Microsomal triglyceride transfer protein and nonalcoholic fatty liver disease

Expert Review of Gastroenterology and Hepatology

Volumn 5, Issue 2, 2011, Pages 245-251

  Pereira, Isabel V A ^a   Stefano, José T ^a   Oliveira, Clàudia P M S ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

microsomal triglyceride transfer protein; MTP; NASH; nonalcoholic fatty liver disease; steatosis

Indexed keywords

CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; FARNESOID X RECEPTOR; FATTY ACID SYNTHASE; GLUCOSE TRANSPORTER 1; INSULIN RECEPTOR SUBSTRATE 1; INSULIN RECEPTOR SUBSTRATE 2; LIVER X RECEPTOR; MICROSOMAL TRIGLYCERIDE TRANSFER PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN; STEROL REGULATORY ELEMENT BINDING PROTEIN 1;

AMINO TERMINAL SEQUENCE; BIOGENESIS; CELL DIFFERENTIATION; CELL PROLIFERATION; ENDOPLASMIC RETICULUM STRESS; ESTERIFICATION; FATTY ACID OXIDATION; FATTY ACID SYNTHESIS; GENE FREQUENCY; GENETIC ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; GLYCOGEN SYNTHESIS; HUMAN; INSULIN RESISTANCE; LIPID ABSORPTION; LIPID ANALYSIS; LIPID METABOLISM; LIPOGENESIS; LIVER BIOPSY; LIVER CELL; NONALCOHOLIC FATTY LIVER; NONHUMAN; PATHOGENESIS; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; PROTEIN SECRETION; REVIEW; SIGNAL TRANSDUCTION; UPREGULATION;

ANIMALS; APOLIPOPROTEIN B-100; CARRIER PROTEINS; FATTY ACIDS; FATTY LIVER; INSULIN; LIPID METABOLISM; LIPIDS; LIPOPROTEINS; LIVER; LIVER CIRRHOSIS; MALE; MICE; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION;

EID: 79954468466     PISSN: 17474124     EISSN: None     Source Type: Journal    
DOI: 10.1586/egh.11.22     Document Type: Review

References (40)

