The Protein 4.1 family: Hub proteins in animals for organizing membrane proteins

Biochimica et Biophysica Acta - Biomembranes

Volumn 1838, Issue 2, 2014, Pages 605-619

  Baines, Anthony J ^a   Lu, Hui Chun ^b   Bennett, Pauline M ^b  

^a UNIVERSITY OF KENT   (United Kingdom)

^b KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

FERM domain; Hub protein; Integral membrane protein; Membrane trafficking; Spectrin actin binding domain

Indexed keywords

ACTIN; ANKYRIN; CELL ADHESION MOLECULE; ERYTHROCYTE BAND 4.1 PROTEIN; F ACTIN; G PROTEIN COUPLED RECEPTOR; GUANYLATE KINASE; LIGAND GATED ION CHANNEL; MEMBRANE ASSOCIATED GUANYLATE CYCLASE KINASE; MEMBRANE PROTEIN; MESSENGER RNA; PDZ PROTEIN; PHOSPHOLIPID; SPECTRIN;

ANEMIA; CARBOXY TERMINAL SEQUENCE; CELL ADHESION; COMPLEX FORMATION; DIFFERENTIALLY EXPRESSED IN ADENOCARCINOMA OF THE LUNG GENE; ERYTHROCYTE; ERYTHROPOIESIS; FERM DOMAIN; HEART MUSCLE CELL; HUMAN; KNOCKOUT MOUSE; MEMBRANE STRUCTURE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN LIPID INTERACTION; PROTEIN PHOSPHORYLATION; REVIEW; RNA SPLICING; TUMOR SUPPRESSOR GENE; TUMOR SUPPRESSOR IN LUNG CANCER 1 GENE;

ACTINOPTERYGII; ANIMALIA; EUMETAZOA; INVERTEBRATA; MAMMALIA; VERTEBRATA;

C-TERMINAL DOMAIN; CTD; FA; FERM ADJACENT DOMAIN; FERM DOMAIN; HUB PROTEIN; INTEGRAL MEMBRANE PROTEIN; MEMBRANE TRAFFICKING; SAB; SPECTRIN-ACTIN BINDING DOMAIN;

ANIMALS; CYTOSKELETAL PROTEINS; MEMBRANE PROTEINS;

EID: 84892158141     PISSN: 00052736     EISSN: 18792642     Source Type: Journal    
DOI: 10.1016/j.bbamem.2013.05.030     Document Type: Review

References (191)

