메뉴 건너뛰기




Volumn , Issue , 2009, Pages

PPARγ2Pro12Ala polymorphism and human health

Author keywords

[No Author keywords available]

Indexed keywords


EID: 72449192922     PISSN: 16874757     EISSN: 16874765     Source Type: Journal    
DOI: 10.1155/2009/849538     Document Type: Article
Times cited : (46)

References (224)
  • 1
    • 0012473279 scopus 로고
    • The nuclear receptor superfamily: The second decade
    • D. J. Mangelsdorf, C. Thummel, M. Beato, et al., "The nuclear receptor superfamily: the second decade, " Cell, vol. 83, no. 6, pp. 835-839, 1995.
    • (1995) Cell , vol.83 , Issue.6 , pp. 835-839
    • Mangelsdorf, D.J.1    Thummel, C.2    Beato, M.3
  • 2
    • 33244482536 scopus 로고    scopus 로고
    • Combinatorial roles of nuclear receptors in inflammation and immunity
    • C. K. Glass and S. Ogawa, "Combinatorial roles of nuclear receptors in inflammation and immunity, " Nature Reviews Immunology, vol. 6, no. 1, pp. 44-55, 2006.
    • (2006) Nature Reviews Immunology , vol.6 , Issue.1 , pp. 44-55
    • Glass, C.K.1    Ogawa, S.2
  • 3
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • D. J. Mangelsdorf and R. M. Evans, "The RXR heterodimers and orphan receptors, " Cell, vol. 83, no. 6, pp. 841-850, 1995.
    • (1995) Cell , vol.83 , Issue.6 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 4
    • 21744435965 scopus 로고    scopus 로고
    • Controlling nuclear receptors: The circular logic of cofactor cycles
    • V. Perissi and M. G. Rosenfeld, "Controlling nuclear receptors: the circular logic of cofactor cycles, " Nature Reviews Molecular Cell Biology, vol. 6, no. 7, pp. 542-554, 2005.
    • (2005) Nature Reviews Molecular Cell Biology , vol.6 , Issue.7 , pp. 542-554
    • Perissi, V.1    Rosenfeld, M.G.2
  • 5
    • 0030835678 scopus 로고    scopus 로고
    • The organization, promoter analysis, and expression of the human PPARy gene
    • L. Fajas, D. Auboeuf, E. Raspe, et al., "The organization, promoter analysis, and expression of the human PPARy gene, " The Journal of Biological Chemistry, vol. 272, no. 30, pp. 18779-18789, 1997.
    • (1997) The Journal of Biological Chemistry , vol.272 , Issue.30 , pp. 18779-18789
    • Fajas, L.1    Auboeuf, D.2    Raspe, E.3
  • 6
    • 0029152375 scopus 로고
    • Isolation of the human peroxisome proliferator activated receptor gamma cDNA: Expression in hematopoietic cells and chromosomal mapping
    • M. E. Greene, B. Blumberg, O. W. McBride, et al., "Isolation of the human peroxisome proliferator activated receptor gamma cDNA: expression in hematopoietic cells and chromosomal mapping, " Gene Expression, vol. 4, no. 4-5, pp. 281-299, 1995.
    • (1995) Gene Expression , vol.4 , Issue.4-5 , pp. 281-299
    • Greene, M.E.1    Blumberg, B.2    McBride, O.W.3
  • 7
    • 0030047806 scopus 로고    scopus 로고
    • Differential expression of peroxisome proliferator-activated receptors (PPARs): Tissue distribution of PPAR-A,-/3, and-y in the adult rat
    • O. Braissant, F. Foufelle, C. Scotto, M. Dauca, and W. Wahli, "Differential expression of peroxisome proliferator-activated receptors (PPARs): tissue distribution of PPAR-a,-/3, and-y in the adult rat, " Endocrinology, vol. 137, no. 1, pp. 354-366, 1996.
    • (1996) Endocrinology , vol.137 , Issue.1 , pp. 354-366
    • Braissant, O.1    Foufelle, F.2    Scotto, C.3    Dauca, M.4    Wahli, W.5
  • 9
    • 0031898610 scopus 로고    scopus 로고
    • PPAR-y: Adipogenic regulator and thia-zolidinedione receptor
    • B. M. Spiegelman, "PPAR-y: adipogenic regulator and thia-zolidinedione receptor, " Diabetes, vol. 47, no. 4, pp. 507-514, 1998.
    • (1998) Diabetes , vol.47 , Issue.4 , pp. 507-514
    • Spiegelman, B.M.1
  • 10
    • 0033213637 scopus 로고    scopus 로고
    • PPARy is required for placental, cardiac, and adipose tissue development
    • Y. Barak, M. C. Nelson, E. S. Ong, et al., "PPARy is required for placental, cardiac, and adipose tissue development, " Molecular Cell, vol. 4, no. 4, pp. 585-595, 1999.
    • (1999) Molecular Cell , vol.4 , Issue.4 , pp. 585-595
    • Barak, Y.1    Nelson, M.C.2    Ong, E.S.3
  • 11
    • 0033213631 scopus 로고    scopus 로고
    • PPARy is required for the differentiation of adipose tissue in vivo and in vitro
    • E. D. Rosen, P. Sarraf, A. E. Troy, et al., "PPARy is required for the differentiation of adipose tissue in vivo and in vitro, " Molecular Cell, vol. 4, no. 4, pp. 611-617, 1999.
    • (1999) Molecular Cell , vol.4 , Issue.4 , pp. 611-617
    • Rosen, E.D.1    Sarraf, P.2    Troy, A.E.3
  • 12
    • 0028641559 scopus 로고
    • Stimulation of adipogenesis in fibroblasts by PPARy2, a lipid-activated transcription factor
    • P. Tontonoz, E. Hu, and B. M. Spiegelman, "Stimulation of adipogenesis in fibroblasts by PPARy2, a lipid-activated transcription factor, " Cell, vol. 79, no. 7, pp. 1147-1156, 1994.
    • (1994) Cell , vol.79 , Issue.7 , pp. 1147-1156
    • Tontonoz, P.1    Hu, E.2    Spiegelman, B.M.3
  • 13
    • 0033212964 scopus 로고    scopus 로고
    • PPARy mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance
    • N. Kubota, Y. Terauchi, H. Miki, et al., "PPARy mediates high-fat diet-induced adipocyte hypertrophy and insulin resistance, " Molecular Cell, vol. 4, no. 4, pp. 597-609, 1999.
    • (1999) Molecular Cell , vol.4 , Issue.4 , pp. 597-609
    • Kubota, N.1    Terauchi, Y.2    Miki, H.3
  • 14
    • 9144229185 scopus 로고    scopus 로고
    • Adipose-specific peroxisome proliferator-activated receptor y knockout causes insulin resistance in fat and liver but not in muscle
    • W. He, Y Barak, A. Hevener, et al., "Adipose-specific peroxisome proliferator-activated receptor y knockout causes insulin resistance in fat and liver but not in muscle, " Proceedings of the National Academy of Sciences of the United States of America, vol. 100, no. 26, pp. 15712-15717, 2003.
    • (2003) Proceedings of the National Academy of Sciences of the United States of America , vol.100 , Issue.26 , pp. 15712-15717
    • He, W.1    Barak, Y.2    Hevener, A.3
  • 15
    • 12144291563 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor y is required in mature white and brown adipocytes for their survival in the mouse
    • T. Imai, R. Takakuwa, S. Marchand, et al., "Peroxisome proliferator-activated receptor y is required in mature white and brown adipocytes for their survival in the mouse, " Proceedings of the National Academy of Sciences of the United States of America, vol. 101, no. 13, pp. 4543-4547, 2004.
    • (2004) Proceedings of the National Academy of Sciences of the United States of America , vol.101 , Issue.13 , pp. 4543-4547
    • Imai, T.1    Takakuwa, R.2    Marchand, S.3
  • 16
    • 20944439189 scopus 로고    scopus 로고
    • Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance
    • J. R. Jones, C. Barrick, K.-A. Kim, et al., "Deletion of PPARγ in adipose tissues of mice protects against high fat diet-induced obesity and insulin resistance, " Proceedings of the National Academy of Sciences of the United States of America, vol. 102, no. 17, pp. 6207-6212, 2005.
    • (2005) Proceedings of the National Academy of Sciences of the United States of America , vol.102 , Issue.17 , pp. 6207-6212
    • Jones, J.R.1    Barrick, C.2    Kim, K.-A.3
  • 17
    • 0032540325 scopus 로고    scopus 로고
    • Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ
    • L. Nagy, P. Tontonoz, J. G. A. Alvarez, H. Chen, and R. M. Evans, "Oxidized LDL regulates macrophage gene expression through ligand activation of PPARγ, " Cell, vol. 93, no. 2, pp. 229-240, 1998.
    • (1998) Cell , vol.93 , Issue.2 , pp. 229-240
    • Nagy, L.1    Tontonoz, P.2    Alvarez, J.G.A.3    Chen, H.4    Evans, R.M.5
  • 18
    • 0032540012 scopus 로고    scopus 로고
    • PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL
    • P. Tontonoz, L. Nagy, J. G. A. Alvarez, V. A. Thomazy, and R. M. Evans, "PPARγ promotes monocyte/macrophage differentiation and uptake of oxidized LDL, " Cell, vol. 93, no. 2, pp. 241-252, 1998.
    • (1998) Cell , vol.93 , Issue.2 , pp. 241-252
    • Tontonoz, P.1    Nagy, L.2    Alvarez, J.G.A.3    Thomazy, V.A.4    Evans, R.M.5
  • 19
    • 17744376173 scopus 로고    scopus 로고
    • A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis
    • A. Chawla, W. A. Boisvert, C.-H. Lee, et al., "A PPARγ-LXR-ABCA1 pathway in macrophages is involved in cholesterol efflux and atherogenesis, " Molecular Cell, vol. 7, no. 1, pp. 161-171, 2001.
    • (2001) Molecular Cell , vol.7 , Issue.1 , pp. 161-171
    • Chawla, A.1    Boisvert, W.A.2    Lee, C.-H.3
  • 20
    • 0035139016 scopus 로고    scopus 로고
    • The role of PPAR-γ in macrophage differentiation and cholesterol uptake
    • K. J. Moore, E. D. Rosen, M. L. Fitzgerald, et al., "The role of PPAR-γ in macrophage differentiation and cholesterol uptake, " Nature Medicine, vol. 7, no. 1, pp. 41-47, 2001.
    • (2001) Nature Medicine , vol.7 , Issue.1 , pp. 41-47
    • Moore, K.J.1    Rosen, E.D.2    Fitzgerald, M.L.3
  • 21
    • 0031886864 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation
    • M. Ricote, A. C. Li, T. M. Willson, C. J. Kelly, and C. K. Glass, "The peroxisome proliferator-activated receptor-γ is a negative regulator of macrophage activation, " Nature, vol. 391, no. 6662, pp. 79-82, 1998.
    • (1998) Nature , vol.391 , Issue.6662 , pp. 79-82
    • Ricote, M.1    Li, A.C.2    Willson, T.M.3    Kelly, C.J.4    Glass, C.K.5
  • 22
    • 33745428666 scopus 로고    scopus 로고
    • Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation
    • D. Vats, L. Mukundan, J. I. Odegaard, et al., "Oxidative metabolism and PGC-1β attenuate macrophage-mediated inflammation, " Cell Metabolism, vol. 4, no. 1, pp. 13-24, 2006.
    • (2006) Cell Metabolism , vol.4 , Issue.1 , pp. 13-24
    • Vats, D.1    Mukundan, L.2    Odegaard, J.I.3
  • 23
    • 34249907880 scopus 로고    scopus 로고
    • Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidine-diones
    • A. L. Hevener, J. M. Olefsky, D. Reichart, et al., "Macrophage PPARγ is required for normal skeletal muscle and hepatic insulin sensitivity and full antidiabetic effects of thiazolidine-diones, " The Journal of Clinical Investigation, vol. 117, no. 6, pp. 1658-1669, 2007.
    • (2007) The Journal of Clinical Investigation , vol.117 , Issue.6 , pp. 1658-1669
    • Hevener, A.L.1    Olefsky, J.M.2    Reichart, D.3
  • 24
    • 34347354309 scopus 로고    scopus 로고
    • Macrophage-specific PPARγ controls alternative activation and improves insulin resistance
    • J. I. Odegaard, R. R. Ricardo-Gonzalez, M. H. Goforth, C. R. Morel, V. Subramanian, and L. Mukundan, "Macrophage-specific PPARγ controls alternative activation and improves insulin resistance, " Nature, vol. 447, no. 7148, pp. 1116-1120, 2007.
    • (2007) Nature , vol.447 , Issue.7148 , pp. 1116-1120
    • Odegaard, J.I.1    Ricardo-Gonzalez, R.R.2    Goforth, M.H.3    Morel, C.R.4    Subramanian, V.5    Mukundan, L.6
  • 25
    • 0346027235 scopus 로고    scopus 로고
    • Muscle-specific Pparg deletion causes insulin resistance
    • A. L. Hevener, W. He, Y. Barak, et al., "Muscle-specific Pparg deletion causes insulin resistance, " Nature Medicine, vol. 9, no. 12, pp. 1491-1497, 2003.
    • (2003) Nature Medicine , vol.9 , Issue.12 , pp. 1491-1497
    • Hevener, A.L.1    He, W.2    Barak, Y.3
  • 26
    • 85047693638 scopus 로고    scopus 로고
    • Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones
    • A. W. Norris, L. Chen, S. J. Fisher, et al., "Muscle-specific PPARγ-deficient mice develop increased adiposity and insulin resistance but respond to thiazolidinediones, " The Journal of Clinical Investigation, vol. 112, no. 4, pp. 608-618, 2003.
    • (2003) The Journal of Clinical Investigation , vol.112 , Issue.4 , pp. 608-618
    • Norris, A.W.1    Chen, L.2    Fisher, S.J.3
  • 27
    • 0141446024 scopus 로고    scopus 로고
    • Liver peroxi-some proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass
    • O. Gavrilova, M. Haluzik, K. Matsusue, et al., "Liver peroxi-some proliferator-activated receptor γ contributes to hepatic steatosis, triglyceride clearance, and regulation of body fat mass, " The Journal of Biological Chemistry, vol. 278, no. 36, pp. 34268-34276, 2003.
    • (2003) The Journal of Biological Chemistry , vol.278 , Issue.36 , pp. 34268-34276
    • Gavrilova, O.1    Haluzik, M.2    Matsusue, K.3
  • 28
    • 0037373008 scopus 로고    scopus 로고
    • Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes
    • K. Matsusue, M. Haluzik, G. Lambert, et al., "Liver-specific disruption of PPARγ in leptin-deficient mice improves fatty liver but aggravates diabetic phenotypes, " The Journal of Clinical Investigation, vol. 111, no. 5, pp. 737-747, 2003.
    • (2003) The Journal of Clinical Investigation , vol.111 , Issue.5 , pp. 737-747
    • Matsusue, K.1    Haluzik, M.2    Lambert, G.3
  • 29
    • 36849034568 scopus 로고    scopus 로고
    • PPAR-γ regulates osteoclastogenesis in mice
    • Y. Wan, L.-W. Chong, and R. M. Evans, "PPAR-γ regulates osteoclastogenesis in mice, " Nature Medicine, vol. 13, no. 12, pp. 1496-1503, 2007.
    • (2007) Nature Medicine , vol.13 , Issue.12 , pp. 1496-1503
    • Wan, Y.1    Chong, L.-W.2    Evans, R.M.3
  • 30
    • 36649035297 scopus 로고    scopus 로고
    • Cardiac peroxisome proliferator-activated receptor γ is essential in protecting cardiomyocytes from oxidative damage
    • G. Ding, M. Fu, Q. Qin, et al., "Cardiac peroxisome proliferator-activated receptor γ is essential in protecting cardiomyocytes from oxidative damage, " Cardiovascular Research, vol. 76, no. 2, pp. 269-279, 2007.
