Bauhinia championi (Benth.) Benth. polysaccharides upregulate Wnt/β-catenin signaling in chondrocytes

International Journal of Molecular Medicine

Volumn 32, Issue 6, 2013, Pages 1329-1336

  Li, Huiting ^a   Li, Xihai ^a   Liu, Guozhong ^b   Chen, Jiashou ^a   Weng, Xiaping ^a   Liu, Fayuan ^a   Xu, Huifeng ^a   Liu, Xianxiang ^a   Ye, Hongzhi ^a  

^a FUJIAN UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b FUJIAN MEDICAL UNIVERSITY   (China)

Author keywords

Bauhinia championi (Benth.) Benth. polysaccharides; Chondrocytes; Osteoarthritis; Signaling pathway

Indexed keywords

ARABINOSE; BAUHINIA CHAMPIONI EXTRACT; BETA CATENIN; COLLAGEN TYPE 2; CYCLIN D1; FRIZZLED 2 PROTEIN; FRIZZLED PROTEIN; GALACTOSE; GALACTURONIC ACID; GLUCOSE; GLUCURONIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; MANNOSE; MESSENGER RNA; PLANT EXTRACT; POLYSACCHARIDE; RHAMNOSE; UNCLASSIFIED DRUG; WNT PROTEIN; WNT4 PROTEIN;

ANIMAL CELL; ARTICLE; BAUHINIA; BAUHINIA CHAMPIONI; CARTILAGE CELL; CELL PROLIFERATION; CELL VIABILITY; CONTROLLED STUDY; DRUG ISOLATION; DRUG PURIFICATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; IMMUNOHISTOCHEMISTRY; MALE; MTT ASSAY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SPRAGUE DAWLEY RAT; UPREGULATION; WESTERN BLOTTING; WNT SIGNALING PATHWAY;

ANIMALS; BAUHINIA; CELL SHAPE; CELL SURVIVAL; CHONDROCYTES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; MALE; POLYSACCHARIDES; RATS; RATS, SPRAGUE-DAWLEY; RNA, MESSENGER; UP-REGULATION; WNT SIGNALING PATHWAY;

EID: 84892166049     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2013.1527     Document Type: Article

References (30)

