Mitochondrial targeting of α-tocopheryl succinate enhances its anti-mesothelioma efficacy

Redox Report

Volumn 19, Issue 1, 2014, Pages 16-25

  Kovarova, Jaromira ^a   Bajzikova, Martina ^a   Vondrusova, Magdalena ^a   Stursa, Jan ^b   Goodwin, Jacob ^c   Nguyen, Maria ^c   Zobalova, Renata ^a,c   Pesdar, Elham Alizadeh ^c   Truksa, Jaroslav ^a   Tomasetti, Marco ^d   Dong, Lan Feng ^c   Neuzil, Jiri ^a,c  

^a INSTITUTE OF BIOTECHNOLOGY   (Czech Republic)

^b INSTITUTE OF ORGANIC CHEMISTRY AND BIOCHEMISTRY   (Czech Republic)

^c GRIFFITH UNIVERSITY   (Australia)

^d UNIVERSITÀ POLITECNICA DELLE MARCHE   (Italy)

Author keywords

Apoptosis; Mesothelioma; Mitochondrial targeting; Reactive oxygen species; Respiratory complexes; Vitamin E analogues

Indexed keywords

ALPHA TOCOPHEROL SUCCINATE; PHOSPHONIUM DERIVATIVE; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE (PHOSPHATE) DEHYDROGENASE (QUINONE);

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG EFFICACY; DRUG TARGETING; HUMAN; HUMAN CELL; MESOTHELIOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NONHUMAN; NUDE MOUSE; PRIORITY JOURNAL;

APOPTOSIS; MESOTHELIOMA; MITOCHONDRIAL TARGETING; REACTIVE OXYGEN SPECIES; RESPIRATORY COMPLEXES; VITAMIN E ANALOGUES;

ALPHA-TOCOPHEROL; ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DRUG DELIVERY SYSTEMS; DRUG SCREENING ASSAYS, ANTITUMOR; ELECTRON TRANSPORT COMPLEX II; HUMANS; INHIBITORY CONCENTRATION 50; MEMBRANE POTENTIAL, MITOCHONDRIAL; MESOTHELIOMA; MICE; MICE, INBRED BALB C; MICE, NUDE; MITOCHONDRIA; MOLECULAR STRUCTURE; NEOPLASM PROTEINS; REACTIVE OXYGEN SPECIES; RNA INTERFERENCE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84891880843     PISSN: 13510002     EISSN: 17432928     Source Type: Journal    
DOI: 10.1179/1351000213y.0000000064     Document Type: Article

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