Alternative splicing of protein 4.1R exon 16: Ordered excision of flanking introns ensures proper splice site choice

Blood

Volumn 95, Issue 2, 2000, Pages 692-699

  Gee, Sherry L ^a   Aoyagi, Kazuko ^a   Lersch, Robert ^b   Wu Victor Hou, Michael ^a   Conboy, John G ^b  

^a University of California Berkeley   (United States)

^b LAWRENCE BERKELEY NATIONAL LABORATORY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIN; CYTOSKELETON PROTEIN; ERYTHROCYTE BAND 4.1 PROTEIN; MESSENGER RNA; MESSENGER RNA PRECURSOR; SPECTRIN;

ARTICLE; ERYTHROCYTE; EXON; HUMAN; HUMAN CELL; INTRON; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RNA SPLICING;

EID: 0034650955     PISSN: 00064971     EISSN: None     Source Type: Journal    
DOI: 10.1182/blood.v95.2.692     Document Type: Article

References (40)

1. Tang TK, Leto T, Marches! VT, Benz EJ. Heterogeneity of mRNA and protein products arising Irom the protein 4.1 gene in erythroid and nonerythroid tissues. J Cell Biol. 1990:110:617-624.
2. Conboy JG, Chan J, Chasis JA, Kan YW, Mohandas N. Tissue- and development-specific alternative RNA splicing regulates expression of multiple isoforms of erythroid membrane protein 4.1. J Biol Chem. 1991;266:8273-8280.
3. Chasis JA, Coulombel L, Conboy J, et al. Differentiation-associated switches in protein 4.1 expression: synthesis of multiple structural isoforms during normal human hematopoiesis. J Clin Invest. 1993:91:329-338.
4. Baklouti F, Huang S-C, Tang TK, Delaunay J, Marches! VT, Benz EJ Jr. Asynchronous regulation of splicing events within protein 4.1 premRNA during erythroid differentiation. Blood. 1996:87:3934-3941.
5. Huang J-P, Tang C-J, Kou G-H, Marches! T, Benz EJ Jr, Tang TK. Genomic structure of the locus encoding protein 4.1 : strucural basis for complex combinational patterns of tissue-specific alternative RNA splicing. J Biol Chem. 1993:268:37583766.
6. Winardi R, Discher D, Kelley C, et al. Evolutionarily conserved alternative pre-mRNA splicing regulates structure and function of the spectrinactin binding domain of erythroid protein 4.1. Blood. 1995:86:4315-4322.
7. Schischmanoff PO, Yaswen P, Parra MK, et al. Cell-shape dependent regulation of protein 4.1 alternative splicing in mammary epithelial cells. J Biol Chem. 1997:272:10,254-10,259.
8. Baklouti F, Huang S-C, Vulliamy TJ, Delaunay J, Benz EJ Jr. Organization of the human protein 4.1 genomic locus: new insights into the tissuespecific alternative splicing of the pre-mRNA. Genomics. 1997:39:289-302.
9. Home WC, Huang SC, Becker PS, Tang TK, Benz EJ Jr. Tissue-specific alternative splicing of protein 4.1 inserts an exon necessary for formation of the ternary complex with erythrocyte spectrin and F-actin. Blood. 1993:82:2558-2563.
10. Tchernia G. Mohandas N, Shohet SB. Deficiency of skeletal membrane protein 4.1 in homozygous hereditary elliptocytosis: implications for erythro-cyte membrane stability. J Clin Invest. 1981 ;68: 454-460.
11. Takakuwa Y, Tchernia G, Rossi M, Benabadji M, Mohandas N. Restoration of normal membrane stability to unstable protein 4.1 -deficient membranes by incorporation of purified protein 4.1. J Clin Invest. 1986;78:80-85.
12. Discher D, Parra M, Conboy JG. Mohandas N. Mechanochemistry of the alternatively spliced spectrin-actin binding domain in membrane skeletal protein 4.1. J Biol Chem. 1993:268:71867195.
13. Discher DE, Winardi R, Schischmanoff PO, Parra M, Conboy JG, Mohandas N. Mechanochemistry of protein 4.1's spectrin-actin binding domain: ternary complex associations, network integration, structural strengthening. J Cell Biol. 1995; 130:897-907.
14. Schischmanoff PO, Winardi R, Discher DD, et al. Defining of the minimal domain of protein 4.1 involved in spectrin-actin binding. J Biol Chem. 1995:270:21,243-21,250.
15. Luque CM, Lallena MJ, Alonso MA, Correas I. An alternative domain determines nuclear localization in multifunctional protein 4.1. J Biol Chem. 1998:273:11,643-11,649.
16. Gascard P, Nunomura W, Lee G, et al. Deciphering the nuclear import pathway for the cytoskeletal protein 4.1R. Mol Biol Cell. 1999:10:17831798.
