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Volumn 44, Issue 1, 2014, Pages 102-113

Novel effect of ezetimibe to inhibit the development of non-alcoholic fatty liver disease in fatty liver shionogi mouse

Author keywords

Ezetimibe; Microsomal triglyceride transfer protein; Non alcoholic fatty liver disease; Reactive oxygen species

Indexed keywords

BETA ACTIN; CELL CYCLE PROTEIN 20; EZETIMIBE; LIPID; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; REACTIVE OXYGEN METABOLITE; S PHASE KINASE ASSOCIATED PROTEIN 2; STEROL REGULATORY ELEMENT BINDING PROTEIN 1; STEROL REGULATORY ELEMENT BINDING PROTEIN 1C; VERY LOW DENSITY LIPOPROTEIN;

EID: 84891820153     PISSN: 13866346     EISSN: 1872034X     Source Type: Journal    
DOI: 10.1111/hepr.12092     Document Type: Article
Times cited : (23)

References (30)
  • 1
    • 34548306754 scopus 로고    scopus 로고
    • Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future
    • Wieckowska A, McCullough AJ, Feldstein AE. Noninvasive diagnosis and monitoring of nonalcoholic steatohepatitis: present and future. Hepatology 2007; 46: 582-589.
    • (2007) Hepatology , vol.46 , pp. 582-589
    • Wieckowska, A.1    McCullough, A.J.2    Feldstein, A.E.3
  • 2
    • 18244364864 scopus 로고    scopus 로고
    • NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome
    • Chitturi S, Abeygunasekera S, Farrell GC etal. NASH and insulin resistance: insulin hypersecretion and specific association with the insulin resistance syndrome. Hepatology 2002; 35: 373-379.
    • (2002) Hepatology , vol.35 , pp. 373-379
    • Chitturi, S.1    Abeygunasekera, S.2    Farrell, G.C.3
  • 3
    • 0037129380 scopus 로고    scopus 로고
    • Nonalcoholic fatty liver disease
    • Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-1231.
    • (2002) N Engl J Med , vol.346 , pp. 1221-1231
    • Angulo, P.1
  • 4
    • 33644955272 scopus 로고    scopus 로고
    • Mouse models in non-alcoholic fatty liver disease and steatohepatitis research
    • Anstee QM, Goldin RD. Mouse models in non-alcoholic fatty liver disease and steatohepatitis research. Int J Exp Pathol 2006; 87: 1-16.
    • (2006) Int J Exp Pathol , vol.87 , pp. 1-16
    • Anstee, Q.M.1    Goldin, R.D.2
  • 5
    • 13044256397 scopus 로고    scopus 로고
    • The FLS mouse: a new inbred strain with spontaneous fatty liver
    • Soga M, Kishimoto Y, Kawaguchi J etal. The FLS mouse: a new inbred strain with spontaneous fatty liver. Lab Anim Sci 1999; 49: 269-275.
    • (1999) Lab Anim Sci , vol.49 , pp. 269-275
    • Soga, M.1    Kishimoto, Y.2    Kawaguchi, J.3
  • 6
    • 33646812161 scopus 로고    scopus 로고
    • Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver
    • Harano Y, Yasui K, Toyama T etal. Fenofibrate, a peroxisome proliferator-activated receptor alpha agonist, reduces hepatic steatosis and lipid peroxidation in fatty liver Shionogi mice with hereditary fatty liver. Liver Int 2006; 26: 613-620.
    • (2006) Liver Int , vol.26 , pp. 613-620
    • Harano, Y.1    Yasui, K.2    Toyama, T.3
  • 7
    • 66849084268 scopus 로고    scopus 로고
    • A novel mouse model for type 2 diabetes and non-alcoholic fatty liver disease: spontaneous amelioration of diabetes by augmented beta cell mass
    • Oze-Fukai A, Fujisawa T, Sugimoto K etal. A novel mouse model for type 2 diabetes and non-alcoholic fatty liver disease: spontaneous amelioration of diabetes by augmented beta cell mass. Endocr J 2009; 56: 227-234.
    • (2009) Endocr J , vol.56 , pp. 227-234
    • Oze-Fukai, A.1    Fujisawa, T.2    Sugimoto, K.3
  • 8
    • 77952425688 scopus 로고    scopus 로고
    • Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model
    • Shindo N, Fujisawa T, Sugimoto K etal. Involvement of microsomal triglyceride transfer protein in nonalcoholic steatohepatitis in novel spontaneous mouse model. J Hepatol 2010; 52: 903-912.
    • (2010) J Hepatol , vol.52 , pp. 903-912
    • Shindo, N.1    Fujisawa, T.2    Sugimoto, K.3
  • 9
    • 70349249503 scopus 로고    scopus 로고
    • Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis
    • Fujita K, Nozaki Y, Wada K etal. Dysfunctional very-low-density lipoprotein synthesis and release is a key factor in nonalcoholic steatohepatitis pathogenesis. Hepatology 2009; 50: 772-780.