1. S.J. Singer, and G.L. Nicolson The fluid mosaic model of the structure of cell membranes Science 175 1972 720 731
2. J. Yu, D.A. Fischman, and T.L. Steck Selective solubilization of proteins and phospholipids from red blood cell membranes by nonionic detergents J. Supramol. Struct. 1 1973 233 248
3. L.L. Peters, H.U. Weier, L.D. Walensky, S.H. Snyder, M. Parra, N. Mohandas, and J.G. Conboy Four paralogous protein 4.1 genes map to distinct chromosomes in mouse and human Genomics 54 1998 348 350 (Pubitemid 28553647)
4. R.G. Fehon, I.A. Dawson, and S. Artavanistsakonas A Drosophila homolog of membrane-skeleton protein-4.1 is associated with septate junctions and is encoded by the coracle gene Development 120 1994 545 557 (Pubitemid 24071197)
5. A.J. Baines Evolution of spectrin function in cytoskeletal and membrane networks Biochem. Soc. Trans. 37 2009 796 803
6. J.G. Conboy, J. Chan, N. Mohandas, and Y.W. Kan Multiple protein 4.1 isoforms produced by alternative splicing in human erythroid cells Proc. Natl. Acad. Sci. U. S. A. 85 1988 9062 9065 (Pubitemid 19001841)
7. J. Conboy The role of alternative pre-mRNA splicing in regulating the structure and function of skeletal protein 4.1 Proc. Soc. Exp. Biol. Med. 220 1999 73 78
8. M. Parra, S. Gee, N. Chan, D. Ryaboy, I. Dubchak, N. Mohandas, P.D. Gascard, and J.G. Conboy Differential domain evolution and complex RNA processing in a family of paralogous EPB41 (protein 4.1) genes facilitate expression of diverse tissue-specific isoforms Genomics 84 2004 637 646 (Pubitemid 39310941)
9. A.J. Baines A FERM-adjacent (FA) region defines a subset of the 4.1 superfamily and is a potential regulator of FERM domain function BMC Genomics 7 2006 85
10. B.G. Han, W. Nunomura, Y. Takakuwa, N. Mohandas, and B.K. Jap Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization Nat. Struct. Biol. 7 2000 871 875
11. C. Scott, G.W. Phillips, and A.J. Baines Properties of the C-terminal domain of 4.1 proteins Eur. J. Biochem. 268 2001 3709 3717 (Pubitemid 32862909)
12. W. Nunomura, P. Gascard, and Y. Takakuwa Insights into the function of the unstructured n-terminal domain of proteins 4.1R and 4.1G in erythropoiesis Int. J. Cell Biol. 2011 2011 943272
13. J.A. Gimm, X. An, W. Nunomura, and N. Mohandas Functional characterization of spectrin-actin-binding domains in 4.1 family of proteins Biochemistry 41 2002 7275 7282 (Pubitemid 34602443)
14. T.L. Leto, and V.T. Marchesi A structural model of human-erythrocyte protein-4.1 J. Biol. Chem. 259 1984 4603 4608
15. J. Conboy, Y.W. Kan, S.B. Shohet, and N. Mohandas Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton Proc. Natl. Acad. Sci. U. S. A. 83 1986 9512 9516 (Pubitemid 17223390)
16. A.M. Cohen, S.C. Liu, J. Lawler, L. Derick, and J. Palek Identification of the protein 4.1 binding site to phosphatidylserine vesicles Biochemistry 27 1988 614 619 (Pubitemid 18043507)
17. A.H. Chishti, A.C. Kim, S.M. Marfatia, M. Lutchman, M. Hanspal, H. Jindal, S.C. Liu, P.S. Low, G.A. Rouleau, N. Mohandas, J.A. Chasis, J.G. Conboy, P. Gascard, Y. Takakuwa, S.C. Huang, E.J. Benz, A. Bretscher, R.G. Fehon, A.F. Gusella, V. Ramesh, F. Solomon, V.T. Marchesi, S. Tsukita, M. Arpin, D. Louvard, N.K. Tonks, J.M. Anderson, A.S. Fanning, P.J. Bryant, D.F. Woods, and K.B. Hoover The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane Trends Biochem. Sci. 23 1998 281 282 (Pubitemid 28461889)
18. U. Tepass FERM proteins in animal morphogenesis Curr. Opin. Genet. Dev. 19 2009 357 367
19. R.D. Busam, A.-G. Thorsell, A. Flores, M. Hammarström, C. Persson, B. Öbrink, and B.M. Hallberg Structural basis of Tumor Suppressor in Lung Cancer 1 (TSLC1) binding to Differentially Expressed in Adenocarcinoma of the Lung (DAL-1/4.1B) J. Biol. Chem. 286 2011 4511 4516
20. C. Vogel, C. Berzuini, M. Bashton, J. Gough, and S.A. Teichmann Supra-domains: evolutionary units larger than single protein domains J. Mol. Biol. 336 2004 809 823 (Pubitemid 38183030)
21. X.L. An, Y. Takakuwa, S. Manno, B.G. Han, P. Gascard, and N. Mohandas Structural and functional characterization of protein 4.1R- phosphatidylserine interaction: potential role in 4.1R sorting within cells J. Biol. Chem. 276 2001 35778 35785
22. H. Kusunoki, and T. Kohno Solution structure and glycophorin C binding studies of the protein 4.1R FERM alpha-lobe domain Proteins 76 2009 255 260
23. W. Nunomura, and Y. Takakuwa Regulation of protein 4.1R interactions with membrane proteins by Ca2 + and calmodulin Front. Biosci. 11 2006 1522 1539 (Pubitemid 43253439)
24. M. Salomao, X. Zhang, Y. Yang, S. Lee, J.H. Hartwig, J.A. Chasis, N. Mohandas, and X. An Protein 4.1R-dependent multiprotein complex: new insights into the structural organization of the red blood cell membrane Proc. Natl. Acad. Sci. U. S. A. 105 2008 8026 8031 (Pubitemid 351904701)
25. K.L. Waller, W. Nunomura, X. An, B.M. Cooke, N. Mohandas, and R.L. Coppel Mature parasite-infected erythrocyte surface antigen (MESA) of Plasmodium falciparum binds to the 30-kDa domain of protein 4.1 in malaria-infected red blood cells Blood 102 2003 1911 1914 (Pubitemid 37022592)
26. P.S. Seo, J.J. Jeong, L. Zeng, C.G. Takoudis, B.J. Quinn, A.A. Khan, T. Hanada, and A.H. Chishti Alternatively spliced exon 5 of the FERM domain of protein 4.1R encodes a novel binding site for erythrocyte p55 and is critical for membrane targeting in epithelial cells Biochim. Biophys. Acta 1793 2009 281 289
27. X. An, X. Zhang, G. Debnath, A.J. Baines, and N. Mohandas Phosphatidylinositol-4,5-biphosphate (PIP2) differentially regulates the interaction of human erythrocyte protein 4.1 (4.1R) with membrane proteins Biochemistry 45 2006 5725 5732
28. E. Gauthier, X. Guo, N. Mohandas, and X. An Phosphorylation-dependent perturbations of the 4.1R-associated multiprotein complex of the erythrocyte membrane Biochemistry 50 2011 4561 4567
29. S. Manno, Y. Takakuwa, and N. Mohandas Modulation of erythrocyte membrane mechanical function by protein 4.1 phosphorylation J. Biol. Chem. 280 2005 7581 7587 (Pubitemid 40349650)
30. E. Leclerc, and S. Vetter Characterization of a calcium-dependent calmodulin-binding domain in the 135-kD human protein 4.1 isoform Eur. J. Biochem. 258 1998 567 571 (Pubitemid 28557923)