17. Liu HX, Zhang M, rainer AR. Identification of functional exonic splicing enhancer motifs recognized by individual SR proteins. Genes Dev 1998; 12:1998-2012.
18. Modafleri EF, Black DL. A complex intronic splicing enhancer from the c-src pre-mRNA activates inclusion of a heterologous exon. Mol Cell Biol. 1997;17:6537-6545.
19. Ashiya M, Grabowski PJ. A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brainspecific PTB counterpart. RNA. 1997;3:996-1015.
20. Tsukahara T, Casciato C, Helfman DM. Alternative splicing of beta-tropomyosin pre-mRNA: multiple cis-elements can contribute to the use of the 5'- and 3'-splice sites of the nonmuscle/smooth muscle exon 6. Nucleic Acids Res. 1997:22:23182325.
21. Helfman DM, Ricci WM, Finn LA. Alternative splicing of tropomyosin pre-mRNAs in vitro and in vivo. Genes Dev. 1988:2:1627-1638.
22. Nasim FH, Spears PA, Hoffmann HM, Kuo HC, Grabowski PJ. A sequential splicing mechanism promotes selection of an optimal exon by repositioning a downstream 5' splice site in preprotachykinin pre-mRNA. Genes Dev. 1990:4:11721184.
23. Chan RC, Black DL. Conserved intron elements repress splicing of a neuron-specific c-src exon in vitro. Mol Cell Biol. 1995:15:6377-6385.
24. Norton RM, Hunt HO, Ho SN, Pullen JK, Pease LR. Engineering hybrid genes without the use of restriction enzymes: gene splicing by overlap extension. Gene, 1989:77:61-68.
25. Dumont JN. Oogenesis in Xenopus laevis (Daudin), I: Stages of oocyte development in laboratory maintained animals. J Morphol. 1972:136: 153-179.
26. Mayeda A, Krainer AR. Preparation of HeLa Cell Nuclear and Cytosolic S100 Extracts for in Vitro Splicing. In: Haynes S, ed. RNA-Protein Interaction Protocols. Methods in Molecular Biology; Vol 118. Totowa, NJ: Humana Press; 1999:309-321.
27. Caceres JF, Stamm S, Helfman DM, Krainer AR. Regulation of alternative splicing in vivo by overexpression of antagonistic splicing factors. Science. 1994:265:1706-1709.
28. Green MR, Maniatis T, Melton DA. Human -globin pre-mRNA synthesized in vitro is accurately spliced in Xenopus oocyte nuclei. Cell. 1983:32: 681-694.
29. Siebel CW, Fresco LD, Rio DC. The mechanism of somatic inhibition of Drosophila P-element premRNA splicing: multiprotein complexes at an exon pseudo-5' splice site control U1 snRNP binding. Genes Dev. 1992:6:1386-1401.
30. Nagy E, Maquat LE. A rule for termination-codon position within intron-containing genes: when nonsense affects RNA abundance. Trends Biochem Sei. 1998:23:198-199.
31. Reed R. Initial splice-site recognition and pairing during pre-mRNA splicing. Curr Opin Genet Dev. 1996:6:215-220.
32. Fu XD. The superfamily of arginine/serine-rich splicing factors. RNA. 1995;1:663-680.
33. Manley JL, Tacke R. SR proteins and splicing control. Genes Dev. 1996:10:1569-1579.
34. Tacke R, Manley JL. Determinants of SR protein specificity. CurrOpin Cell Biol. 1999:11:358-362.
35. Xu R, Teng J, Cooper TA. The cardiac troponin T alternative exon contains a novel purine-rich positive splicing element. Mol Cell Biol. 1993;13: 3660-3674.
36. Caputi M, Mayeda A, Krainer AR, Zahler AM. hnRNP A/B proteins are required for inhibition of HIV-1 pre-mRNA splicing. EMBO J. 1999;18: 4060-4067.
37. Si Z, Amenât BA, Stoltzfus CM. Splicing efficiency of human immunodeficiency virus type 1 tat RNA is determined by both a suboptimai 3' splice site and a 10 nucieotide exon splicing silencer element locafed within tat exon 2. Nucleic Acids Res. 1997;25:861-867.
38. Del Gatto-Konczak F, Olive M, Gesnel MC, Brealhnach R. hnRNP A1 recruited to an exon In vivo can function as an exon splicing silencer. Mol Cell Biol. 1999;19:251 -260.
39. Kan JL, Green MR. Pre-mRNA splicing of IgM exons M1 and M2 is directed by a juxtaposed splicing enhancer and inhibitor. Genes Dev. 1999; 13:462-471.
40. Conboy JG, Shitamoto R, Parra M, et al. Hereditary elliptocytosis due to both qualitative and quantitative defects in membrane skeletal protein 4.1. Blood. 1991:78:2438-2443.