    • (2009) Hepatology , vol.50 , pp. 772-780
    • Fujita, K.1    Nozaki, Y.2    Wada, K.3
  • 10
    • 34248657027 scopus 로고    scopus 로고
    • Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH?
    • Gambino R, Cassader M, Pagano G, Durazzo M, Musso G. Polymorphism in microsomal triglyceride transfer protein: a link between liver disease and atherogenic postprandial lipid profile in NASH? Hepatology 2007; 45: 1097-1107.
    • (2007) Hepatology , vol.45 , pp. 1097-1107
    • Gambino, R.1    Cassader, M.2    Pagano, G.3    Durazzo, M.4    Musso, G.5
  • 11
    • 79952788652 scopus 로고    scopus 로고
    • Novel findings for the development of drug therapy for various liver diseases: liver microsomal triglyceride transfer protein activator may be a possible therapeutic agent in non-alcoholic steatohepatitis
    • Fujita K, Imajo K, Shinohara Y etal. Novel findings for the development of drug therapy for various liver diseases: liver microsomal triglyceride transfer protein activator may be a possible therapeutic agent in non-alcoholic steatohepatitis. J Pharmacol Sci 2011; 115: 270-273.
    • (2011) J Pharmacol Sci , vol.115 , pp. 270-273
    • Fujita, K.1    Imajo, K.2    Shinohara, Y.3
  • 12
    • 10744221008 scopus 로고    scopus 로고
    • Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption
    • Altmann SW, Davis HR Jr, Zhu LJ etal. Niemann-Pick C1 Like 1 protein is critical for intestinal cholesterol absorption. Science 2004; 303: 1201-1204.
    • (2004) Science , vol.303 , pp. 1201-1204
    • Altmann, S.W.1    Davis Jr, H.R.2    Zhu, L.J.3
  • 13
    • 41149120450 scopus 로고    scopus 로고
    • Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice
    • Zheng S, Hoos L, Cook J etal. Ezetimibe improves high fat and cholesterol diet-induced non-alcoholic fatty liver disease in mice. Eur J Pharmacol 2008; 584: 118-124.
    • (2008) Eur J Pharmacol , vol.584 , pp. 118-124
    • Zheng, S.1    Hoos, L.2    Cook, J.3
  • 14
    • 82255185591 scopus 로고    scopus 로고
    • Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice
    • Matono T, Koda M, Tokunaga S etal. Therapeutic effects of ezetimibe for non-alcoholic steatohepatitis in fatty liver shionogi-ob/ob mice. Hepatol Res 2011; 41: 1240-1248.
    • (2011) Hepatol Res , vol.41 , pp. 1240-1248
    • Matono, T.1    Koda, M.2    Tokunaga, S.3
  • 15
    • 68049123104 scopus 로고    scopus 로고
    • Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease
    • Nozaki Y, Fujita K, Yoneda M etal. Long-term combination therapy of ezetimibe and acarbose for non-alcoholic fatty liver disease. J Hepatol 2009; 51: 548-556.
    • (2009) J Hepatol , vol.51 , pp. 548-556
    • Nozaki, Y.1    Fujita, K.2    Yoneda, M.3
  • 16
    • 79954415297 scopus 로고    scopus 로고
    • Induction of microsomal triglyceride transfer protein expression is a candidate mechanism by which ezetimibe therapy might exert beneficial effects in patients with nonalcoholic steatohepatitis
    • Yoneda M, Fujita K, Imajo K etal. Induction of microsomal triglyceride transfer protein expression is a candidate mechanism by which ezetimibe therapy might exert beneficial effects in patients with nonalcoholic steatohepatitis. J Gastroenterol 2011; 46: 415-416.
    • (2011) J Gastroenterol , vol.46 , pp. 415-416
    • Yoneda, M.1    Fujita, K.2    Imajo, K.3
  • 17
    • 20044374023 scopus 로고    scopus 로고
    • Design and validation of a histological scoring system for nonalcoholic fatty liver disease
    • Kleiner DE, Brunt EM, Van Natta M etal. Design and validation of a histological scoring system for nonalcoholic fatty liver disease. Hepatology 2005; 41: 1313-1321.
    • (2005) Hepatology , vol.41 , pp. 1313-1321
    • Kleiner, D.E.1    Brunt, E.M.2    Van Natta, M.3
  • 18
    • 23244441822 scopus 로고    scopus 로고
    • Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein
    • Rava P, Athar H, Johnson C, Hussain MM. Transfer of cholesteryl esters and phospholipids as well as net deposition by microsomal triglyceride transfer protein. J Lipid Res 2005; 46: 1779-1785.
    • (2005) J Lipid Res , vol.46 , pp. 1779-1785
    • Rava, P.1    Athar, H.2    Johnson, C.3    Hussain, M.M.4
