The membrane-cytoskeletal protein 4.1N is involved in the process of cell adhesion, migration and invasion of breast cancer cells

Experimental and Therapeutic Medicine

Volumn 4, Issue 4, 2012, Pages 736-740

  Ji, Zhenyu ^a   Shi, Xiaofang ^a   Liu, Xin ^a   Shi, Yu ^a   Zhou, Qingqing ^a   Liu, Xilong ^a   Li, Li ^a   Ji, Xiang ^a   Gao, Yanfeng ^a   Qi, Yuanming ^a   Kang, Qiaozhen ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Breast cancer; Metastasis; Protein 4.1 superfamily; Protein 4.1N

Indexed keywords

CYTOSKELETON PROTEIN; MEMBRANE PROTEIN; PROTEIN 4.1N; UNCLASSIFIED DRUG;

ARTICLE; BREAST CANCER; CANCER CELL; CANCER CELL CULTURE; CELL ADHESION; CELL ASSAY; CELL INVASION; CELL JUNCTION; CELL MEMBRANE; CELL MIGRATION; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CYTOSKELETON; HUMAN; HUMAN CELL; METASTASIS; PROTEIN EXPRESSION; STABLE TRANSFECTION;

EID: 84865372434     PISSN: 17920981     EISSN: 17921015     Source Type: Journal    
DOI: 10.3892/etm.2012.653     Document Type: Article

References (30)