31. W. Nunomura, M. Parra, M. Hebiguchi, K.I. Sawada, N. Mohandas, and Y. Takakuwa Marked difference in membrane protein binding properties of the two isoforms of protein 4.1R expressed at early and late stages of erythroid differentiation Biochem. J. 417 2009 141 148
32. Y. Takakuwa, and N. Mohandas Modulation of erythrocyte membrane material properties by Ca2 + and calmodulin. Implications for their role in regulation of skeletal protein interactions J. Clin. Invest. 82 1988 394 400
33. W. Nunomura, Y. Takakuwa, M. Parra, J.G. Conboy, and N. Mohandas Ca(2 +)-dependent and Ca(2 +)-independent calmodulin binding sites in erythrocyte protein 4.1. Implications for regulation of protein 4.1 interactions with transmembrane proteins J. Biol. Chem. 275 2000 6360 6367 (Pubitemid 30129930)
34. L. Shen, F. Liang, L.D. Walensky, and R.L. Huganir Regulation of AMPA receptor GluR1 subunit surface expression by a 4. 1N-linked actin cytoskeletal association J. Neurosci. 20 2000 7932 7940
35. S.K. Coleman, C. Cai, D.G. Mottershead, J.P. Haapalahti, and K. Keinanen Surface expression of GluR-D AMPA receptor is dependent on an interaction between its C-terminal domain and a 4.1 protein J. Neurosci. 23 2003 798 806 (Pubitemid 36206170)
36. K. Chen, C. Merino, S.J. Sigrist, and D.E. Featherstone The 4.1 protein coracle mediates subunit-selective anchoring of Drosophila glutamate receptors to the postsynaptic actin cytoskeleton J. Neurosci. 25 2005 6667 6675 (Pubitemid 40995299)
37. C. Liu, H. Weng, L. Chen, S. Yang, H. Wang, G. Debnath, X. Guo, L. Wu, N. Mohandas, and X. An Impaired intestinal calcium absorption in protein 4.1R-deficient mice due to altered expression of plasma membrane calcium ATPase 1b (PMCA1b) J. Biol. Chem. 288 2013 11407 11415
38. S.N. Mattagajasingh, S.C. Huang, J.S. Hartenstein, M. Snyder, V.T. Marchesi, and E.J. Benz A nonerythroid isoform of protein 4.1R interacts with the nuclear mitotic apparatus (NuMA) protein J. Cell Biol. 145 1999 29 43 (Pubitemid 29177673)
39. L.D. Walensky, P. Gascard, M.E. Fields, S. Blackshaw, J.G. Conboy, N. Mohandas, and S.H. Snyder The 13-kD FK506 binding protein, FKBP13, interacts with a novel homologue of the erythrocyte membrane cytoskeletal protein 4.1 J. Cell Biol. 141 1998 143 153 (Pubitemid 28182647)
40. M. Parra, P. Gascard, L.D. Walensky, J.A. Gimm, S. Blackshaw, N. Chan, Y. Takakuwa, T. Berger, G. Lee, J.A. Chasis, S.H. Snyder, N. Mohandas, and J.G. Conboy Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain J. Biol. Chem. 275 2000 3247 3255 (Pubitemid 30083025)
41. J.P. Huang, C.J. Tang, G.H. Kou, V.T. Marchesi, E.J. Benz Jr., and T.K. Tang Genomic structure of the locus encoding protein 4.1. Structural basis for complex combinational patterns of tissue-specific alternative RNA splicing J. Biol. Chem. 268 1993 3758 3766 (Pubitemid 23071026)
42. F. Baklouti, S.C. Huang, T.J. Vulliamy, J. Delaunay, and E.J. Benz Jr. Organization of the human protein 4.1 genomic locus: new insights into the tissue-specific alternative splicing of the pre-mRNA Genomics 39 1997 289 302 (Pubitemid 27078695)
43. P. Gascard, G. Lee, L. Coulombel, I. Auffray, M. Lum, M. Parra, J.G. Conboy, N. Mohandas, and J.A. Chasis Characterization of multiple isoforms of protein 4.1R expressed during erythroid terminal differentiation Blood 92 1998 4404 4414 (Pubitemid 28544358)
44. J.G. Conboy, J.Y. Chan, J.A. Chasis, Y.W. Kan, and N. Mohandas Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1 J. Biol. Chem. 266 1991 8273 8280 (Pubitemid 21906508)
45. W. Nunomura, Y. Jinbo, N. Isozumi, S. Ohki, Y. Izumi, N. Matsushima, and Y. Takakuwa Novel mechanism of regulation of protein 4.1G binding properties through Ca(2 +)/calmodulin-mediated structural changes Cell Biochem. Biophys. 2013
46. I. Correas, D.W. Speicher, and V.T. Marchesi Structure of the spectrin-actin binding-site of erythrocyte protein 4.1 J. Biol. Chem. 261 1986 3362 3366
47. D. Discher, M. Parra, J.G. Conboy, and N. Mohandas Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1 J. Biol. Chem. 268 1993 7186 7195 (Pubitemid 23105609)
48. D.E. Discher, R. Winardi, P.O. Schischmanoff, M. Parra, J.G. Conboy, and N. Mohandas Mechanochemistry of protein 4.1's spectrin-actin-binding domain: ternary complex interactions, membrane binding, network integration, structural strengthening J. Cell Biol. 130 1995 897 907
49. J.A. Chasis, L. Coulombel, J. Conboy, S. McGee, K. Andrews, Y.W. Kan, and N. Mohandas Differentiation-associated switches in protein 4.1 expression. Synthesis of multiple structural isoforms during normal human erythropoiesis J. Clin. Invest. 91 1993 329 338 (Pubitemid 23037288)
50. F. Baklouti, S.C. Huang, T.K. Tang, J. Delaunay, V.T. Marchesi, and E.J. Benz Jr. Asynchronous regulation of splicing events within protein 4.1 pre-mRNA during erythroid differentiation Blood 87 1996 3934 3941 (Pubitemid 26129624)
51. P.O. Schischmanoff, P. Yaswen, M.K. Parra, G. Lee, J.A. Chasis, N. Mohandas, and J.G. Conboy Cell shape-dependent regulation of protein 4.1 alternative pre-mRNA splicing in mammary epithelial cells J. Biol. Chem. 272 1997 10254 10259 (Pubitemid 27171706)
52. A.J. Baines Evolution of the spectrin-based membrane skeleton Transfus. Clin. Biol. 17 2010 95 103
53. S.L. Gee, K. Aoyagi, R. Lersch, V. Hou, M. Wu, and J.G. Conboy Alternative splicing of protein 4.1R exon 16: ordered excision of flanking introns ensures proper splice site choice Blood 95 2000 692 699 (Pubitemid 30041688)
54. M.L. Yamamoto, T.A. Clark, S.L. Gee, J.A. Kang, A.C. Schweitzer, A. Wickrema, and J.G. Conboy Alternative pre-mRNA splicing switches modulate gene expression in late erythropoiesis Blood 113 2009 3363 3370
55. P.M. Taylor-Harris, L.A. Keating, A.M. Maggs, G.W. Phillips, E.J. Birks, R.C. Franklin, M.H. Yacoub, A.J. Baines, and J.C. Pinder Cardiac muscle cell cytoskeletal protein 4.1: analysis of transcripts and subcellular location-relevance to membrane integrity, microstructure, and possible role in heart failure Mamm. Genome 16 2005 137 151 (Pubitemid 40569190)
56. J.C. Pinder, and W.B. Gratzer Structural and dynamic states of actin in the erythrocyte J. Cell Biol. 96 1983 768 775 (Pubitemid 13131339)