1. Adams L, Waters O, Knuiman M, Elliott R, Olynyk J. NAFLD as a risk factor for the development of diabetes and the metabolic syndrome: an eleven-year follow-up study. Am. J. Gastroenterol. 104(4), 861-867 (2009).
2. Bugianesi E. Non-alcoholic steatohepatitis and cancer. Clin. Liver Dis. 11(1), 191-207, x-xi (2007). (Pubitemid 46829971)
3. Begriche K, Igoudjil A, Pessayre D, Fromenty B. Mitochondrial dysfunction in NASH: causes, consequences and possible means to prevent it. Mitochondrion 6(1), 1-28 (2006).
4. Tessari P, Coracina A, Cosma A, Tiengo A. Hepatic lipid metabolism and non-alcoholic fatty liver disease. Nutr. Metab. Cardiovasc. Dis. 19(4), 291-302 (2009).
5. Larter CZ, Farrell GC. Insulin resistance, adiponectin, cytokines in NASH: which is the best target to treat? J. Hepatol. 44(2), 253-261 (2006). (Pubitemid 43071224)
6. Nagle CA, Klett EL, Coleman RA. Hepatic triacylglycerol accumulation and insulin resistance. J. Lipid Res. 50(Suppl.), S74-S79 (2009).
7. Capeau J. Insulin resistance and steatosis in humans. Diabetes Metab 34(6 Pt 2), 649-657 (2008).
8. Haeusler RA, Accili D. The double life of IRS. Cell Metab. 8(1), 7-9 (2008). (Pubitemid 351859234)
9. Kubota N, Kubota T, Itoh S et al. Dynamic functional relay between insulin receptor substrate 1 and 2 in hepatic insulin signaling during fasting and feeding. Cell Metab. 8(1), 49-64 (2008). (Pubitemid 351859226)
10. Chen G, Liang G, Ou J, Goldstein JL, Brown MS. Central role for liver X receptor in insulin-mediated activation of SREBP-1c transcription and stimulation of fatty acid synthesis in liver. Proc. Natl Acad. Sci. USA 101(31), 11245-11250 (2004). (Pubitemid 39038332)
11. Postic C, Girard J. The role of the lipogenic pathway in the development of hepatic steatosis. Diabetes Metab. 34(6 Pt 2), 643-648 (2008).
12. Toshimitsu K, Matsuura B, Ohkubo I et al. Dietary habits and nutrient intake in non-alcoholic steatohepatitis. Nutrition 23(1), 46-52 (2007). (Pubitemid 44959764)
13. Musso G, Gambino R, Cassader M. Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog. Lipid Res. 48(1), 1-26 (2009).
14. Wang L, Fast D, Attie A. The enzymatic and non-enzymatic roles of protein-disulfde isomerase in apolipoprotein B secretion. J. Biol. Chem. 272(44), 27644-27651 (1997). (Pubitemid 27473558)
15. Wetterau J, Aggerbeck L, Bouma M et al. Absence of microsomal triglyceride transfer protein in individuals with abet alipoproteinemia. Science 258(5084), 999-1001 (1992).
16. Hussain MM, Bakillah A, Jamil H. Apolipoprotein B binding to microsomal triglyceride transfer protein decreases with increases in length and lipidation: implications in lipoprotein biosynthesis. Biochemistry 36(42), 13060-13067 (1997). (Pubitemid 27465421)
17. Partin J, Partin J, Schubert W, McAdams A. Liver ultrastructure in abet alipoproteinemia: evolution of micronodular cirrhosis. Gastroenterology 67(1), 107-118 (1974).
18. Phillips C, Mullan K, Owens D, Tomkin G. Microsomal triglyceride transfer protein polymorphisms and lipoprotein levels in Type 2 diabetes. QJM 97(4), 211-218 (2004). (Pubitemid 38489161)
19. Mirandola S, Realdon S, Iqbal J et al. Liver microsomal triglyceride transfer protein is involved in hepatitis C liver steatosis. Gastroenterology 130(6), 1661-1669 (2006). (Pubitemid 43668848)
20. Hussain MM, Bakillah A, Nayak N, Shelness GS. Amino acids 430-570 in apolipoprotein B are critical for its binding to microsomal triglyceride transfer protein. J. Biol. Chem. 273(40), 25612-25615 (1998). (Pubitemid 28475781)
21. Hussain M, Bakillah A. New approaches to target microsomal triglyceride transfer protein. Curr. Opin. Lipidol. 19(6), 572-578 (2008).
22. Bennett AJ, Bruce JS, Salter AM, White DA, Billett MA. Hepatic microsomal triglyceride transfer protein messenger RNA concentrations are increased by dietary cholesterol in hamsters. FEBS Lett. 394(3), 247-250 (1996). (Pubitemid 26341452)
23. Sato R. [Sterol regulatory element binding protein that controls cholesterol metabolism]. Nippon Rinsho 57(12), 2678-2683 (1999).
