Cardiovascular molecular imaging: The road ahead

Journal of Nuclear Medicine

Volumn 53, Issue 5, 2012, Pages 673-676

  Majmudar, Maulik D ^a,b   Nahrendorf, Matthias ^a  

^a MASSACHUSETTS GENERAL HOSPITAL   (United States)

^b BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Cardiovascular; Molecular imaging; MRI; Multimodality; Nuclear medicine

Indexed keywords

ARGINYLGLYCYLASPARTIC ACID; BRU 59 21 TC 99M; CHOLESTEROL ESTER TRANSFER PROTEIN INHIBITOR; COPPER 64; FLUORINE 18; FLUORODEOXYGLUCOSE F 18; INDIUM 111; MATRIX METALLOPROTEINASE INHIBITOR TC 99M; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE; N SEC BUTYL 1 (2 CHLOROPHENYL) N METHYL 3 ISOQUINOLINECARBOXAMIDE C 11; NANOPARTICLE; PLACEBO; RADIOPHARMACEUTICAL AGENT; RP 748 TC 99M; RP 782; RP 805 TC 99M; TRACER; UNCLASSIFIED DRUG; VASCULAR CELL ADHESION MOLECULE 1; VASCULAR CELL ADHESION MOLECULE 1 F 18; VASCULOTROPIN 121 DOTA CU 64;

ARTICLE; ATHEROSCLEROSIS; CARDIOVASCULAR DISEASE; CARDIOVASCULAR INFECTION; CARDIOVASCULAR INFLAMMATION; CAUSE OF DEATH; DEVICE THERAPY; EARLY DIAGNOSIS; HEART INFARCTION; HEART VENTRICLE FUNCTION; HUMAN; IMAGING; IN VIVO STUDY; INFARCTION; MOLECULAR IMAGING; NON INVASIVE MEASUREMENT; NONHUMAN; NUCLEAR MAGNETIC RESONANCE IMAGING; OPTICAL IMAGING; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; SCINTISCANNING; SUDDEN DEATH; TISSUE INJURY; UNITED STATES; UPREGULATION;

ANIMALS; CARDIOVASCULAR DISEASES; ENDOCARDITIS; HUMANS; INFLAMMATION; MOLECULAR IMAGING; MYOCARDIAL INFARCTION; VENTRICULAR REMODELING;

EID: 84860776999     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.111.099838     Document Type: Article

References (25)

