Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas

Human Molecular Genetics

Volumn 9, Issue 10, 2000, Pages 1495-1500

  Gutmann, David H ^a   Donahoe, Jessica ^a   Perry, Arie ^a   Lemke, Nancy ^b   Gorse, Karen ^b   Kittiniyom, Kanokwan ^b,c   Rempel, Sandra A ^b   Gutierrez, Jorge A ^c   Newsham, Irene F ^b,c  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b HENRY FORD HOSPITAL   (United States)

^c VIRGINIA COMMONWEALTH UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ERYTHROCYTE BAND 4.1 PROTEIN;

ARTICLE; CANCER GENETICS; CHROMOSOME 18Q; HETEROZYGOSITY LOSS; HUMAN; HUMAN TISSUE; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MENINGIOMA; PATHOGENESIS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR GENE;

FALCO COLUMBARIUS;

EID: 0034640901     PISSN: 09646906     EISSN: None     Source Type: Journal    
DOI: 10.1093/hmg/9.10.1495     Document Type: Article

References (28)

1. Simon, M., von Deimling, A., Larson, J.J., Wellenreuther, R., Kaskel, P., Waha, A., Warnick, R.E., Tew, J.M. and Menon, A.G. (1995) Allelic losses on chromosome 14, 10, and 1 in atypical and malignant meningiomas: A genetic model of meningioma progression. Cancer Res., 55, 4696-4701.
2. Weber, R.G., Bostrom, J., Wolter, M., Baudis, M., Collins, V.P., Reifenberger, G. and Lichter, P. (1997) Analysis of genomic alterations in benign, atypical and anaplastic meningiomas: Towards a genetic model of meningioma progression. Proc. Natl Acad. Sci. USA, 94, 14719-14724.
3. Trofatter, J.A., MacCollin, M.M., Rutter, J.L., Murrell, J.R., Duyao, M.P., Parry, D.M., Eldridge, R., Kley, N., Menon, A.C., Pulaski, K. et al. (1993) A novel moesin-, ezrin-, radixin-like gene is a candidate for the neurofibromatosis 2 tumor suppressor. Cell. 72, 1-20.
4. Rouleau, G.A., Merci, P., Lutchman, M., Sanson, M., Zucman, J., Marineau, C., Hoang-Xuan, K., Demczuk, M., Desmaze, C., Plougastel, B. et al. (1993) Alteration in a new gene encoding a putative membrane-organizing protein causes neuro-fibromatosis type 2. Nature, 363, 515-521.
5. Evans, D.G.R., Huson, S.M., Donnai, D., Neary, W., Blair, V., Newton, V. and Harris, R. (1992) A clinical study of type 2 neurofibromatosis. Q. J. Med., 304, 603-618.
6. Ruttledge, M.H., Sarrazin, J., Rangaratnam, S., Phelan, C.M., Twist, E., Merel, P., Delattre, O., Thomas, G., Nordenskjold, M., Collins, V.P. et al. (1994) Evidence for the complete inactivation of the NF2 gene in the majority of sporadic meningiomas. Nature Genet., 6, 180-184.
7. Lee, J.H., Sundaram, V., Stein, D.J., Kinney, S.E., Stacey, D.W. and Golubic, M. (1997) Reduced expression of schwannomin/merlin in human sporadic meningiomas. Neurosurgery, 40, 578-587.
8. Merel, P., Hoang-Xuan, K., Sanson, M., Moreau-Aubry, A., Bijisma, E.K., Lazaro, C., Moisan, J.P., Resche, F., Nishisho, I., Estivill, X. et al. (1995) Predominant occurrence of somatic mutations of the NF2 gene in meningiomas and schwannomas. Genes Chromosomes Cancer, 13, 211-216.
9. Slavc, I., MacCollin, M.M., Dunn, M., Jones, M., Sutton, L. and Gusella, J.F. (1995) Exon scanning for mutations of the NF2 gene in pediatric ependymomas, rhabdoid tumors and meningiomas. Int. J. Cancer. 64, 243-247.
10. Wolff, R.K., Frazer, K. A., Jackler, R.K., Lanser, M.J., Pitts, L.H. and Cox, D.R. (1992) Analysis of chromosome 22 deletions in neurofibromatosis type 2-related tumors. Am. J. Hum. Genet., 51, 478-485.