    • (2007) Cardiovascular Research , vol.76 , Issue.2 , pp. 269-279
    • Ding, G.1    Fu, M.2    Qin, Q.3
  • 31
    • 24044476859 scopus 로고    scopus 로고
    • Cardiomyocyte-specffic knockout and agonist of peroxisome proliferator-activated receptor-γ both induce cardiac hypertrophy in mice
    • S. Z. Duan, C. Y. Ivashchenko, M. W. Russell, D. S. Milstone, and R. M. Mortensen, "Cardiomyocyte-specffic knockout and agonist of peroxisome proliferator-activated receptor-γ both induce cardiac hypertrophy in mice, " Circulation Research, vol. 97, no. 4, pp. 372-379, 2005.
    • (2005) Circulation Research , vol.97 , Issue.4 , pp. 372-379
    • Duan, S.Z.1    Ivashchenko, C.Y.2    Russell, M.W.3    Milstone, D.S.4    Mortensen, R.M.5
  • 32
    • 17044430286 scopus 로고    scopus 로고
    • PPARγ in endothelial cells influences high fat diet-induced hypertension
    • C. J. Nicol, M. Adachi, T. E. Akiyama, and F. J. Gonzalez, "PPARγ in endothelial cells influences high fat diet-induced hypertension, " American Journal of Hypertension, vol. 18, no. 4, pp. 549-556, 2005.
    • (2005) American Journal of Hypertension , vol.18 , Issue.4 , pp. 549-556
    • Nicol, C.J.1    Adachi, M.2    Akiyama, T.E.3    Gonzalez, F.J.4
  • 33
    • 1942518840 scopus 로고    scopus 로고
    • PPARs and the complex journey to obesity
    • R. M. Evans, G. D. Barish, and Y.-X. Wang, "PPARs and the complex journey to obesity, " Nature Medicine, vol. 10, no. 4, pp. 355-361, 2004.
    • (2004) Nature Medicine , vol.10 , Issue.4 , pp. 355-361
    • Evans, R.M.1    Barish, G.D.2    Wang, Y.-X.3
  • 34
    • 0033659881 scopus 로고    scopus 로고
    • Unraveling the mechanism of action of thiazolidinediones
    • C. R. Kahn, L. Chen, and S. E. Cohen, "Unraveling the mechanism of action of thiazolidinediones, " The Journal of Clinical Investigation, vol. 106, no. 11, pp. 1305-1307, 2000.
    • (2000) The Journal of Clinical Investigation , vol.106 , Issue.11 , pp. 1305-1307
    • Kahn, C.R.1    Chen, L.2    Cohen, S.E.3
  • 35
    • 0033857387 scopus 로고    scopus 로고
    • Treatment of insulin resistance with peroxi-some proliferator-activated receptor γ agonists
    • J. M. Olefsky, "Treatment of insulin resistance with peroxi-some proliferator-activated receptor γ agonists, " The Journal of Clinical Investigation, vol. 106, no. 4, pp. 467-472, 2000.
    • (2000) The Journal of Clinical Investigation , vol.106 , Issue.4 , pp. 467-472
    • Olefsky, J.M.1
  • 36
    • 0029016829 scopus 로고
    • An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ)
    • J. M. Lehmann, L. B. Moore, T. A. Smith-Oliver, W. O. Wilkison, T. M. Willson, and S. A. Kliewer, "An antidiabetic thiazolidinedione is a high affinity ligand for peroxisome proliferator-activated receptor γ (PPARγ), " The Journal of Biological Chemistry, vol. 270, no. 22, pp. 12953-12956, 1995.
    • (1995) The Journal of Biological Chemistry , vol.270 , Issue.22 , pp. 12953-12956
    • Lehmann, J.M.1    Moore, L.B.2    Smith-Oliver, T.A.3    Wilkison, W.O.4    Willson, T.M.5    Kliewer, S.A.6
  • 37
    • 0345164399 scopus 로고    scopus 로고
    • Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: Identification of a Pro12Ala PPARγ2 missense mutation
    • Y. Chung-Jen, B. A. Beamer, C. Negri, et al., "Molecular scanning of the human peroxisome proliferator activated receptor γ (hPPARγ) gene in diabetic Caucasians: identification of a Pro12Ala PPARγ2 missense mutation, " Biochemical and Biophysical Research Communications, vol. 241, no. 2, pp. 270-274, 1997.
    • (1997) Biochemical and Biophysical Research Communications , vol.241 , Issue.2 , pp. 270-274
    • Chung-Jen, Y.1    Beamer, B.A.2    Negri, C.3
  • 38
    • 0036146384 scopus 로고    scopus 로고
    • A novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy
    • A. K. Agarwal and A. Garg, "A novel heterozygous mutation in peroxisome proliferator-activated receptor-γ gene in a patient with familial partial lipodystrophy, " The Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 1, pp. 408-411, 2002.
    • (2002) The Journal of Clinical Endocrinology & Metabolism , vol.87 , Issue.1 , pp. 408-411
    • Agarwal, A.K.1    Garg, A.2
  • 39
    • 12144291700 scopus 로고    scopus 로고
    • Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor γ
    • M. Agostini, M. Gurnell, D. B. Savage, et al., "Tyrosine agonists reverse the molecular defects associated with dominant-negative mutations in human peroxisome proliferator-activated receptor γ, " Endocrinology, vol. 145, no. 4, pp. 1527-1538, 2004.
    • (2004) Endocrinology , vol.145 , Issue.4 , pp. 1527-1538
    • Agostini, M.1    Gurnell, M.2    Savage, D.B.3
  • 40
    • 33748937223 scopus 로고    scopus 로고
    • Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance
    • M. Agostini, E. Schoenmakers, C. Mitchell, et al., "Non-DNA binding, dominant-negative, human PPARγ mutations cause lipodystrophic insulin resistance, " Cell Metabolism, vol. 4, no. 4, pp. 303-311, 2006.
    • (2006) Cell Metabolism , vol.4 , Issue.4 , pp. 303-311
    • Agostini, M.1    Schoenmakers, E.2    Mitchell, C.3
  • 41
    • 0033599038 scopus 로고    scopus 로고
    • Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension
    • I. Barroso, M. Gurnell, V. E. F. Crowley, et al., "Dominant negative mutations in human PPARγ associated with severe insulin resistance, diabetes mellitus and hypertension, " Nature, vol. 402, no. 6764, pp. 880-883, 1999.
    • (1999) Nature , vol.402 , Issue.6764 , pp. 880-883
    • Barroso, I.1    Gurnell, M.2    Crowley, V.E.F.3
  • 42
    • 0036894397 scopus 로고    scopus 로고
    • PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy
    • R. A. Hegele, H. Cao, C. Frankowski, S. T. Mathews, and T. Leff, "PPARG F388L, a transactivation-deficient mutant, in familial partial lipodystrophy, " Diabetes, vol. 51, no. 12, pp. 3586-3590, 2002.
    • (2002) Diabetes , vol.51 , Issue.12 , pp. 3586-3590
    • Hegele, R.A.1    Cao, H.2    Frankowski, C.3    Mathews, S.T.4    Leff, T.5
  • 43
  • 44
    • 18644382993 scopus 로고    scopus 로고
    • Digenic inheritance of severe insulin resistance in a human pedigree
    • D. B. Savage, M. Agostini, I. Barroso, et al., "Digenic inheritance of severe insulin resistance in a human pedigree, " Nature Genetics, vol. 31, no. 4, pp. 379-384, 2002.
    • (2002) Nature Genetics , vol.31 , Issue.4 , pp. 379-384
    • Savage, D.B.1    Agostini, M.2    Barroso, I.3
  • 45
    • 0344375097 scopus 로고    scopus 로고
    • Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ
    • D. B. Savage, G. D. Tan, C. L. Acerini, et al., "Human metabolic syndrome resulting from dominant-negative mutations in the nuclear receptor peroxisome proliferator-activated receptor-γ, " Diabetes, vol. 52, no. 4, pp. 910-917, 2003.
    • (2003) Diabetes , vol.52 , Issue.4 , pp. 910-917
    • Savage, D.B.1    Tan, G.D.2    Acerini, C.L.3
  • 46
    • 0032587731 scopus 로고    scopus 로고
    • Pluripotent PPARγ polymorphisms
    • J. P. Berg, "Pluripotent PPARγ polymorphisms, " European Journal of Endocrinology, vol. 140, no. 4, pp. 293-295, 1999.
    • (1999) European Journal of Endocrinology , vol.140 , Issue.4 , pp. 293-295
    • Berg, J.P.1
  • 47
    • 0041324880 scopus 로고    scopus 로고
    • PPARγ and metabolism: Insights from the study of human genetic variants
    • M. Gurnell, "PPARγ and metabolism: insights from the study of human genetic variants, " Clinical Endocrinology, vol. 59, no. 3, pp. 267-277, 2003.
    • (2003) Clinical Endocrinology , vol.59 , Issue.3 , pp. 267-277
    • Gurnell, M.1
  • 49
    • 18444418534 scopus 로고    scopus 로고
    • Single nucleotide polymorphisms of thrifty genes for energy metabolism: Evolutionary origins and prospects for intervention to prevent obesity-related diseases
    • Y. Kagawa, Y. Yanagisawa, K. Hasegawa, et al., "Single nucleotide polymorphisms of thrifty genes for energy metabolism: evolutionary origins and prospects for intervention to prevent obesity-related diseases, " Biochemical and Biophysical Research Communications, vol. 295, no. 2, pp. 207-222, 2002.
    • (2002) Biochemical and Biophysical Research Communications , vol.295 , Issue.2 , pp. 207-222
    • Kagawa, Y.1    Yanagisawa, Y.2    Hasegawa, K.3
  • 50
    • 4744340732 scopus 로고    scopus 로고
    • Impact of genetic variation of PPARγ in humans
    • A. Meirhaeghe and P. Amouyel, "Impact of genetic variation of PPARγ in humans, " Molecular Genetics and Metabolism, vol. 83, no. 1-2, pp. 93-102, 2004.
    • (2004) Molecular Genetics and Metabolism , vol.83 , Issue.1-2 , pp. 93-102
    • Meirhaeghe, A.1    Amouyel, P.2
  • 51
    • 0031595923 scopus 로고    scopus 로고
    • A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity
    • S. S. Deeb, L. Fajas, M. Nemoto, et al., "A Pro12Ala substitution in PPARγ2 associated with decreased receptor activity, lower body mass index and improved insulin sensitivity, " Nature Genetics, vol. 20, no. 3, pp. 284-287, 1998.
    • (1998) Nature Genetics , vol.20 , Issue.3 , pp. 284-287
    • Deeb, S.S.1    Fajas, L.2    Nemoto, M.3
  • 52
    • 0034607051 scopus 로고    scopus 로고
    • Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-γ 2 on thiazolidinedione- induced adipogenesis
    • J. Masugi, Y. Tamori, H. Mori, T. Koike, and M. Kasuga, "Inhibitory effect of a proline-to-alanine substitution at codon 12 of peroxisome proliferator-activated receptor-γ 2 on thiazolidinedione-induced adipogenesis, " Biochemical and Biophysical Research Communications, vol. 268, no. 1, pp. 178-182, 2000.
    • (2000) Biochemical and Biophysical Research Communications , vol.268 , Issue.1 , pp. 178-182
    • Masugi, J.1    Tamori, Y.2    Mori, H.3    Koike, T.4    Kasuga, M.5
  • 53
    • 0037073439 scopus 로고    scopus 로고
    • Haplotype analysis of the PPARγ Prol 12Ala and CI431T variants reveals opposing associations with body weight
    • article 21
    • A. Doney, B. Fischer, D. Frew, et al., "Haplotype analysis of the PPARγ Prol 12Ala and CI431T variants reveals opposing associations with body weight, " BMC Genetics, vol. 3, article 21, pp. 1-8, 2002.
    • (2002) BMC Genetics , vol.3 , pp. 1-8
    • Doney, A.1    Fischer, B.2    Frew, D.3
  • 54
    • 23044444817 scopus 로고    scopus 로고
    • Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors
    • M. Barbieri, M. R. Rizzo, M. Papa, et al., "Role of interaction between variants in the PPARG and interleukin-6 genes on obesity related metabolic risk factors, " Experimental Gerontology, vol. 40, no. 7, pp. 599-604, 2005.
    • (2005) Experimental Gerontology , vol.40 , Issue.7 , pp. 599-604
    • Barbieri, M.1    Rizzo, M.R.2    Papa, M.3
  • 55
    • 1842610797 scopus 로고    scopus 로고
    • Genetic variation in fatty acid-binding protein-4 and peroxi-some proliferator-activated receptor γ interactively influence insulin sensitivity and body composition in males
    • C. M. Damcott, S. P. Moffett, E. Feingold, et al., "Genetic variation in fatty acid-binding protein-4 and peroxi-some proliferator-activated receptor γ interactively influence insulin sensitivity and body composition in males, " Metabolism: Clinical and Experimental, vol. 53, no. 3, pp. 303-309, 2004.
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.3 , pp. 303-309
    • Damcott, C.M.1    Moffett, S.P.2    Feingold, E.3
  • 56
    • 35748933502 scopus 로고    scopus 로고
    • Polymorphism in the PPARgamma2 and beta2-adrenergic genes and diet lipid effects on body composition, energy expenditure and eating behavior of obese women
    • E. L. Rosado, J. Bressan, M. F. Martins, P. R. Cecon, and J. A. Mart'inez, "Polymorphism in the PPARgamma2 and beta2-adrenergic genes and diet lipid effects on body composition, energy expenditure and eating behavior of obese women, " Appetite, vol. 49, no. 3, pp. 635-643, 2007.
    • (2007) Appetite , vol.49 , Issue.3 , pp. 635-643
    • Rosado, E.L.1    Bressan, J.2    Martins, M.F.3    Cecon, P.R.4    Mart'Inez, J.A.5
  • 57
    • 33645062714 scopus 로고    scopus 로고
    • ACDC/adiponectin and PPAR-γ gene polymorphisms: Implications for features of obesity
    • L. B. Tankó, A. Siddiq, C. Lecoeur, et al., "ACDC/adiponectin and PPAR-γ gene polymorphisms: implications for features of obesity, " Obesity Research, vol. 13, no. 12, pp. 2113-2121, 2005.
    • (2005) Obesity Research , vol.13 , Issue.12 , pp. 2113-2121
    • Tankó, L.B.1    Siddiq, A.2    Lecoeur, C.3
  • 58
    • 48949088059 scopus 로고    scopus 로고
    • Effect of ENPP1/PC-1-K121Q and PPARγ-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population
    • R. Bouhaha, D. Meyre, H. A. Kamoun, et al., "Effect of ENPP1/PC-1-K121Q and PPARγ-Pro12Ala polymorphisms on the genetic susceptibility to T2D in the Tunisian population, " Diabetes Research and Clinical Practice, vol. 81, no. 3, pp. 278-283, 2008.
    • (2008) Diabetes Research and Clinical Practice , vol.81 , Issue.3 , pp. 278-283
    • Bouhaha, R.1    Meyre, D.2    Kamoun, H.A.3
  • 59
    • 20444446401 scopus 로고    scopus 로고
    • Inverse effects of the PPARγ2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites: The CARDIA study
    • M. Fornage, D. R. Jacobs Jr., M. W. Steffes, M. D. Gross, M. S. Bray, and P. J. Schreiner, "Inverse effects of the PPARγ2 Pro12Ala polymorphism on measures of adiposity over 15 years in African Americans and whites: the CARDIA study, " Metabolism: Clinical and Experimental, vol. 54, no. 7, pp. 910-917, 2005.
    • (2005) Metabolism: Clinical and Experimental , vol.54 , Issue.7 , pp. 910-917
    • Fornage, M.1    Jacobs Jr., D.R.2    Steffes, M.W.3    Gross, M.D.4    Bray, M.S.5    Schreiner, P.J.6
  • 60
    • 33750492641 scopus 로고    scopus 로고
    • Patterns of association between PPARγ genetic variation and indices of adiposity and insulin action in African-Americans and whites: The CARDIA Study
    • Q. Wei, D. R. Jacobs Jr., P. J. Schreiner, D. S. Siscovick, M. W. Steffes, and M. Fornage, "Patterns of association between PPARγ genetic variation and indices of adiposity and insulin action in African-Americans and whites: the CARDIA Study, " Journal of Molecular Medicine, vol. 84, no. 11, pp. 955-965, 2006.
