Positron emission tomography/computed tomographic and magnetic resonance imaging in a murine model of progressive atherosclerosis using 64Cu-labeled glycoprotein VI-Fc

Circulation: Cardiovascular Imaging

Volumn 6, Issue 6, 2013, Pages 957-964

  Bigalke, Boris ^a,b   Phinikaridou, Alkystis ^b   Andia, Marcelo E ^b   Cooper, Margaret S ^b   Schuster, Andreas ^b,e   Schönberger, Tanja ^a   Griessinger, Christoph M ^a   Wurster, Thomas ^a   Onthank, David ^c   Ungerer, Martin ^d   Gawaz, Meinrad ^a   Nagel, Eike ^b   Botnar, Rene M ^b  

^a UNIVERSITY OF TÜBINGEN   (Germany)

^b KING'S COLLEGE LONDON   (United Kingdom)

^c A Subsidiary of Lantheus Holdings   (United States)

^d ADVANCECOR GMBH   (Germany)

^e DZHK GERMAN CENTRE FOR CARDIOVASCULAR RESEARCH   (Germany)

Author keywords

Atherosclerosis; Magnetic resonance imaging; Positron emission tomography and computed tomography

Indexed keywords

APOLIPOPROTEIN E; GADOLINIUM; GLYCOPROTEIN VI FC CU 64; RADIOPHARMACEUTICAL AGENT; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AORTA ARCH; ARTICLE; ATHEROSCLEROSIS; ATHEROSCLEROTIC PLAQUE; CARDIOVASCULAR MAGNETIC RESONANCE; CAROTID ARTERY LIGATION; COMPUTER ASSISTED EMISSION TOMOGRAPHY; CONTROLLED STUDY; DRUG UPTAKE; EX VIVO STUDY; HISTOPATHOLOGY; IN VIVO STUDY; ISOTOPE LABELING; LIPID DIET; MALE; MOUSE; MURINE MODEL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SCANNER; PET-CT SCANNER; PRIORITY JOURNAL; RESPONSE TIME; WILD TYPE;

ATHEROSCLEROSIS; MAGNETIC RESONANCE IMAGING; POSITRON-EMISSION TOMOGRAPHY AND COMPUTED TOMOGRAPHY;

ANIMALS; ATHEROSCLEROSIS; CAROTID ARTERY, COMMON; COPPER RADIOISOTOPES; DISEASE MODELS, ANIMAL; MAGNETIC RESONANCE IMAGING; MALE; MICE; MICE, INBRED C57BL; PLATELET MEMBRANE GLYCOPROTEINS; POSITRON-EMISSION TOMOGRAPHY; REPRODUCIBILITY OF RESULTS; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84892154556     PISSN: 19419651     EISSN: 19420080     Source Type: Journal    
DOI: 10.1161/CIRCIMAGING.113.000488     Document Type: Article

References (39)