57. V.M. Fowler Regulation of actin filament length in erythrocytes and striated muscle Curr. Opin. Cell Biol. 8 1996 86 96 (Pubitemid 26059707)
58. V.M. Fowler Tropomodulin: a cytoskeletal protein that binds to the end of erythrocyte tropomyosin and inhibits tropomyosin binding to actin J. Cell Biol. 111 1990 471 481
59. P.A. Kuhlman, C.A. Hughes, V. Bennett, and V.M. Fowler A new function for adducin. Calcium/calmodulin-regulated capping of the barbed ends of actin filaments J. Biol. Chem. 271 1996 7986 7991
60. T. Franco, and P.S. Low Erythrocyte adducin: a structural regulator of the red blood cell membrane Transfus. Clin. Biol. 17 2010 87 94
61. J.C. Pinder, V. Ohanian, and W.B. Gratzer Spectrin and protein 4.1 as an actin filament capping complex FEBS Lett. 169 1984 161 164 (Pubitemid 14140532)
62. X. An, G. Debnath, X. Guo, S. Liu, S.E. Lux, A. Baines, W. Gratzer, and N. Mohandas Identification and functional characterization of protein 4.1R and actin-binding sites in erythrocyte beta spectrin: regulation of the interactions by phosphatidylinositol-4,5-bisphosphate Biochemistry 44 2005 10681 10688 (Pubitemid 41098244)
63. A. Kontrogianni-Konstantopoulos, S.C. Huang, and E.J. Benz Jr. A nonerythroid isoform of protein 4.1R interacts with components of the contractile apparatus in skeletal myofibers Mol. Biol. Cell 11 2000 3805 3817
64. X. An, X. Guo, W. Gratzer, and N. Mohandas Phospholipid binding by proteins of the spectrin family: a comparative study Biochem. Biophys. Res. Commun. 327 2005 794 800 (Pubitemid 40092819)
65. X. An, X. Guo, Y. Wu, and N. Mohandas Phosphatidylserine binding sites in red cell spectrin Blood Cells Mol. Dis. 32 2004 430 432 (Pubitemid 38581865)
66. W. Diakowski, and A. Sikorski Brain spectrin exerts much stronger effect on anionic phospholipid monolayers than erythroid spectrin Biochim. Biophys. Acta 1564 2002 403 411
67. A.F. Sikorski, K. Michalak, and M. Bobrowska Interaction of spectrin with phospholipids. Quenching of spectrin intrinsic fluorescence by phospholipid suspensions Biochim. Biophys. Acta 904 1987 55 60
68. S.C. Liu, L.H. Derick, and J. Palek Visualization of the hexagonal lattice in the erythrocyte membrane skeleton J. Cell Biol. 104 1987 527 536 (Pubitemid 17024707)
69. G. Tchernia, N. Mohandas, and S.B. Shohet Deficiency of skeletal membrane protein band 4.1 in homozygous hereditary elliptocytosis. Implications for erythrocyte membrane stability J. Clin. Invest. 68 1981 454 460 (Pubitemid 11039625)
70. Y. Takakuwa, G. Tchernia, M. Rossi, M. Benabadji, and N. Mohandas Restoration of normal membrane stability to unstable protein 4.1-deficient erythrocyte membranes by incorporation of purified protein 4.1 J. Clin. Invest. 78 1986 80 85 (Pubitemid 16068184)
71. P.G. Gallagher Hereditary elliptocytosis: spectrin and protein 4.1R Semin. Hematol. 41 2004 142 164 (Pubitemid 38509639)
72. X. An, and N. Mohandas Disorders of red cell membrane Br. J. Haematol. 141 2008 367 375 (Pubitemid 351521152)
73. M.E. Reid, Y. Takakuwa, J. Conboy, G. Tchernia, and N. Mohandas Glycophorin C content of human erythrocyte membrane is regulated by protein 4.1 Blood 75 1990 2229 2234 (Pubitemid 20181176)
74. N. Dalla Venezia, F. Gilsanz, N. Alloisio, M.T. Ducluzeau, E. Benz Jr., and J. Delaunay Homozygous 4.1(-) hereditary elliptocytosis associated with a point mutation in the downstream initiation codon of protein 4.1 gene J. Clin. Invest. 90 1992 1713 1717
75. K.P. Jeremy, Z.E. Plummer, D.J. Head, T.E. Madgett, K.L. Sanders, A. Wallington, J.R. Storry, F. Gilsanz, J. Delaunay, and N.D. Avent 4.1R-deficient human red blood cells have altered phosphatidylserine exposure pathways and are deficient in CD44 and CD47 glycoproteins Haematologica 94 2009 1354 1361
76. N. Alloisio, N. Dalla Venezia, A. Rana, K. Andrabi, P. Texier, F. Gilsanz, J.P. Cartron, J. Delaunay, and A.H. Chishti Evidence that red blood cell protein p55 may participate in the skeleton-membrane linkage that involves protein 4.1 and glycophorin C Blood 82 1993 1323 1327 (Pubitemid 23254009)
77. Z.T. Shi, V. Afzal, B. Coller, D. Patel, J.A. Chasis, M. Parra, G. Lee, C. Paszty, M. Stevens, L. Walensky, L.L. Peters, N. Mohandas, E. Rubin, and J.G. Conboy Protein 4.1R-deficient mice are viable but have erythroid membrane skeleton abnormalities J. Clin. Invest. 103 1999 331 340 (Pubitemid 29069982)
78. Z.T. Shi, L.D. Walensky, S.H. Snyder, R.J. Nelson, J.G. Conboy, N. Mohandas, and E. Rubin Protein 4.1-R knockout mice exhibit mechanically unstable erythrocytes and unexpected neurological defects Blood 90 1997 1168-1168
79. E. Lospitao, C.M. Perez-Ferreiro, A. Gosalbez, M.A. Alonso, and I. Correas An internal ribosome entry site element directs the synthesis of the 80 kDa isoforms of protein 4.1R BMC Biol. 6 2008 51
80. M.A. Stagg, E. Carter, N. Sohrabi, U. Siedlecka, G.K. Soppa, F. Mead, N. Mohandas, P. Taylor-Harris, A. Baines, P. Bennett, M.H. Yacoub, J.C. Pinder, and C.M.N. Terracciano Cytoskeletal protein 4.1R affects repolarization and regulates calcium handling in the heart Circ. Res. 103 2008 855 863
81. A. Rivera, L. De Franceschi, L.L. Peters, P. Gascard, N. Mohandas, and C. Brugnara Effect of complete protein 4.1R deficiency on ion transport properties of murine erythrocytes Am. J. Physiol. Cell Physiol. 291 2006 C880 C886
82. W. Nunomura, S.P. Denker, D.L. Barber, Y. Takakuwa, and P. Gascard Characterization of cytoskeletal protein 4.1R interaction with NHE1 (Na +/H + exchanger isoform 1) Biochem. J. 446 2012 427 435
83. J.C. Pinder, P.M. Taylor-Harris, P.M. Bennett, E. Carter, N.V. Hayes, M.D. King, M.R. Holt, A.M. Maggs, P. Gascard, and A.J. Baines Isoforms of protein 4.1 are differentially distributed in heart muscle cells: relation of 4.1R and 4.1G to components of the Ca(2 +) homeostasis system Exp. Cell Res. 318 2012 1467 1479
84. Q. Kang, Y. Yu, X. Pei, R. Hughes, S. Heck, X. Zhang, X. Guo, G. Halverson, N. Mohandas, and X. An Cytoskeletal protein 4.1R negatively regulates T-cell activation by inhibiting the phosphorylation of LAT Blood 113 2009 6128 6137
85. L. Chen, R.A. Hughes, A.J. Baines, J. Conboy, N. Mohandas, and X. An Protein 4.1R regulates cell adhesion, spreading, migration and motility of mouse keratinocytes by modulating surface expression of {beta}1 integrin J. Cell Sci. 124 2011 2478 2487
