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Volumn 111, Issue 1, 2014, Pages 46-54

Dietary N-acetylcysteine supplementation alleviates liver injury in lipopolysaccharide-challenged piglets

Author keywords

Lipopolysaccharide; Liver injury; N Acetylcysteine; Piglets

Indexed keywords

ACETYLCYSTEINE; ADENOSINE PHOSPHATE; ADENOSINE TRIPHOSPHATE; ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; GLUTATHIONE PEROXIDASE; HEAT SHOCK PROTEIN 70; HYDROGEN PEROXIDE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INTERLEUKIN 6; LIPOPOLYSACCHARIDE; PROSTAGLANDIN E2; SODIUM CHLORIDE; SUPEROXIDE DISMUTASE; TUMOR NECROSIS FACTOR ALPHA; ADENOSINE DIPHOSPHATE;

EID: 84891789938     PISSN: 00071145     EISSN: 14752662     Source Type: Journal    
DOI: 10.1017/S0007114513002171     Document Type: Article
Times cited : (61)

References (47)
  • 1
    • 0028329503 scopus 로고
    • The fate of intravenously injected endotoxin in normal rats and in rats with liver failure
    • Nakao A, Taki S, Yasui M, et al. (1994) The fate of intravenously injected endotoxin in normal rats and in rats with liver failure. Hepatology 19, 1251-1256.
    • (1994) Hepatology , vol.19 , pp. 1251-1256
    • Nakao, A.1    Taki, S.2    Yasui, M.3
  • 2
    • 0035013950 scopus 로고    scopus 로고
    • Green tea suppresses lipopolysaccharide-induced liver injury in D-galactosamine sensitized rats
    • He P, Noda Y & Sugiyama K (2001) Green tea suppresses lipopolysaccharide-induced liver injury in D-galactosamine sensitized rats. J Nutr 131, 1560-1567.
    • (2001) J Nutr , vol.131 , pp. 1560-1567
    • He, P.1    Noda, Y.2    Sugiyama, K.3
  • 3
    • 0036074141 scopus 로고    scopus 로고
    • Lipopolysaccharides in liver injury: Molecular mechanisms of Kupffer cell activation
    • Su GL (2002) Lipopolysaccharides in liver injury: molecular mechanisms of Kupffer cell activation. Am J Physiol Gastro-intest Liver Physiol 283, G256-G265.
    • (2002) Am J Physiol Gastro-intest Liver Physiol , vol.283
    • Su, G.L.1
  • 4
    • 3042699353 scopus 로고    scopus 로고
    • Adiponectin protects LPS-Induced liver injury through modulation of TNF-a in KK-Ay obese mice
    • Masaki T, Chiba S, Tatsukawa H, et al. (2004) Adiponectin protects LPS-Induced liver injury through modulation of TNF-a in KK-Ay obese mice. Hepatology 40, 177-184.
    • (2004) Hepatology , vol.40 , pp. 177-184
    • Masaki, T.1    Chiba, S.2    Tatsukawa, H.3
  • 5
    • 0024362042 scopus 로고
    • Expression of tumor necrosis factor-a and transforming growth factor-b1 in acute liver injury
    • Czaja MJ, Flanders KC, Biempica L, et al. (1989) Expression of tumor necrosis factor-a and transforming growth factor-b1 in acute liver injury. Growth Factors 1, 219-226.
    • (1989) Growth Factors , vol.1 , pp. 219-226
    • Czaja, M.J.1    Flanders, K.C.2    Biempica, L.3
  • 6
    • 0029121402 scopus 로고
    • Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease
    • Kamimura S & Tsukamoto H (1995) Cytokine gene expression by Kupffer cells in experimental alcoholic liver disease. Hepatology 22, 1304-1309.
    • (1995) Hepatology , vol.22 , pp. 1304-1309
    • Kamimura, S.1    Tsukamoto, H.2
  • 7
    • 0031909523 scopus 로고    scopus 로고
    • Modulation of lipopolysaccharide-mediated activation in rat Kupffer cells by antioxidants
    • Bellezzo JM, Leingang KA, Bulla GA, et al. (1998) Modulation of lipopolysaccharide-mediated activation in rat Kupffer cells by antioxidants. J Lab Clin Med 121, 36-74.