11. Gutmann, D.H., Giordano, M.J., Fishback, A.S. and Cuba, A. (1997) Loss of merlin expression in sporadic meningiomas, ependymomas, and schwannomas. Neurology, 48, 267-270.
12. Ng, H.-k., Lau, K.-m., Tse, J.Y.M., Lo, K.-w., Wong, J.H.C., Poon, W.-s. and Huang, D.P. (1995) Combined molecular genetic studies of chromosome 22q and the neurofibromatosis type 2 gene in central nervous system tumors. Neurosurgery, 37, 764-773.
13. Tsukita, S., Oishi, K., Sato, N., Sagara, J., Kawai, A. and Tsukita, S. (1994) ERM family: from cytoskeleton to signal transduction. J. Cell Biol., 126, 391-401.
14. Tran, Y.K., Bogler, O., Gorse, K.M., Wieland, I., Green, M.R. and Newsham, I.F. (1999) A novel member of the NF2/ERM/4.1 superfamily with growth suppressor properties in lung cancer. Cancer Res., 59, 35-43.
15. Tran, Y., Benbatoul, K., Gorse, K., Rempel, S., Futreal, A., Green, M. and Newsham, I. (1998) Novel regions of allelic deletion on chromosome 18p in tumors of the lung, brain and breast. Oncogene, 17, 3499-3505.
16. McCartney, B.M. and Fehon, R.G. (1996) Distinct cellular and subcellular patterns of expression imply distinct functions for the Drosophila homologues of moesin and the neurofibromatosis 2 tumor suppressor, merlin. J. Cell Biol., 133, 843-852.
17. Cairns, P., Mao, L., Merlo, A., Lee, D.J., Schwab, D., Eby, Y., Tokino, K., van der Riet, P., Blaugrund, J.E. and Sidransky, D. (1994) Rates of p16 (MTS 1) mutations in primary tumors with 9p loss. Science, 265, 415-416.
18. ink4A alleles in neoplasia. Cancer Res., 58, 591-593.
19. Merlo, A., Herman, J.G., Mao, K., Lee, D.J., Gabrielson, E., Burger, P.C., Baylin, S.B. and Sidransky, D. (1995) 5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers. Nature Med., 1, 686-692.
20. Perry, A., Stafford, S.L., Scheithauer, B.W., Suman, V.J. and Lohse, C.M. (1997) Meningioma grading: an analysis of histologic parameters. Am. J. Surg. Pathol., 21, 1455-1465.
21. Perry, A., Scheithauer, B.W., Stafford, S.L., Lohse, C.M. and Wollan, P.C. (1999) 'Malignancy' in meningiomas: a clinicopathologic study of 116 patients, with grading implications. Cancer, 85, 2046-2056.
22. Gonzalez-Agosti, C., Xu, L., Pinney, D., Beauchamp, R., Hobbs, W., Gusella, J. and Ramesh, V. (1996) The merlin tumor suppressor localizes preferentially in membrane ruffles. Oncogene, 13, 1239-1247.
23. Xu, H.-M. and Gutmann, D.H. (1998) Merlin differentially associates with the microtubule and actin cytoskeleton. J. Neurosci. Res., 51, 403-415.
24. Pelton, P.D., Sherman, L.S., Rizvi, T.A., Marchionni, M.A., Wood, P., Friedman, R.A. and Ratner, N. (1998) Ruffling membrane, stress fiber, cell spreading and proliferation abnormalities in human schwannoma cells. Oncogene, 17, 2195-2209.
25. Gutmann, D.H., Sherman, L., Seftor, L., Haipek, C., Lu, K.H. and Hendrix, M. (1999) Increased expression of the NF2 tumor suppressor gene product, merlin, impairs cell motility, adhesion and spreading. Hum. Mol. Genet., 8, 267-275.
26. Murphy, M., Chen, J.N. and George, D.L. (1991) Establishment and characterization of a human leptomeningeal cell line. J. Neurosci. Res., 30, 475-483.
27. Gutmann, D.H., Geist, R.T., Wright, D.E. and Snider, W.D. (1995) Expression of the neurofibromatosis 1 (NF1) isoforms in developing and adult rat tissues. Cell Growth Differ., 6, 315-322.
28. Geist, R.T., Reddy, A.J., Zhang, J. and Gutmann, D.H. (1996) Expression of the tuberous sclerosis 2 gene product, tuberin, in adult and developing nervous system tissues. Neurobiol. Dis., 3, 111-120.