86. Y.K. Tran, O. Bogler, K.M. Gorse, I. Wieland, M.R. Green, and I.F. Newsham A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer Cancer Res. 59 1999 35 43 (Pubitemid 29062951)
87. Y. Zhang, R. Xu, G. Li, X. Xie, J. Long, and H. Wang Loss of expression of the differentially expressed in adenocarcinoma of the lung (DAL-1) protein is associated with metastasis of non-small cell lung carcinoma cells Tumour Biol. 33 2012 1915 1925
88. M. Yageta, M. Kuramochi, M. Masuda, T. Fukami, H. Fukuhara, T. Maruyama, M. Shibuya, and Y. Murakami Direct association of TSLC1 and DAL-1, two distinct tumor suppressor proteins in lung cancer Cancer Res. 62 2002 5129 5133 (Pubitemid 35024580)
89. Y. Takahashi, M. Iwai, T. Kawai, A. Arakawa, T. Ito, M. Sakurai-Yageta, A. Ito, A. Goto, M. Saito, F. Kasumi, and Y. Murakami Aberrant expression of tumor suppressors CADM1 and 4.1B in invasive lesions of primary breast cancer Breast Cancer 19 2012 242 252
90. M. Nagata, M. Sakurai-Yageta, D. Yamada, A. Goto, A. Ito, H. Fukuhara, H. Kume, T. Morikawa, M. Fukayama, Y. Homma, and Y. Murakami Aberrations of a cell adhesion molecule CADM4 in renal clear cell carcinoma Int. J. Cancer 130 2012 1329 1337
91. T. Tsujiuchi, T. Masaoka, E. Sugata, M. Onishi, H. Fujii, K. Shimizu, and K. Honoki Hypermethylation of the Dal-1 gene in lung adenocarcinomas induced by N-nitrosobis(2-hydroxypropyl)amine in rats Mol. Carcinog. 46 2007 819 823 (Pubitemid 47549768)
92. D.H. Gutmann, J. Donahoe, A. Perry, N. Lemke, K. Gorse, K. Kittiniyom, S.A. Rempel, J.A. Gutierrez, and I.F. Newsham Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas Hum. Mol. Genet. 9 2000 1495 1500 (Pubitemid 30386704)
93. A. Perry, D.X. Cai, B.W. Scheithauer, P.E. Swanson, C.M. Lohse, I.F. Newsham, A. Weaver, and D.H. Gutmann Merlin, DAL-1, and progesterone receptor expression in clinicopathologic subsets of meningioma: a correlative immunohistochemical study of 175 cases J. Neuropathol. Exp. Neurol. 59 2000 872 879
94. D.H. Gutmann, A.C. Hirbe, Z. Huang, and C.A. Haipek The protein 4.1 tumor suppressor, dal-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion Neurobiol. Dis. 8 2001 266 278 (Pubitemid 32382480)
95. S.Y. Wong, H. Haack, J.L. Kissil, M. Barry, R.T. Bronson, S.S. Shen, C.A. Whittaker, D. Crowley, and R.O. Hynes Protein 4.1B suppresses prostate cancer progression and metastasis Proc. Natl. Acad. Sci. U. S. A. 104 2007 12784 12789 (Pubitemid 47255232)
96. R. Kuns, J.L. Kissil, I.F. Newsham, T. Jacks, D.H. Gutmann, and L.S. Sherman Protein 4.1B expression is induced in mammary epithelial cells during pregnancy and regulates their proliferation Oncogene 24 2005 6502 6515 (Pubitemid 41486633)
97. V.A. Robb, W. Li, P. Gascard, A. Perry, N. Mohandas, and D.H. Gutmann Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis Neurobiol. Dis. 13 2003 191 202 (Pubitemid 36937202)
98. L.M. Negi, S. Talegaonkar, M. Jaggi, F.J. Ahmad, Z. Iqbal, and R.K. Khar Role of CD44 in tumour progression and strategies for targeting J. Drug Target. 20 2012 561 573
99. Z. Ji, X. Shi, X. Liu, Y. Shi, Q. Zhou, X. Liu, L. Li, X. Ji, Y. Gao, Y. Qi, and Q. Kang The membrane-cytoskeletal protein 4.1N is involved in the process of cell adhesion, migration and invasion of breast cancer cells Exp. Ther. Med. 4 2012 736 740
100. C.X. Sun, V.A. Robb, and D.H. Gutmann Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation J. Cell Sci. 115 2002 3991 4000 (Pubitemid 35446798)
101. M. Ramez, M. Blot-Chabaud, F. Cluzeaud, S. Chanan, M. Patterson, L.D. Walensky, S. Marfatia, A.J. Baines, J.A. Chasis, J.G. Conboy, N. Mohandas, and P. Gascard Distinct distribution of specific members of protein 4.1 gene family in the mouse nephron Kidney Int. 63 2003 1321 1337 (Pubitemid 36349998)
102. S. Yang, X. Guo, G. Debnath, N. Mohandas, and X. An Protein 4.1R links E-cadherin/beta-catenin complex to the cytoskeleton through its direct interaction with beta-catenin and modulates adherens junction integrity Biochim. Biophys. Acta 1788 2009 1458 1465
103. S. Yang, H. Weng, L. Chen, X. Guo, M. Parra, J. Conboy, G. Debnath, A.J. Lambert, L.L. Peters, A.J. Baines, N. Mohandas, and X. An Lack of protein 4.1G causes altered expression and localization of the cell adhesion molecule nectin-like 4 in testis and can cause male infertility Mol. Cell. Biol. 31 2011 2276 2286
104. Y. Zhou, G. Du, X. Hu, S. Yu, Y. Liu, Y. Xu, X. Huang, J. Liu, B. Yin, M. Fan, X. Peng, B. Qiang, and J. Yuan Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane Biochim. Biophys. Acta 1669 2005 142 154 (Pubitemid 40704732)
105. E.D. Buttermore, J.L. Dupree, J. Cheng, X. An, L. Tessarollo, and M.A. Bhat The cytoskeletal adaptor protein band 4.1B is required for the maintenance of paranodal axoglial septate junctions in myelinated axons J. Neurosci. 31 2011 8013 8024
106. C. Cifuentes-Diaz, F. Chareyre, M. Garcia, J. Devaux, M. Carnaud, G. Levasseur, M. Niwa-Kawakita, S. Harroch, J.A. Girault, M. Giovannini, and L. Goutebroze Protein 4.1B contributes to the organization of peripheral myelinated axons PLoS One 6 2011 e25043
107. L. Gollan, H. Sabanay, S. Poliak, E.O. Berglund, B. Ranscht, and E. Peles Retention of a cell adhesion complex at the paranodal junction requires the cytoplasmic region of Caspr J. Cell Biol. 157 2002 1247 1256 (Epub 2002 Jun 1224) (Pubitemid 34847794)
108. N. Denisenko-Nehrbass, K. Oguievetskaia, L. Goutebroze, T. Galvez, H. Yamakawa, O. Ohara, M. Carnaud, and J.A. Girault Protein 4.1B associates with both Caspr/paranodin and Caspr2 at paranodes and juxtaparanodes of myelinated fibres Eur. J. Neurosci. 17 2003 411 416 (Pubitemid 36469295)
109. Y. Jung, J.L. Kissil, and J.H. McCarty beta8 integrin and band 4.1B cooperatively regulate morphogenesis of the embryonic heart Dev. Dyn. 240 2011 271 277
110. R.E.t. Ward, R.S. Lamb, and R.G. Fehon A conserved functional domain of Drosophila coracle is required for localization at the septate junction and has membrane-organizing activity J. Cell Biol. 140 1998 1463 1473 (Pubitemid 28152994)
111. J.L. Genova, and R.G. Fehon Neuroglian, Gliotactin, and the Na +/K + ATPase are essential for septate junction function in Drosophila J. Cell Biol. 161 2003 979 989 (Pubitemid 36718430)