1. Pitsillides AA and Beier F: Cartilage biology in osteoarthritis-lessons from developmental biology. Nat Rev Rheumatol 7: 654-663, 2011.
2. Wu Q, Zhu M, Rosier RN, Zuscik MJ, O'Keefe RJ and Chen D: Beta-catenin, cartilage, and osteoarthritis. Ann N Y Acad Sci 1192: 344-350, 2010.
3. Tao HY, He B, Liu SQ, et al: Effect of carboxymethylated chitosan on the biosynthesis of NGF and activation of the Wnt/β-catenin signaling pathway in the proliferation of Schwann cells. Eur J Pharmacol 702: 85-92, 2013.
4. Lu W, Tinsley HN, Keeton A, Qu Z, Piazza GA and Li Y: Suppression of Wnt/β-catenin signaling inhibits prostate cancer cell proliferation. Eur J Pharmacol 602: 8-14, 2009.
5. Akiyama T: Wnt/β-catenin signaling. Cytokine Growth Factor Rev 11: 273-282, 2000.
6. Li X, Peng J, Wu M, et al: BMP2 promotes chondrocyte proliferation via the Wnt/β-catenin signaling pathway. Mol Med Rep 4: 621-626, 2011.
7. Blom AB, van Lent PL, van der Kraan PM and van den Berg WB: To seek shelter from the Wnt in osteoarthritis? Wnt-signaling as a target for osteoarthritis therapy. Curr Drug Targets 11: 620-629, 2010.
8. Vlad-Fiegen A, Langerak A, Eberth S and Müller O: The Wnt pathway destabilizes adherens junctions and promotes cell migration via β-catenin and its target gene cyclin D1. FEBS Open Bio 2: 26-31, 2012.
9. Schepetkin IA and Quinn MT: Botanical polysaccharides: Macrophage immunomodulation and therapeutic potential. Int Immunopharmacol 6: 317-333, 2006.
10. Yu F, Li X, Cai L, et al: Achyranthes bidentata polysaccharides induce chondrocyte proliferation via the promotion of the G1/S cell cycle transition. Mol Med Rep 7: 935-940, 2013.
11. Gescher K and Deters AM: Typha latifolia L. fruit polysaccharides induce the differentiation and stimulate the proliferation of human keratinocytes in vitro. J Ethnopharmacol 137: 352-358, 2011.
12. Liu H, Fan Y, Wang W, Liu N, Zhang H, Zhu Z and Liu A: Polysaccharides from Lycium barbarum leaves: isolation, characterization and splenocyte proliferation activity. Int J Bio Macromol 51: 417-422, 2012.
13. Yao H, Chen Y, Li S, Huang L, Chen W and Lin X: Promotion proliferation effect of a polysaccharide from Aloe barbadensis Miller on human fibroblasts in vitro. Int J Bio Macromol 45: 152-156, 2009.
14. The Ministry of Science and Technology of the People's Republic of China: Guidance Suggestion for the Care and Use of Laboratory Animals, 2006.
15. Sevag MG: A new physical de-proteination method for representation of biologically effective substances-isolation of carbohygrates in chicken-protein and pneumococci. Biochemis Zeitschrift 273: 419-429, 1934.
16. Li X, Zhang H and Xu H: Analysis of chemical components of shiitake polysaccharides and its anti-fatigue effect under vibrational. Int J Bio Macromol 45: 377-380, 2009.
17. Yang Q, Wang S, Xie Y, Sun J and Wang J: HPLC analysis of Ganoderma lucidum polysaccharides and its effect on antioxidant enzymes activity and Bax, Bcl-2 expression. Int J Biol Macromol 46: 167-172, 2010.
18. Li X, Du M, Liu X, Chen W, Wu M, Lin J and Wu G: Milimeter wave treatment promote chondrocyte proliferation by upregulating the expression of cyclin-dependent kinase 2 and cyclin A. Int J Mol Med 26: 77-84, 2010.
19. Cai L, Ye H, Yu F, Li H, Chen J and Liu X: Effects of Bauhinia championii (Benth.) Benth. polysaccharides on the proliferation and cell cycle of chondrocytes. Mol Med Rep 7: 1624-1630, 2013.
20. Hirsch C, Campano LM, Wöhrle S and Hecht A: Canonical Wnt signaling transiently stimulates proliferation and enhances neurogenesis in neonatal neural progenitor cultures. Exp Cell Res 313: 572-587, 2007.
21. Chen Y, Guan Y, Liu H, et al: Activation of the Wnt/β-catenin signaling pathway is associated with glial proliferation in the adult spinal cord of ALS transgenic mice. Biochem Biophys Res Commun 420: 397-403, 2012.
22. Kang K, Lee KM, Yoo JH, Lee HJ, Kim CY and Nho CW: Dibenzocyclooctadie-ne lignans, gomisins J and N inhibit the Wnt/β-catenin signaling pathway in HCT116 cells. Biochem Biophys Res Commun 428: 285-291, 2012.
23. Kitagaki J, Iwamoto M, Liu JG, Tamamura Y, Pacifci M and Enomoto-lwamoto M: Activation of β-catenin -LEF/TCF signal pathway in chondrocytes stimulates ectopic endochondral ossification. Osteoarthritis Cartilage 11: 36-43, 2003.
24. Andrade AC, Nilsson O, Barnes KM and Baron J: Wnt gene expression in the post-natal growth plate: regulation with chondrocyte differentiation. Bone 40: 1361-1369, 2007.
25. Van Vijven JP, Luijsterburq PA, Verhagen AP, van Osch GJ, Kloppenburg M and Bierma-Zeinstra SM: Symptomatic and chondroprotective treatment with collagen derivatives in osteoarthritis: a systematic review. Osteoarthritis Cartilage 20: 809-821, 2012.
26. Kang M, Junq I, Hur J, et al: The analgesic and anti-inflammatory effect of WIN-34B, a new herbal formula for osteoarthritis composed of Lonicera japonica Thunb and Anemarrhena asphodeloides BUNGE in vivo. J Ethnopharmacol 131: 485-496, 2010.
27. Chan BY, Fuller ES, Russell AK, et al: Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis. Osteoarthritis Cartilage 19: 874-885, 2011.
28. Huang JG, Xia C, Zheng XP, Yi TT, Wang XY, Song G and Zhang B: 17β-Estradiol promotes cell proliferation in rat osteoarthritis model chondrocytes via PI3K/Akt pathway. Cell Mol Biol Lett 16: 564-575, 2011.
29. Wang C, Yuan X and Yang S: IFT80 is essential for chondrocyte differentiation by regulating Hedgehog and Wnt signaling pathways. Exp Cell Res 319: 623-632, 2013.
30. Bueno MJ and Malumbres M: MicroRNAs and the cell cycle. Biochim Biophys Acta 1812: 592-601, 2011.