    • (2006) Journal of Molecular Medicine , vol.84 , Issue.11 , pp. 955-965
    • Wei, Q.1    Jacobs Jr., D.R.2    Schreiner, P.J.3    Siscovick, D.S.4    Steffes, M.W.5    Fornage, M.6
  • 61
    • 15944412174 scopus 로고    scopus 로고
    • Influence of the PPAR-γ2 Pro12Ala and ACE I/D polymorphisms on insulin sensitivity and training effects in healthy offspring of type 2 diabetic subjects
    • T. Østergård, J. Ek, Y. Hamid, et al., "Influence of the PPAR-γ2 Pro12Ala and ACE I/D polymorphisms on insulin sensitivity and training effects in healthy offspring of type 2 diabetic subjects, " Hormone and Metabolic Research, vol. 37, no. 2, pp. 99-105, 2005.
    • (2005) Hormone and Metabolic Research , vol.37 , Issue.2 , pp. 99-105
    • Østergård, T.1    Ek, J.2    Hamid, Y.3
  • 62
    • 33846612310 scopus 로고    scopus 로고
    • Weight regain after slimming induced by an energy-restricted diet depends on interleukin-6 and peroxisome-proliferator-activated-receptor-γ2 gene polymorphisms
    • E. Goyenechea, M. D. Parra, and J. A. Mart'inez, "Weight regain after slimming induced by an energy-restricted diet depends on interleukin-6 and peroxisome-proliferator-activated-receptor-γ2 gene polymorphisms, " British Journal of Nutrition, vol. 96, no. 5, pp. 965-972, 2006.
    • (2006) British Journal of Nutrition , vol.96 , Issue.5 , pp. 965-972
    • Goyenechea, E.1    Parra, M.D.2    Mart'Inez, J.A.3
  • 63
    • 27744455929 scopus 로고    scopus 로고
    • Relation of weight maintenance and dietary restraint to peroxisome proliferator-activated receptor γ2, glucocorticoid receptor, and ciliary neurotrophic factor polymorphisms
    • N. Vogels, E. C. Mariman, F. G. Bouwman, A. D. Kester, K. Diepvens, and M. S. Westerterp-Plantenga, "Relation of weight maintenance and dietary restraint to peroxisome proliferator-activated receptor γ2, glucocorticoid receptor, and ciliary neurotrophic factor polymorphisms, " The American Journal of Clinical Nutrition, vol. 82, no. 4, pp. 740-746, 2005.
    • (2005) The American Journal of Clinical Nutrition , vol.82 , Issue.4 , pp. 740-746
    • Vogels, N.1    Mariman, E.C.2    Bouwman, F.G.3    Kester, A.D.4    Diepvens, K.5    Westerterp-Plantenga, M.S.6
  • 64
    • 34250682927 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ 2 and acyl-CoA synthetase 5 polymorphisms influence diet response
    • K. B. Adamo, R. Dent, C. D. Langefeld, et al., "Peroxisome proliferator-activated receptor γ 2 and acyl-CoA synthetase 5 polymorphisms influence diet response, " Obesity, vol. 15, no. 5, pp. 1068-1075, 2007.
    • (2007) Obesity , vol.15 , Issue.5 , pp. 1068-1075
    • Adamo, K.B.1    Dent, R.2    Langefeld, C.D.3
  • 65
    • 0034076458 scopus 로고    scopus 로고
    • The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans
    • S. A. Cole, B. D. Mitchell, W.-C. Hsueh, et al., "The Pro12Ala variant of peroxisome proliferator-activated receptor-γ2 (PPAR-γ2) is associated with measures of obesity in Mexican Americans, " International Journal of Obesity and Related Metabolic Disorders, vol. 24, no. 4, pp. 522-524, 2000.
    • (2000) International Journal of Obesity and Related Metabolic Disorders , vol.24 , Issue.4 , pp. 522-524
    • Cole, S.A.1    Mitchell, B.D.2    Hsueh, W.-C.3
  • 66
    • 0036772369 scopus 로고    scopus 로고
    • Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population
    • J. L. González Sánchez, M. Serrano, C. Fernández Pérez, M. Laakso, and M. T. Martínez Larrad, "Effect of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor γ-2 gene on adiposity, insulin sensitivity and lipid profile in the Spanish population, " European Journal of Endocrinology, vol. 147, no. 4, pp. 495-501, 2002.
    • (2002) European Journal of Endocrinology , vol.147 , Issue.4 , pp. 495-501
    • González Sánchez, J.L.1    Serrano, M.2    Fernández Pérez, C.3    Laakso, M.4    Martínez Larrad, M.T.5
  • 67
    • 9444288703 scopus 로고    scopus 로고
    • Gene-gene interaction between PPARγ2 and ADRβ3 increases obesity risk in children and adolescents
    • M. C. Ochoa, A. Marti, C. Azcona, et al., "Gene-gene interaction between PPARγ2 and ADRβ3 increases obesity risk in children and adolescents, " International Journal of Obesity, vol. 28, supplement 3, pp. S37-S41, 2004.
    • (2004) International Journal of Obesity , vol.28 , Issue.SUPPL. 3
    • Ochoa, M.C.1    Marti, A.2    Azcona, C.3
  • 68
    • 19444373703 scopus 로고    scopus 로고
    • Study of a new PPARγ2 promoter polymorphism and haplotype analysis in a French population
    • A. Meirhaeghe, M. W. T. Tanck, L. Fajas, et al., "Study of a new PPARγ2 promoter polymorphism and haplotype analysis in a French population, " Molecular Genetics and Metabolism, vol. 85, no. 2, pp. 140-148, 2005.
    • (2005) Molecular Genetics and Metabolism , vol.85 , Issue.2 , pp. 140-148
    • Meirhaeghe, A.1    Tanck, M.W.T.2    Fajas, L.3
  • 69
    • 44449120021 scopus 로고    scopus 로고
    • Interaction between PPARγ2 variants and gender on the modulation of body weight
    • E. Morini, V. Tassi, D. Capponi, et al., "Interaction between PPARγ2 variants and gender on the modulation of body weight, " Obesity, vol. 16, no. 6, pp. 1467-1470, 2008.
    • (2008) Obesity , vol.16 , Issue.6 , pp. 1467-1470
    • Morini, E.1    Tassi, V.2    Capponi, D.3
  • 70
    • 0041630975 scopus 로고    scopus 로고
    • The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: Results from the Québec Family Study
    • J. Robitaille, J.-P. Després, L. Pérusse, and M.-C. Vohl, "The PPAR-gamma P12A polymorphism modulates the relationship between dietary fat intake and components of the metabolic syndrome: results from the Québec Family Study, " Clinical Genetics, vol. 63, no. 2, pp. 109-116, 2003.
    • (2003) Clinical Genetics , vol.63 , Issue.2 , pp. 109-116
    • Robitaille, J.1    Després, J.-P.2    Pérusse, L.3    Vohl, M.-C.4
  • 72
    • 24944541350 scopus 로고    scopus 로고
    • A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 gene with obesity in native Javanese in Indonesia
    • C. W. Danawati, M. Nagata, H. Moriyama, et al., "A possible association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ2 gene with obesity in native Javanese in Indonesia, " Diabetes/Metabolism Research and Reviews, vol. 21, no. 5, pp. 465-469, 2005.
    • (2005) Diabetes/Metabolism Research and Reviews , vol.21 , Issue.5 , pp. 465-469
    • Danawati, C.W.1    Nagata, M.2    Moriyama, H.3
  • 73
    • 38149119550 scopus 로고    scopus 로고
    • Genetic polymorphism of peroxisome proliferator-activated receptor-γ2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects
    • L.-L. Li, X.-L. Ma, J.-X. Ran, et al., "Genetic polymorphism of peroxisome proliferator-activated receptor-γ2 Pro12Ala on ethnic susceptibility to diabetes in Uygur, Kazak and Han subjects, " Clinical and Experimental Pharmacology and Physiology, vol. 35, no. 2, pp. 187-191, 2008.
    • (2008) Clinical and Experimental Pharmacology and Physiology , vol.35 , Issue.2 , pp. 187-191
    • Li, L.-L.1    Ma, X.-L.2    Ran, J.-X.3
  • 74
    • 41549103012 scopus 로고    scopus 로고
    • Impact of perox-isome proliferator-activated receptors γ and δ on adiposity in toddlers and preschoolers in the GENESIS study
    • V. Lagou, R. A. Scott, Y. Manios, et al., "Impact of perox-isome proliferator-activated receptors γ and δ on adiposity in toddlers and preschoolers in the GENESIS study, " Obesity, vol. 16, no. 4, pp. 913-918, 2008.
    • (2008) Obesity , vol.16 , Issue.4 , pp. 913-918
    • Lagou, V.1    Scott, R.A.2    Manios, Y.3
  • 75
    • 0031667127 scopus 로고    scopus 로고
    • Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations
    • B. A. Beamer, C.-J. Yen, R. E. Andersen, et al., "Association of the Pro12Ala variant in the peroxisome proliferator-activated receptor-γ2 gene with obesity in two Caucasian populations, " Diabetes, vol. 47, no. 11, pp. 1806-1808, 1998.
    • (1998) Diabetes , vol.47 , Issue.11 , pp. 1806-1808
    • Beamer, B.A.1    Yen, C.-J.2    Andersen, R.E.3
  • 76
    • 0033304551 scopus 로고    scopus 로고
    • Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women
    • R. Valve, K. Sivenius, R. Miettinen, et al., "Two polymorphisms in the peroxisome proliferator-activated receptor-γ gene are associated with severe overweight among obese women, " The Journal of Clinical Endocrinology & Metabolism, vol. 84, no. 10, pp. 3708-3712, 1999.
    • (1999) The Journal of Clinical Endocrinology & Metabolism , vol.84 , Issue.10 , pp. 3708-3712
    • Valve, R.1    Sivenius, K.2    Miettinen, R.3
  • 77
    • 9344259695 scopus 로고    scopus 로고
    • Effects of peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism on body fat distribution in female Korean subjects
    • K. S. Kim, S. M. Choi, S. U. Shin, H. S. Yang, and Y. Yoon, "Effects of peroxisome proliferator-activated receptor-γ2 Pro12Ala polymorphism on body fat distribution in female Korean subjects, " Metabolism: Clinical and Experimental, vol. 53, no. 12, pp. 1538-1543, 2004.
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.12 , pp. 1538-1543
    • Kim, K.S.1    Choi, S.M.2    Shin, S.U.3    Yang, H.S.4    Yoon, Y.5
  • 79
    • 0035461855 scopus 로고    scopus 로고
    • Genetic variation in the peroxisome proliferator-activated receptor-γ2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight regain
    • B. J. Nicklas, E. F. C. van Rossum, D. M. Berman, A. S. Ryan, K. E. Dennis, and A. R. Shuldiner, "Genetic variation in the peroxisome proliferator-activated receptor-γ2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight regain, " Diabetes, vol. 50, no. 9, pp. 2172-2176, 2001.
    • (2001) Diabetes , vol.50 , Issue.9 , pp. 2172-2176
    • Nicklas, B.J.1    Van Rossum, E.F.C.2    Berman, D.M.3    Ryan, A.S.4    Dennis, K.E.5    Shuldiner, A.R.6
  • 80
    • 0034036693 scopus 로고    scopus 로고
    • Variation in the gene for human peroxisome proliferator activated receptor γ (PPARγ) does not play a major role in the development of morbid obesity
    • D. Evans, W. A. Mann, J. de Heer, et al., "Variation in the gene for human peroxisome proliferator activated receptor γ (PPARγ) does not play a major role in the development of morbid obesity, " International Journal of Obesity, vol. 24, no. 5, pp. 647-651, 2000.
    • (2000) International Journal of Obesity , vol.24 , Issue.5 , pp. 647-651
    • Evans, D.1    Mann, W.A.2    De Heer, J.3
  • 81
    • 26444588777 scopus 로고    scopus 로고
    • Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population
    • article 11
    • M. Ghoussaini, D. Meyre, S. Lobbens, et al., "Implication of the Pro12Ala polymorphism of the PPAR-gamma 2 gene in type 2 diabetes and obesity in the French population, " BMC Medical Genetics, vol. 6, article 11, pp. 1-8, 2005.
    • (2005) BMC Medical Genetics , vol.6 , pp. 1-8
    • Ghoussaini, M.1    Meyre, D.2    Lobbens, S.3
  • 82
    • 34548104939 scopus 로고    scopus 로고
    • The PPARγ Pro12Ala polymorphism is not associated with body mass index or waist circumference among hispanics from Colorado
    • T. L. Nelson, T. E. Fingerlin, L. Moss, M. M. Barmada, R. E. Ferrell, and J. M. Norris, "The PPARγ Pro12Ala polymorphism is not associated with body mass index or waist circumference among hispanics from Colorado, " Annals of Nutrition and Metabolism, vol. 51, no. 3, pp. 252-257, 2007.
    • (2007) Annals of Nutrition and Metabolism , vol.51 , Issue.3 , pp. 252-257
    • Nelson, T.L.1    Fingerlin, T.E.2    Moss, L.3    Barmada, M.M.4    Ferrell, R.E.5    Norris, J.M.6
  • 83
    • 0032500747 scopus 로고    scopus 로고
    • Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor γ2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men
    • Y. Mori, H. Kim-Motoyama, T. Katakura, et al., "Effect of the Pro12Ala variant of the human peroxisome proliferator-activated receptor γ2 gene on adiposity, fat distribution, and insulin sensitivity in Japanese men, " Biochemical and Biophysical Research Communications, vol. 251, no. 1, pp. 195-198, 1998.
    • (1998) Biochemical and Biophysical Research Communications , vol.251 , Issue.1 , pp. 195-198
    • Mori, Y.1    Kim-Motoyama, H.2    Katakura, T.3
  • 84
    • 0034186496 scopus 로고    scopus 로고
    • 12Ala mutation in peroxisome proliferator-activated receptor-γ2 in Korean diabetic and obese subjects
    • 12Ala mutation in peroxisome proliferator-activated receptor-γ2 in Korean diabetic and obese subjects, " The Journal of Clinical Endocrinology & Metabolism, vol. 85, no. 5, pp. 1801-1804, 2000.
    • (2000) The Journal of Clinical Endocrinology & Metabolism , vol.85 , Issue.5 , pp. 1801-1804
    • Oh, E.Y.1    Min, K.M.2    Chung, J.H.3
  • 85
    • 34547682095 scopus 로고    scopus 로고
    • Association of Pro12Ala polymorphism in the peroxisome proliferative-activated receptor γ2 gene with obesity and hypertension in Korean women
    • K. Kim, S. Lee, and R. J. Valentine, "Association of Pro12Ala polymorphism in the peroxisome proliferative-activated receptor γ2 gene with obesity and hypertension in Korean women, " Journal of Nutritional Science and Vitaminology, vol. 53, no. 3, pp. 239-246, 2007.
    • (2007) Journal of Nutritional Science and Vitaminology , vol.53 , Issue.3 , pp. 239-246
    • Kim, K.1    Lee, S.2    Valentine, R.J.3
  • 86
    • 33745677651 scopus 로고    scopus 로고
    • Lack of association between the Pro12Ala polymorphism in PPAR-γ2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes
    • A. Stefanski, L. Majkowska, A. Ciechanowicz, et al., "Lack of association between the Pro12Ala polymorphism in PPAR-γ2 gene and body weight changes, insulin resistance and chronic diabetic complications in obese patients with type 2 diabetes, " Archives of Medical Research, vol. 37, no. 6, pp. 736-743, 2006.
