mRNA 3′end processing: A tale of the tail reaches the clinic

EMBO Molecular Medicine

Volumn 6, Issue 1, 2014, Pages 16-26

  Hollerer, Ina ^a,b,c   Grund, Kerstin ^a,b   Hentze, Matthias W ^b,c   Kulozik, Andreas E ^a,b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b Molecular Medicine Partnership Unit (MMPU)   (Germany)

^c EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

Author keywords

Clinical importance of 3 end mRNA processing; Control of polyadenylation; Post transcriptional gene regulation; Regulation of 3 end mRNA processing

Indexed keywords

CIS ACTING ELEMENT; CLEAVAGE AND POLYADENYLATION SPECIFICITY FACTOR; CLEAVAGE STIMULATION FACTOR; GLIAL FIBRILLARY ACIDIC PROTEIN; HEAT SHOCK TRANSCRIPTION FACTOR 1; MESSENGER RNA; MESSENGER RNA PRECURSOR; MISMATCH REPAIR PROTEIN PMS2; POLYADENYLIC ACID; POLYADENYLIC ACID BINDING PROTEIN; POLYNUCLEOTIDE ADENYLYLTRANSFERASE; PROTEIN MSH2; PROTEIN MSH6; PROTEIN P53; RNA POLYMERASE II; TRANSCRIPTION FACTOR IID;

3' UNTRANSLATED REGION; ALTERNATIVE POLYADENYLATION; ARTICLE; ASTROCYTE; CELL ACTIVATION; CELL PROLIFERATION; CENTRAL NERVOUS SYSTEM; CYTOSKELETON; DEGENERATIVE DISEASE; DISEASE ASSOCIATION; ENZYME ACTIVITY; GENE EXPRESSION REGULATION; HEMATOLOGIC DISEASE; HEREDITARY NONPOLYPOSIS COLORECTAL CANCER; MUTATION; NEOPLASM; OCULOPHARYNGEAL MUSCULAR DYSTROPHY; POLYADENYLATION; PRIORITY JOURNAL; PROTEIN FUNCTION; RNA CAPPING; RNA CLEAVAGE; RNA PROCESSING; RNA SEQUENCE; RNA SPLICING; RNA SYNTHESIS; ANIMAL; GENETICS; HUMAN; METABOLISM; PATHOPHYSIOLOGY; REVIEW;

3' UNTRANSLATED REGIONS; ANIMALS; HEMATOLOGIC DISEASES; HUMANS; MRNA CLEAVAGE AND POLYADENYLATION FACTORS; NEOPLASMS; NEURODEGENERATIVE DISEASES; POLY(A)-BINDING PROTEINS; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA, MESSENGER;

EID: 84891955589     PISSN: 17574676     EISSN: 17574684     Source Type: Journal    
DOI: 10.1002/emmm.201303300     Document Type: Article

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