    • (1998) J Lab Clin Med , vol.121 , pp. 36-74
    • Bellezzo, J.M.1    Leingang, K.A.2    Bulla, G.A.3
  • 8
    • 0024413403 scopus 로고
    • Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor
    • Chaudhri G & Clark IA (1989) Reactive oxygen species facilitate the in vitro and in vivo lipopolysaccharide-induced release of tumor necrosis factor. J Immunol 143, 1290-1294.
    • (1989) J Immunol , vol.143 , pp. 1290-1294
    • Chaudhri, G.1    Clark, I.A.2
  • 9
    • 1542376929 scopus 로고    scopus 로고
    • Glutathione metabolism and its implications for health
    • Wu G, Fang YZ, Yang S, et al. (2004) Glutathione metabolism and its implications for health. J Nutr 134, 489-492.
    • (2004) J Nutr , vol.134 , pp. 489-492
    • Wu, G.1    Fang, Y.Z.2    Yang, S.3
  • 10
    • 63649111659 scopus 로고    scopus 로고
    • Amino acids: Metabolism, functions, and nutrition
    • Wu G (2009) Amino acids: metabolism, functions, and nutrition. Amino Acids 37, 1-17.
    • (2009) Amino Acids , vol.37 , pp. 1-17
    • Wu, G.1
  • 11
    • 0942287101 scopus 로고    scopus 로고
    • N-Acetylcysteine in the prevention of radiocontrast-induced nephropathy
    • Fishbane S, Durham JH, Marzo K, et al. (2004) N-Acetylcysteine in the prevention of radiocontrast-induced nephropathy. J Am Soc Nephrol 15, 251-260.
    • (2004) J Am Soc Nephrol , vol.15 , pp. 251-260
    • Fishbane, S.1    Durham, J.H.2    Marzo, K.3
  • 12
    • 0010471495 scopus 로고
    • Cellular defenses against damage from reactive oxygen species
    • Yu BP (1994) Cellular defenses against damage from reactive oxygen species. Physiol Rev 74, 139-162.
    • (1994) Physiol Rev , vol.74 , pp. 139-162
    • Yu, B.P.1
  • 13
    • 84867086460 scopus 로고    scopus 로고
    • Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide
    • Hou YQ, Wang L, Zhang W, et al. (2012) Protective effects of N-acetylcysteine on intestinal functions of piglets challenged with lipopolysaccharide. Amino Acids 43, 1233-1242.
    • (2012) Amino Acids , vol.43 , pp. 1233-1242
    • Hou, Y.Q.1    Wang, L.2    Zhang, W.3
  • 14
    • 84880919496 scopus 로고    scopus 로고
    • N-Acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling
    • (epublication ahead of print version 25 April 2012)
    • Hou YQ, Wang L, Yi D, et al. (2012) N-Acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling. Amino Acids (epublication ahead of print version 25 April 2012).
    • (2012) Amino Acids
    • Hou, Y.Q.1    Wang, L.2    Yi, D.3
  • 15
    • 80655135451 scopus 로고    scopus 로고
    • Dietary a-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets
    • Hou YQ, Wang L, Ding BY, et al. (2010) Dietary a-ketoglutarate supplementation ameliorates intestinal injury in lipopolysaccharide-challenged piglets. Amino Acids 39, 555-564.
    • (2010) Amino Acids , vol.39 , pp. 555-564
    • Hou, Y.Q.1    Wang, L.2    Ding, B.Y.3
  • 16
    • 80052878653 scopus 로고    scopus 로고
    • Effects of a-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysac-charide
    • Hou YQ, Yao K, Wang L, et al. (2011) Effects of a-ketoglutarate on energy status in the intestinal mucosa of weaned piglets chronically challenged with lipopolysac-charide. Br J Nutr 106, 357-363.
