwide population-based prospective cohort study. J Child Psychol Psychiatry 2013, 54:1208-1214.
13. Conners C.K. Conners' rating scales-revised: technical manual 1997, Multi-Health Systems Inc., New York.
14. Conners C.K., Erhardt D., Sparrow M.A. Conners' adult ADHD rating scales (CAARS). Arch Clin Neuropsychol 2003, 18:431-437.
15. Cook J.D., Lipschitz D.A., Miles L.E.M., Finch C.A. Serum ferritin as a measure of iron stores in normal subjects. Am J Clin Nutr 1974, 27:681-687.
16. Cortese S., Konofal E., Bernardina B.D., Mouren M.-C., Lecendreux M. Sleep disturbances and serum ferritin levels in children with attention-deficit/hyperactivity disorder. Eur Child Adolesc Psychiatry 2009, 18:393-399.
17. Davis P., McLeod K., Ransom M., Ongley P. The New Zealand socioeconomic index of occupational status (NZSEI) 1997, Statistics New Zealand, Wellington.
18. Donev R., Thome J. Inflammation: good or bad for ADHD?. ADHD Atten Defic Hyperact Disord 2010, 2:257-266.
19. Donfrancesco R., Parisi P., Vanacore N., Martines F., Sargentini V., Cortese S. Iron and ADHD: time to move beyond serum ferritin levels. J Atten Disord 2013, 17:347-357.
20. Epstein J., Johnson D., Conners C. Conners' adult ADHD diagnostic interview for DSM-IV™ (CAADID): technical manual 2002, MHS, New York.
21. Figueiredo J.C., Grau M.V., Haile R.W., Sandler R.S., Summers R.W., Bresalier R.S., et al. Folic acid and risk of prostate cancer: results from a randomized clinical trial. J Natl Cancer Inst 2009, 101:432-435.
22. First M.B., Spitzer R.L., Gibbon M., Williams J.B.W. Structured clinical interview for DSM-IV-TR axis I disorders, research version 2002, Biometrics Research, New York State Psychiatric Institute, New York. Patient ed.
23. Galler J.R., Bryce C.P., Zichlin M.L., Fitzmaurice G., Eaglesfield G.D., Waber D.P. Infant malnutrition is associated with persisting attention deficits in middle adulthood. J Nutr 2012, 142:788-794.
24. Gardner A., Boles R.G. Is a "mitochondrial psychiatry" in the future? A review. Curr Psychiatr Rev 2005, 1:255-271.
25. Guy W. ECDEU assessment manual for psychopharmacology 1976, U.S. Department of Health, Education, and Welfare, Rockville, MD.
26. Harrison R., Rucklidge J.J., Blampied N. Use of micronutrients attenuates cannabis and nicotine abuse as evidenced from a reversal design: a case study. J Psychoactive Drugs 2013, 45:1-11.
27. Hunt J.R., Penland J.G. Iron status and depression in premenopausal women: an MMPI study. Behav Med 1999, 25:62-68.
28. Huskisson E., Maggini S., Ruf M. The influence of micronutrients on cognitive function and performance. J Int Med Res 2007, 35:1-19.
29. Insel T., Cuthbert B., Garvey M., Heinssen R., Pine D.S., Quinn K., et al. Research domain criteria (RDoC): toward a new classification framework for research on mental disorders. Am J Psychiatry 2010, 167:748-751.
30. Jackson J., Eaton W., Cascella N., Fasano A., Kelly D. Neurologic and psychiatric manifestations of celiac disease and gluten sensitivity. Psychiatr Q 2012, 83:91-102.
31. Kalantar-Zadeh K., Rodriguez R.A., Humphreys M.H. Association between serum ferritin and measures of inflammation, nutrition and iron in haemodialysis patients. Nephrol Dial Transplant 2004, 19:141-149.
