Sodium orthovanadate (vanadate), a potent mitigator of radiation-induced damage to the hematopoietic system in mice

Journal of Radiation Research

Volumn 54, Issue 4, 2013, Pages 620-629

  Wang, Bing ^a   Tanaka, Kaoru ^a   Morita, Akinori ^b   Ninomiya, Yasuharu ^a   Maruyama, Kouichi ^a   Fujita, Kazuko ^c   Hosoi, Yoshio ^b   Nenoi, Mitsuru ^a  

^a NATIONAL INSTITUTE OF RADIOLOGICAL SCIENCES   (Japan)

^b HIROSHIMA UNIVERSITY   (Japan)

^c TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

Author keywords

Bone marrow micronucleated erythrocytes; Mice; Mitigator; Radiation induced hematopoietic syndrome; Vanadate

Indexed keywords

BONE; CELL DEATH; MAMMALS; RADIATION EFFECTS; SODIUM; TRANSCRIPTION; VANADIUM COMPOUNDS;

BONE MARROW; BONE MARROW MICRONUCLEATED ERYTHROCYTE; MITIGATOR; MOUSE; RADIATION-INDUCED; RADIATION-INDUCED HEMATOPOIETIC SYNDROME; SODIUM ORTHOVANADATE; SURVIVAL TESTS; TOTAL BODY IRRADIATION; VANADATE;

BLOOD;

PROTEIN P53; RADIOPROTECTIVE AGENT; VANADIC ACID;

ANIMAL; BONE MARROW; DRUG EFFECTS; ERYTHROCYTE; FEMALE; HEMATOPOIETIC STEM CELL; HEMATOPOIETIC SYSTEM; INSTITUTE FOR CANCER RESEARCH MOUSE; METABOLISM; MICRONUCLEUS TEST; MOUSE; RADIATION INJURIES; RADIATION RESPONSE; TIME FACTOR; WHOLE BODY RADIATION; X RAY; ARTICLE; BONE MARROW MICRONUCLEATED ERYTHROCYTES; DRUG EFFECT; MITIGATOR; RADIATION EXPOSURE; RADIATION INJURY; RADIATION-INDUCED HEMATOPOIETIC SYNDROME; TIME;

ANIMALS; BONE MARROW; ERYTHROCYTES; FEMALE; HEMATOPOIETIC STEM CELLS; HEMATOPOIETIC SYSTEM; MICE; MICE, INBRED ICR; MICRONUCLEUS TESTS; RADIATION INJURIES; RADIATION-PROTECTIVE AGENTS; TIME FACTORS; TUMOR SUPPRESSOR PROTEIN P53; VANADATES; WHOLE-BODY IRRADIATION; X-RAYS;

BONE MARROW MICRONUCLEATED ERYTHROCYTES; MICE; MITIGATOR; RADIATION-INDUCED HEMATOPOIETIC SYNDROME; VANADATE;

EID: 84891800167     PISSN: 04493060     EISSN: 13499157     Source Type: Journal    
DOI: 10.1093/jrr/rrs140     Document Type: Article

References (48)