    • (2006) Archives of Medical Research , vol.37 , Issue.6 , pp. 736-743
    • Stefanski, A.1    Majkowska, L.2    Ciechanowicz, A.3
  • 87
    • 33845472305 scopus 로고    scopus 로고
    • Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ with pre-diabetic phenotypes: Meta-analysis of 57 studies on nondiabetic individuals
    • A. Tönjes, M. Scholz, M. Loeffler, and M. Stumvoll, "Association of Pro12Ala polymorphism in peroxisome proliferator-activated receptor γ with pre-diabetic phenotypes: meta-analysis of 57 studies on nondiabetic individuals, " Diabetes Care, vol. 29, no. 11, pp. 2489-2497, 2006.
    • (2006) Diabetes Care , vol.29 , Issue.11 , pp. 2489-2497
    • Tönjes, A.1    Scholz, M.2    Loeffler, M.3    Stumvoll, M.4
  • 88
    • 0035123646 scopus 로고    scopus 로고
    • Evidence for gene-nutrient interaction at the PPARγ locus
    • J. Luan, P. O. Browne, A.-H. Harding, et al., "Evidence for gene-nutrient interaction at the PPARγ locus, " Diabetes, vol. 50, no. 3, pp. 686-689, 2001.
    • (2001) Diabetes , vol.50 , Issue.3 , pp. 686-689
    • Luan, J.1    Browne, P.O.2    Harding, A.-H.3
  • 89
    • 0345306138 scopus 로고    scopus 로고
    • Interaction between a peroxisome proliferator-activated receptor γ gene polymorphism and dietary fat intake in relation to body mass
    • A. Memisoglu, F. B. Hu, S. E. Hankinson, et al., "Interaction between a peroxisome proliferator-activated receptor γ gene polymorphism and dietary fat intake in relation to body mass, " Human Molecular Genetics, vol. 12, no. 22, pp. 2923-2929, 2003.
    • (2003) Human Molecular Genetics , vol.12 , Issue.22 , pp. 2923-2929
    • Memisoglu, A.1    Hu, F.B.2    Hankinson, S.E.3
  • 91
    • 34249942558 scopus 로고    scopus 로고
    • Association of β3 adrenergic receptor and peroxisome proliferator-activated receptor gamma 2 polymorphisms with insulin sensitivity: A twin study
    • T.-J. Chen, C.-Y. Ji, X.-Y. Zheng, and Y.-H. Hu, "Association of β3 adrenergic receptor and peroxisome proliferator-activated receptor gamma 2 polymorphisms with insulin sensitivity: a twin study, " Biomedical and Environmental Sciences, vol. 20, no. 2, pp. 99-105, 2007.
    • (2007) Biomedical and Environmental Sciences , vol.20 , Issue.2 , pp. 99-105
    • Chen, T.-J.1    Ji, C.-Y.2    Zheng, X.-Y.3    Hu, Y.-H.4
  • 92
    • 0034741548 scopus 로고    scopus 로고
    • Interactions between variants in the β3-adrenergic receptor and perox-isome proliferator-activated receptor-γ2 genes and obesity
    • W.-C. Hsueh, S. A. Cole, A. R. Shuldiner, et al., "Interactions between variants in the β3-adrenergic receptor and perox-isome proliferator-activated receptor-γ2 genes and obesity, " Diabetes Care, vol. 24, no. 4, pp. 672-677, 2001.
    • (2001) Diabetes Care , vol.24 , Issue.4 , pp. 672-677
    • Hsueh, W.-C.1    Cole, S.A.2    Shuldiner, A.R.3
  • 94
    • 34147104587 scopus 로고    scopus 로고
    • The minor allele of the PPARγ2 Pro12Ala polymorphism is associated with lower postprandial TAG and insulin levels in non-obese healthy men
    • U. Helwig, D. Rubin, J. Kiosz, et al., "The minor allele of the PPARγ2 Pro12Ala polymorphism is associated with lower postprandial TAG and insulin levels in non-obese healthy men, " British Journal of Nutrition, vol. 97, no. 5, pp. 847-854, 2007.
    • (2007) British Journal of Nutrition , vol.97 , Issue.5 , pp. 847-854
    • Helwig, U.1    Rubin, D.2    Kiosz, J.3
  • 95
    • 0037313934 scopus 로고    scopus 로고
    • PPARγ gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men
    • T. Kahara, T. Takamura, T. Hayakawa, et al., "PPARγ gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men, " Metabolism: Clinical and Experimental, vol. 52, no. 2, pp. 209-212, 2003.
    • (2003) Metabolism: Clinical and Experimental , vol.52 , Issue.2 , pp. 209-212
    • Kahara, T.1    Takamura, T.2    Hayakawa, T.3
  • 96
    • 0035032780 scopus 로고    scopus 로고
    • Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene
    • N. Stefan, A. Fritsche, H. Häring, and M. Stumvoll, "Effect of experimental elevation of free fatty acids on insulin secretion and insulin sensitivity in healthy carriers of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene, " Diabetes, vol. 50, no. 5, pp. 1143-1148, 2001.
    • (2001) Diabetes , vol.50 , Issue.5 , pp. 1143-1148
    • Stefan, N.1    Fritsche, A.2    Häring, H.3    Stumvoll, M.4
  • 97
    • 23044478560 scopus 로고    scopus 로고
    • The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-γ2 gene on skeletal muscle glucose uptake depends on obesity: A positron emission tomography study
    • M. Vänttinen, P. Nuutila, J. Pihlajamäki, et al., "The effect of the Ala12 allele of the peroxisome proliferator-activated receptor-γ2 gene on skeletal muscle glucose uptake depends on obesity: a positron emission tomography study, " The Journal of Clinical Endocrinology & Metabolism, vol. 90, no. 7, pp. 4249-4254, 2005.
    • (2005) The Journal of Clinical Endocrinology & Metabolism , vol.90 , Issue.7 , pp. 4249-4254
    • Vänttinen, M.1    Nuutila, P.2    Pihlajamäki, J.3
  • 98
    • 11144249859 scopus 로고    scopus 로고
    • PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity
    • R. Buzzetti, A. Petrone, A. M. Caiazzo, et al., "PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity in childhood obesity, " Pediatric Research, vol. 57, no. 1, pp. 138-140, 2005.
    • (2005) Pediatric Research , vol.57 , Issue.1 , pp. 138-140
    • Buzzetti, R.1    Petrone, A.2    Caiazzo, A.M.3
  • 99
    • 33748916239 scopus 로고    scopus 로고
    • PPAR-γ2 Pro12Ala variant, insulin resistance and plasma long-chain polyunsaturated fatty acids in childhood obesity
    • S. Scaglioni, E. Verduci, M. Salvioni, et al., "PPAR-γ2 Pro12Ala variant, insulin resistance and plasma long-chain polyunsaturated fatty acids in childhood obesity, " Pediatric Research, vol. 60, no. 4, pp. 485-489, 2006.
    • (2006) Pediatric Research , vol.60 , Issue.4 , pp. 485-489
    • Scaglioni, S.1    Verduci, E.2    Salvioni, M.3
  • 100
    • 10044291717 scopus 로고    scopus 로고
    • The common PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity
    • R. Buzzetti, A. Petrone, M. C. Ribaudo, et al., "The common PPAR-γ2 Pro12Ala variant is associated with greater insulin sensitivity, " European Journal of Human Genetics, vol. 12, no. 12, pp. 1050-1054, 2004.
    • (2004) European Journal of Human Genetics , vol.12 , Issue.12 , pp. 1050-1054
    • Buzzetti, R.1    Petrone, A.2    Ribaudo, M.C.3
  • 101
    • 0032589053 scopus 로고    scopus 로고
    • The PPARγ2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects
    • M. Koch, K. Rett, E. Maerker, et al., "The PPARγ2 amino acid polymorphism Pro 12 Ala is prevalent in offspring of type II diabetic patients and is associated to increased insulin sensitivity in a subgroup of obese subjects, " Diabetologia, vol. 42, no. 6, pp. 758-762, 1999.
    • (1999) Diabetologia , vol.42 , Issue.6 , pp. 758-762
    • Koch, M.1    Rett, K.2    Maerker, E.3
  • 102
    • 23844478959 scopus 로고    scopus 로고
    • Association between Pro12Ala polymorphism of the PPAR-γ2 gene and insulin sensitivity in Brazilian patients with type-2 diabetes mellitus
    • V. Tavares, R. D. C. Hirata, A. C. Rodrigues, et al., "Association between Pro12Ala polymorphism of the PPAR-γ2 gene and insulin sensitivity in Brazilian patients with type-2 diabetes mellitus, " Diabetes, Obesity and Metabolism, vol. 7, no. 5, pp. 605-611, 2005.
    • (2005) Diabetes, Obesity and Metabolism , vol.7 , Issue.5 , pp. 605-611
    • Tavares, V.1    Hirata, R.D.C.2    Rodrigues, A.C.3
  • 103
    • 23844479300 scopus 로고    scopus 로고
    • 12Ala perox-isome proliferator-activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes
    • 12Ala perox-isome proliferator- activated receptor γ2 polymorphism on glucose response to exercise training in type 2 diabetes, " Diabetologia, vol. 48, no. 8, pp. 1503-1509, 2005.
    • (2005) Diabetologia , vol.48 , Issue.8 , pp. 1503-1509
    • Adamo, K.B.1    Sigal, R.J.2    Williams, K.3    Kenny, G.4    Prud'Homme, D.5    Tesson, F.6
  • 104
    • 23444457610 scopus 로고    scopus 로고
    • Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes
    • E. S. Kang, S. Y. Park, H. J. Kim, et al., "Effects of Pro12Ala polymorphism of peroxisome proliferator-activated receptor γ2 gene on rosiglitazone response in type 2 diabetes, " Clinical Pharmacology & Therapeutics, vol. 78, no. 2, pp. 202-208, 2005.
    • (2005) Clinical Pharmacology & Therapeutics , vol.78 , Issue.2 , pp. 202-208
    • Kang, E.S.1    Park, S.Y.2    Kim, H.J.3
  • 105
    • 0037221208 scopus 로고    scopus 로고
    • Impact of two common polymorphisms in the PPARγ gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: Thrifty genotype, thrifty phenotype, or both?
    • P. Poulsen, G. Andersen, M. Fenger, et al., "Impact of two common polymorphisms in the PPARγ gene on glucose tolerance and plasma insulin profiles in monozygotic and dizygotic twins: thrifty genotype, thrifty phenotype, or both?" Diabetes, vol. 52, no. 1, pp. 194-198, 2003.
    • (2003) Diabetes , vol.52 , Issue.1 , pp. 194-198
    • Poulsen, P.1    Andersen, G.2    Fenger, M.3
  • 106
    • 33748286941 scopus 로고    scopus 로고
    • Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid
    • F. Soriguer, S. Morcillo, F. Cardona, et al., "Pro12Ala polymorphism of the PPARG2 gene is associated with type 2 diabetes mellitus and peripheral insulin sensitivity in a population with a high intake of oleic acid, " The Journal of Nutrition, vol. 136, no. 9, pp. 2325-2330, 2006.
    • (2006) The Journal of Nutrition , vol.136 , Issue.9 , pp. 2325-2330
    • Soriguer, F.1    Morcillo, S.2    Cardona, F.3
  • 108
    • 0347316400 scopus 로고    scopus 로고
    • Does peroxisome proliferator-activated receptor γ genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?
    • P. W. Franks, J. Luan, P. O. Browne, et al., "Does peroxisome proliferator-activated receptor γ genotype (Pro12ala) modify the association of physical activity and dietary fat with fasting insulin level?" Metabolism: Clinical and Experimental, vol. 53, no. 1, pp. 11-16, 2004.
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.1 , pp. 11-16
    • Franks, P.W.1    Luan, J.2    Browne, P.O.3
  • 110
    • 0033624575 scopus 로고    scopus 로고
    • The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes
    • D. Altshuler, J. N. Hirschhorn, M. Klannemark, et al., "The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes, " Nature Genetics, vol. 26, no. 1, pp. 76-80, 2000.
    • (2000) Nature Genetics , vol.26 , Issue.1 , pp. 76-80
    • Altshuler, D.1    Hirschhorn, J.N.2    Klannemark, M.3
  • 111
    • 0036169343 scopus 로고    scopus 로고
    • Interaction effect between common polymorphisms in PPARγ 2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity
    • M. Stumvoll, N. Stefan, A. Fritsche, et al., "Interaction effect between common polymorphisms in PPARγ 2 (Pro12Ala) and insulin receptor substrate 1 (Gly972Arg) on insulin sensitivity, " Journal of Molecular Medicine, vol. 80, no. 1, pp. 33-38, 2002.
    • (2002) Journal of Molecular Medicine , vol.80 , Issue.1 , pp. 33-38
    • Stumvoll, M.1    Stefan, N.2    Fritsche, A.3
  • 112
    • 0344944629 scopus 로고    scopus 로고
    • Evidence for genetic epistasis in human insulin resistance: The combined effect of PC-1 (K121Q) and PPARγ2 (P12A) polymorphisms
    • R. Baratta, R. Di Paola, D. Spampinato, et al., "Evidence for genetic epistasis in human insulin resistance: the combined effect of PC-1 (K121Q) and PPARγ2 (P12A) polymorphisms, " Journal of Molecular Medicine, vol. 81, no. 11, pp. 718-723, 2003.
    • (2003) Journal of Molecular Medicine , vol.81 , Issue.11 , pp. 718-723
    • Baratta, R.1    Di Paola, R.2    Spampinato, D.3
  • 113
    • 0032857338 scopus 로고    scopus 로고
    • A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance
    • A. Pizzuti, L. Frittitta, A. Argiolas, et al., "A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance, " Diabetes, vol. 48, no. 9, pp. 1881-1884, 1999.
    • (1999) Diabetes , vol.48 , Issue.9 , pp. 1881-1884
    • Pizzuti, A.1    Frittitta, L.2    Argiolas, A.3
  • 114
    • 0034728762 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes
    • K. Hara, T. Okada, K. Tobe, et al., "The Pro12Ala polymorphism in PPAR γ2 may confer resistance to type 2 diabetes, " Biochemical and Biophysical Research Communications, vol. 271, no. 1, pp. 212-216, 2000.
    • (2000) Biochemical and Biophysical Research Communications , vol.271 , Issue.1 , pp. 212-216
    • Hara, K.1    Okada, T.2    Tobe, K.3
  • 115
    • 9644275540 scopus 로고    scopus 로고
    • Association of Pro12Ala polymorphism of PPARγ gene with insulin resistance and related diseases
    • M. Horiki, H. Ikegami, T. Fujisawa, et al., "Association of Pro12Ala polymorphism of PPARγ gene with insulin resistance and related diseases, " Diabetes Research and Clinical Practice, vol. 66, supplement 1, pp. S63-S67, 2004.
    • (2004) Diabetes Research and Clinical Practice , vol.66 , Issue.SUPPL. 1
    • Horiki, M.1    Ikegami, H.2    Fujisawa, T.3
  • 116
    • 0034745185 scopus 로고    scopus 로고
    • 12 → Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: Possible involvement in impairment of insulin secretion in individuals with type 2 diabetes
    • 12 → Ala substitution in PPAR-γ is associated with resistance to development of diabetes in the general population: possible involvement in impairment of insulin secretion in individuals with type 2 diabetes, " Diabetes, vol. 50, no. 4, pp. 891-894, 2001.
    • (2001) Diabetes , vol.50 , Issue.4 , pp. 891-894
    • Mori, H.1    Ikegami, H.2    Kawaguchi, Y.3
  • 117
    • 24044534766 scopus 로고    scopus 로고
    • Genetic polymorphisms in peroxisome proliferator-activated receptor γ are associated with type 2 diabetes mellitus and obesity in the Korean population
    • M. K. Moon, Y. M. Cho, H. S. Jung, et al., "Genetic polymorphisms in peroxisome proliferator-activated receptor γ are associated with type 2 diabetes mellitus and obesity in the Korean population, " Diabetic Medicine, vol. 22, no. 9, pp. 1161-1166, 2005.
    • (2005) Diabetic Medicine , vol.22 , Issue.9 , pp. 1161-1166
    • Moon, M.K.1    Cho, Y.M.2    Jung, H.S.3
  • 118
    • 34247355013 scopus 로고    scopus 로고
    • Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population
    • R. Meshkani, M. Taghikhani, B. Larijani, et al., "Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 (PPARγ-2) gene is associated with greater insulin sensitivity and decreased risk of type 2 diabetes in an Iranian population, " Clinical Chemistry and Laboratory Medicine, vol. 45, no. 4, pp. 477-482, 2007.
