Membrane ERα attenuates myocardial fibrosis via RhoA/ROCK-mediated actin remodeling in ovariectomized female infarcted rats

Journal of Molecular Medicine

Volumn 92, Issue 1, 2014, Pages 43-51

  Lee, Tsung Ming ^a,b,c   Lin, Shinn Zong ^a,b,d   Chang, Nen Chung ^c,e  

^a Tainan Municipal An Nan Hospital China Medical University   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c TAIPEI MEDICAL UNIVERSITY   (Taiwan)

^d CHINA MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

^e TAIPEI MEDICAL UNIVERSITY HOSPITAL   (Taiwan)

Author keywords

Cofilin; Estrogen receptor; Fibrosis; Myocardial infarction; RhoA ROCK

Indexed keywords

2,3 BIS(4 HYDROXY PHENYL)PROPIONITRILE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACTIN; COFILIN; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FULVESTRANT; G 15; HORMONE RECEPTOR STIMULATING AGENT; HYDROXYPROLINE; PROTEIN INHIBITOR; RHO KINASE; UNCLASSIFIED DRUG;

ACTIN POLYMERIZATION; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; CORONARY ARTERY LIGATION; ENZYME ACTIVITY; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; FEMALE; HEART INFARCTION; HEART INFARCTION SIZE; HEART MUSCLE FIBROSIS; NONHUMAN; OVARIECTOMY; RAT;

ACTIN DEPOLYMERIZING FACTORS; ACTINS; ANIMALS; BODY WEIGHT; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; ESTRADIOL; ESTROGEN RECEPTOR ALPHA; FEMALE; FIBROSIS; HEMODYNAMICS; MYOCARDIAL INFARCTION; MYOCARDIUM; ORGAN SIZE; OVARIECTOMY; PHOSPHORYLATION; RATS; RHO-ASSOCIATED KINASES; RHOA GTP-BINDING PROTEIN; SIGNAL TRANSDUCTION; UTERUS;

EID: 84891839662     PISSN: 09462716     EISSN: 14321440     Source Type: Journal    
DOI: 10.1007/s00109-013-1103-4     Document Type: Article

References (34)