1. Moulder JE. Report on an interagency workshop on the radiobiology of nuclear terrorism. Molecular and cellular biology dose (1-10 Sv) radiation and potential mechanisms of radiation protection (Bethesda, Maryland, December 17-18, 2001). Radiat Res 2002;158:118-24.
2. Mettler FA., Jr., Voelz GL. Major radiation exposure - what to expect and how to respond. N Engl J Med 2002;346:1554-61.
3. Coleman CN, Blakely WF, Fike JR et al. Molecular and cellular biology of moderate-dose (1-10 Gy) radiation and potential mechanisms of radiation protection: report of a workshop at Bethesda, Maryland, December 17-18, 2001. Radiat Res 2003;159:812-34.
4. Epelman S, Hamilton DR. Medical mitigation strategies for acute radiation exposure during spaceflight. Aviat Space Environ Med 2006;77:130-9.
5. Hosseinimehr SJ, Shafiee A, Mozdarani H et al. Radioprotective effects of 2-iminothiazolidine derivatives against lethal doses of gamma radiation in mice. J Radiat Res 2001;42:401-8.
6. Maisin JR. Bacq and Alexander Award lecture - chemical radioprotection: past, present, and future prospects. Int J Radiat Biol 1998;73:443-50.
7. Sowby D., Valentin J. Forty years on: how radiological protection has evolved internationally. J Radiol Prot 2003;23:157-71.
8. Hensley ML, Hagerty KL, Kewalramani T et al. American Society of Clinical Oncology 2008 clinical practice guideline update: use of chemotherapy and radiation therapy protectants. J Clin Oncol 2009;27:127-45.
9. Weiss JF, Srinivasan V, Kumar KS et al. Radioprotection by metals: selenium. Adv Space Res 1992;12:223-31.
10. Fedorocko P, Domonkosova A, Kundratova T et al. Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice: 1. Relationship to the number of myeloid progenitor cells. Physiol Res 1996;45:93-100.
11. Mackova NO, Lenikova S, Fedorocko P et al. Effects of cadmium on haemopoiesis in irradiated and non-irradiated mice: 2. Relationship to the number of circulating blood cells and haemopoiesis. Physiol Res 1996;45:101-6.
12. Sato K, Ichimasa M, Miyahara K et al. Radioprotective effects of sodium tungstate on hematopoietic injury by exposure to 60Co ?-rays in Wistar rats. J Radiat Res 1999;40:101-3.
13. Anzai K, Ikota N, Ueno M et al. Heat-treated mineral-yeast as a potent post-irradiation radioprotector. J Radiat Res 2008;49:425-30.
14. Johnson SM, Torrice CD, Bell JF et al. Mitigation of hematologic radiation toxicity in mice through pharmacological quiescence induced by CDK4/6 inhibition. J Clin Invest 2010;120:2528-36.
15. Kim K, William H. Modifying radiation damage. Curr Drug Targets 2010;11:1352-65.
16. Zhang L, Sun W, Wang J et al. Mitigation effect of an FGF-2 peptide on acute gastrointestinal syndrome after high-dose ionizing radiation. Int J Radiat Oncol Biol Phys 2010;77:261-8.
17. Li D, Wang Y, Wu H et al. Mitigation of ionizing radiation-induced bone marrow suppression by p38 inhibition and G-CSF administration. J Radiat Res 2011;52:712-16.
18. Crescenti EJ, Medina VA, Croci M et al. Radioprotection of sensitive rat tissues by oligoelements Se, Zn, Mn plus Lachesis muta venom. J Radiat Res 2011;52:557-67.
19. Satyamitra MM, Kulkarni S, Ghosh SP et al. Hematopoietic recovery and amelioration of radiation-induced lethality by the vitamin E isoform δ-tocotrienol. Radiat Res 2011;175: 736-45.
20. Satyamitra M, Lombardini E, Graves J, 3rd et al. A TPO receptor agonist, ALXN4100TPO, mitigates radiation-induced lethality and stimulates hematopoiesis in CD2F1 mice. Radiat Res 2011;175:746-58.
21. Fu Q, Berbée M, Wang W et al. Preclinical evaluation of SOM230 as a radiation mitigator in a mouse model: Postexposure time window and mechanisms of action. Radiat Res 2011;175:728-35.
22. Kim H, Bernard ME, Flickinger J et al. The autophagy-inducing drug carbamazepine is a radiation protector and mitigator. Int J Radiat Biol 2011;87:1052-60.
23. Basile LA, Ellefson D, Gluzman-Poltorak Z et al. HemaMax™, a recombinant human interleukin-12, is a potent mitigator of acute radiation injury in mice and non-human primates. PLoS ONE 2012;7:e30434.