1. Jemal A, Siegel R, Ward E, Hao Y, Xu J, MurrayT and ThunMJ: Cancer statistics. CA Cancer J Clin 58: 71-96, 2008.
2. GeigerTR and PeeperDS: Metastasis mechanisms. Biochim Biophys Acta 2: 293-308, 2009.
3. Mahooti S, Porter K, AlpaughML, et al: Breast carcinomatous tumoral emboli can result from encircling lymphovasculogenesis rather than lymphovascular invasion. Oncotarget 2: 131-147, 2010.
4. Conboy J, Kan YW, ShohetSB and MohandasN: Molecular cloning of protein 4.1, a major structural element of the human erythrocyte membrane skeleton. Proc Natl Acad Sci USA 83: 9512-9516, 1986.
5. Parra M, Gascard P, Walensky LD, et al: Molecular and functional characterization of protein 4.1B, a novel member of the protein 4.1 family with high level, focal expression in brain. J Biol Chem 275: 3247-3255, 2000.
6. Parra M, Gascard P, Walensky LD, Snyder SH, MohandasN and ConboyJG: Cloning and characterization of 4.1G (EPB41L2), a new member of the skeletal protein 4.1 (EPB41) gene family. Genomics 49: 298-306, 1998.
7. Walensky LD, Blackshaw S, LiaoD, et al: A novel neuron-enriched homolog of the erythrocyte membrane cytoskeletal protein 4.1. J Neurosci 19: 6457-6467, 1999.
8. Chishti AH, Kim AC, MarfatiaSM, et al: The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane. Trends Biochem Sci 23: 281-282, 1998.
9. Pearson MA, Reczek D, BretscherA and KarplusPA: Structure of the ERM protein moesin reveals the FERM domain fold masked by an extended actin binding tail domain. Cell 101: 259-270, 2000.
10. Han BG, Nunomura W, Takakuwa Y, Mohandas N and JapBK: Protein 4.1R core domain structure and insights into regulation of cytoskeletal organization. Nat Struct Biol 7: 871-875, 2000.
11. Diakowski W, GrzybekM and SikorskiAF: Protein 4.1, a component of the erythrocyte membrane skeleton and its related homologue proteins forming the protein 4.1/FERM superfamily. Folia Histochem Cytobiol 44: 231-248, 2006.
12. Ohtani K, Sakamoto H, Rutherford T, Chen Z, SatohK and NaftolinF: Ezrin, a membrane-cytoskeletal linking protein, is involved in the process of invasion of endometrial cancer cells. Cancer Lett 147: 31-38, 1999.
13. Khanna C, Wan X, BoseS, et al: The membrane-cytoskeleton linker ezrin is necessary for osteosarcoma metastasis. Nat Med 10: 182-186, 2004.
14. Tran YK, Bögler O, Gorse KM, Wieland I, GreenMR and NewshamIF: A novel member of the NF2/ERM/4.1 superfamily with growth suppressing properties in lung cancer. Cancer Res 59: 35-43, 1999.
15. Gutmann DH, Donahoe J, PerryA, et al: Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas. Hum Mol Genet 10: 1495-1500, 2000.
16. Robb VA, Li W, Gascard P, Perry A, MohandasN and GutmannDH: Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis. Neurobiol Dis 13: 191-202, 2003.
17. Cavanna T, Pokorná E, Veselý P, GrayC and ZichaD: Evidence for protein 4.1B acting as a metastasis suppressor. J Cell Sci 120: 606-616, 2007.
18. Sun CX, Robb VA and Gutmann DH: Protein 4.1 tumor suppressors: getting a FERM grip on growth regulation. J Cell Sci 115: 3991-4000, 2002.
19. Kittiniyom K, Gorse KM, Dalbegue F, Lichy JH, TaubenbergerJK and NewshamIF: Allelic loss on chromosome band 18p11.3 occurs early and reveals heterogeneity in breast cancer progression. Breast Cancer Res 3: 192-198, 2001.
20. Ohno N, Terada N, MurataS, et al: Immunolocalization of protein 4.1B/DAL-1 during neoplastic transformation of mouse and human intestinal epithelium. Histochem Cell Biol 122: 579-586, 2004.
21. Terada N, Ohno N, YamakawaH, et al: Protein 4.1B in mouse islets of Langerhans and beta-cell tumorigenesis. Histochem Cell Biol 120: 277-283, 2003.
22. Charboneau AL, Singh V, Yu T and NewshamIF: Suppression of growth and increased cellular attachment after expression of DAL-1 in MCF-7 breast cancer cells. Int J Cancer 100: 181-188, 2002.
23. Ye K, Compton DA, Lai MM, WalenskyLD and SnyderSH: Protein 4.1N binding to nuclear mitotic apparatus protein in PC12 cells mediates the antiproliferative actions of nerve growth factor. J Neurosci 19: 10747-10756, 1999.
24. Zhou Y, Du G, HuX, et al: Nectin-like molecule 1 is a protein 4.1N associated protein and recruits protein 4.1N from cytoplasm to the plasma membrane. Biochim Biophys Acta 1669: 142-154, 2005.
25. Shen L, Liang F, WalenskyLD and HuganirRL: Regulation of AMPA receptor GluR1 subunit surface expression by a 4.1N-linked actin cytoskeletal association. J Neurosci 20: 7932-7940, 2000.
26. Binda AV, Kabbani N, Lin R and Levenson R: D2 and D3 dopamine receptor cell surface localization mediated by interaction with protein 4.1N. Mol Pharmacol 62: 507-513, 2002.
27. Maximov A, TangTS and BezprozvannyI: Association of the type 1 inositol (1,4,5)-trisphosphate receptor with 4.1N protein in neurons. Mol Cell Neurosci 22: 271-283, 2003.
28. Heller G, Geradts J, ZieglerB, et al: Downregulation of TSLC1 and DAL-1 expression occurs frequently in breast cancer. Breast Cancer Res Treat 3: 283-291, 2007.
29. Gutmann DH, Hirbe AC, Huang ZY and HaipekCA: The protein 4.1 tumor suppressor, DAL-1, impairs cell motility, but regulates proliferation in a cell-type-specific fashion. Neurobiol Dis 8: 266-278, 2001.
30. Gutmann DH, Sherman L, Seftor L, Haipek C, Hoang LuK and HendrixM: Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading. Hum Mol Genet 8: 267-275, 1999.