    • (2007) Clinical Chemistry and Laboratory Medicine , vol.45 , Issue.4 , pp. 477-482
    • Meshkani, R.1    Taghikhani, M.2    Larijani, B.3
  • 119
    • 1842866370 scopus 로고    scopus 로고
    • Association of the Pro12Ala and C1431T variants of PPARG and their hap-lotypes with susceptibility to type 2 diabetes
    • A. S. F. Doney, B. Fischer, J. E. Cecil, et al., "Association of the Pro12Ala and C1431T variants of PPARG and their hap-lotypes with susceptibility to type 2 diabetes, " Diabetologia, vol. 47, no. 3, pp. 555-558, 2004.
    • (2004) Diabetologia , vol.47 , Issue.3 , pp. 555-558
    • Doney, A.S.F.1    Fischer, B.2    Cecil, J.E.3
  • 120
    • 4243353569 scopus 로고    scopus 로고
    • Studies of the Pro12Ala polymorphism of the PPAR-γ gene in the Danish MONICA cohort: Homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome
    • L. Frederiksen, K. Brødbæk, M. Fenger, et al., "Studies of the Pro12Ala polymorphism of the PPAR-γ gene in the Danish MONICA cohort: homozygosity of the Ala allele confers a decreased risk of the insulin resistance syndrome, " The Journal of Clinical Endocrinology & Metabolism, vol. 87, no. 8, pp. 3989-3992, 2002.
    • (2002) The Journal of Clinical Endocrinology & Metabolism , vol.87 , Issue.8 , pp. 3989-3992
    • Frederiksen, L.1    Brødbæk, K.2    Fenger, M.3
  • 121
    • 12944308811 scopus 로고    scopus 로고
    • Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial
    • L. Andrulionytè, J. Zacharova, J.-L. Chiasson, and M. Laakso, "Common polymorphisms of the PPAR-γ2 (Pro12Ala) and PGC-1α (Gly482Ser) genes are associated with the conversion from impaired glucose tolerance to type 2 diabetes in the STOP-NIDDM trial, " Diabetologia, vol. 47, no. 12, pp. 2176-2184, 2004.
    • (2004) Diabetologia , vol.47 , Issue.12 , pp. 2176-2184
    • Andrulionytè, L.1    Zacharova, J.2    Chiasson, J.-L.3    Laakso, M.4
  • 122
    • 33745291825 scopus 로고    scopus 로고
    • The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: The data from an epidemiological study on the insulin resistance syndrome (DESIR) study
    • R. Jaziri, S. Lobbens, R. Aubert, et al., "The PPARG Pro12Ala polymorphism is associated with a decreased risk of developing hyperglycemia over 6 years and combines with the effect of the APM1 G-11391A single nucleotide polymorphism: the data from an epidemiological study on the insulin resistance syndrome (DESIR) study, " Diabetes, vol. 55, no. 4, pp. 1157-1162, 2006.
    • (2006) Diabetes , vol.55 , Issue.4 , pp. 1157-1162
    • Jaziri, R.1    Lobbens, S.2    Aubert, R.3
  • 123
    • 0141781066 scopus 로고    scopus 로고
    • Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARγ gene and type 2 diabetes
    • A. Memisoglu, F. B. Hu, S. E. Hankinson, et al., "Prospective study of the association between the proline to alanine codon 12 polymorphism in the PPARγ gene and type 2 diabetes, " Diabetes Care, vol. 26, no. 10, pp. 2915-2917, 2003.
    • (2003) Diabetes Care , vol.26 , Issue.10 , pp. 2915-2917
    • Memisoglu, A.1    Hu, F.B.2    Hankinson, S.E.3
  • 124
    • 33744755015 scopus 로고    scopus 로고
    • Role of genetic polymorphism peroxisome proliferator-activated receptor-γ2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: Evidence for heterogeneity
    • V. Radha, K. S. Vimaleswaran, H. N. S. Babu, et al., "Role of genetic polymorphism peroxisome proliferator-activated receptor-γ2 Pro12Ala on ethnic susceptibility to diabetes in South-Asian and Caucasian subjects: evidence for heterogeneity, " Diabetes Care, vol. 29, no. 5, pp. 1046-1051, 2006.
    • (2006) Diabetes Care , vol.29 , Issue.5 , pp. 1046-1051
    • Radha, V.1    Vimaleswaran, K.S.2    Babu, H.N.S.3
  • 125
    • 0035002488 scopus 로고    scopus 로고
    • Association between the P12A and c1431t polymorphisms in the per-oxisome proliferator activated receptor γ (PPARγ) gene and type 2 diabetes
    • D. Evans, J. de Heer, C. Hagemann, et al., "Association between the P12A and c1431t polymorphisms in the per-oxisome proliferator activated receptor γ (PPARγ) gene and type 2 diabetes, " Experimental and Clinical Endocrinology and Diabetes, vol. 109, no. 3, pp. 151-154, 2001.
    • (2001) Experimental and Clinical Endocrinology and Diabetes , vol.109 , Issue.3 , pp. 151-154
    • Evans, D.1    De Heer, J.2    Hagemann, C.3
  • 126
    • 54049110420 scopus 로고    scopus 로고
    • Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies
    • C. Herder, W. Rathmann, K. Strassburger, et al., "Variants of the PPARG, IGF2BP2, CDKAL1, HHEX, and TCF7L2 genes confer risk of type 2 diabetes independently of BMI in the German KORA studies, " Hormone and Metabolic Research, vol. 40, no. 10, pp. 722-726, 2008.
    • (2008) Hormone and Metabolic Research , vol.40 , Issue.10 , pp. 722-726
    • Herder, C.1    Rathmann, W.2    Strassburger, K.3
  • 127
    • 38049053572 scopus 로고    scopus 로고
    • SNPs in PPARG associate with type 2 diabetes and interact with physical activity
    • T. O. Kilpeläinen, T. A. Lakka, D. E. Laaksonen, et al., "SNPs in PPARG associate with type 2 diabetes and interact with physical activity, " Medicine and Science in Sports and Exercise, vol. 40, no. 1, pp. 25-33, 2008.
    • (2008) Medicine and Science in Sports and Exercise , vol.40 , Issue.1 , pp. 25-33
    • Kilpeläinen, T.O.1    Lakka, T.A.2    Laaksonen, D.E.3
  • 128
    • 39149142225 scopus 로고    scopus 로고
    • Interaction of DIO2 T92A and PPARγ2 P12A polymorphisms in the modulation of metabolic syndrome
    • M. Fiorito, I. Torrente, S. De Cosmo, et al., "Interaction of DIO2 T92A and PPARγ2 P12A polymorphisms in the modulation of metabolic syndrome, " Obesity, vol. 15, no. 12, pp. 2889-2895, 2007.
    • (2007) Obesity , vol.15 , Issue.12 , pp. 2889-2895
    • Fiorito, M.1    Torrente, I.2    De Cosmo, S.3
  • 129
    • 33746372990 scopus 로고    scopus 로고
    • The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene on glucose/insulin metabolism interact with prenatal exposure to famine
    • S. R. de Rooij, R. C. Painter, D. I. W. Phillips, et al., "The effects of the Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ2 gene on glucose/insulin metabolism interact with prenatal exposure to famine, " Diabetes Care, vol. 29, no. 5, pp. 1052-1057, 2006.
    • (2006) Diabetes Care , vol.29 , Issue.5 , pp. 1052-1057
    • De Rooij, S.R.1    Painter, R.C.2    Phillips, D.I.W.3
  • 130
    • 34147106645 scopus 로고    scopus 로고
    • Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone
    • J. C. Florez, K. A. Jablonski, M. W. Sun, et al., "Effects of the type 2 diabetes-associated PPARG P12A polymorphism on progression to diabetes and response to troglitazone, " The Journal of Clinical Endocrinology & Metabolism, vol. 92, no. 4, pp. 1502-1509, 2007.
    • (2007) The Journal of Clinical Endocrinology & Metabolism , vol.92 , Issue.4 , pp. 1502-1509
    • Florez, J.C.1    Jablonski, K.A.2    Sun, M.W.3
  • 131
    • 30044432152 scopus 로고    scopus 로고
    • Examining the relationships between the Pro12Ala variant in PPARG and type 2 diabetes-related traits in UK samples
    • E. Zeggini, J. R. C. Parkinson, S. Halford, et al., "Examining the relationships between the Pro12Ala variant in PPARG and type 2 diabetes-related traits in UK samples, " Diabetic Medicine, vol. 22, no. 12, pp. 1696-1700, 2005.
    • (2005) Diabetic Medicine , vol.22 , Issue.12 , pp. 1696-1700
    • Zeggini, E.1    Parkinson, J.R.C.2    Halford, S.3
  • 132
    • 47749128415 scopus 로고    scopus 로고
    • Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk
    • article 59
    • D. K. Sanghera, L. Ortega, S. Han, et al., "Impact of nine common type 2 diabetes risk polymorphisms in Asian Indian Sikhs: PPARG2 (Pro12Ala), IGF2BP2, TCF7L2 and FTO variants confer a significant risk, " BMC Medical Genetics, vol. 9, article 59, pp. 1-9, 2008.
    • (2008) BMC Medical Genetics , vol.9 , pp. 1-9
    • Sanghera, D.K.1    Ortega, L.2    Han, S.3
  • 133
    • 0842268321 scopus 로고    scopus 로고
    • Influence of the polymorphisms Tpr64Arg in the β3-adrenergic receptor gene and Pro12Ala in the PPARγ2 gene on metabolic syndrome-related phenotypes in an indigenous population of the Brazilian Amazon
    • J. P. B. Vieira-Filho, A. F. Reis, T. S. Kasamatsu, et al., "Influence of the polymorphisms Tpr64Arg in the β3-adrenergic receptor gene and Pro12Ala in the PPARγ2 gene on metabolic syndrome-related
    • (2004) Diabetes Care , vol.27 , Issue.2 , pp. 621-622
    • Vieira-Filho, J.P.B.1    Reis, A.F.2    Kasamatsu, T.S.3
  • 134
    • 33644877202 scopus 로고    scopus 로고
    • The peroxi-some proliferator-activated receptor-γ2 P12A polymorphism and type 2 diabetes in an Arab population
    • S. M. Wakil, K. Al-Rubeaan, O. Alsmadi, et al., "The peroxi-some proliferator-activated receptor-γ2 P12A polymorphism and type 2 diabetes in an Arab population, " Diabetes Care, vol. 29, no. 1, pp. 171-172, 2006.
    • (2006) Diabetes Care , vol.29 , Issue.1 , pp. 171-172
    • Wakil, S.M.1    Al-Rubeaan, K.2    Alsmadi, O.3
  • 135
    • 0033060302 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ2 is not associated with type 2 diabetes
    • F. P. Mancini, O. Vaccaro, L. Sabatino, et al., "Pro12Ala substitution in the peroxisome proliferator-activated receptor-γ2 is not associated with type 2 diabetes, " Diabetes, vol. 48, no. 7, pp. 1466-1468, 1999.
    • (1999) Diabetes , vol.48 , Issue.7 , pp. 1466-1468
    • Mancini, F.P.1    Vaccaro, O.2    Sabatino, L.3
  • 136
    • 17744398695 scopus 로고    scopus 로고
    • The perox-isome proliterator activated receptorγ2 (PPARγ2) Pro12Ala variant: Lack of association with type 2 diabetes in obese and non obese Tunisian patients
    • K. Z. Bouassida, L. Chouchane, K. Jellouli, et al., "The perox-isome proliterator activated receptorγ2 (PPARγ2) Pro12Ala variant: lack of association with type 2 diabetes in obese and non obese Tunisian patients, " Diabetes and Metabolism, vol. 31, no. 2, pp. 119-123, 2005.
    • (2005) Diabetes and Metabolism , vol.31 , Issue.2 , pp. 119-123
    • Bouassida, K.Z.1    Chouchane, L.2    Jellouli, K.3
  • 137
    • 39049159123 scopus 로고    scopus 로고
    • Lack of association between the Pro12Ala polymorphism of the PPAR-γ2 gene and type 2 diabetes mellitus in the Qatari consanguineous population
    • R. Badii, A. Bener, M. Zirie, et al., "Lack of association between the Pro12Ala polymorphism of the PPAR-γ2 gene and type 2 diabetes mellitus in the Qatari consanguineous population, " Acta Diabetologica, vol. 45, no. 1, pp. 15-21, 2008.
    • (2008) Acta Diabetologica , vol.45 , Issue.1 , pp. 15-21
    • Badii, R.1    Bener, A.2    Zirie, M.3
  • 138
    • 0142199870 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism of PPARγ2 gene and susceptibility to type 2 diabetes mellitus in a Polish population
    • M. T. Malecki, J. Frey, T. Klupa, et al., "The Pro12Ala polymorphism of PPARγ2 gene and susceptibility to type 2 diabetes mellitus in a Polish population, " Diabetes Research and Clinical Practice, vol. 62, no. 2, pp. 105-111, 2003.
    • (2003) Diabetes Research and Clinical Practice , vol.62 , Issue.2 , pp. 105-111
    • Malecki, M.T.1    Frey, J.2    Klupa, T.3
  • 139
    • 27344447399 scopus 로고    scopus 로고
    • The C161 → T polymorphism in peroxisome proliferator-activated receptor gamma, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: Evidence for another functional variant in perox-isome proliferator-activated receptor gamma
    • S. P. Moffett, E. Feingold, M. M. Barmada, et al., "The C161 → T polymorphism in peroxisome proliferator-activated receptor gamma, but not P12A, is associated with insulin resistance in Hispanic and non-Hispanic white women: evidence for another functional variant in perox-isome proliferator-activated receptor gamma, " Metabolism: Clinical and Experimental, vol. 54, no. 11, pp. 1552-1556, 2005.
    • (2005) Metabolism: Clinical and Experimental , vol.54 , Issue.11 , pp. 1552-1556
    • Moffett, S.P.1    Feingold, E.2    Barmada, M.M.3
  • 140
    • 34250631631 scopus 로고    scopus 로고
    • Heterogeneous effect of peroxisome proliferator-activated receptor γ2 Ala12 variant on type 2 diabetes risk
    • O. Ludovico, F. Pellegrini, R. Di Paola, et al., "Heterogeneous effect of peroxisome proliferator-activated receptor γ2 Ala12 variant on type 2 diabetes risk, " Obesity, vol. 15, no. 5, pp. 1076-1081, 2007.
    • (2007) Obesity , vol.15 , Issue.5 , pp. 1076-1081
    • Ludovico, O.1    Pellegrini, F.2    Di Paola, R.3
  • 141
    • 35348856195 scopus 로고    scopus 로고
    • An analysis of peroxisome proliferator-activated receptor gamma (PPAR-γ2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits
    • R. Scacchi, A. Pinto, O. Rickards, et al., "An analysis of peroxisome proliferator-activated receptor gamma (PPAR-γ2) Pro12Ala polymorphism distribution and prevalence of type 2 diabetes mellitus (T2DM) in world populations in relation to dietary habits, " Nutrition, Metabolism and Cardiovascular Diseases, vol. 17, no. 9, pp. 632-641, 2007.
    • (2007) Nutrition, Metabolism and Cardiovascular Diseases , vol.17 , Issue.9 , pp. 632-641
    • Scacchi, R.1    Pinto, A.2    Rickards, O.3
  • 142
    • 4444250259 scopus 로고    scopus 로고
    • High incidence of type 2 diabetes in peroxisome proliferator-activated receptor γ2 Pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids
    • R. E. Pisabarro, C. Sanguinetti, M. Stoll, and D. Pren-dez, "High incidence of type 2 diabetes in peroxisome proliferator-activated receptor γ2 Pro12Ala carriers exposed to a high chronic intake of trans fatty acids and saturated fatty acids, " Diabetes Care, vol. 27, no. 9, pp. 2251-2252, 2004.