    • (2011) Br J Nutr , vol.106 , pp. 357-363
    • Hou, Y.Q.1    Yao, K.2    Wang, L.3
  • 17
    • 79955003044 scopus 로고    scopus 로고
    • Alpha-ketoglutarate and intestinal function
    • Hou YQ, Wang L, Ding BY, et al. (2011) Alpha-ketoglutarate and intestinal function. Front Biosci 16, 1186-1196.
    • (2011) Front Biosci , vol.16 , pp. 1186-1196
    • Hou, Y.Q.1    Wang, L.2    Ding, B.Y.3
  • 19
    • 79954439116 scopus 로고    scopus 로고
    • Composition of amino acids in feed ingredients for animal diets
    • Li X, Rezaei R, Li P, et al. (2011) Composition of amino acids in feed ingredients for animal diets. Amino Acids 40, 1159-1168.
    • (2011) Amino Acids , vol.40 , pp. 1159-1168
    • Li, X.1    Rezaei, R.2    Li, P.3
  • 20
    • 67349130218 scopus 로고    scopus 로고
    • L-Glutamine or L-alanyl-L-glutamine prevents oxidant-or endotoxin-induced death of neonatal enterocytes
    • Haynes TE, Li P, Li X, et al. (2009) L-Glutamine or L-alanyl-L-glutamine prevents oxidant-or endotoxin-induced death of neonatal enterocytes. Amino Acids 37, 131-142.
    • (2009) Amino Acids , vol.37 , pp. 131-142
    • Haynes, T.E.1    Li, P.2    Li, X.3
  • 21
    • 37849005621 scopus 로고    scopus 로고
    • Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipo-polysaccharide endotoxaemia in a rat
    • Kessel A, Toube E, Pavlotzky E, et al. (2007) Treatment with glutamine is associated with down-regulation of Toll-like receptor-4 and myeloid differentiation factor 88 expression and decrease in intestinal mucosal injury caused by lipo-polysaccharide endotoxaemia in a rat. Clin Exp Immunol 151, 341-347.
    • (2007) Clin Exp Immunol , vol.151 , pp. 341-347
    • Kessel, A.1    Toube, E.2    Pavlotzky, E.3
  • 22
    • 36148989916 scopus 로고    scopus 로고
    • Oral glutamine prevents gut mucosal injury and improves mucosal recovery following lipopolysaccharide endotoxemia in a rat
    • Sukhotnik I, Agam M, Shamir R, et al. (2007) Oral glutamine prevents gut mucosal injury and improves mucosal recovery following lipopolysaccharide endotoxemia in a rat. J Surg Res 143, 379-384.
    • (2007) J Surg Res , vol.143 , pp. 379-384
    • Sukhotnik, I.1    Agam, M.2    Shamir, R.3
  • 23
    • 13444279864 scopus 로고    scopus 로고
    • The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury
    • Uehara K, Takahashi T, Fujii H, et al. (2005) The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury. Crit Care Med 33, 381-390.
    • (2005) Crit Care Med , vol.33 , pp. 381-390
    • Uehara, K.1    Takahashi, T.2    Fujii, H.3
  • 24
    • 84867572064 scopus 로고    scopus 로고
    • Decreased glu-tamate glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: A primary intestinal defect?
    • Boutry C, Matsumoto H, Bos C, et al. (2012) Decreased glu-tamate, glutamine and citrulline concentrations in plasma and muscle in endotoxemia cannot be reversed by glutamate or glutamine supplementation: a primary intestinal defect? Amino Acids 43, 1485-1498.
    • (2012) Amino Acids , vol.43 , pp. 1485-1498
    • Boutry, C.1    Matsumoto, H.2    Bos, C.3
  • 25
    • 84866009942 scopus 로고    scopus 로고
    • Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs
    • Li Q, Liu Y, Che Z, et al. (2012) Dietary L-arginine supplementation alleviates liver injury caused by Escherichia coli LPS in weaned pigs. Innate Immun 18, 804-814.