  • 19
    • 34447136796 scopus 로고    scopus 로고
    • Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis
    • Pan X, Hussain FN, Iqbal J, Feuerman MH, Hussain MM. Inhibiting proteasomal degradation of microsomal triglyceride transfer protein prevents CCl4-induced steatosis. J Biol Chem 2007; 282: 17078-17089.
    • (2007) J Biol Chem , vol.282 , pp. 17078-17089
    • Pan, X.1    Hussain, F.N.2    Iqbal, J.3    Feuerman, M.H.4    Hussain, M.M.5
  • 20
    • 79955018542 scopus 로고    scopus 로고
    • Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet
    • Muraoka T, Aoki K, Iwasaki T etal. Ezetimibe decreases SREBP-1c expression in liver and reverses hepatic insulin resistance in mice fed a high-fat diet. Metab Clin Exp 2011; 60: 617-628.
    • (2011) Metab Clin Exp , vol.60 , pp. 617-628
    • Muraoka, T.1    Aoki, K.2    Iwasaki, T.3
  • 21
  • 22
    • 0033255912 scopus 로고    scopus 로고
    • [Sterol regulatory element binding protein that controls cholesterol metabolism]
    • Sato R. [Sterol regulatory element binding protein that controls cholesterol metabolism]. Nihon Rinsho 1999; 57: 2678-2683.
    • (1999) Nihon Rinsho , vol.57 , pp. 2678-2683
    • Sato, R.1
  • 23
    • 79953755370 scopus 로고    scopus 로고
    • AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice
    • Li Y, Xu S, Mihaylova MM etal. AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011; 13: 376-388.
    • (2011) Cell Metab , vol.13 , pp. 376-388
    • Li, Y.1    Xu, S.2    Mihaylova, M.M.3
  • 24
    • 21744457262 scopus 로고    scopus 로고
    • Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption
    • Repa JJ, Turley SD, Quan G, Dietschy JM. Delineation of molecular changes in intrahepatic cholesterol metabolism resulting from diminished cholesterol absorption. J Lipid Res 2005; 46: 779-789.
    • (2005) J Lipid Res , vol.46 , pp. 779-789
    • Repa, J.J.1    Turley, S.D.2    Quan, G.3    Dietschy, J.M.4
  • 25
    • 0242551536 scopus 로고    scopus 로고
    • Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover
    • Reed SI. Ratchets and clocks: the cell cycle, ubiquitylation and protein turnover. Nat Rev Mol Cell Biol 2003; 4: 855-864.
    • (2003) Nat Rev Mol Cell Biol , vol.4 , pp. 855-864
    • Reed, S.I.1
  • 26
    • 4444318673 scopus 로고    scopus 로고
    • The SCF ubiquitin ligase: insights into a molecular machine
    • Cardozo T, Pagano M. The SCF ubiquitin ligase: insights into a molecular machine. Nat Rev Mol Cell Biol 2004; 5: 739-751.
    • (2004) Nat Rev Mol Cell Biol , vol.5 , pp. 739-751
    • Cardozo, T.1    Pagano, M.2
  • 27
    • 33646345376 scopus 로고    scopus 로고
    • Ubiquitin ligases: cell-cycle control and cancer
    • Nakayama KI, Nakayama K. Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer 2006; 6: 369-381.
    • (2006) Nat Rev Cancer , vol.6 , pp. 369-381
    • Nakayama, K.I.1    Nakayama, K.2
  • 28
    • 1642562815 scopus 로고    scopus 로고
    • Melatonin prevents disruption of hepatic reactive oxygen species metabolism in rats treated with carbon tetrachloride
    • Ohta Y, Kongo-Nishimura M, Matsura T, Yamada K, Kitagawa A, Kishikawa T. Melatonin prevents disruption of hepatic reactive oxygen species metabolism in rats treated with carbon tetrachloride. J Pineal Res 2004; 36: 10-17.
    • (2004) J Pineal Res , vol.36 , pp. 10-17
    • Ohta, Y.1    Kongo-Nishimura, M.2    Matsura, T.3    Yamada, K.4    Kitagawa, A.5    Kishikawa, T.6
  • 29
    • 70350468701 scopus 로고    scopus 로고
    • Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance
    • Nomura M, Ishii H, Kawakami A, Yoshida M. Inhibition of hepatic Niemann-Pick C1-like 1 improves hepatic insulin resistance. Am J Physiol Endocrinol Metab 2009; 297: E1030-1038.
    • (2009) Am J Physiol Endocrinol Metab , vol.297
    • Nomura, M.1    Ishii, H.2    Kawakami, A.3    Yoshida, M.4
  • 30
    • 79958138508 scopus 로고    scopus 로고
    • Romo1 is a negative-feedback regulator of Myc
    • Lee SB, Kim JJ, Chung JS etal. Romo1 is a negative-feedback regulator of Myc. J Cell Sci 2011; 124: 1911-1924.
    • (2011) J Cell Sci , vol.124 , pp. 1911-1924
    • Lee, S.B.1    Kim, J.J.2    Chung, J.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.