Efficient amide bond formation through a rapid and strong activation of carboxylic acids in a microflow reactor

Angewandte Chemie - International Edition

Volumn 53, Issue 3, 2014, Pages 851-855

  Fuse, Shinichiro ^a   Mifune, Yuto ^a   Takahashi, Takashi ^b  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

^b YOKOHAMA COLLEGE OF PHARMACY   (Japan)

Author keywords

amides; amino acids; continuous flow; natural products; peptides

Indexed keywords

AMIDES; AMINES; AMINO ACIDS; CHEMICAL ACTIVATION; CHLORINE COMPOUNDS; PEPTIDES; REAGENTS;

ACTIVE SPECIES; AMIDE BOND FORMATION; CONTINUOUS FLOWS; COUPLING REAGENTS; ELECTROPHILIC SPECIES; MICRO-FLOW REACTOR; NATURAL PRODUCTS; PEPTIDE SYNTHESIS;

CARBOXYLIC ACIDS;

AMIDE; AMINO ACID; BIS(TRICHLOROMETHYL) CARBONATE; CARBOXYLIC ACID; DRUG DERIVATIVE; PEPTIDE; PHOSGENE; SOLVENT;

ARTICLE; CHEMISTRY; CONTINUOUS FLOW; NATURAL PRODUCTS; STEREOISOMERISM; SYNTHESIS;

AMIDES; AMINO ACIDS; CONTINUOUS FLOW; NATURAL PRODUCTS; PEPTIDES;

AMIDES; AMINO ACIDS; CARBOXYLIC ACIDS; PEPTIDES; PHOSGENE; SOLVENTS; STEREOISOMERISM;

EID: 84891854708     PISSN: 14337851     EISSN: 15213773     Source Type: Journal    
DOI: 10.1002/anie.201307987     Document Type: Article

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