    • (2012) Innate Immun , vol.18 , pp. 804-814
    • Li, Q.1    Liu, Y.2    Che, Z.3
  • 26
    • 84862789866 scopus 로고    scopus 로고
    • A diet rich in n-3 poly-unsaturated fatty acids reduced prostaglandin biosynthesis ovulation rate, and litter size in mice
    • Yi D, Zeng SM & Guo YM (2012) A diet rich in n-3 poly-unsaturated fatty acids reduced prostaglandin biosynthesis, ovulation rate, and litter size in mice. Theriogenology 78, 28-38.
    • (2012) Theriogenology , vol.78 , pp. 28-38
    • Yi, D.1    Zeng, S.M.2    Guo, Y.M.3
  • 27
    • 84891803272 scopus 로고    scopus 로고
    • Decreased sperm quality in mice fed a diet with fish oil
    • Yi D, Zeng SM & Guo YM (2011) Decreased sperm quality in mice fed a diet with fish oil. J Anim Sci Biotechnol 2, 165-173.
    • (2011) J Anim Sci Biotechnol , vol.2 , pp. 165-173
    • Yi, D.1    Zeng, S.M.2    Guo, Y.M.3
  • 28
    • 0014353859 scopus 로고
    • The energy charge of the adenylate pool as a regulatory parameter, Interaction with feedback modifiers
    • Atkinson DE (1968) The energy charge of the adenylate pool as a regulatory parameter. Interaction with feedback modifiers. Biochemistry 7, 4030-4034.
    • (1968) Biochemistry , vol.7 , pp. 4030-4034
    • De, A.1
  • 29
    • 84862758196 scopus 로고    scopus 로고
    • Comparisons of treatment means when factors do not interact in two-factorial studies
    • Wei JW, Carroll RJ, Harden KK, et al. (2012) Comparisons of treatment means when factors do not interact in two-factorial studies. Amino Acids 42, 2031-2035.
    • (2012) Amino Acids , vol.42 , pp. 2031-2035
    • Wei, J.W.1    Carroll, R.J.2    Harden, K.K.3
  • 30
    • 77953807632 scopus 로고    scopus 로고
    • Statistics and bioinformatics in nutritional sciences: Analysis of complex data in the era of systems biology
    • Fu WJ, Stromberg AJ, Viele K, et al. (2010) Statistics and bioinformatics in nutritional sciences: analysis of complex data in the era of systems biology. J Nutr Biochem 21, 561-572.
    • (2010) J Nutr Biochem , vol.21 , pp. 561-572
    • Fu, W.J.1    Stromberg, A.J.2    Viele, K.3
  • 31
    • 0034905322 scopus 로고    scopus 로고
    • Inflammatory responses to lipopolysaccharide are suppressed in 40% energy-restricted mice
    • Matsuzaki J, Kuwamura M, Yamaji R, et al. (2001) Inflammatory responses to lipopolysaccharide are suppressed in 40% energy-restricted mice. J Nutr 131, 2139-2144.
    • (2001) J Nutr , vol.131 , pp. 2139-2144
    • Matsuzaki, J.1    Kuwamura, M.2    Yamaji, R.3
  • 32
    • 0028014478 scopus 로고
    • Endotoxin-induced cytokine gene expression and excretion in the liver
    • Luster MI, Germolec DR, Yoshida T, et al. (1994) Endotoxin-induced cytokine gene expression and excretion in the liver. Hepatology 19, 480-488.
    • (1994) Hepatology , vol.19 , pp. 480-488
    • Luster, M.I.1    Germolec, D.R.2    Yoshida, T.3
  • 33
    • 0027243948 scopus 로고
    • Cytokines and alcoholic liver disease
    • McClain C, Hill D, Schmidt J, et al. (1993) Cytokines and alcoholic liver disease. Semin Liver Dis 13, 170-182.
    • (1993) Semin Liver Dis , vol.13 , pp. 170-182
    • McClain, C.1    Hill, D.2    Schmidt, J.3
  • 34
  • 35
    • 0028972845 scopus 로고
    • Mechanistic aspects of NF-kB regulation: The emerging role of phosphorylation and proteolysis
    • Finco TS & Baldwin AS (1995) Mechanistic aspects of NF-kB regulation: the emerging role of phosphorylation and proteolysis. Immunity 3, 263-272.