    • (2004) Diabetes Care , vol.27 , Issue.9 , pp. 2251-2252
    • Pisabarro, R.E.1    Sanguinetti, C.2    Stoll, M.3    Pren-Dez, D.4
  • 143
    • 34247158946 scopus 로고    scopus 로고
    • Gene polymorphisms, size at birth, and the development of hypertension and type 2 diabetes
    • J. G. Eriksson, "Gene polymorphisms, size at birth, and the development of hypertension and type 2 diabetes, " The Journal of Nutrition, vol. 137, no. 4, pp. 1063-1065, 2007.
    • (2007) The Journal of Nutrition , vol.137 , Issue.4 , pp. 1063-1065
    • Eriksson, J.G.1
  • 144
    • 26844513588 scopus 로고    scopus 로고
    • Effect of the Pro12Ala polymorphism of the PPARγ2 gene on serum adiponectin changes
    • F. Mousavinasab, T. Tähtinen, J. Jokelainen, et al., "Effect of the Pro12Ala polymorphism of the PPARγ2 gene on serum adiponectin changes, " Endocrine, vol. 27, no. 3, pp. 307-309, 2005.
    • (2005) Endocrine , vol.27 , Issue.3 , pp. 307-309
    • Mousavinasab, F.1    Tähtinen, T.2    Jokelainen, J.3
  • 145
    • 12444285439 scopus 로고    scopus 로고
    • Genetic epistasis of adiponectin and PPARγ2 genotypes in modulation of insulin sensitivity: A family-based association study
    • W.-S. Yang, C. A. Hsiung, L.-T. Ho, et al., "Genetic epistasis of adiponectin and PPARγ2 genotypes in modulation of insulin sensitivity: a family-based association study, " Dia-betologia, vol. 46, no. 7, pp. 977-983, 2003.
    • (2003) Dia-betologia , vol.46 , Issue.7 , pp. 977-983
    • Yang, W.-S.1    Hsiung, C.A.2    Ho, L.-T.3
  • 146
    • 56349143665 scopus 로고    scopus 로고
    • Pro12Ala polymorphism in PPAR γ 2 associated with essential hypertension in Chinese nonagenarians/centenarians
    • Z. Lu, B. Dong, X. Mo, et al., "Pro12Ala polymorphism in PPAR γ 2 associated with essential hypertension in Chinese nonagenarians/ centenarians, " Experimental Gerontology, vol. 43, no. 12, pp. 1108-1113, 2008.
    • (2008) Experimental Gerontology , vol.43 , Issue.12 , pp. 1108-1113
    • Lu, Z.1    Dong, B.2    Mo, X.3
  • 147
    • 0042733636 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are associated with essential hypertension
    • F. J. Rodŕiguez-Esparragón, J. C. Rodŕiguez- Pérez, A. Maćias-Reyes, and F. Alamo-Santana, "Peroxisome proliferator-activated receptor-gamma2-Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are associated with essential hypertension, " Journal of Hypertension, vol. 21, no. 9, pp. 1649-1655, 2003.
    • (2003) Journal of Hypertension , vol.21 , Issue.9 , pp. 1649-1655
    • Rodŕiguez-Esparragón, F.J.1    Rodŕiguez-Pérez, J.C.2    MaćIas-Reyes, A.3    Alamo-Santana, F.4
  • 148
    • 0042733635 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project
    • C. J. Ostgren, U. Lindblad, O. Melander, A. Melander, L. Groop, and L. Råstam, "Peroxisome proliferator-activated receptor-γPro12Ala polymorphism and the association with blood pressure in type 2 diabetes: Skaraborg Hypertension and Diabetes Project, " Journal of Hypertension, vol. 21, no. 9, pp. 1657-1662, 2003.
    • (2003) Journal of Hypertension , vol.21 , Issue.9 , pp. 1657-1662
    • Ostgren, C.J.1    Lindblad, U.2    Melander, O.3    Melander, A.4    Groop, L.5    Råstam, L.6
  • 149
    • 3042833890 scopus 로고    scopus 로고
    • Interactions between peroxisome proliferator-activated receptor-γ2 polymorphisms and size at birth on blood pressure and the use of antihypertensive medication
    • H. Ylihärsilä, J. G. Eriksson, T. Forsén, et al., "Interactions between peroxisome proliferator-activated receptor-γ2 polymorphisms and size at birth on blood pressure and the use of antihypertensive medication, " Journal of Hypertension, vol. 22, no. 7, pp. 1283-1287, 2004.
    • (2004) Journal of Hypertension , vol.22 , Issue.7 , pp. 1283-1287
    • Ylihärsilä, H.1    Eriksson, J.G.2    Forsén, T.3
  • 150
    • 33747635987 scopus 로고    scopus 로고
    • Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes
    • A. Stefański, L. Majkowska, A. Ciechanowicz, et al., "Association between the Pro12Ala variant of the peroxisome proliferator-activated receptor-gamma2 gene and increased 24-h diastolic blood pressure in obese patients with type II diabetes, " Journal of Human Hypertension, vol. 20, no. 9, pp. 684-692, 2006.
    • (2006) Journal of Human Hypertension , vol.20 , Issue.9 , pp. 684-692
    • Stefański, A.1    Majkowska, L.2    Ciechanowicz, A.3
  • 151
    • 14044268174 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2
    • I. Gouni-Berthold, E. Giannakidou, D. Muller-Wieland, et al., "Peroxisome proliferator-activated receptor-γ2 Pro12Ala and endothelial nitric oxide synthase-4a/b gene polymorphisms are not associated with hypertension in diabetes mellitus type 2, " Journal of Hypertension, vol. 23, no. 2, pp. 301-308, 2005.
    • (2005) Journal of Hypertension , vol.23 , Issue.2 , pp. 301-308
    • Gouni-Berthold, I.1    Giannakidou, E.2    Muller-Wieland, D.3
  • 152
    • 0035062772 scopus 로고    scopus 로고
    • A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-γ2 is associated with combined hyperlipidaemia in obesity
    • M. M. Swarbrick, C. M. Chapman, B. M. McQuillan, J. Hung, P. L. Thompson, and J. P. Beilby, "A Pro12Ala polymorphism in the human peroxisome proliferator-activated receptor-γ2 is associated with combined hyperlipidaemia in obesity, " European Journal of Endocrinology, vol. 144, no. 3, pp. 277-282, 2001.
    • (2001) European Journal of Endocrinology , vol.144 , Issue.3 , pp. 277-282
    • Swarbrick, M.M.1    Chapman, C.M.2    McQuillan, B.M.3    Hung, J.4    Thompson, P.L.5    Beilby, J.P.6
  • 153
    • 0034771048 scopus 로고    scopus 로고
    • Mutations of the peroxisome proliferator-activated receptor γ (PPARγ) gene in a Japanese population: The Pro12Ala mutation in PPARγ 2 is associated with lower concentrations of serum total and non-HDL cholesterol
    • E. Iwata, H. Matsuda, T. Fukuda, et al., "Mutations of the peroxisome proliferator-activated receptor γ (PPARγ) gene in a Japanese population: the Pro12Ala mutation in PPARγ 2 is associated with lower concentrations of serum total and non-HDL cholesterol, " Diabetologia, vol. 44, no. 10, pp. 1354-1355, 2001.
    • (2001) Diabetologia , vol.44 , Issue.10 , pp. 1354-1355
    • Iwata, E.1    Matsuda, H.2    Fukuda, T.3
  • 154
    • 34247570371 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes
    • R. L. Pollex, M. Mamakeesick, B. Zinman, S. B. Harris, R. A. Hegele, and A. J. G. Hanley, "Peroxisome proliferator-activated receptor γ polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes, " Journal of Diabetes and Its Complications, vol. 21, no. 3, pp. 166-171, 2007.
    • (2007) Journal of Diabetes and Its Complications , vol.21 , Issue.3 , pp. 166-171
    • Pollex, R.L.1    Mamakeesick, M.2    Zinman, B.3    Harris, S.B.4    Hegele, R.A.5    Hanley, A.J.G.6
  • 155
    • 27244447175 scopus 로고    scopus 로고
    • Alcohol intake modulates the genetic association between HDL cholesterol and the PPARγ2 Pro12Ala polymorphism
    • S.-M. Brand-Herrmann, T. Kuznetsova, A. Wiechert, et al., "Alcohol intake modulates the genetic association between HDL cholesterol and the PPARγ2 Pro12Ala polymorphism, " Journal of Lipid Research, vol. 46, no. 5, pp. 913-919, 2005.
    • (2005) Journal of Lipid Research , vol.46 , Issue.5 , pp. 913-919
    • Brand-Herrmann, S.-M.1    Kuznetsova, T.2    Wiechert, A.3
  • 156
    • 1642465495 scopus 로고    scopus 로고
    • Differential effects of the C1431T and Pro12Ala PPARγ gene variants on plasma lipids and diabetes risk in an Asian population
    • E. S. Tai, D. Corella, M. Deurenberg-Yap, et al., "Differential effects of the C1431T and Pro12Ala PPARγ gene variants on plasma lipids and diabetes risk in an Asian population, " Journal of Lipid Research, vol. 45, no. 4, pp. 674-685, 2004.
    • (2004) Journal of Lipid Research , vol.45 , Issue.4 , pp. 674-685
    • Tai, E.S.1    Corella, D.2    Deurenberg-Yap, M.3
  • 157
    • 34548657949 scopus 로고    scopus 로고
    • Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor γ2 gene with small dense low-density lipoprotein in the general population
    • T. Hamada, K. Kotani, K. Tsuzaki, et al., "Association of Pro12Ala polymorphism in the peroxisome proliferator-activated receptor γ2 gene with small dense low-density lipoprotein in the general population, " Metabolism: Clinical and Experimental, vol. 56, no. 10, pp. 1345-1349, 2007.
    • (2007) Metabolism: Clinical and Experimental , vol.56 , Issue.10 , pp. 1345-1349
    • Hamada, T.1    Kotani, K.2    Tsuzaki, K.3
  • 158
    • 0141886852 scopus 로고    scopus 로고
    • The effects of the Pro12Ala polymorphism of the PPARγ-2 gene on lipid metabolism interact with body size at birth
    • J. Eriksson, V. Lindi, M. Uusitupa, et al., "The effects of the Pro12Ala polymorphism of the PPARγ-2 gene on lipid metabolism interact with body size at birth, " Clinical Genetics, vol. 64, no. 4, pp. 366-370, 2003.
    • (2003) Clinical Genetics , vol.64 , Issue.4 , pp. 366-370
    • Eriksson, J.1    Lindi, V.2    Uusitupa, M.3
  • 159
    • 33947142338 scopus 로고    scopus 로고
    • No association of Pro12Ala polymorphism of PPAR-γ gene with coronary artery disease in Korean subjects
    • E. J. Rhee, C. H. Kwon, W. Y. Lee, et al., "No association of Pro12Ala polymorphism of PPAR-γ gene with coronary artery disease in Korean subjects, " Circulation Journal, vol. 71, no. 3, pp. 338-342, 2007.
    • (2007) Circulation Journal , vol.71 , Issue.3 , pp. 338-342
    • Rhee, E.J.1    Kwon, C.H.2    Lee, W.Y.3
  • 160
    • 44049101537 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: A case-cohort study and meta-analyses
    • M. H. Zafarmand, Y. T. van der Schouw, D. E. Grobbee, P. W. de Leeuw, and M. L. Bots, "Peroxisome proliferator-activated receptor gamma-2 P12A polymorphism and risk of acute myocardial infarction, coronary heart disease and ischemic stroke: a case-cohort study and meta-analyses, " Vascular Health and Risk Management, vol. 4, no. 2, pp. 427-436, 2008.
    • (2008) Vascular Health and Risk Management , vol.4 , Issue.2 , pp. 427-436
    • Zafarmand, M.H.1    Van Der Schouw, Y.T.2    Grobbee, D.E.3    De Leeuw, P.W.4    Bots, M.L.5
  • 161
    • 34248175043 scopus 로고    scopus 로고
    • The Pro12Ala polymorphism in PPARG2 increases the effectiveness of primary prevention of cardiovascular disease by a lifestyle intervention
    • K. Rittig, C. Thamer, F. Machicao, et al., "The Pro12Ala polymorphism in PPARG2 increases the effectiveness of primary prevention of cardiovascular disease by a lifestyle intervention, " Diabetologia, vol. 50, no. 6, pp. 1345-1347, 2007.
    • (2007) Diabetologia , vol.50 , Issue.6 , pp. 1345-1347
    • Rittig, K.1    Thamer, C.2    MacHicao, F.3
  • 162
    • 4344563444 scopus 로고    scopus 로고
    • Genetic variation in PPARG encoding peroxisome proliferator-activated receptor γ associated with carotid atherosclerosis
    • K. Z. Al-Shali, A. A. House, A. J. G. Hanley, et al., "Genetic variation in PPARG encoding peroxisome proliferator-activated receptor γ associated with carotid atherosclerosis, " Stroke, vol. 35, no. 9, pp. 2036-2040, 2004.
    • (2004) Stroke , vol.35 , Issue.9 , pp. 2036-2040
    • Al-Shali, K.Z.1    House, A.A.2    Hanley, A.J.G.3
  • 163
    • 0142199853 scopus 로고    scopus 로고
    • The association of Pro12Ala polymorphism in PPARγ2 with lower carotid artery IMT in Japanese
    • E. Iwata, I. Yamamoto, T. Motomura, et al., "The association of Pro12Ala polymorphism in PPARγ2 with lower carotid artery IMT in Japanese, " Diabetes Research and Clinical Practice, vol. 62, no. 1, pp. 55-59, 2003.
    • (2003) Diabetes Research and Clinical Practice , vol.62 , Issue.1 , pp. 55-59
    • Iwata, E.1    Yamamoto, I.2    Motomura, T.3
  • 164
  • 165
    • 33745905950 scopus 로고    scopus 로고
    • Association between Pro12Ala polymorphism of peroxi-some proliferator-activated receptor-gamma 2 and myocar-dial infarction in the Chinese han population
    • L. Li, L.-X. Cheng, R. Nsenga, M.-A. He, and T.-C. Wu, "Association between Pro12Ala polymorphism of peroxi-some proliferator-activated receptor-gamma 2 and myocar-dial infarction in the Chinese han population, " Clinical Cardiology, vol. 29, no. 7, pp. 300-304, 2006.
    • (2006) Clinical Cardiology , vol.29 , Issue.7 , pp. 300-304
    • Li, L.1    Cheng, L.-X.2    Nsenga, R.3    He, M.-A.4    Wu, T.-C.5
  • 166
    • 23244451839 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ2 P12A polymorphism and risk of coronary heart disease in US men and women
    • T. Pischon, J. K. Pai, J. E. Manson, et al., "Peroxisome proliferator-activated receptor-γ2 P12A polymorphism and risk of coronary heart disease in US men and women, " Arteriosclerosis, Thrombosis, and Vascular Biology, vol. 25, no. 8, pp. 1654-1658, 2005.
    • (2005) Arteriosclerosis, Thrombosis, and Vascular Biology , vol.25 , Issue.8 , pp. 1654-1658
    • Pischon, T.1    Pai, J.K.2    Manson, J.E.3
  • 167
    • 35148857059 scopus 로고    scopus 로고
    • Ala12 variant of the peroxisome proliferator-activated receptor-γ gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction
    • E. A. Ruiz-Narváez, P. Kraft, and H. Campos, "Ala12 variant of the peroxisome proliferator-activated receptor-γ gene (PPARG) is associated with higher polyunsaturated fat in adipose tissue and attenuates the protective effect of polyunsaturated fat intake on the risk of myocardial infarction, " The American Journal of Clinical Nutrition, vol. 86, no. 4, pp. 1238-1242, 2007.
