αB-crystallin is a novel oncoprotein associated with poor prognosis in breast cancer

Journal of Breast Cancer

Volumn 14, Issue 1, 2011, Pages 14-19

  Kim, Hae Sung ^a   Lee, Younok ^a   Lim, Young Ah ^a   Kang, Hee Joon ^a   Kim, Lee Su ^a  

^a Hallym University College of Medicine   (South Korea)

Author keywords

B crystallin; Breast neoplasms; Lymph node metastasis; Triple negative breast cancer

Indexed keywords

CRYSTALLIN; EPIDERMAL GROWTH FACTOR RECEPTOR; ESTROGEN RECEPTOR; ONCOPROTEIN; PROGESTERONE RECEPTOR; TUMOR MARKER;

ADULT; AGED; ARTICLE; BREAST CANCER; CANCER INVASION; CANCER RECURRENCE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; PROGNOSIS; PROTEIN EXPRESSION;

EID: 79955393339     PISSN: 17386756     EISSN: None     Source Type: Journal    
DOI: 10.4048/jbc.2011.14.1.14     Document Type: Article

References (22)

1. Yehiely F, Moyano JV, Evans JR, Nielsen TO, Cryns VL. Deconstructing the molecular portrait of basal-like breast cancer. Trends Mol Med 2006; 12:537-544.
2. Pinder SE, Balsitis M, Ellis IO, Landon M, Mayer RJ, Lowe J. Te expression of alpha B-crystallin in epithelial tumours: a useful tumour marker? JPathol 1994;174:209-215.
3. Mehlen P, Mehlen A, Guillet D, Preville X, Arrigo AP. Tumor necrosis factor-alpha induces changes in the phosphorylation, cellular localization, and oligomerization of human hsp27, a stress protein that confers cellular resistance to this cytokine. J Cell Biochem 1995;58:248-259.
4. Sørlie T, Perou CM, Tibshirani R, Aas T, Geisler S, Johnsen H, et al. Gene expression patterns of breast carcinomas distinguish tumor subclasses with clinical implications. Proc Natl Acad Sci USA 2001;98:10869-10874.
5. Chelouche-Lev D, Kluger HM, Berger AJ, Rimm DL, Price JE. Alpha B-crystallin as a marker of lymph node involvement in breast carcinoma. Cancer 2004;100:2543-258.
6. Chin D, Boyle GM, Williams RM, Ferguson K, Pandeya N, Pedley J, et al. Alpha B-crystallin, a new independent marker for poor prognosis in head and neck cancer. Laryngoscope 2005;115:1239-1242.
7. Moyano JV, Evans JR, Chen F, Lu M, Werner ME, Yehiely F, et al. Alpha B-crystallin is a novel oncoprotein that predicts poor clinical outcome in breast cancer. J Clin Invest 2006;116:261-270.
8. Bosman JD, Yehiely F, Evans JR, Cryns VL. Regulation of alphaB-crys-tallin gene expression by the transcription factor Ets1 in breast cancer. Breast Cancer Res Treat 2010;119:63-70.
9. Fisher ER Anderson S, Redmond C, Fisher B. Pathologic findings from the National Surgical Adjuvant Breast Project protocol B-06.10-year pathologic and clinical prognostic discriminants. Cancer 1993;71:2507-2514.
10. Kim JO, Suh KS, Lee DH, Sul HJ, Lee JU, Song KS. Expression of CXCR4 and SDF-1 alpha in primary breast cancers and metastatic lymph nodes. J Breast Cancer 2009;12:249-256.
11. Dent R, Trudeau M, Pritchard KI, Hanna WM, Kahn HK, Sawka CA, et al. Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res 2007;13(15Pt 1):4429-4434.
12. Tischkowitz M, Brunet JS, Bégin LR, Huntsman DG, Cheang MC, Akslen LA, et al. Use of immunohistochemical markers can refine prognosis in triple negative breast cancer. BMC Cancer 2007;7:134.
13. Carey LA, Dees EC, Sawyer L, Gatti L, Moore DT, Collichio F, et al. Te triple negative paradox primary tumor chemosensitivity of breast cancer subtypes. Clin Cancer Res 2007;13:2329-2334.
14. Rakha EA, Tan DS, Foulkes WD, Ellis IO, Tutt A, Nielsen TO, et al. Are triple-negative tumours and basal-like breast cancer synonymous? Breast Cancer Res 2007;9:404.
15. Nielsen TO, Hsu FD, Jensen K, Cheang M, Karaca G, Hu Z, et al. Immunohistochemical and clinical characterization of the basal-like subtype of invasive breast carcinoma. Clin Cancer Res 2004; 10:5367-5374.
16. Perou CM, Sørlie T, Eisen MB, van de Rijn M, Jefrey SS, Rees CA, et al. Molecular portraits of human breast tumours. Nature 2000;406:747-752.
17. Sorlie T, Tibshirani R, Parker J, Hastie T, Marron JS, Nobel A, et al. Repeated observation of breast tumor subtypes in independent gene ex- pression data sets. Proc Natl Acad Sci USA 2003; 100:8418-8423.
18. Sitterding SM, Wiseman WR, Schiller CL, Luan C, Chen F, Moyano JV, et al. AlphaB-crystallin: a novel marker of invasive basal-like andmeta-plastic breast carcinomas. Ann Diagn Pathol 2008; 12:33-40.
19. Ivanov O, Chen F, Wiley EL, Keswani A, Diaz LK, Memmel HC, et al. AlphaB-crystallin is a novel predictor of resistance to neoadjuvant chemotherapy in breast cancer. Breast Cancer Res Treat 2008; 111:411-7.
20. Parcellier A, Gurbuxani S, Schmitt E, Solary E, Garrido C. Heat shock proteins, cellular chaperones that modulate mitochondrial cell death pathways. Biochem Biophys Res Commun 2003;304:505-512.
21. Beere HM. Stressed to death: regulation of apoptotic signaling pathways by the heat shock proteins. Sci STKE 2001;2001:re1.
22. Kamradt MC, Chen F, Cryns VL. Te small heat shock protein alpha B-crystallin negatively regulates cytochrome c- and caspase-8-dependent activation of caspase-3 by inhibiting its autoproteolytic maturation. J Biol Chem 2001;276:16059-16063.