Interaction of genetic risk factors confers increased risk for metabolic syndrome: The role of peroxisome proliferator-Activated receptor γ

Genetic Testing and Molecular Biomarkers

Volumn 18, Issue 1, 2014, Pages 32-40

  Božina, Tamara ^a   Sertić, Jadranka ^a,b   Lovrić, Jasna ^a   Jelaković, Bojan ^b   Šimić, Iveta ^b   Reiner, Željko ^b  

^a UNIVERSITY OF ZAGREB   (Croatia)

^b KBC Zagreb   (Croatia)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN 1 RECEPTOR; DIPEPTIDYL CARBOXYPEPTIDASE; GLUCOSE; INTERLEUKIN 6; LIPOPROTEIN LIPASE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA;

ADULT; ALLELE; ARTICLE; CONTROLLED STUDY; FEMALE; GENE INTERACTION; GENE TARGETING; GENETIC RISK; GENETIC VARIABILITY; GENOTYPE; GLUCOSE BLOOD LEVEL; HETEROZYGOTE; HIGH RISK POPULATION; HUMAN; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; MIDDLE AGED; RESTRICTION FRAGMENT LENGTH POLYMORPHISM;

ADULT; FEMALE; GENETIC PREDISPOSITION TO DISEASE; HUMANS; MALE; METABOLIC SYNDROME X; MIDDLE AGED; PPAR GAMMA; RISK FACTORS;

EID: 84891875602     PISSN: 19450265     EISSN: 19450257     Source Type: Journal    
DOI: 10.1089/gtmb.2013.0344     Document Type: Article

References (58)