1. Clemetson KJ, Clemetson JM Platelet collagen receptors. Thromb Haemost. 2001; 86:189-197.
2. Nieswandt B, Watson S P. Platelet-collagen interaction: is GPVI the central receptor? Blood. 2003; 102:449-461.
3. Bigalke B, Pohlmeyer I, Schönberger T, Griessinger C.M., Ungerer M., Botnar RM, Pichler BJ, Gawaz M. Imaging of injured and atherosclerotic arteries in mice using fluorescence-labeled glycoprotein VI-Fc. Eur J Radiol. 2011; 79:e63-e69.
4. Gawaz M, Konrad I, Hauser A.I., Sauer S., Li Z, Wester HJ, Bengel F.M., Schwaiger M., Schömig A, Massberg S., Haubner R. Non-invasive imaging of glycoprotein VI binding to injured arterial lesions. Thromb Haemost. 2005; 93:910-913.
5. Schönberger T., Siegel-Axel D, Bussl R., Richter S, Judenhofer MS, Haubner R, Reischl G., Klingel K, Münch G, Seizer P., Pichler BJ, Gawaz M. The immunoadhesin glycoprotein VI-Fc regulates arterial remodelling after mechanical injury in ApoE-/-mice. Cardiovasc Res. 2008; 80:131-137.
6. Bai B, Ruangma A, Laforest R., Tai YC, Leahy RM Positron range modeling for statistical PET image reconstruction. IEEE Nucl Sci Symp Conf Rec. 2004; 4:2501-2505.
7. Naghavi M, Libby P, Falk E., Casscells SW, Litovsky S, Rumberger J, Badimon J.J., Stefanadis C., Moreno P, Pasterkamp G, Fayad Z., Stone PH, Waxman S, Raggi P, Madjid M., Zarrabi A, Burke A, Yuan C., Fitzgerald PJ, Siscovick DS, de Korte CL, Aikawa M, Juhani Airaksinen KE, Assmann G, Becker CR, Chesebro JH, Farb A, Galis ZS, Jackson C, Jang IK, Koenig W, Lodder RA, March K, Demirovic J, Navab M, Priori SG, Rekhter MD, Bahr R, Grundy SM, Mehran R, Colombo A, Boerwinkle E, Ballantyne C, Insull W Jr, Schwartz RS, Vogel R, Serruys PW, Hansson GK, Faxon DP, Kaul S, Drexler H, Greenland P, Muller JE, Virmani R, Ridker PM, Zipes DP, Shah PK, Willerson JT. From vulnerable plaque to vulnerable patient: a call for new definitions and risk assessment strategies: part I. Circulation. 2003; 108:1664-1672.
8. Plump AS, Smith JD, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft JG, Rubin EM, Breslow JL. Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell. 1992; 71:343-353.
9. Reddick RL, Zhang SH, Maeda N. Atherosclerosis in mice lacking apo E. Evaluation of lesional development and progression. Arterioscler Thromb. 1994; 14:141-147.
10. Johnson JL, Jackson CL Atherosclerotic plaque rupture in the apolipopro-tein E knockout mouse. Atherosclerosis. 2001; 154:399-406.
11. Cooper MS, Sabbah E, Mather SJ Conjugation of chelating agents to proteins and radiolabeling with trivalent metallic isotopes. Nat Protoc. 2006; 1:314-317.
12. Makowski MR, Varma G, Wiethoff A.J., Smith A., Mattock K, Jansen CH, Warley A, Taupitz M., Schaeffter T, Botnar RM Noninvasive assessment of atherosclerotic plaque progression in ApoE-/-mice using susceptibility gradient mapping. Circ Cardiovasc Imaging. 2011; 4:295-303.
13. Makowski MR, Wiethoff AJ, Blume U, Cuello F., Warley A, Jansen CH, Nagel E, Razavi R., Onthank DC, Cesati RR, Marber MS, Schaeffter T, Smith A., Robinson SP, Botnar RM Assessment of atherosclerotic plaque burden with an elastin-specific magnetic resonance contrast agent. Nat Med. 2011; 17:383-388.
14. Phinikaridou A, Andia ME, Protti A, Indermuehle A., Shah A, Smith A, Warley A., Botnar RM Noninvasive magnetic resonance imaging evaluation of endothelial permeability in murine atherosclerosis using an albumin-binding contrast agent. Circulation. 2012; 126:707-719.
15. Noutsias M, Hohmann C, Pauschinger M., Schwimmbeck PL, Ostermann K, Rode U, Yacoub M.H., Kühl U, Schultheiss HP sICAM-1 correlates with myocardial ICAM-1 expression in dilated cardiomyopathy. Int J Cardiol. 2003; 91:153-161.
16. Pichler BJ, Kneilling M, Haubner R., Braumüller H, Schwaiger M., Röcken M, Weber WA Imaging of delayed-type hypersensitivity reaction by PET and 18F-galacto-RGD. J Nucl Med. 2005; 46:184-189.
17. Szanda I, Mackewn J, Patay G., Major P, Sunassee K, Mullen G.E., Nemeth G., Haemisch Y, Blower PJ, Marsden PK National Electrical Manufacturers Association NU-4 performance evaluation of the PET component of the NanoPET/CT preclinical PET/CT scanner. J Nucl Med. 2011; 52:1741-1747.
18. Szanda I, Livieratos L, Patay G., Tsoumpas C, Sunassee K, Mullen G.E., Nemeth G., Major P, Marsden PK Partial-volume effect and a partial-volume correction for the NanoPET/CTTM Preclinical PET/CT Scanner. IEEE Nucl Sci Symp Conf Rec. 2011; 1:3605-3609.
