Loss of aryl hydrocarbon receptor promotes gene changes associated with premature hematopoietic stem cell exhaustion and development of a myeloproliferative disorder in aging mice

Stem Cells and Development

Volumn 23, Issue 2, 2014, Pages 95-106

  Singh, Kameshwar P ^a   Bennett, John A ^a   Casado, Fanny L ^b   Walrath, Jason L ^a   Welle, Stephen L ^a   Gasiewicz, Thomas A ^a  

^a UNIVERSITY OF ROCHESTER SCHOOL OF MEDICINE AND DENTISTRY   (United States)

^b MCMASTER UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

AROMATIC HYDROCARBON RECEPTOR; PROTEIN P21; REACTIVE OXYGEN METABOLITE; TRANSCRIPTION FACTOR GATA 1; AHR PROTEIN, MOUSE; BASIC HELIX LOOP HELIX TRANSCRIPTION FACTOR; CYCLIN DEPENDENT KINASE INHIBITOR 2A; GAMMA-H2AX PROTEIN, MOUSE; HISTONE; KI 67 ANTIGEN; MKI67 PROTEIN, MOUSE;

ACUTE GRANULOCYTIC LEUKEMIA; AGING; ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; GENE EXPRESSION; GENETIC ASSOCIATION; HEAT SHOCK RESPONSE; HEMATOPOIETIC STEM CELL; LEUKOCYTE; MOUSE; MYELOPROLIFERATIVE DISORDER; NONHUMAN; ONCOGENE C MYC; OXIDATIVE STRESS; PHENOTYPE; PREMATURITY; PRIORITY JOURNAL; SPLENOMEGALY; SURVIVAL RATE; TRANSPLANTATION; WILD TYPE; ANIMAL; BIOSYNTHESIS; BONE MARROW CELL; C57BL MOUSE; CELL MOTION; CELL PROLIFERATION; CYTOLOGY; FEMALE; GENETICS; HEMATOPOIETIC STEM CELL TRANSPLANTATION; IMMUNOLOGY; KNOCKOUT MOUSE; LEUKOCYTE COUNT; METABOLISM; SIGNAL TRANSDUCTION;

AGING; ANEMIA; ANIMALS; BASIC HELIX-LOOP-HELIX TRANSCRIPTION FACTORS; BONE MARROW CELLS; CELL MOVEMENT; CELL PROLIFERATION; CYCLIN-DEPENDENT KINASE INHIBITOR P16; FEMALE; GENE EXPRESSION; HEMATOPOIETIC STEM CELL TRANSPLANTATION; HEMATOPOIETIC STEM CELLS; HISTONES; KI-67 ANTIGEN; LEUKOCYTE COUNT; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MYELOPROLIFERATIVE DISORDERS; OXIDATIVE STRESS; REACTIVE OXYGEN SPECIES; RECEPTORS, ARYL HYDROCARBON; SIGNAL TRANSDUCTION; SPLENOMEGALY; SURVIVAL RATE;

EID: 84891871574     PISSN: 15473287     EISSN: 15578534     Source Type: Journal    
DOI: 10.1089/scd.2013.0346     Document Type: Article

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