1. Angelakopoulou A, Shah T, Sofat R, et al. (2012) Comparative analysis of genome-wide association studies signals for lipids, diabetes, and coronary heart disease: cardiovascular biomarker genetics collaboration. Eur Heart J 33:393-407.
2. Azhar S (2010) Peroxisome proliferator-Activated receptors, metabolic syndrome and cardiovascular disease. Future Cardiol 6:657-691.
3. Bell-Parikh LC, Ide T, Lawson JA, et al. (2003) Biosynthesis of 15- deoxydelta12,14-PGJ2 and the ligation of PPARgamma. J Clin Invest 112:945-955.
4. Berthier MT, Paradis AM, Tchernof A, et al. (2003) The interleukin 6-174G/C polymorphism is associated with indices of obesity in men. J Hum Genet 48:14-19.
5. Bhatt SP, Misra A, Sharma M, et al. (2012) Ala/Ala genotype of Pro12Ala polymorphism in the peroxisome proliferatoractivated receptor-g2 gene is associated with obesity and insulin resistance in Asian Indians. Diabetes Technol Ther 14:828-834.
6. Bonnardeaux A, Davies E, Jeunemaitre X, et al. (1994) Angiotensin II type 1 receptor gene polymorphisms in human essential hypertension. Hypertension 24:63-69.
7. Curti ML, Jacob P, Borges MC, et al. (2011) Studies of gene variants related to inflammation, oxidative stress, dyslipidemia, and obesity: implications for a nutrigenetic approach. J Obes 2011:497401.
8. Damcott CM, Moffett SP, Feingold E, et al. (2004) Genetic variation in fatty acid-binding protein-4 and peroxisome proliferator- activated receptor gamma interactively influence insulin sensitivity and body composition in males. Metabolism 53:303-309.
9. de Rooij SR, Painter RC, Phillips DI, et al. (2006) The effects of the Pro12Ala polymorphism of the peroxisome proliferatoractivated receptor-gamma2 gene on glucose/insulin metabolism interact with prenatal exposure to famine. Diabetes Care 29:1052-1057.
10. Deeb SS, Fajas L, Nemoto M, et al. (1998) A Pro12Ala substitution in PPARg2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity. Nat Genet 20:284-287.
11. Engeli S, Negrel R, Sharma AM (2000) Physiology and pathophysiology of the adipose tissue renin angiotensin system. Hypertension 35:1270-1277.
12. Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (2001) Executive Summary of The Third Report of The National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults Adult Treatment Panel III). JAMA 285 2486-2497.
13. Fernandez-Real JM, Broch M, Vendrell J, et al. (2000) Interleukin- 6 gene polymorphism and lipid abnormalities in healthy subjects. J Clin Endocrinol Metab 85:1334-1339.
14. Fernandez-Real JM, Vayreda M, Richart C, et al. (2001) Circulating interleukin 6 levels, blood pressure, and insulin sensitivity in apparently healthy men and women. J Clin Endocrinol Metab 86:1154-1159.
15. Gouda HN, Sagoo GS, Harding AH, et al. (2010) The association between the peroxisome proliferator-Activated receptor-gamma2 (PPARG2) Pro12Ala gene variant and type 2 diabetes mellitus: a HuGE review and meta-Analysis. Am J Epidemiol 171:645-655.
16. Groop L (2000) Genetics of the metabolic syndrome. Br J Nutr 83(Suppl 1):S39-S48.
17. He W (2009) PPARgamma2 Polymorphism and Human Health. PPAR Res 2009:849538.
18. Hilgers KF, Langenfeld MRW, Schlaich M, et al. (1999) 1166 A/C polymorphism of the angiotensin II type 1 receptor gene and the response to short-term infusion of angiotensin II. Circulation 100:1394-1399.
19. Huang HY, Thuita L, Strickland P, et al. (2007) Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population. BMC Genet 8:7.
20. Huang X, Zhao J, Zhao T (2011) Effects of peroxisome proliferator activated receptor-gamma 2 gene Pro12Ala polymorphism on fasting blood lipids: a meta-Analysis. Atherosclerosis 215:136-144.
21. Hutch C, Illig T, Herder C, et al. (2009) Joint analysis of individual participants data from17 studies on the association of the IL-6 variant - 174G C with circulating glucose levels, interleukin-6 levels, and boy mass index. Ann Med 41:128-138.
22. Ide T, Egan K, Bell-Parikh LC, et al. (2003) Activation of nuclear receptors by prostaglandins. Thromb Res 110:311-315.
23. Jaccard J (2001) Interaction Effects in Logistic Regression. Sage University Papers Series on Quantitative Applications in the Social Sciences. SAGE, Thousand Oaks, CA, pp 07-135.
24. Jamie WE, Edwards RK, Ferguson RJ, et al. (2005) The interleukin- 6-174 single nucleotide polymorphism: cervical protein production and the risk of preterm delivery. Am J Obstet Gynecol 192:1023-1027.
25. Kleinbaum DG and Klein M (2002) Logistic regression: A self learning text (2nd ed.). Springer, New York.
26. Kraja AT, Borecki IB, North K, et al. (2006) Longitudinal and age trends of metabolic syndrome and its risk factors: the Family Heart Study. Nutr Metab (Lond) 3:41.
27. Kubaszek A, Pihlajamaki J, Punnonen K, et al. (2003) The C-174G promoter polymorphism of the IL-6 gene affects energy expenditure and insulin sensitivity. Diabetes 52:558-561.
28. Lin HF, Boden-Albala B, Juo SH, et al. (2005) Heritabilities of the metabolic syndrome and its components in the Northern Manhattan Family Study. Diabetologia 48:2006-2012.
29. Lusis AJ, Attie AD, Reue K (2008) Metabolic syndrome: from epidemiology to systems biology. Nat Rev Genet 9: 819-830.
30. Masud S, Ye S; SAS Group (2003) Effect of the peroxisome proliferator activated receptor-gamma gene Pro12Ala variant on body mass index: a meta-Analysis. J Med Genet 40:773-780.