32. Kaplan B.J., Crawford S.G., Field C.J., Simpson J.S. Vitamins, minerals, and mood. Psychol Bull 2007, 133:747-760.
33. Kaufman J., Birmaher B., Brent D., Rao U., Flynn C., Moreci P., et al. Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): initial reliability and validity data. J Am Acad Child Adolesc Psychiatry 1997, 36:980-987.
34. Kessler R.C., Adler L., Barkley R., Biederman J., Conners C.K., Demler O., et al. The prevalence and correlates of adult ADHD in the United States: results from the National Comorbidity Survey Replication. Am J Psychiatry 2006, 163:716-723.
35. Klein R.G., Mannuzza S., OMA R., Roizen E., Hutchison J.A., Lashau E.C., et al. Clinical and functional outcome of childhood Attention-Deficit/Hyperactivity Disorder 33years later. Arch Gen Psychiatry 2012, 1-9.
36. Konofal E., Lecendreux M., Arnulf I., Mouren M.-C. Iron deficiency in children with attention-deficit/hyperactivity disorder. Arch Pediatr Adolesc Med 2004, 158:1113-1115.
37. Konofal E., Lecendreux M., Deron J., Marchand M., Cortese S., Zaïm M., et al. Effects of iron supplementation on attention deficit hyperactivity disorder in children. Pediatr Neurol 2008, 38:20-26.
38. Lansdowne A.T.G., Provost S.C. Vitamin D3 enhances mood in healthy subjects during winter. Psychopharmacology (Berl) 1998, 135:319-323.
39. Lepping P., Huber M. Role of zinc in the pathogenesis of attention-deficit hyperactivity disorder: implications for research and treatment. CNS Drugs 2010, 24:721-728.
40. Levitt A.J., Joffe R.T. Folate, B12 and thyroid function in depression. Biol Psychiatry 1993, 33:52-53.
41. Lozoff B., Jimenez E., Hagen J., Mollen E., Wolf A.W. Poorer behavioral and developmental outcome more than 10years after treatment for iron deficiency in infancy. Pediatrics 2000, 105:E51.
42. Milte C.M., Parletta N., Buckley J.D., Coates A.M., Young R.M., Howe P.R.C. Eicosapentaenoic and docosahexaenoic acids, cognition, and behavior in children with attention-deficit/hyperactivity disorder: a randomized controlled trial. Nutrition 2012, 28:670-677.
43. Montgomery S.A., Åsberg M. A new depression scale designed to be sensitive to change. Br J Psychiatry 1979, 134:382-389.
44. Nahar Z., Azad M.A., Rahman M.A., Rahman M.A., Bari W., et al. Comparative analysis of serum manganese, zinc, calcium, copper and magnesium level in panic disorder patients. Biol Trace Elem Res 2010, 133:284-290.
45. National Health, Medical Research Council Nutrient reference values for Australia and New Zealand: including recommended dietary intakes 2006, Department of Health and Ageing, Canberra.
46. Nigg J.T., Lewis K., Edinger T., Falk M. Meta-analysis of Attention-Deficit/Hyperactivity Disorder or Attention-Deficit/Hyperactivity Disorder symptoms, restriction diet, and synthetic food color additives. J Am Acad Child Adolesc Psychiatry 2012, 51:86-97.
47. Oner P., Oner O. Relationship of ferritin to symptom ratings in children with attention deficit hyperactivity disorder: effect of comorbidity. Child Psychiatry Hum Dev 2008, 39:323-330.
48. Oner O., Oner P., Bozkurt O.H., Odabas E., Keser N., Karadag H., et al. Effects of zinc and ferritin levels on parent and teacher reported symptom scores in attention deficit hyperactivity disorder. Child Psychiatry Hum Dev 2010, 41:441-447.
49. Parker G., Brotchie H. 'D' for depression: any role for vitamin D?. Acta Psychiatr Scand 2011, 124:243-249.
50. Prousky J.E. Understanding the serum vitamin level and its implications for treating neuropsychiatrie conditions: an orthomolecular perspective. J Orthomolecular Med 2010, 25.