    • (2007) The American Journal of Clinical Nutrition , vol.86 , Issue.4 , pp. 1238-1242
    • Ruiz-Narváez, E.A.1    Kraft, P.2    Campos, H.3
  • 168
    • 51149110542 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma gene polymorphism and risk of cardiovascular disease in patients with diabetic nephropathy
    • C.-C. Szeto, K.-M. Chow, P. Y.-K. Poon, B. C.-H. Kwan, and P. K.-T. Li, "Peroxisome proliferator-activated receptor-gamma gene polymorphism and risk of cardiovascular disease in patients with diabetic nephropathy, " American Journal of Nephrology, vol. 28, no. 5, pp. 715-722, 2008.
    • (2008) American Journal of Nephrology , vol.28 , Issue.5 , pp. 715-722
    • Szeto, C.-C.1    Chow, K.-M.2    Poon, P.Y.-K.3    Kwan, B.C.-H.4    Li, P.K.-T.5
  • 169
    • 0345275787 scopus 로고    scopus 로고
    • The human peroxisome proliferator-activated receptor γ2 (PPARγ2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes
    • M. L. Caramori, L. H. Canani, L. A. Costa, and J. L. Gross, "The human peroxisome proliferator-activated receptor γ2 (PPARγ2) Pro12Ala polymorphism is associated with decreased risk of diabetic nephropathy in patients with type 2 diabetes, " Diabetes, vol. 52, no. 12, pp. 3010-3013, 2003.
    • (2003) Diabetes , vol.52 , Issue.12 , pp. 3010-3013
    • Caramori, M.L.1    Canani, L.H.2    Costa, L.A.3    Gross, J.L.4
  • 170
    • 0036320727 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: The Berlin Diabetes Mellitus (BeDiaM) Study
    • S.-M. Herrmann, J. Ringel, J.-G. Wang, J. A. Staessen, and E. Brand, "Peroxisome proliferator-activated receptor-γ2 polymorphism Pro12Ala is associated with nephropathy in type 2 diabetes: the Berlin Diabetes Mellitus (BeDiaM) Study, " Diabetes, vol. 51, no. 8, pp. 2653-2657, 2002.
    • (2002) Diabetes , vol.51 , Issue.8 , pp. 2653-2657
    • Herrmann, S.-M.1    Ringel, J.2    Wang, J.-G.3    Staessen, J.A.4    Brand, E.5
  • 171
    • 40849142513 scopus 로고    scopus 로고
    • Alanine variant of the Pro12Ala polymorphism of the PPARγ gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes
    • M. T. Malecki, K. Cyganek, B. Mirkiewicz-Sieradzka, et al., "Alanine variant of the Pro12Ala polymorphism of the PPARγ gene might be associated with decreased risk of diabetic retinopathy in type 2 diabetes, " Diabetes Research and Clinical Practice, vol. 80, no. 1, pp. 139-145, 2008.
    • (2008) Diabetes Research and Clinical Practice , vol.80 , Issue.1 , pp. 139-145
    • Malecki, M.T.1    Cyganek, K.2    Mirkiewicz-Sieradzka, B.3
  • 172
    • 0032948363 scopus 로고    scopus 로고
    • Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: A prospective, controlled study in 254 affected women
    • R. S. Legro, A. R. Kunselman, W. C. Dodson, and A. Dunaif, "Prevalence and predictors of risk for type 2 diabetes mellitus and impaired glucose tolerance in polycystic ovary syndrome: a prospective, controlled study in 254 affected women, " The Journal of Clinical Endocrinology & Metabolism, vol. 84, no. 1, pp. 165-169, 1999.
    • (1999) The Journal of Clinical Endocrinology & Metabolism , vol.84 , Issue.1 , pp. 165-169
    • Legro, R.S.1    Kunselman, A.R.2    Dodson, W.C.3    Dunaif, A.4
  • 173
    • 0037342943 scopus 로고    scopus 로고
    • Polymorphism in the peroxisome proliferator-activated receptor-γ gene in women with polycystic ovary syndrome
    • S. Korhonen, S. Heinonen, M. Hiltunen, et al., "Polymorphism in the peroxisome proliferator-activated receptor-γ gene in women with polycystic ovary syndrome, " Human Reproduction, vol. 18, no. 3, pp. 540-543, 2003.
    • (2003) Human Reproduction , vol.18 , Issue.3 , pp. 540-543
    • Korhonen, S.1    Heinonen, S.2    Hiltunen, M.3
  • 174
    • 33745366449 scopus 로고    scopus 로고
    • Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in women with poly-cystic ovary syndrome
    • M. Yilmaz, M. A. Ergün, A. Karakoç, E. Yurtçu, N. Çakir, and M. Arslan, "Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in women with poly-cystic ovary syndrome, " Gynecological Endocrinology, vol. 22, no. 6, pp. 336-342, 2006.
    • (2006) Gynecological Endocrinology , vol.22 , Issue.6 , pp. 336-342
    • Yilmaz, M.1    Ergün, M.A.2    Karakoç, A.3    Yurtçu, E.4    Çakir, N.5    Arslan, M.6
  • 175
    • 20844448393 scopus 로고    scopus 로고
    • The per-oxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome
    • Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population, " Metabolism: Clinical and Experimental, vol. 51, no. 11, pp. 1407-1409, 2002
    • S. Hahn, A. Fingerhut, U. Khomtsiv, et al., "The per-oxisome proliferator activated receptor gamma Pro12Ala polymorphism is associated with a lower hirsutism score and increased insulin sensitivity in women with polycystic ovary syndrome, " Clinical Endocrinology, vol. 62, no. 5, pp. 573-579, 2005.
    • (2005) Clinical Endocrinology , vol.62 , Issue.5 , pp. 573-579
    • Hahn, S.1    Fingerhut, A.2    Khomtsiv, U.3
  • 177
    • 20744444275 scopus 로고    scopus 로고
    • Evaluation of glucose metabolism and reproductive hormones in polycystic ovary syndrome on the basis of per-oxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala genotype
    • E. C. Tok, A. Aktas, D. Ertunc, E. M. Erdal, and S. Dilek, "Evaluation of glucose metabolism and reproductive hormones in polycystic ovary syndrome on the basis of per-oxisome proliferator-activated receptor (PPAR)-γ2 Pro12Ala genotype, " Human Reproduction, vol. 20, no. 6, pp. 1590-1595, 2005.
    • (2005) Human Reproduction , vol.20 , Issue.6 , pp. 1590-1595
    • Tok, E.C.1    Aktas, A.2    Ertunc, D.3    Erdal, E.M.4    Dilek, S.5
  • 178
    • 28844489933 scopus 로고    scopus 로고
    • Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in first-degree relatives of subjects with polycystic ovary syndrome
    • M. Yilmaz, M. A. Ergün, A. Karakoç, et al., "Pro12Ala polymorphism of the peroxisome proliferator-activated receptor-γ gene in first-degree relatives of subjects with polycystic ovary syndrome, " Gynecological Endocrinology, vol. 21, no. 4, pp. 206-210, 2005.
    • (2005) Gynecological Endocrinology , vol.21 , Issue.4 , pp. 206-210
    • Yilmaz, M.1    Ergün, M.A.2    Karakoç, A.3
  • 179
    • 0036314819 scopus 로고    scopus 로고
    • The proline 12 alanine substitution in the peroxisome proliferator-activated receptor-γ2 gene is associated with lower lipoprotein lipase activity in vivo
    • J. Schneider, J. Kreuzer, A. Hamann, P. P. Nawroth, and K. A. Dugi, "The proline 12 alanine substitution in the peroxisome proliferator- activated receptor-γ2 gene is associated with lower lipoprotein lipase activity in vivo, " Diabetes, vol. 51, no. 3, pp. 867-870, 2002.
    • (2002) Diabetes , vol.51 , Issue.3 , pp. 867-870
    • Schneider, J.1    Kreuzer, J.2    Hamann, A.3    Nawroth, P.P.4    Dugi, K.A.5
  • 181
    • 31444436445 scopus 로고    scopus 로고
    • The in vivo effects of the Pro12Ala PPARγ2 polymorphism on adipose tissue NEFA metabolism: The first use of the Oxford Biobank
    • G. D. Tan, M. J. Neville, E. Liverani, et al., "The in vivo effects of the Pro12Ala PPARγ2 polymorphism on adipose tissue NEFA metabolism: the first use of the Oxford Biobank, " Diabetologia, vol. 49, no. 1, pp. 158-168, 2006.
    • (2006) Diabetologia , vol.49 , Issue.1 , pp. 158-168
    • Tan, G.D.1    Neville, M.J.2    Liverani, E.3
  • 183
    • 0034745183 scopus 로고    scopus 로고
    • 2 gene is associated with increased antilipolytic insulin sensitivity
    • 2 gene is associated with increased antilipolytic insulin sensitivity, " Diabetes, vol. 50, no. 4, pp. 876-881, 2001.
    • (2001) Diabetes , vol.50 , Issue.4 , pp. 876-881
    • Stumvoll, M.1
  • 184
    • 0033517284 scopus 로고    scopus 로고
    • Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy
    • I. Shimomura, R. E. Hammer, S. Ikemoto, M. S. Brown, and J. L. Goldstein, "Leptin reverses insulin resistance and diabetes mellitus in mice with congenital lipodystrophy, " Nature, vol. 401, no. 6748, pp. 73-76, 1999.
    • (1999) Nature , vol.401 , Issue.6748 , pp. 73-76
    • Shimomura, I.1    Hammer, R.E.2    Ikemoto, S.3    Brown, M.S.4    Goldstein, J.L.5
  • 185
    • 0036851817 scopus 로고    scopus 로고
    • Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase
    • T. Yamauchi, J. Kamon, Y. Minokoshi, et al., "Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase, " Nature Medicine, vol. 8, no. 11, pp. 1288-1295, 2002.
    • (2002) Nature Medicine , vol.8 , Issue.11 , pp. 1288-1295
    • Yamauchi, T.1    Kamon, J.2    Minokoshi, Y.3
  • 186
    • 0036389428 scopus 로고    scopus 로고
    • Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus
    • I. Simón, J. Vendrell, C. Gutiérrez, et al., "Pro12Ala substitution in the peroxisome proliferator-activated receptor-gamma is associated with increased leptin levels in women with type-2 diabetes mellitus, " Hormone Research, vol. 58, no. 3, pp. 143-149, 2002.
    • (2002) Hormone Research , vol.58 , Issue.3 , pp. 143-149
    • Simón, I.1
  • 187
    • 9344231937 scopus 로고    scopus 로고
    • Pro12Ala substitution in peroxisome proliferator-activated receptorγ2 is associated with low adiponectin concentrations in young Japanese men
    • N. Takata, T. Awata, K. Inukai, et al., "Pro12Ala substitution in peroxisome proliferator-activated receptorγ2 is associated with low adiponectin concentrations in young Japanese men, " Metabolism: Clinical and Experimental, vol. 53, no. 12, pp. 1548-1551, 2004.
    • (2004) Metabolism: Clinical and Experimental , vol.53 , Issue.12 , pp. 1548-1551
    • Takata, N.1    Awata, T.2    Inukai, K.3
  • 188
    • 0036835826 scopus 로고    scopus 로고
    • 2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population
    • 2 gene Pro12Ala polymorphism may influence serum level of an adipocyte-derived protein, adiponectin, in the Japanese population, " Metabolism: Clinical and Experimental, vol. 51, no. 11, pp. 1407-1409, 2002.
    • (2002) Metabolism: Clinical and Experimental , vol.51 , Issue.11 , pp. 1407-1409
    • Yamamoto, Y.1    Hirose, H.2    Miyashita, K.3
  • 189
    • 6344248797 scopus 로고    scopus 로고
    • Lack of an association between peroxisome proliferator-activated receptor-γ gene Pro12Ala polymorphism and adiponectin levels in the polycystic ovary syndrome
    • F. Orio Jr., S. Palomba, T. Cascella, et al., "Lack of an association between peroxisome proliferator-activated receptor-γ gene Pro12Ala polymorphism and adiponectin levels in the polycystic ovary syndrome, " The Journal of Clinical Endocrinology & Metabolism, vol. 89, no. 10, pp. 5110-5115, 2004.
    • (2004) The Journal of Clinical Endocrinology & Metabolism , vol.89 , Issue.10 , pp. 5110-5115
    • Orio Jr., F.1    Palomba, S.2    Cascella, T.3
  • 190
    • 33947415800 scopus 로고    scopus 로고
    • Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians
    • V. Radha, K. S. Vimaleswaran, S. Babu, et al., "Lack of association between serum adiponectin levels and the Pro12Ala polymorphism in Asian Indians, " Diabetic Medicine, vol. 24, no. 4, pp. 398-402, 2007.
    • (2007) Diabetic Medicine , vol.24 , Issue.4 , pp. 398-402
    • Radha, V.1    Vimaleswaran, K.S.2    Babu, S.3
  • 191
    • 85030434746 scopus 로고    scopus 로고
    • Increased oxidative stress in obesity and its impact on metabolic syndrome
    • S. Furukawa, T. Fujita, M. Shimabukuro, et al., "Increased oxidative stress in obesity and its impact on metabolic syndrome, " The Journal of Clinical Investigation, vol. 114, no. 12, pp. 1752-1761, 2004.
    • (2004) The Journal of Clinical Investigation , vol.114 , Issue.12 , pp. 1752-1761
    • Furukawa, S.1    Fujita, T.2    Shimabukuro, M.3
  • 192
    • 33645860825 scopus 로고    scopus 로고
    • Reactive oxygen species have a causal role in multiple forms of insulin resistance
    • N. Houstis, E. D. Rosen, and E. S. Lander, "Reactive oxygen species have a causal role in multiple forms of insulin resistance, " Nature, vol. 440, no. 7086, pp. 944-948, 2006.
    • (2006) Nature , vol.440 , Issue.7086 , pp. 944-948
    • Houstis, N.1    Rosen, E.D.2    Lander, E.S.3
  • 193
    • 39149100287 scopus 로고    scopus 로고
    • Adipose tissue-specific PPARγ deficiency increases resistance to oxidative stress
    • W. Luo, J. Cao, J. Li, and W. He, "Adipose tissue-specific PPARγ deficiency increases resistance to oxidative stress, " Experimental Gerontology, vol. 43, no. 3, pp. 154-163, 2008.
    • (2008) Experimental Gerontology , vol.43 , Issue.3 , pp. 154-163
    • Luo, W.1    Cao, J.2    Li, J.3    He, W.4
  • 194
    • 50649097541 scopus 로고    scopus 로고
    • Fat and beyond: The diverse biology of PPARγ
    • P. Tontonoz and B. M. Spiegelman, "Fat and beyond: the diverse biology of PPARγ, " Annual Review of Biochemistry, vol. 77, pp. 289-312, 2008.
    • (2008) Annual Review of Biochemistry , vol.77 , pp. 289-312
    • Tontonoz, P.1    Spiegelman, B.M.2
  • 195
    • 16244397393 scopus 로고    scopus 로고
    • The PPARγ Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas
    • Z. Gong, D. Xie, Z. Deng, et al., "The PPARγ Pro12Ala polymorphism and risk for incident sporadic colorectal adenomas, " Carcinogenesis, vol. 26, no. 3, pp. 579-585, 2005.
    • (2005) Carcinogenesis , vol.26 , Issue.3 , pp. 579-585
    • Gong, Z.1    Xie, D.2    Deng, Z.3
  • 196
    • 18544373384 scopus 로고    scopus 로고
    • Interactions of peroxisome proliferator-activated receptor γ and diet in etiology of colorectal cancer
    • M. A. Murtaugh, K. Ma, B. J. Caan, et al., "Interactions of peroxisome proliferator-activated receptor γ and diet in etiology of colorectal cancer, " Cancer Epidemiology Biomarkers & Prevention, vol. 14, no. 5, pp. 1224-1229, 2005.
    • (2005) Cancer Epidemiology Biomarkers & Prevention , vol.14 , Issue.5 , pp. 1224-1229
    • Murtaugh, M.A.1    Ma, K.2    Caan, B.J.3
  • 197
    • 33748313397 scopus 로고    scopus 로고
    • Relation between common polymorphisms in genes related to inflammatory response and colarectal cancer
    • G. Theodoropoulos, I. Papaconstantinou, E. Felekouras, et al., "Relation between common polymorphisms in genes related to inflammatory response and colarectal cancer, " World Journal of Gastroenterology, vol. 12, no. 31, pp. 5037-5043, 2006.