24. Bennett AJ, Billett MA, Salter AM, White DA. Regulation of hamster hepatic microsomal triglyceride transfer protein mRNA levels by dietary fats. Biochem. Biophys. Res. Commun. 212(2), 473-478 (1995).
25. Gambino R, Bo S, Musso G et al. Microsomal triglyceride transfer protein 493-T variant is associated with resistin levels and C-reactive protein. Clin. Biochem. 40(16-17), 1219-1224 (2007). (Pubitemid 47562417)
26. Namikawa C, Shu-Ping Z, Vyselaar J et al. Polymorphisms of microsomal triglyceride transfer protein gene and manganese superoxide dismutase gene in non-alcoholic steatohepatitis. J. Hepatol. 40(5), 781-786 (2004). (Pubitemid 38507358)
27. Karpe F, Lundahl B, Ehrenborg E, Eriksson P, Hamsten A. A common functional polymorphism in the promoter region of the microsomal triglyceride transfer protein gene infuences plasma LDL levels. Arterioscler. Thromb. Vasc. Biol. 18(5), 756-761 (1998). (Pubitemid 28267655)
28. Bernard S, Touzet S, Personne I et al. Association between microsomal triglyceride transfer protein gene polymorphism and the biological features of liver steatosis in patients with Type II diabetes. Diabetologia 43(8), 995-999 (2000). (Pubitemid 30655718)
29. Oliveira CP, Stefano JT, Cavaleiro AM et al. Association of polymorphisms of glutamate-cystein ligase and microsomal triglyceride transfer protein genes in non-alcoholic fatty liver disease. J. Gastroenterol. Hepatol. 25(2), 357-361 (2010).
30. Zák A, Jáchymová M, Tvrzická E et al. The infuence of polymorphism of-493G/T MTP gene promoter and metabolic syndrome on lipids, fatty acids and oxidative stress. J. Nutr. Biochem. 19(9), 634-641 (2008).
31. Musso G, Gambino R, Cassader M. Lipoprotein metabolism mediates the association of MTP polymorphism with ß-cell dysfunction in healthy subjects and in nondiabetic normolipidemic patients with nonalcoholic steatohepatitis. J. Nutr. Biochem. 21(9), 834-840 (2010).
32. Perlemuter G, Sabile A, Letteron P et al. Hepatitis C virus core protein inhibits microsomal triglyceride transfer protein activity and very low density lipoprotein secretion: a model of viral-related steatosis. FASEB J. 16(2), 185-194 (2002). (Pubitemid 34113012)
33. Richardson M, Powell E, Barrie H, Clouston A, Purdie D, Jonsson J. A combination of genetic polymorphisms increases the risk of progressive disease in chronic hepatitis C J. Med. Genet. 42(7), e45 (2005).
34. Mirandola S, Osterreicher CH, Marcolongo M et al. Microsomal triglyceride transfer protein polymorphism (-493G/T) is associated with hepatic steatosis in patients with chronic hepatitis C. Liver Int. 29(4), 557-565 (2009).
35. Zampino R, Ingrosso D, Durante-Mangoni E et al. Microsomal triglyceride transfer protein (MTP)-493G/T gene polymorphism contributes to fat liver accumulation in HCV genotype 3 infected patients. J. Viral Hepat. 15(10), 740-746 (2008).
36. Petit J, Masson D, Minello A et al. Lack of association between microsomal triglyceride transfer protein gene polymorphism and liver steatosis in HCV-infected patients. Mol. Genet. Metab. 88(2), 196-198 (2006).
37. Siqueira ER, Oliveira CPMS, Stefano JT et al. Microsomal triglyceride protein (MTP)-493 G/T polymorphism is associated with fbrosis in chronic hepatitis C (CHC) genotype 1 infected patients. J. Hepatol. S418 (2010).
38. Cuchel M, Lund-Katz S, de la Llera-Moya M et al. Pathways by which reconstituted high-density lipoprotein mobilizes free cholesterol from whole body and from macrophages. Arterioscler. Thromb. Vasc. Biol. 30(3), 526-532 (2010).
39. Oliveira C, Alves V, Lima V et al. Modulation of hepatic microsomal triglyceride transfer protein (MTP) induced by S-nitroso-N-acetylcysteine in ob/ob mice. Biochem. Pharmacol. 74(2), 290-297 (2007). (Pubitemid 46890819)
40. Stefano JT, de Oliveira CP, Correa-Giannella ML et al. Nonalcoholic steatohepatitis (NASH) in ob/ob mice treated with yo jyo hen shi ko (YHK): effects on peroxisome proliferator-activated receptors (PPARs) and microsomal triglyceride transfer protein (MTP). Dig Dis. Sci. 52(12), 3448-3454 (2007). (Pubitemid 350077199)