1. Cohen MV, Downey JM (2008) Oestrogen plays a permissive role in cardioprotection. Cardiovasc Res 79:353-354
2. Petrov G, Regitz-Zagrosek V, Lehmkuhl E, Krabatsch T, Dunkel A, Dandel M, Dworatzek E, Mahmoodzadeh S, Schubert C, Becher E et al (2010) Regression of myocardial hypertrophy after aortic valve replacement: faster in women? Circulation 122:S23-S28
3. Xu Y, Arenas IA, Armstrong SJ, Davidge ST (2003) Estrogen modulation of left ventricular remodeling in the aged heart. Cardiovasc Res 57:388-394 (Pubitemid 36144217)
4. Revankar CM, Cimino DF, Sklar LA, Arterburn JB, Prossnitz ER (2005) A transmembrane intracellular estrogen receptor mediates rapid cell signaling. Science 307:1625-1630 (Pubitemid 40354745)
5. Stewart JA Jr, Massey EP, Fix C, Zhu J, Goldsmith EC, Carver W (2010) Temporal alterations in cardiac fibroblast function following induction of pressure overload. Cell Tissue Res 340:117-126
6. Weber KT (1989) Cardiac interstitium in health and disease: the fibrillar collagen network. J Am Coll Cardiol 13:1637-1652 (Pubitemid 19145564)
7. Chaturvedi RR, Herron T, Simmons R, Shore D, Kumar P, Sethia B, Chua F, Vassiliadis E, Kentish JC (2010) Passive stiffness of myocardium from congential heart disease and implications for diastole. Circulation 121:979-988
8. Kai H, Mori T, Tokuda K, Takayama N, Tahara N, Takemiya K, Kudo H, Sugi Y, Fukui D, Yasukawa H et al (2006) Pressure overload-induced transient oxidative stress mediates perivascular inflammation and cardiac fibrosis through angiotensin II. Hypertens Res 29:711-718 (Pubitemid 44605370)
9. Pollard TD, Borisy GG (2003) Cellular motility driven by assembly and disassembly of actin filaments. Cell 112:453-465 (Pubitemid 36263079)
10. Simoncini T, Scorticati C, Mannella P, Fadiel A, Giretti MS, Fu XD, Baldacci C, Garibaldi S, Caruso A, Fornari L et al (2006) Estrogen receptor alpha interacts with Galpha13 to drive actin remodeling and endothelial cell migration via the RhoA/Rho kinase/moesin pathway. Mol Endocrinol 20:1756-1771 (Pubitemid 44148082)
11. Li Q, Xu Y, Li X, Guo Y, Liu G (2012) Inhibition of Rho-kinase ameliorates myocardial remodeling and fibrosis in pressure overload and myocardial infarction: role of TGF-β1-TAK1. Toxicol Lett 211:91-97
12. Zhang YM, Bo J, Taffet GE, Chang J, Shi J, Reddy AK, Michael LH, Schneider MD, Entman ML, Schwartz RJ et al (2006) Targeted deletion of ROCK1 protects the heart against pressure overload by inhibiting reactive fibrosis. FASEB J 20:916-925 (Pubitemid 44943949)
13. Brown JH, Del Re DP, Sussman MA (2006) The Rac and rho hall of fame: a decade of hypertrophic signaling hits. Circ Res 98:730-742
14. Forget MA, Desrosiers RR, Gingras D, Beliveau R (2002) Phosphorylation states of Cdc42 and RhoA regulate their interactions with Rho GDP dissociation inhibitor and their extraction from biological membranes. Biochem J 361:243-254 (Pubitemid 34174491)
15. Ellerbroek SM, Wennerberg K, Burridge K (2003) Serine phosphorylation negatively regulates RhoA in vivo. J Biol Chem 278:19023-19031 (Pubitemid 36799287)
16. Maekawa M, Ishizaki T, Boku S, Watanabe N, Fujita A, Iwamatsu A, Obinata T, Ohashi K, Mizuno K, Narumiya S (1999) Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase. Science 285:895-898 (Pubitemid 29381991)
17. Pho M, Lee W, Watt DR, Laschinger C, Simmons CA, McCulloch CA (2008) Cofilin is a marker of myofibroblast differentiation in cells from porcine aortic cardiac valves. Am J Physiol Heart Circ Physiol 294:H1767-H1778 (Pubitemid 351490607)
18. Lee TM, Lin MS, Chang NC (2008) Physiological concentration of 17beta-estradiol on sympathetic reinnervation in ovariectomized infarcted rats. Endocrinology 149:1205-1213 (Pubitemid 351397934)
19. + channels in canine hearts. J Mol Cell Cardiol 32:1147-1158
20. Bélichard P, Savard P, Cardinal R, Nadeau R, Gosselin H, Paradis P, Rouleau JL (1994) Markedly different effects on ventricular remodeling result in a decrease in inducibility of ventricular arrhythmias. J Am Coll Cardiol 23:505-513 (Pubitemid 24049385)
21. Ghisletti S, Meda C, Maggi A, Vegeto E (2005) 17beta-estradiol inhibits inflammatory gene expression by controlling NF-kappaB intracellular localization. Mol Cell Biol 25:2957-2968 (Pubitemid 40464301)
22. Lindberg K, Helguero LA, Omoto Y, Gustafsson JÅ, Haldosén LA (2011) Estrogen receptor β represses Akt signaling in breast cancer cells via downregulation of HER2/HER3 and upregulation of PTEN: implications for tamoxifen sensitivity. Breast Cancer Res 13:R43
23. Jin L, Ying Z, Webb RC (2004) Activation of Rho/Rho kinase signaling pathway by reactive oxygen species in rat aorta. Am J Physiol Heart Circ Physiol 287:H1495-H1500 (Pubitemid 39313251)
24. Stegemann H, Stalder K (1967) Determination of hydroxyproline. Clin Chim Acta 18:267-273
25. Kimura M, Irahara M, Yasui T, Saito S, Tezuka M, Yamano S, Kamada M, Aono T (2002) The obesity in bilateral ovariectomized rats is related to a decrease in the expression of leptin receptors in the brain. Biochem Biophys Res Commun 290:1349-1353 (Pubitemid 34694454)
26. Ropero AB, Eghbali M, Minosyan TY, Tang G, Toro L, Stefani E (2006) Heart estrogen receptor alpha: distinct membrane and nuclear distribution patterns and regulation by estrogen. J Mol Cell Cardiol 41:496-510 (Pubitemid 44344280)
27. Dominguez R, Micevych P (2010) Estradiol rapidly regulates membrane estrogen receptor α levels in hypothalamic neurons. J Neurosci 30:12589-12596
28. Mahmoodzadeh S, Dworatzek E, Fritschka S, Pham TH, Regitz-Zagrosek V (2010) 17beta-estradiol inhibits matrix metalloproteinase-2 transcription via MAP kinase in fibroblasts. Cardiovasc Res 85:719-728
29. Bjornstrom L, Sjoberg M (2005) Mechanisms of estrogen receptor signaling: convergence of genomic and nongenomic actions on target genes. Mol Endocrinol 19:833-842 (Pubitemid 40397050)
30. Grohé C, Kahlert S, Löbbert K, Meyer R, Linz KW, Karas RH, Vetter H (1996) Modulation of hypertensive heart disease by estrogen. Steroids 61:201-204 (Pubitemid 26144423)
31. Stossel TP, Fenteany G, Hartwig JH (2006) Cell surface actin remodeling. J Cell Sci 119:3261-3264 (Pubitemid 44405211)
32. Nobes CD, Hall A (1995) Rho, rac, and cdc42 GTPases regulate the assembly of mutlimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62
33. Kramar EA, Chen LY, Brandon NJ, Christopher SR, Liu F, Gall CM, Lynch G (2009) Cytoskeletal changes underlie estrogen's acute effects on synaptic transmission and plasticity. J Neurosci 29:12982-12993
34. van Nieuwenhoven FA, Turner NA (2013) The role of cardiac fibroblasts in the transition from inflammation to fibrosis following myocardial infarction. Vasc Pharmacol 58:182-188