112. D. Dhermy, M. Garbarz, M.C. Lecomte, C. Feo, O. Bournier, I. Chaveroche, H. Gautero, C. Galand, and P. Boivin Hereditary elliptocytosis: clinical, morphological and biochemical studies of 38 cases Nou.v Rev. Fr. Hemato. 28 1986 129 140
113. M. Salomao, K. Chen, J. Villalobos, N. Mohandas, X. An, and J.A. Chasis Hereditary spherocytosis and hereditary elliptocytosis: aberrant protein sorting during erythroblast enucleation Blood 116 2010 267 269
114. W.A. Anong, T. Franco, H. Chu, T.L. Weis, E.E. Devlin, D.M. Bodine, X. An, N. Mohandas, and P.S. Low Adducin forms a bridge between the erythrocyte membrane and its cytoskeleton and regulates membrane cohesion Blood 114 2009 1904 1912
115. A.A. Khan, T. Hanada, M. Mohseni, J.J. Jeong, L. Zeng, M. Gaetani, D. Li, B.C. Reed, D.W. Speicher, and A.H. Chishti Dematin and adducin provide a novel link between the spectrin cytoskeleton and human erythrocyte membrane by directly interacting with glucose transporter-1 J. Biol. Chem. 283 2008 14600 14609
116. P.M. Bennett, A.M. Maggs, A.J. Baines, and J.C. Pinder The transitional junction: a new functional subcellular domain at the intercalated disc Mol. Biol. Cell 17 2006 2091 2100 (Pubitemid 44011621)
117. J.S. Lowe, O. Palygin, N. Bhasin, T.J. Hund, P.A. Boyden, E. Shibata, M.E. Anderson, and P.J. Mohler Voltage-gated Nav channel targeting in the heart requires an ankyrin-G dependent cellular pathway J. Cell Biol. 180 2008 173 186
118. P.J. Mohler, I. Rivolta, C. Napolitano, G. LeMaillet, S. Lambert, S.G. Priori, and V. Bennett Nav1.5 E1053K mutation causing Brugada syndrome blocks binding to ankyrin-G and expression of Nav1.5 on the surface of cardiomyocytes Proc. Natl. Acad. Sci. U. S. A. 101 2004 17533 17538 (Pubitemid 39657438)
119. A.V. Binda, N. Kabbani, R. Lin, and R. Levenson D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N Mol. Pharmacol. 62 2002 507 513 (Pubitemid 36329368)
120. D. Lu, H. Yan, T. Othman, and S.A. Rivkees Cytoskeletal protein 4.1G is a binding partner of the metabotropic glutamate receptor subtype 1alpha J. Neurosci. Res. 78 2004 49 55 (Pubitemid 39305153)
121. D. Lu, H. Yan, T. Othman, C.P. Turner, T. Woolf, and S.A. Rivkees Cytoskeletal protein 4.1G binds to the third intracellular loop of the A1 adenosine receptor and inhibits receptor action Biochem. J. 377 2004 51 59 (Pubitemid 38114431)
122. M. Saito, M. Sugai, Y. Katsushima, T. Yanagisawa, J. Sukegawa, and N. Nakahata Increase in cell-surface localization of parathyroid hormone receptor by cytoskeletal protein 4.1G Biochem. J. 392 2005 75 81 (Pubitemid 41689403)
123. D.T. Lin, Y. Makino, K. Sharma, T. Hayashi, R. Neve, K. Takamiya, and R.L. Huganir Regulation of AMPA receptor extrasynaptic insertion by 4.1N, phosphorylation and palmitoylation Nat. Neurosci. 12 2009 879 887
124. J.L. Hoy, J.R. Constable, S. Vicini, Z. Fu, and P. Washbourne SynCAM1 recruits NMDA receptors via protein 4.1B Mol. Cell. Neurosci. 42 2009 466 483
125. C. Wozny, J. Breustedt, F. Wolk, F. Varoqueaux, S. Boretius, A.R. Zivkovic, A. Neeb, J. Frahm, D. Schmitz, N. Brose, and A. Ivanovic The function of glutamatergic synapses is not perturbed by severe knockdown of 4.1N and 4.1G expression J. Cell Sci. 122 2009 735 744
126. M.J. Fiedler, and M.H. Nathanson The type I inositol 1,4,5-trisphosphate receptor interacts with protein 4.1N to mediate neurite formation through intracellular Ca waves Neurosignals 19 2011 75 85
127. K. Fukatsu, H. Bannai, T. Inoue, and K. Mikoshiba 4.1N binding regions of inositol 1,4,5-trisphosphate receptor type 1 Biochem. Biophys. Res. Commun. 342 2006 573 576 (Pubitemid 43289028)
128. K. Fukatsu, H. Bannai, S. Zhang, H. Nakamura, T. Inoue, and K. Mikoshiba Lateral diffusion of inositol 1,4,5-trisphosphate receptor type 1 is regulated by actin filaments and 4.1N in neuronal dendrites J. Biol. Chem. 279 2004 48976 48982 (Pubitemid 39625779)
129. A. Maximov, T.S. Tang, and I. Bezprozvanny Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons Mol. Cell. Neurosci. 22 2003 271 283 (Pubitemid 36379190)
130. S. Sehgal, M.T. Guerra, E.A. Kruglov, J. Wang, and M.H. Nathanson Protein 4.1N does not interact with the inositol 1,4,5-trisphosphate receptor in an epithelial cell line Cell Calcium 38 2005 469 480 (Pubitemid 41403663)
131. S. Zhang, A. Mizutani, C. Hisatsune, T. Higo, H. Bannai, T. Nakayama, M. Hattori, and K. Mikoshiba Protein 4.1N is required for translocation of inositol 1,4,5-trisphosphate receptor type 1 to the basolateral membrane domain in polarized Madin-Darby canine kidney cells J. Biol. Chem. 278 2003 4048 4056 (Pubitemid 36801139)
132. D.L. Cioffi, S. Wu, M. Alexeyev, S.R. Goodman, M.X. Zhu, and T. Stevens Activation of the endothelial store-operated ISOC Ca2 + channel requires interaction of protein 4.1 with TRPC4 Circ. Res. 97 2005 1164 1172
133. H. Li, S. Khirug, C. Cai, A. Ludwig, P. Blaesse, J. Kolikova, R. Afzalov, S.K. Coleman, S. Lauri, M.S. Airaksinen, K. Keinanen, L. Khiroug, M. Saarma, K. Kaila, and C. Rivera KCC2 interacts with the dendritic cytoskeleton to promote spine development Neuron 56 2007 1019 1033 (Pubitemid 350251117)
134. P. Penzes Pumping up the synapse Neuron 56 2007 942 944 (Pubitemid 350251125)
135. R.A. Lue, S.M. Marfatia, D. Branton, and A.H. Chishti Cloning and characterization of hdlg: the human homologue of the Drosophila discs large tumor suppressor binds to protein 4.1 Proc. Natl. Acad. Sci. U. S. A. 91 1994 9818 9822 (Pubitemid 24311899)
136. T. Hanada, A. Takeuchi, G. Sondarva, and A.H. Chishti Protein 4.1-mediated membrane targeting of human discs large in epithelial cells J. Biol. Chem. 278 2003 34445 34450 (Pubitemid 37553291)
137. S.M. Marfatia, R.A. Lue, D. Branton, and A.H. Chishti In-vitro binding-studies suggest a membrane-associated complex between erythroid P55, Protein-4.1, and Glycophorin-C J. Biol. Chem. 269 1994 8631 8634 (Pubitemid 24209163)
138. N.J. Hemming, D.J. Anstee, M.A. Staricoff, M.J.A. Tanner, and N. Mohandas Identification of the membrane attachment sites for protein-4.1 in the human erythrocyte J. Biol. Chem. 270 1995 5360 5366