31. Miller SA, Dykes DD, Polesky HF (1988) A simple salting out procedure for extracting DNA from human nucleated cells. Nucleic Acids Res 16:1215.
32. Mo llsten A, Stegmayr B, Wiklund PG (2008) Genetic polymorphisms in the renin-Angiotensin system confer increased risk of stroke independently of blood pressure: a nested casecontrol study. J Hypertens 26:1367-1372.
33. Monda KL, North KE, Hunt SC, et al. (2010) The genetics of obesity and the metabolic syndrome. Endocr Metab Immune Disord Drug Targets 10:86-108.
34. Ochoa MC, Marti A, Azcona C, et al. (2004) Gene-gene interaction between PPAR gamma 2 and ADR beta 3 increases obesity risk in children and adolescents. Int J Obes Relat Metab Disord 28(Suppl 3):S37-S41.
35. Oh EY, Min KM, Chung JH, et al. (2000) Significance of Pro12Ala mutation in peroxisome proliferator-Activated receptorgamma2 in Korean diabetic and obese subjects. J Clin Endocrinol Metab 85:1801-1804.
36. Olefsky JM (2000) Treatment of insulin resistance with peroxisome proliferator-Activated receptor gamma agonists. J Clin Invest 106:467-472.
37. Palatini P, Ceolotto G, Dorigatti F, et al. (2009) Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome. Am J Hypertens 22:208-214.
38. Paracchini V, Pedotti P, Taioli E (2005) Genetics of leptin and obesity: a HuGE review. Am J Epidemiol 162:101-114.
39. Park YM, Province MA, Gao X, et al. (2009) Longitudinal trends in the association of metabolic syndrome with 550 k singlenucleotide polymorphisms in the Framingham Heart Study. BMC Proc 3(Suppl 7):S116.
40. Passaro A, Dalla Nora E, Marcello C, et al. (2011) PPARg Pro12Ala and ACE ID polymorphisms are associated with BMI and fat distribution, but not metabolic syndrome. Cardiovasc Diabetol 10:112.
41. Pujia A, Gnasso A, Irace C, et al. (1994) Association between ACE-D/D polymorphism and hypertension in type II diabetic subjects. J Hum Hypertens 8:687-691.
42. Qi L, Zhang C, van Dam RM, et al. (2007) Interleukin-6 genetic variability and adiposity: associations in two prospective cohorts and systematic review in 26,944 individuals. J Clin Endocrinol Metab 92:3618-3625.
43. Rangwala SM Lazar MA (2000) Transcriptional control of adipogenesis. Annu Rev Nutr 20:535-559.
44. Rigat B, Hubert C, Alhenc-Gelas F, et al. (1990) An insertion/ deletion polymorphism in the angiotensin I-converting enzyme gene accounting for half the variance of serum enzyme levels. J Clin Invest 86:1343-1346.
45. Rigat B, Hubert C, Corvol P, et al. (1992) PCR detection of the insertion/deletion polymorphism of the human angiotensin converting enzyme gene (DCP1) (dipeptidyl carboxypeptidase 1). Nucleic Acids Res 20:1433.
46. Roszer T, Ricote M (2010) PPARs in the renal regulation of systemic blood pressure. PPAR Res 2010:698730.
47. Saint-Marc P, Kozak LP, Ailhaud G, et al. (2001) Angiotensin II as a trophic factor of white adipose tissue: stimulation of adipose cell formation. Endocrinology 142:487-492.
48. Sattar N, Perry CG, Petrie JR (2003) Type 2 diabetes as an inflammatory disorder. Br J Diabetes Vasc Dis 3:36-41.
49. Scacchi R, Pinto A, Rickards O, et al. (2007) An analysis of peroxisome proliferator-Activated receptor gamma (PPARgamma 2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits. Nutr Metab Cardiovasc Dis 17:632-41.
50. Schneider J, Kreuzer J, Hamann A, et al. (2002) The proline12alanine substitution in the peroxisome proliferator-Activated receptor-g2 gene is associated with lower lipoprotein lipase activity in vivo. Diabetes 51:867-870.
51. Schoonjans K, Peinado-Onsurbe J, Lefebvre AM, et al. (1996) PPARalpha and PPARgamma activators direct a distinct tissue- specific transcriptional response via a PPRE in the lipoprotein lipase gene. EMBO J 15:5336-5348.
52. Semenkovich CF, Wims M, Noe L, et al. (1989) Insulin regulation of lipoprotein lipase activity in 3T3-L1 adipocytes is mediated at posttranscriptional and posttranslational levels. J Biol Chem 264:9030-9038.
53. Sharma AM Staels B (2007) Review: Peroxisome proliferatoractivated receptor gamma and adipose tissue-understanding obesity-related changes in regulation of lipid and glucose metabolism. J Clin Endocrinol Metab 92:386-395.
54. Stephens JW, Hurel SJ, Cooper JA, et al. (2004) A common functional variant in the interleukin-6 gene is associated with increased body mass index in subjects with type 2 diabetes mellitus. Mol Genet Metab 82:180-186.
55. Stephens JW, Hurel SJ, Lowe GDO, et al. (2007) Association between plasma IL-6, the IL6-174G C gene variant and the metabolic syndrome in type 2 diabetes mellitus. Mol Genet Metab 90:422-428.
56. Tiret L, Blanc H, Ruidavets JB, et al. (1998) Gene polymorphisms of the renin-Angiotensin system in relation to hypertension and parental history of myocardial infarction and stroke: the PEGASE study. Projet dEtude des Genes de lHypertension Arterielle Severe a moderee Essentielle. J Hypertens 16:37-44.
57. Tiret L, Rigat B, Visvikis S, et al. (1992) Evidence, from combined segregation and linkage analysis, that a variant of the angiotensin I-converting enzyme (ACE) gene controls plasma ACE levels. Am J Hum Genet 51:197-205.
58. Xu E, Li W, Zhan L, et al. (2008) Polymorphisms of the lipoprotein lipase gene are associated with atherosclerotic cerebral infarction in the Chinese. Neuroscience 155:403-408.