51. Reynolds E.H. Benefits and risks of folic acid to the nervous system. J Neurol Neurosurg Psychiatry 2002, 72:567-571.
52. Roswall N., Larsen S., Friis S., Outzen M., Olsen A., Christensen J., et al. Micronutrient intake and risk of prostate cancer in a cohort of middle-aged, Danish men. Cancer Causes Control 2013, 1-7.
53. Rucklidge J.J., Kaplan B.J. Broad-spectrum micronutrient formulas for the treatment of psychiatric symptoms: a systematic review. Expert Rev Neurother 2013, 13:49-73.
54. Rucklidge J.J., Frampton C.M.A., Gorman B., Boggis A. Vitamin-mineral treatment of ADHD in adults: a double-blind, randomized, placebo controlled trial. Br J Psychiatry 2014, [in press]. 10.1192/bjp.bp.113.132126.
55. Rucklidge J.J., Johnstone J., Kaplan B.J. Single bullet madness-why do we continue to perpetuate this fallacy? (Letter). Br J Psychiatry 2013, 203:154-155.
56. Scassellati C., Bonvicini C., Faraone S.V., Gennarelli M. Biomarkers and attention-deficit/hyperactivity disorder: a systematic review and meta-analyses. J Am Acad Child Adolesc Psychiatry 2012, 51:1003-1019.
57. Seppala J., Koponen H., Kautiainen H., Eriksson J., Kampman O., Leiviska J., et al. Association between vitamin b12 levels and melancholic depressive symptoms: a Finnish population-based study. BMC Psychiatry 2013, 13:145.
58. Sever Y., Ashkenazi A., Tyano S., Weizman A. Iron treatment in children with attention deficit hyperactivity disorder: a preliminary report. Neuropsychobiology 1997, 35:178-180.
59. Simpson J.S.A., Crawford S.G., Goldstein E.T., Field C., Burgess E., Kaplan B.J. Systematic review of safety and tolerability of a complex micronutrient formula used in mental health. BMC Psychiatry 2011, 11.
60. Stewart R., Hirani V. Relationship between vitamin D levels and depressive symptoms in older residents from a national survey population. Psychosom Med 2010, 72:608-612.
61. Taylor M.J., Carney S.M., Goodwin G.M., Geddes J.R. Folate for depressive disorders: systematic review and meta-analysis of randomized controlled trials. J Psychopharmacol (Oxf) 2004, 18:251-256.
62. Torgersen T., Gjervan B., Rasmussen K. Treatment of adult ADHD: is current knowledge useful for clinicians?. J Neuropsychiatr Dis Treat 2008, 4:177-186.
63. Uckardes Y., Ozmert E.N., Unal F., Yurdakok K. Effects of zinc supplementation on parent and teacher behaviour rating scores in low socioeconomic level Turkish primary school children. Acta Paediatr 2009, 98:731-736.
64. Wapnir R.A. Copper absorption and bioavailability. Am J Clin Nutr 1998, 67:1054S-1060S.
65. Wechsler D. Manual for the WAIS-III 1997, Psychological Corporation, New York, NY.
66. Wilens T.E., Haight B.R., Horrigan J.P., Hudziak J.J., Rosenthal N.E., Connor D.F., et al. Bupropion XL in adults with attention-deficit/hyperactivity disorder: a randomized, placebo-controlled study. Biol Psychiatry 2005, 57:793-801.
67. Wilkins C.H., Sheline Y.I., Roe C.M., Birge S.J., Morris J.C. Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults. Am J Geriatr Psychiatry 2006, 14:1032-1040.
68. Zhang S.M., Cook N.R., Albert C.M., Gaziano J., Buring J.E., Manson J.E. Effect of combined folic acid, vitamin B6, and vitamin B12 on cancer risk in women: a randomized trial. JAMA 2008, 300:2012-2021.