24. Greenberger JS, Clump D, Kagan V et al. Strategies for discovery of small molecule radiation protectors and radiation mitigators. Front Oncol 2011;1:59.
25. Komarov PG, Komarova EA, Kondratov RV et al. A chemical inhibitor of p53 that protects mice from the side effects of cancer therapy. Science 1999;285:1733-7.
26. Komarova EA, Kondratov RV, Wang KH et al. Dual effect of p53 on radiation sensitivity in vivo: p53 promotes hematopoietic injury, but protects from gastro-intestinal syndrome in mice. Oncogene 2004;23:3265-71.
27. Strom E, Sathe S, Komarov PG et al. Small-molecule inhibitor of p53 binding to mitochondria protects mice from gamma radiation. Nat Chem Biol 2006;2:474-9.
28. Chernov MV., Stark GR. The p53 activation and apoptosis induced by DNA damage are reversibly inhibited by salicylate. Oncogene 1997;14:2503-10.
29. Meplan C, Mann K, Hainaut P. Cadmium induces conformational modifications of wild-type p53 and suppresses p53 response to DNA damage in cultured cells. J Biol Chem 1999;274:31663-70.
30. Sugioka R, Shimizu S, Funatsu T et al. BH4-domain peptide from Bcl-x(L) exerts anti-apoptotic activity in vivo. Oncogene 2003;22:8432-40.
31. Burdelya LG, Krivokrysenko VI, Tallant TC et al. An agonist of toll-like receptor 5 has radioprotective activity in mouse and primate models. Science 2008;320:226-30.
32. Berns A. Can less be more for p53? Nature 2006;443:153-4.
33. Christophorou MA, Ringhausen I, Finch A et al. The pathological response to DNA damage does not contribute to p53-mediated tumour suppression. Nature 2006;443: 214-17.
34. Efeyan A, Garcia-Cao I, Herranz D et al. Tumour biology: Policing of oncogene activity by p53. Nature 2006;443:159.
35. Fillat C, Rodriguez-Gil JE, Guinovart JJ. Molybdate and tungstate act like vanadate on glucose metabolism in isolated hepatocytes. Biochem J 1992;282:659-63.
36. Aiton JF., Cramb G. The effects of vanadate on rabbit ventricular muscle adenylate cyclase and sodium pump activities. Biochem Pharmacol 1985;34:1543-8.
37. Cortizo AM., Etcheverry SB. Vanadium derivatives act as growth factor - mimetic compounds upon differentiation and proliferation of osteoblast-like UMR106 cells. Mol Cell Biochem 1995;145:97-102.
38. Chakraborty A., Chatterjee M. Enhanced erythropoietin and suppression of gamma-glutamyl transpeptidase (GGT) activity in murine lymphoma following administration of vanadium. Neoplasma 1994;41:291-6.
39. Zaporowska H., Wasilewski W. Some selected peripheral blood and haemopoietic system indices in Wistar rats with chronic vanadium intoxication. Comp Biochem Physiol C 1989;93:175-80.
40. Morita A, Zhu J, Suzuki N et al. Sodium orthovanadate suppresses DNA damage-induced caspase activation and apoptosis by inactivating p53. Cell Death Differ 2006;13:499-511.
41. Morita A, Yamamoto S, Wang B et al. Sodium orthovanadate inhibits p53-mediated apoptosis. Cancer Res 2010;70:257-65.
42. Schmid M. The micronucleus test. Mutat Res 1975;31:9-153.
43. Wang B, Tanaka K, Ninomiya Y et al. X-ray-induced radioresistance against high-LET radiations from accelerated neon-ion beams in mice. In: Nenoi M (ed). Current Topics in Ionizing Radiation Research. Rijeka: Intech-Open Access Publisher, 2012, 199-214.
44. Wang B, Tanaka K, Ninomiya Y et al. Relieved residual damage in the hematopoietic system of mice rescued by radiation-induced adaptive response (Yonezawa Effect). J Radiat Res 2013;54:45-51.
45. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001;29:e45.
46. Takeda A, Yonezawa M, Katoh N. Restoration of radiation injury by Ginseng. I. Responses of X-irradiated mice to Ginseng extract. J Radiat Res 1981;22:323-35.
47. Weiss JF., Landauer MR. Protection against ionizing radiation by antioxidant nutrients and phytochemicals. Toxicol 2003; 189:1-20.
48. Sorenson JR., Cu Fe, Mn, and Zn chelates offer a medicinal chemistry approach to overcoming radiation injury. Curr Med Chem 2002;9:639-62.