19. Blume U, Orbell J, Waltham M., Smith A, Razavi R, Schaeffter T. 3D T(1)-mapping for the characterization of deep vein thrombosis. MAGMA. 2009; 22:375-383.
20. Langer H, Schönberger T, Bigalke B., Gawaz M. Where is the trace? Molecular imaging of vulnerable atherosclerotic plaques. Semin Thromb Hemost. 2007; 33:151-158.
21. Judenhofer MS, Wehrl HF, Newport D.F., Catana C., Siegel SB, Becker M, Thielscher A, Kneilling M., Lichy MP, Eichner M, Klingel K, Reischl G., Widmaier S, Röcken M, Nutt R.E., Machulla HJ, Uludag K, Cherry SR, Claussen C.D., Pichler BJ Simultaneous PET-MRI: a new approach for functional and morphological imaging. Nat Med. 2008; 14:459-465.
22. Matter CM, Stuber M, Nahrendorf M. Imaging of the unstable plaque: how far have we got? Eur Heart J. 2009; 30:2566-2574.
23. Schuster A, Makowski MR, Jansen C.H., Gawaz M., Botnar RM, Nagel E, Bigalke B. Platelets in cardiovascular imaging. Curr Vasc Pharmacol. 2012; 10:619-625.
24. Schäfers M., Schober O, Hermann S. Matrix-metalloproteinases as imaging targets for inflammatory activity in atherosclerotic plaques. J Nucl Med. 2010; 51:663-666.
25. Lee WW, Marinelli B, van der Laan AM, Sena BF, Gorbatov R, Leuschner F, Dutta P, Iwamoto Y, Ueno T, Begieneman MP, Niessen HW, Piek JJ, Vinegoni C, Pittet MJ, Swirski FK, Tawakol A, Di Carli M, Weissleder R, Nahrendorf M. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol. 2012; 59:153-163.
26. Majmudar MD, Nahrendorf M. Cardiovascular molecular imaging: the road ahead. J Nucl Med. 2012; 53:673-676.
27. Temma T, Ogawa Y, Kuge Y., Ishino S, Takai N, Nishigori K., Shiomi M, Ono M, Saji H. Tissue factor detection for selectively discriminating unstable plaques in an atherosclerotic rabbit model. J Nucl Med. 2010; 51:1979-1986.
28. Lusis AJ. Atherosclerosis. Nature. 2000; 407:233-241.
29. Minar E, Ehringer H, Dudczak R., Schöfl R, Jung M., Koppensteiner R, Ahmadi R, Kretschmer G. Indium-111-labeled platelet scintigraphy in carotid atherosclerosis. Stroke. 1989; 20:27-33.
30. Moriwaki H, Matsumoto M, Handa N., Isaka Y, Hashikawa K, Oku N., Nakamura M, Kamada T, Nishimura T. Functional and anatomic evaluation of carotid atherothrombosis. A combined study of indium 111 platelet scintigraphy and B-mode ultrasonography. Arterioscler Thromb Vasc Biol. 1995; 15:2234-2240.
31. Smyth JV, Dodd PD, Walker MG Indium-111 platelet scintigraphy in vascular disease. Br J Surg. 1995; 82:588-595.
32. Vallabhajosula S. Technetium-99m-P748, platelet specific techtide for imaging arterial thrombus: preclinical studies in a canine model of intra-arterial thrombus. J Nucl Med. 2005; 37:152P.
33. Bigalke B, Lindemann S, Schönberger T, Pohlmeyer I., Chiribiri A, Schuster A, Botnar R.M., Griessinger CM, Pichler BJ, Gawaz M. Ex vivo-imaging of injured arteries in rabbits using fluorescence-labelled glyco-protein VI-Fc. Platelets. 2012; 23:1-6.
34. Shidahara M, Tsoumpas C, Hammers A., Boussion N, Visvikis D, Suhara T., Kanno I, Turkheimer FE Functional and structural synergy for resolution recovery and partial Volume correction in brain PET. Neuroimage. 2009; 44:340-348.
35. Camici PG, Rimoldi OE, Gaemperli O, Libby P. Non-invasive anatomic and functional imaging of vascular inflammation and unstable plaque. Eur Heart J. 2012; 33:1309-1317.
36. Hermann S, Starsichova A, Waschkau B., Kuhlmann M, Wenning C, Schober O., Schäfers M. Non-FDG imaging of atherosclerosis: will imaging of MMPs assess plaque vulnerability? J Nucl Cardiol. 2012; 19:609-617.
37. Herdeg C, Goehring-Frischholz K, Zuern C., Geisler T, Hartmann U, Hoevelborn T., Haase KK, Gawaz M. Local catheter-based delivery of an-tithrombotic or antiproliferative drugs: a new concept for prevention of restenosis. Thromb Res. 2008; 123:236-243.
38. Geisler T, Zürn C, Simonenko R., Rapin M, Kraibooj H, Kilias A., Bigalke B, Stellos K, Schwab M., May AE, Herdeg C, Gawaz M. Early but not late stent thrombosis is influenced by residual platelet aggregation in patients undergoing coronary interventions. Eur Heart J. 2010; 31:59-66.
39. Ungerer M, Rosport K, Bültmann A, Piechatzek R., Uhland K, Schlieper P, Gawaz M., Münch G. Novel antiplatelet drug revacept (Dimeric Glycoprotein VI-Fc) specifically and efficiently inhibited collagen-induced platelet aggregation without affecting general hemostasis in humans. Circulation. 2011; 123:1891-1899.