139. S.M. Marfatia, R.A. Leu, D. Branton, and A.H. Chishti Identification of the protein 4.1 binding interface on glycophorin C and p55, a homologue of the Drosophila discs-large tumor suppressor protein J. Biol. Chem. 270 1995 715 719
140. S.N. Mattagajasingh, S.C. Huang, J.S. Hartenstein, and E.J. Benz Jr. Characterization of the interaction between protein 4.1R and ZO-2. A possible link between the tight junction and the actin cytoskeleton J. Biol. Chem. 275 2000 30573 30585
141. N. Terada, N. Ohno, S. Saitoh, G. Seki, M. Komada, T. Suzuki, H. Yamakawa, M. Soleimani, and S. Ohno Interaction of membrane skeletal protein, protein 4.1B and p55, and sodium bicarbonate cotransporter1 in mouse renal S1-S2 proximal tubules J. Histochem. Cytochem. 55 2007 1199 1206 (Pubitemid 350156077)
142. G. Rumbaugh, G.M. Sia, C.C. Garner, and R.L. Huganir Synapse-associated protein-97 isoform-specific regulation of surface AMPA receptors and synaptic function in cultured neurons J. Neurosci. 23 2003 4567 4576 (Pubitemid 36706187)
143. J. Douyard, L. Shen, R.L. Huganir, and M.E. Rubio Differential neuronal and glial expression of GluR1 AMPA receptor subunit and the scaffolding proteins SAP97 and 4.1N during rat cerebellar development J. Comp. Neurol. 502 2007 141 156 (Pubitemid 46481935)
144. D. Karnak, S. Lee, and B. Margolis Identification of multiple binding partners for the amino-terminal domain of synapse-associated protein 97 J. Biol. Chem. 277 2002 46730 46735 (Pubitemid 35417675)
145. D. Leonoudakis, L.R. Conti, C.M. Radeke, L.M. McGuire, and C.A. Vandenberg A multiprotein trafficking complex composed of SAP97, CASK, Veli, and Mint1 is associated with inward rectifier Kir2 potassium channels J. Biol. Chem. 279 2004 19051 19063 (Epub 12004 Feb 19011) (Pubitemid 38623336)
146. O. Jeyifous, C.L. Waites, C.G. Specht, S. Fujisawa, M. Schubert, E.I. Lin, J. Marshall, C. Aoki, T. de Silva, J.M. Montgomery, C.C. Garner, and W.N. Green SAP97 and CASK mediate sorting of NMDA receptors through a previously unknown secretory pathway Nat. Neurosci. 12 2009 1011 1019
147. N. Terada, Y. Saitoh, N. Ohno, M. Komada, S. Saitoh, E. Peles, and S. Ohno Essential function of protein 4.1G in targeting of membrane protein palmitoylated 6 into Schmidt-Lanterman incisures in myelinated nerves Mol. Cell. Biol. 32 2012 199 205
148. K.J. Ralston, S.L. Hird, X. Zhang, J.L. Scott, B. Jin, R.F. Thorne, M.C. Berndt, A.W. Boyd, and G.F. Burns The LFA-1-associated molecule PTA-1 (CD226) on T cells forms a dynamic molecular complex with protein 4.1G and human discs large J. Biol. Chem. 279 2004 33816 33828 (Pubitemid 39063031)
149. T. Goto, A. Chiba, J. Sukegawa, T. Yanagisawa, M. Saito, and N. Nakahata Suppression of adenylyl cyclase-mediated cAMP production by plasma membrane associated cytoskeletal protein 4.1G Cell. Signal. 25 2012 690 697
150. T. Jons, and D. Drenckhahn Identification of the binding interface involved in linkage of cytoskeletal protein 4.1 to the erythrocyte anion exchanger EMBO J. 11 1992 2863 2867
151. B.H. Paw, A.J. Davidson, Y. Zhou, R. Li, S.J. Pratt, C. Lee, N.S. Trede, A. Brownlie, A. Donovan, E.C. Liao, J.M. Ziai, A.H. Drejer, W. Guo, C.H. Kim, B. Gwynn, L.L. Peters, M.N. Chernova, S.L. Alper, A. Zapata, S.N. Wickramasinghe, M.J. Lee, S.E. Lux, A. Fritz, J.H. Postlethwait, and L.I. Zon Cell-specific mitotic defect and dyserythropoiesis associated with erythroid band 3 deficiency Nat. Genet. 34 2003 59 64 (Pubitemid 36548791)
152. K.B. Hoover, and P.J. Bryant The genetics of the protein 4.1 family: organizers of the membrane and cytoskeleton Curr. Opin. Cell Biol. 12 2000 229 234 (Pubitemid 30142571)
153. S.M. Marfatia, J.H. Morais-Cabral, A.C. Kim, O. Byron, and A.H. Chishti The PDZ domain of human erythrocyte p55 mediates its binding to the cytoplasmic carboxyl terminus of glycophorin C. Analysis of the binding interface by in vitro mutagenesis J. Biol. Chem. 272 1997 24191 24197 (Pubitemid 27418618)
154. W. Nunomura, Y. Takakuwa, M. Parra, J. Conboy, and N. Mohandas Regulation of protein 4.1R, p55, and glycophorin C ternary complex in human erythrocyte membrane J. Biol. Chem. 275 2000 24540 24546 (Pubitemid 30626549)
155. A.C. Azim, J.H. Knoll, S.M. Marfatia, D.J. Peel, P.J. Bryant, and A.H. Chishti DLG1: chromosome location of the closest human homologue of the Drosophila discs large tumor suppressor gene Genomics 30 1995 613 616 (Pubitemid 26038560)
156. D. Ekman, S. Light, A. Bjorklund, and A. Elofsson What properties characterize the hub proteins of the protein-protein interaction network of Saccharomyces cerevisiae? Genome Biol. 7 2006 R45
157. H. Jeong, S. Mason, A. Barabasi, and Z. Oltvai Lethality and centrality in protein networks Nature 411 2001 41 42 (Pubitemid 32428180)
158. P. Uetz, and R. Finley From protein networks to biological systems FEBS Lett. 579 2005 1821 1827 (Pubitemid 40342659)
159. S. Kerrien, B. Aranda, L. Breuza, A. Bridge, F. Broackes-Carter, C. Chen, M. Duesbury, M. Dumousseau, M. Feuermann, U. Hinz, C. Jandrasits, R.C. Jimenez, J. Khadake, U. Mahadevan, P. Masson, I. Pedruzzi, E. Pfeiffenberger, P. Porras, A. Raghunath, B. Roechert, S. Orchard, and H. Hermjakob The IntAct molecular interaction database in 2012 Nucleic Acids Res. 40 2012 D841 D846
160. A.J. Baines The spectrin-ankyrin-4.1-adducin membrane skeleton: adapting eukaryotic cells to the demands of animal life Protoplasma 244 2010 99 131
161. L.J. Bruce, R. Beckmann, M.L. Ribeiro, L.L. Peters, J.A. Chasis, J. Delaunay, N. Mohandas, D.J. Anstee, and M.J. Tanner A band 3-based macrocomplex of integral and peripheral proteins in the RBC membrane Blood 101 2003 4180 4188 (Pubitemid 36857902)
162. W. Nunomura, Y. Takakuwa, R. Tokimitsu, S.W. Krauss, M. Kawashima, and N. Mohandas Regulation of CD44-protein 4.1 interaction by Ca2 + and calmodulin. Implications for modulation of CD44-ankyrin interaction J. Biol. Chem. 272 1997 30322 30328 (Pubitemid 27512238)
163. V.B. Lokeshwar, N. Fregien, and L.Y. Bourguignon Ankyrin-binding domain of CD44(GP85) is required for the expression of hyaluronic acid-mediated adhesion function J. Cell Biol. 126 1994 1099 1109 (Pubitemid 24252154)