1. Dobrucki LW, Sinusas AJ. PET and SPECT in cardiovascular molecular imaging. Nat Rev Cardiol. 2010;7:38-47.
2. Sadeghi MM, Glover DK, Lanza GM, et al. Imaging atherosclerosis and vulnerable plaque. J Nucl Med. 2010;51(suppl 1):51S-65S.
3. Kramer CM, Sinusas AJ, Sosnovik DE, et al. Multimodality imaging of myocardial injury and remodeling. J Nucl Med. 2010;51(suppl 1):107S-121S.
4. Nahrendorf M, Keliher E, Panizzi P, et al. 18F-4V for PET-CT imaging of VCAM-1 expression in atherosclerosis. JACC Cardiovasc Imaging. 2009;2:1213-1222.
5. Nahrendorf M, Zhang H, Hembrador S, et al. Nanoparticle PET-CT imaging of macrophages in inflammatory atherosclerosis. Circulation. 2008;117:379-387.
6. Gaemperli O, Shalhoub J, Owen DR, et al. Imaging intraplaque inflammation in carotid atherosclerosis with 11C-PK11195 positron emission tomography/computed tomography. Eur Heart J. September 19, 2011 [Epub ahead of print].
7. Fujimoto S, Hartung D, Ohshima S, et al. Molecular imaging of matrix metalloproteinase in atherosclerotic lesions: Resolution with dietary modification and statin therapy. J Am Coll Cardiol. 2008;52:1847-1857.
8. Ohshima S, Petrov A, Fujimoto S, et al. Molecular imaging of matrix metalloproteinase expression in atherosclerotic plaques of mice deficient in apolipoprotein E or low-density-lipoprotein receptor. J Nucl Med. 2009;50:612-617.
9. Haider N, Hartung D, Fujimoto S, et al. Dual molecular imaging for targeting metalloproteinase activity and apoptosis in atherosclerosis: Molecular imaging facilitates understanding of pathogenesis. J Nucl Cardiol. 2009;16:753-762.
10. Rudd JH, Myers KS, Bansilal S, et al. Atherosclerosis inflammation imaging with 18F-FDG PET: Carotid, iliac, and femoral uptake reproducibility, quantification methods, and recommendations. J Nucl Med. 2008;49:871-878. (Pubitemid 351793426)
11. Fayad ZA, Mani V, Woodward M, et al. Safety and efficacy of dalcetrapib on atherosclerotic disease using novel non-invasive multimodality imaging (dal-PLAQUE): A randomised clinical trial. Lancet. 2011;378:1547-1559.
12. Nahrendorf M, Keliher E, Marinelli B, et al. Detection of macrophages in aortic aneurysms by nanoparticle positron emission tomography-computed tomography. Arterioscler Thromb Vasc Biol. 2011;31:750-757.
13. Razavian M, Zhang J, Nie L, et al. Molecular imaging of matrix metalloproteinase activation to predict murine aneurysm expansion in vivo. J Nucl Med. 2010;51: 1107-1115.
14. Panizzi P, Nahrendorf M, Figueiredo JL, et al. In vivo detection of Staphylococcus aureus endocarditis by targeting pathogen-specific prothrombin activation. Nat Med. 2011;17:1142-1146.
15. Nahrendorf M, Pittet MJ, Swirski FK. Monocytes: Protagonists of infarct inflammation and repair after myocardial infarction. Circulation. 2010;121: 2437-2445.
16. Berr SS, Xu Y, Roy RJ, et al. Images in cardiovascular medicine: Serial multimodality assessment of myocardial infarction in mice using magnetic resonance imaging and micro-positron emission tomography provides complementary information on the progression of scar formation. Circulation. 2007;115:-428-429.
17. Lee WW, Marinelli B, van der Laan AM, et al. PET/MRI of inflammation in myocardial infarction. J Am Coll Cardiol. 2012;59:153-163.
18. Rodriguez-Porcel M, Cai W, Gheysens O, et al. Imaging of VEGF receptor in a rat myocardial infarction model using PET. J Nucl Med. 2008;49:667-673. (Pubitemid 351520616)
19. Sadeghi MM, Bender JR. Activated alphavbeta3 integrin targeting in injuryinduced vascular remodeling. Trends Cardiovasc Med. 2007;17:5-10. (Pubitemid 46038765)
20. Kalinowski L, Dobrucki LW, Meoli DF, et al. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. J Appl Physiol. 2008;104: 1504-1512.
21. Su H, Spinale FG, Dobrucki LW, et al. Noninvasive targeted imaging of matrix metalloproteinase activation in a murine model of postinfarction remodeling. Circulation. 2005;112:3157-3167.
22. Sahul ZH, Mukherjee R, Song J, et al. Targeted imaging of the spatial and temporal variation of matrix metalloproteinase activity in a porcine model of postinfarct remodeling: Relationship to myocardial dysfunction. Circ Cardiovasc Imaging. 2011;4:381-391.
23. Yoo H, Kim JW, Shishkov M, et al. Intra-arterial catheter for simultaneous microstructural and molecular imaging in vivo. Nat Med. 2011;17:1680-1684.
24. Nahrendorf M, Keliher E, Marinelli B, et al. Hybrid PET-optical imaging using targeted probes. Proc Natl Acad Sci USA. 2010;107:7910-7915.
25. Devaraj NK, Weissleder R. Biomedical applications of tetrazine cycloadditions. Acc Chem Res. 2011;44:816-827.