Thermodynamic evaluation of the binding of bisphosphonates to human farnesyl pyrophosphate synthase

Chemical and Pharmaceutical Bulletin

Volumn 62, Issue 1, 2014, Pages 77-83

  Kawasaki, Yuko ^a   Sekiguchi, Mitsuhiro ^a   Kawasaki, Masashi ^a   Hirakura, Yutaka ^a  

^a ASTELLAS PHARMA INC   (Japan)

Author keywords

Differential scanning calorimetry; Drug discovery; Enthalpy; Isothermal titration calorimetry; Thermodynamics

Indexed keywords

ALENDRONIC ACID; BISPHOSPHONIC ACID DERIVATIVE; CLODRONIC ACID; ETIDRONIC ACID; FARNESYL PYROPHOSPHATE SYNTHASE; IBANDRONIC ACID; MINODRONIC ACID; PAMIDRONIC ACID; RISEDRONIC ACID; SYNTHETASE; UNCLASSIFIED DRUG; ZOLEDRONIC ACID;

ARTICLE; BINDING AFFINITY; CALORIMETRY; DENATURATION; DIFFERENTIAL SCANNING CALORIMETRY; DRUG BINDING; DRUG DEVELOPMENT; DRUG STRUCTURE; ENTHALPY; ENZYME BINDING; ENZYME STABILITY; ENZYME STRUCTURE; EVALUATION STUDY; HUMAN; HYDROGEN BOND; ISOTHERMAL TITRATION CALORIMETRY; PROTEIN EXPRESSION; PROTEIN PURIFICATION; TEMPERATURE; THERMODYNAMICS; THERMOSTABILITY;

DIPHOSPHONATES; HUMANS; HYDROGEN BONDING; POLYISOPRENYL PHOSPHATES; PROTEIN BINDING; SESQUITERPENES; TEMPERATURE; THERMODYNAMICS;

EID: 84892141268     PISSN: 00092363     EISSN: 13475223     Source Type: Journal    
DOI: 10.1248/cpb.c13-00710     Document Type: Article

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