164. L.Y. Bourguignon, and H. Jin Identification of the ankyrin-binding domain of the mouse T-lymphoma cell inositol 1,4,5-trisphosphate (IP3) receptor and its role in the regulation of IP3-mediated internal Ca2 + release J. Biol. Chem. 270 1995 7257 7260
165. T.J. Hund, and P.J. Mohler Ankyrin-based targeting pathway regulates human sinoatrial node automaticity Channels (Austin) 2 2008 404 406
166. S. Tuvia, M. Buhusi, L. Davis, M. Reedy, and V. Bennett Ankyrin-B is required for intracellular sorting of structurally diverse Ca2 + homeostasis proteins J. Cell Biol. 147 1999 995 1008
167. H.M. Van Dort, R. Moriyama, and P.S. Low Effect of band 3 subunit equilibrium on the kinetics and affinity of ankyrin binding to erythrocyte membrane vesicles J. Biol. Chem. 273 1998 14819 14826 (Pubitemid 28272769)
168. J.Q. Davis, and V. Bennett Ankyrin binding activity shared by the neurofascin/L1/NrCAM family of nervous system cell adhesion molecules J. Biol. Chem. 269 1994 27163 27166 (Pubitemid 24346527)
169. Y. Jung, and J.H. McCarty Band 4.1 proteins regulate integrin-dependent cell spreading Biochem. Biophys. Res. Commun. 426 2012 578 584
170. Q. Kang, T. Wang, H. Zhang, N. Mohandas, and X. An A Golgi-associated protein 4.1B variant is required for assimilation of proteins in the membrane J. Cell Sci. 122 2009 1091 1099
171. M. Moriniere, L. Ribeiro, N. Dalla Venezia, M. Deguillien, P. Maillet, T. Cynober, F. Delhommeau, H. Almeida, G. Tamagnini, J. Delaunay, and F. Baklouti Elliptocytosis in patients with C-terminal domain mutations of protein 4.1 correlates with encoded messenger RNA levels rather than with alterations in primary protein structure Blood 95 2000 1834 1841 (Pubitemid 30120850)
172. J. Delaunay Molecular basis of red cell membrane disorders Acta Haematol. 108 2002 210 218 (Pubitemid 35356697)
173. F.F. Hamdan, J. Gauthier, Y. Araki, D.T. Lin, Y. Yoshizawa, K. Higashi, A.R. Park, D. Spiegelman, S. Dobrzeniecka, A. Piton, H. Tomitori, H. Daoud, C. Massicotte, E. Henrion, O. Diallo, M. Shekarabi, C. Marineau, M. Shevell, B. Maranda, G. Mitchell, A. Nadeau, G. D'Anjou, M. Vanasse, M. Srour, R.G. Lafreniere, P. Drapeau, J.C. Lacaille, E. Kim, J.R. Lee, K. Igarashi, R.L. Huganir, G.A. Rouleau, and J.L. Michaud Excess of de novo deleterious mutations in genes associated with glutamatergic systems in nonsyndromic intellectual disability Am. J. Hum. Genet. 88 2011 306 316
174. N. Terada, N. Ohno, H. Yamakawa, T. Baba, Y. Fujii, G. Christofori, O. Ohara, and S. Ohno Protein 4.1B in mouse islets of Langerhans and beta-cell tumorigenesis Histochem. Cell Biol. 120 2003 277 283 (Pubitemid 37363585)
175. M.H. Pham, G. Zada, G.M. Mosich, T.C. Chen, S.L. Giannotta, K. Wang, and W.J. Mack Molecular genetics of meningiomas: a systematic review of the current literature and potential basis for future treatment paradigms Neurosurg. Focus. 30 2011 E7
176. S. Baumgartner, J.T. Littleton, K. Broadie, M.A. Bhat, R. Harbecke, J.A. Lengyel, R. Chiquetehrismann, A. Prokop, and H.J. Bellen A Drosophila neurexin is required for septate junction and blood- nerve barrier formation and function Cell 87 1996 1059 1068 (Pubitemid 26427989)
177. R.S. Lamb, and R.G. Fehon Coracle, the Drosophila homologue of protein 4.1, is involved in cell proliferation Mol. Biol. Cell 8 1997 719-719
178. B. Choi, J. Kang, Y.S. Park, J. Lee, and N.J. Cho A possible role for FRM-1, a C. elegans FERM family protein, in embryonic development Mol. Cells 31 2011 455 459
179. W.Z. Wang, R.D. Emes, K. Christoffers, J. Verrall, and S.E. Blackshaw Hirudo medicinalis: a platform for investigating genes in neural repair Cell. Mol. Neurobiol. 25 2005 427 440 (Pubitemid 40768443)
180. T. Kanno, A. Tsuchiya, A. Tanaka, and T. Nishizaki Linoleic acid derivative DCP-LA increases membrane surface localization of alpha7 ACh receptor in a protein 4.1N-dependent manner Biochem. J. 450 2013 303 309
181. D.L. Cioffi, S. Wu, H. Chen, M. Alexeyev, C.M. St Croix, B.R. Pitt, S. Uhlig, and T. Stevens Orai1 determines calcium selectivity of an endogenous TRPC heterotetramer channel Circ. Res. 110 2012 1435 1444
182. M. Rose, E. Dutting, and R. Enz Band 4.1 proteins are expressed in the retina and interact with both isoforms of the metabotropic glutamate receptor type 8 J. Neurochem. 105 2008 2375 2387 (Pubitemid 351782271)
183. G.R. Pasternack, R.A. Anderson, T.L. Leto, and V.T. Marchesi Interactions between protein 4.1 and band 3. An alternative binding site for an element of the membrane skeleton J. Biol. Chem. 260 1985 3676 3683 (Pubitemid 15110960)
184. Y. Kroviarski, W. El Nemer, P. Gane, C. Rahuel, E. Gauthier, M.C. Lecomte, J.P. Cartron, Y. Colin, and C. Le Van Kim Direct interaction between the Lu/B-CAM adhesion glycoproteins and erythroid spectrin Br. J. Haematol. 126 2004 255 264 (Pubitemid 38961946)
185. J.H. McCarty, A.A. Cook, and R.O. Hynes An interaction between {alpha}v{beta}8 integrin and Band 4.1B via a highly conserved region of the Band 4.1 C-terminal domain Proc. Natl. Acad. Sci. U. S. A. 102 2005 13479 13483 (Pubitemid 41420873)
186. J.A. Girault, K. Oguievetskaia, M. Carnaud, N. Denisenko-Nehrbass, and L. Goutebroze Transmembrane scaffolding proteins in the formation and stability of nodes of Ranvier Biol. Cell 95 2003 447 452 (Pubitemid 37441635)
187. J.M. Beekman, J.E. Bakema, C.E. van der Poel, J.A. van der Linden, J.G. van de Winkel, and J.H. Leusen Protein 4.1G binds to a unique motif within the Fc gamma RI cytoplasmic tail Mol. Immunol. 45 2008 2069 2075 (Pubitemid 351226264)
188. L. Licata, L. Briganti, D. Peluso, L. Perfetto, M. Iannuccelli, E. Galeota, F. Sacco, A. Palma, A.P. Nardozza, E. Santonico, L. Castagnoli, and G. Cesareni MINT, the molecular interaction database: 2012 update Nucleic Acids Res. 40 2012 D857 D861
189. L. Salwinski, C.S. Miller, A.J. Smith, F.K. Pettit, J.U. Bowie, and D. Eisenberg The database of interacting proteins: 2004 update Nucleic Acids Res. 32 2004 D449 D451
190. M.E. Smoot, K. Ono, J. Ruscheinski, P.L. Wang, and T. Ideker Cytoscape 2.8: new features for data integration and network visualization Bioinformatics 27 2011 431 432
191. D. Binns, E. Dimmer, R. Huntley, D. Barrell, C. O'Donovan, and R. Apweiler QuickGO: a web-based tool for Gene Ontology searching Bioinformatics 25 2009 3045 3046