    • (2006) World Journal of Gastroenterology , vol.12 , Issue.31 , pp. 5037-5043
    • Theodoropoulos, G.1    Papaconstantinou, I.2    Felekouras, E.3
  • 198
    • 25844524856 scopus 로고    scopus 로고
    • Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population
    • J. Jiang, V. Gajalakshmi, J. Wang, et al., "Influence of the C161T but not Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma on colorectal cancer in an Indian population, " Cancer Science, vol. 96, no. 8, pp. 507-512, 2005.
    • (2005) Cancer Science , vol.96 , Issue.8 , pp. 507-512
    • Jiang, J.1    Gajalakshmi, V.2    Wang, J.3
  • 199
    • 33644886282 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese
    • S.-Y. Liao, Z.-R. Zeng, W. K. Leung, et al., "Peroxisome proliferator-activated receptor-gamma Pro12Ala polymorphism, Helicobacter pylori infection and non-cardia gastric carcinoma in Chinese, " Alimentary Pharmacology & Therapeutics, vol. 23, no. 2, pp. 289-294, 2006.
    • (2006) Alimentary Pharmacology & Therapeutics , vol.23 , Issue.2 , pp. 289-294
    • Liao, S.-Y.1    Zeng, Z.-R.2    Leung, W.K.3
  • 200
    • 46249125608 scopus 로고    scopus 로고
    • Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease
    • K. N. Prasad, A. Saxena, U. C. Ghoshal, M. R. Bhagat, and N. Krishnani, "Analysis of Pro12Ala PPAR gamma polymorphism and Helicobacter pylori infection in gastric adenocarcinoma and peptic ulcer disease, " Annals of Oncology, vol. 19, no. 7, pp. 1299-1303, 2008.
    • (2008) Annals of Oncology , vol.19 , Issue.7 , pp. 1299-1303
    • Prasad, K.N.1    Saxena, A.2    Ghoshal, U.C.3    Bhagat, M.R.4    Krishnani, N.5
  • 201
    • 39849085359 scopus 로고    scopus 로고
    • Influence of per-oxisome proliferator-activated receptor (PPAR)γ Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese
    • T. Tahara, T. Arisawa, T. Shibata, et al., "Influence of per-oxisome proliferator-activated receptor (PPAR)γ Plo12Ala polymorphism as a shared risk marker for both gastric cancer and impaired fasting glucose (IFG) in Japanese, " Digestive Diseases and Sciences, vol. 53, no. 3, pp. 614-621, 2008.
    • (2008) Digestive Diseases and Sciences , vol.53 , Issue.3 , pp. 614-621
    • Tahara, T.1    Arisawa, T.2    Shibata, T.3
  • 202
    • 33746610120 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor-γ polymorphism, body mass and prostate cancer risk: Evidence for gene-environment interaction
    • J. M. Zmuda, F. Modugno, J. L. Weissfeld, et al., "Peroxisome proliferator-activated receptor-γ polymorphism, body mass and prostate cancer risk: evidence for gene-environment interaction, " Oncology, vol. 70, no. 3, pp. 185-189, 2006.
    • (2006) Oncology , vol.70 , Issue.3 , pp. 185-189
    • Zmuda, J.M.1    Modugno, F.2    Weissfeld, J.L.3
  • 203
    • 0037470401 scopus 로고    scopus 로고
    • Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-γ) gene and risk of prostate cancer among men in a large cancer prevention study
    • D. Paltoo, K. Woodson, P. Taylor, D. Albanes, J. Virtamo, and J. Tangrea, "Pro12Ala polymorphism in the peroxisome proliferator-activated receptor-gamma (PPAR-γ) gene and risk of prostate cancer among men in a large cancer prevention study, " Cancer Letters, vol. 191, no. 1, pp. 67-74, 2003.
    • (2003) Cancer Letters , vol.191 , Issue.1 , pp. 67-74
    • Paltoo, D.1    Woodson, K.2    Taylor, P.3    Albanes, D.4    Virtamo, J.5    Tangrea, J.6
  • 204
    • 33847711073 scopus 로고    scopus 로고
    • Nested case-control study of energy regulation candidate gene single nucleotide polymorphisms and breast cancer
    • Y. Wang, M. L. McCullough, V. L. Stevens, et al., "Nested case-control study of energy regulation candidate gene single nucleotide polymorphisms and breast cancer, " Anticancer Research, vol. 27, no. 1B, pp. 589-593, 2007.
    • (2007) Anticancer Research , vol.27 , Issue.1 B , pp. 589-593
    • Wang, Y.1    McCullough, M.L.2    Stevens, V.L.3
  • 205
    • 33847306508 scopus 로고    scopus 로고
    • 12 Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes
    • 12Ala, interaction with alcohol intake and NSAID use, in relation to risk of breast cancer in a prospective study of Danes, " Carcinogenesis, vol. 28, no. 2, pp. 427-434, 2007.
    • (2007) Carcinogenesis , vol.28 , Issue.2 , pp. 427-434
    • Vogel, U.1    Christensen, J.2    Nexø, B.A.3    Wallin, H.4    Friis, S.5    Tjønneland, A.6
  • 206
    • 24944558497 scopus 로고    scopus 로고
    • Polymorphisms in inflammation genes and bladder cancer: From initiation to recurrence, progression, and survival
    • D. Leibovici, H. B. Grossman, C. P. Dinney, et al., "Polymorphisms in inflammation genes and bladder cancer: from initiation to recurrence, progression, and survival, " Journal of Clinical Oncology, vol. 23, no. 24, pp. 5746-5756, 2005.
    • (2005) Journal of Clinical Oncology , vol.23 , Issue.24 , pp. 5746-5756
    • Leibovici, D.1    Grossman, H.B.2    Dinney, C.P.3
  • 207
    • 17944367989 scopus 로고    scopus 로고
    • Opposite association of two PPARG variants with cancer: Overrep-resentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases
    • W. M. Smith, X.-P. Zhou, K. Kurose, et al., "Opposite association of two PPARG variants with cancer: overrep-resentation of H449H in endometrial carcinoma cases and underrepresentation of P12A in renal cell carcinoma cases, " Human Genetics, vol. 109, no. 2, pp. 146-151, 2001.
    • (2001) Human Genetics , vol.109 , Issue.2 , pp. 146-151
    • Smith, W.M.1    Zhou, X.-P.2    Kurose, K.3
  • 208
    • 33646397053 scopus 로고    scopus 로고
    • Associations between vitamin D, vitamin D receptor gene and the andro-gen receptor gene with colon and rectal cancer
    • M. L. Slattery, C. Sweeney, M. Murtaugh, et al., "Associations between vitamin D, vitamin D receptor gene and the andro-gen receptor gene with colon and rectal cancer, " International Journal of Cancer, vol. 118, no. 12, pp. 3140-3146, 2006.
    • (2006) International Journal of Cancer , vol.118 , Issue.12 , pp. 3140-3146
    • Slattery, M.L.1    Sweeney, C.2    Murtaugh, M.3
  • 209
    • 3242724126 scopus 로고    scopus 로고
    • Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)γ-2 with longevity
    • M. Barbieri, M. Bonafè, M. R. Rizzo, et al., "Gender specific association of genetic variation in peroxisome proliferator-activated receptor (PPAR)γ-2 with longevity, " Experimental Gerontology, vol. 39, no. 7, pp. 1095-1100, 2004.
    • (2004) Experimental Gerontology , vol.39 , Issue.7 , pp. 1095-1100
    • Barbieri, M.1    Bonafè, M.2    Rizzo, M.R.3
  • 210
    • 10044225937 scopus 로고    scopus 로고
    • Peroxisome proliferator-activated receptor γ induces a clearance mechanism for the amyloid-β peptide
    • I. E. Camacho, L. Serneels, K. Spittaels, P. Merchiers, D. Dominguez, and B. De Strooper, "Peroxisome proliferator-activated receptor γ induces a clearance mechanism for the amyloid-β peptide, " The Journal of Neuroscience, vol. 24, no. 48, pp. 10908-10917, 2004.
    • (2004) The Journal of Neuroscience , vol.24 , Issue.48 , pp. 10908-10917
    • Camacho, I.E.1    Serneels, L.2    Spittaels, K.3    Merchiers, P.4    Dominguez, D.5    De Strooper, B.6
  • 211
    • 27744510142 scopus 로고    scopus 로고
    • Role of peroxisome proliferator-activated receptor γ in amyloid precursor protein processing and amyloid β-mediated cell death
    • C. d'Abramo, S. Massone, J.-M. Zingg, et al., "Role of peroxisome proliferator-activated receptor γ in amyloid precursor protein processing and amyloid β-mediated cell death, " Biochemical Journal, vol. 391, no. 3, pp. 693-698, 2005.
    • (2005) Biochemical Journal , vol.391 , Issue.3 , pp. 693-698
    • D'Abramo, C.1    Massone, S.2    Et Al. Zingg, J.-M.3
  • 213
    • 33847318631 scopus 로고    scopus 로고
    • The peroxisome proliferator-activated receptor gamma (PPAR-γ2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians
    • R. Scacchi, A. Pinto, G. Gambina, A. Rosano, and R. M. Corbo, "The peroxisome proliferator-activated receptor gamma (PPAR-γ2) Pro12Ala polymorphism is associated with higher risk for Alzheimer's disease in octogenarians, " Brain Research, vol. 1139, no. 1, pp. 1-5, 2007.
    • (2007) Brain Research , vol.1139 , Issue.1 , pp. 1-5
    • Scacchi, R.1    Pinto, A.2    Gambina, G.3    Rosano, A.4    Corbo, R.M.5
  • 214
    • 34250873382 scopus 로고    scopus 로고
    • Candidate gene association study of insulin signaling genes and Alzheimer's disease: Evidence for SOS2, PCK1, and PPARγ as susceptibility loci
    • G. Hamilton, P. Proitsi, L. Jehu, et al., "Candidate gene association study of insulin signaling genes and Alzheimer's disease: evidence for SOS2, PCK1, and PPARγ as susceptibility loci, " American Journal of Medical Genetics Part B, vol. 144, no. 4, pp. 508-516, 2007.
    • (2007) American Journal of Medical Genetics Part B , vol.144 , Issue.4 , pp. 508-516
    • Hamilton, G.1    Proitsi, P.2    Jehu, L.3
  • 215
    • 33750908413 scopus 로고    scopus 로고
    • Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset al.zheimer's disease in the Finnish population
    • A. M. Koivisto, S. Helisalmi, J. Pihlajamäki, et al., "Association analysis of peroxisome proliferator-activated receptor gamma polymorphisms and late onset al.zheimer's disease in the Finnish population, " Dementia and Geriatric Cognitive Disorders, vol. 22, no. 5-6, pp. 449-453, 2006.
    • (2006) Dementia and Geriatric Cognitive Disorders , vol.22 , Issue.5-6 , pp. 449-453
    • Koivisto, A.M.1    Helisalmi, S.2    Pihlajamäki, J.3
  • 216
    • 25144444278 scopus 로고    scopus 로고
    • Influence of peroxisome proliferator-activated receptor γ gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients
    • S. Sauder, H. Kölsch, D. Lütjohann, et al., "Influence of peroxisome proliferator-activated receptor γ gene polymorphism on 24S-hydroxycholesterol levels in Alzheimer's patients, " Journal of Neural Transmission, vol. 112, no. 10, pp. 1381-1389, 2005.
    • (2005) Journal of Neural Transmission , vol.112 , Issue.10 , pp. 1381-1389
    • Sauder, S.1    Kölsch, H.2    Lütjohann, D.3
  • 217
    • 40649104295 scopus 로고    scopus 로고
    • PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes
    • W. Johnson, S. E. Harris, J. M. Starr, L. J. Whalley, and I. J. Deary, "PPARG Pro12Ala genotype and risk of cognitive decline in elders? Maybe with diabetes, " Neuroscience Letters, vol. 434, no. 1, pp. 50-55, 2008.
    • (2008) Neuroscience Letters , vol.434 , Issue.1 , pp. 50-55
    • Johnson, W.1    Harris, S.E.2    Starr, J.M.3    Whalley, L.J.4    Deary, I.J.5
  • 218
    • 84874677633 scopus 로고    scopus 로고
    • The PPAR-gamma Pro12Ala polymorphism and risk of cognitive impairment in a longitudinal study
    • In press
    • N. A. West, M. N. Haan, and H. Morgenstern, "The PPAR-gamma Pro12Ala polymorphism and risk of cognitive impairment in a longitudinal study, " Neurobiology of Aging. In press.
    • Neurobiology of Aging
    • West, N.A.1    Haan, M.N.2    Morgenstern, H.3
  • 219
    • 0027265827 scopus 로고
    • Increased cytokine production in mononuclear cells of healthy elderly people
    • U. Fagiolo, A. Cossarizza, E. Scala, et al., "Increased cytokine production in mononuclear cells of healthy elderly people, " European Journal of Immunology, vol. 23, no. 9, pp. 2375-2378, 1993.
    • (1993) European Journal of Immunology , vol.23 , Issue.9 , pp. 2375-2378
    • Fagiolo, U.1    Cossarizza, A.2    Scala, E.3
  • 220
    • 0344269351 scopus 로고    scopus 로고
    • Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status
    • J. Myśliwska, E. Bryl, J. Foerster, and A. Myśliwski, "Increase of interleukin 6 and decrease of interleukin 2 production during the ageing process are influenced by the health status, " Mechanisms of Ageing and Development, vol. 100, no. 3, pp. 313-328, 1998.
    • (1998) Mechanisms of Ageing and Development , vol.100 , Issue.3 , pp. 313-328
    • Myśliwska, J.1    Bryl, E.2    Foerster, J.3    Myśliwski, A.4
  • 221
    • 47849109721 scopus 로고    scopus 로고
    • Involvement of cholesterol in the pathogenesis of Alzheimer's disease: Role of statins
    • P. Pregelj, "Involvement of cholesterol in the pathogenesis of Alzheimer's disease: role of statins, " Psychiatria Danubina, vol. 20, no. 2, pp. 162-167, 2008.
    • (2008) Psychiatria Danubina , vol.20 , Issue.2 , pp. 162-167
    • Pregelj, P.1
  • 222
    • 34547315810 scopus 로고    scopus 로고
    • Alzheimer's disease: Cholesterol, membrane rafts, iso-prenoids and statins
    • P. C. Reid, Y. Urano, T. Kodama, and T. Hamakubo, "Alzheimer's disease: cholesterol, membrane rafts, iso-prenoids and statins, " Journal of Cellular and Molecular Medicine, vol. 11, no. 3, pp. 383-392, 2007.
    • (2007) Journal of Cellular and Molecular Medicine , vol.11 , Issue.3 , pp. 383-392
    • Reid, P.C.1    Urano, Y.2    Kodama, T.3    Hamakubo, T.4
  • 223
    • 0346373654 scopus 로고    scopus 로고
    • Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium
    • C. S. Carlson, M. A. Eberle, M. J. Rieder, Q. Yi, L. Kruglyak, and D. A. Nickerson, "Selecting a maximally informative set of single-nucleotide polymorphisms for association analyses using linkage disequilibrium, " The American Journal of Human Genetics, vol. 74, no. 1, pp. 106-120, 2004.
    • (2004) The American Journal of Human Genetics , vol.74 , Issue.1 , pp. 106-120
    • Carlson, C.S.1    Eberle, M.A.2    Rieder, M.J.3    Yi, Q.4    Kruglyak, L.5    Nickerson, D.A.6
  • 224
    • 1842435261 scopus 로고    scopus 로고
    • Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations
    • D. C. Crawford, C. S. Carlson, M. J. Rieder, et al., "Haplotype diversity across 100 candidate genes for inflammation, lipid metabolism, and blood pressure regulation in two populations, " The American Journal of Human Genetics, vol. 74, no. 4, pp. 610-622, 2004.
    • (2004) The American Journal of Human Genetics , vol.74 , Issue.4 , pp. 610-622
    • Crawford, D.C.1    Carlson, C.S.2    Rieder, M.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.