    • (1995) Immunity , vol.3 , pp. 263-272
    • Finco, T.S.1    Baldwin, A.S.2
  • 36
    • 0033860297 scopus 로고    scopus 로고
    • Reactive oxygen and mechanisms of inflammatory liver injury
    • Jaeschke H (2000) Reactive oxygen and mechanisms of inflammatory liver injury. J Gastroenterol Hepatol 15, 718-724.
    • (2000) J Gastroenterol Hepatol , vol.15 , pp. 718-724
    • Jaeschke, H.1
  • 37
    • 0037278466 scopus 로고    scopus 로고
    • Molecular mechanisms of N-acetylcysteine actions
    • Zafarullah M, Li WQ, Sylvester J, et al. (2003) Molecular mechanisms of N-acetylcysteine actions. Cell Mol Life Sci 60, 6-20.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 6-20
    • Zafarullah, M.1    Li, W.Q.2    Sylvester, J.3
  • 38
    • 1242316241 scopus 로고    scopus 로고
    • Parenteral sesame oil attenuates oxidative stress after endotoxin intoxication in rats
    • Hsu DZ, Chiang PJ, Chien SP, et al. (2004) Parenteral sesame oil attenuates oxidative stress after endotoxin intoxication in rats. Toxicology 196, 147-153.
    • (2004) Toxicology , vol.196 , pp. 147-153
    • Hsu, D.Z.1    Chiang, P.J.2    Chien, S.P.3
  • 39
    • 0033208673 scopus 로고    scopus 로고
    • Lipopolysac-charide-induced oxidative stress in the liver: Comparison between rat and rabbit
    • Ben-Shaul V, Sofer Y & Bergman M (1999) Lipopolysac-charide-induced oxidative stress in the liver: comparison between rat and rabbit. Shock 12, 288-293.
    • (1999) Shock , vol.12 , pp. 288-293
    • Ben-Shaul, V.1    Sofer, Y.2    Bergman, M.3
  • 40
    • 14244262140 scopus 로고    scopus 로고
    • Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galacto-samine sensitised rats
    • Ravikumar V, Shivashangari KS & Devaki T (2005) Effect of Tridax procumbens on liver antioxidant defense system during lipopolysaccharide-induced hepatitis in D-galacto-samine sensitised rats. Mol Cell Biochem 269, 131-136.
    • (2005) Mol Cell Biochem , vol.269 , pp. 131-136
    • Ravikumar, V.1    Shivashangari, K.S.2    Devaki, T.3
  • 41
    • 0025303147 scopus 로고
    • Interaction of Hsp 70 with newly synthesized proteins: Implications for protein folding and assembly
    • Beckmann RP, Mizzen LE & Welch WJ (1990) Interaction of Hsp 70 with newly synthesized proteins: implications for protein folding and assembly. Science 248, 850-854.
    • (1990) Science , vol.248 , pp. 850-854
    • Beckmann, R.P.1    Mizzen, L.E.2    Welch, W.J.3
  • 42
    • 0036084783 scopus 로고    scopus 로고
    • Heat shock proteins: Modifying factors in physiological stress responses and acquired thermo-tolerance
    • Kregel KC (2002) Heat shock proteins: modifying factors in physiological stress responses and acquired thermo-tolerance. J Appl Physiol 92, 2177-2186.
    • (2002) J Appl Physiol , vol.92 , pp. 2177-2186
    • Kregel, K.C.1
  • 43
    • 33645945605 scopus 로고    scopus 로고
    • The inducible form of heat shock protein 70 in the serum, colon and small intestine of the pig: Comparison to conventional stress markers
    • Sepponen K & Poso AR (2006) The inducible form of heat shock protein 70 in the serum, colon and small intestine of the pig: comparison to conventional stress markers. Vet J 171, 519-524.
    • (2006) Vet J , vol.171 , pp. 519-524
    • Sepponen, K.1    Poso, A.R.2
  • 44
    • 0019870943 scopus 로고
    • Role of gastric mucosal energy metabolism in the etiology of stress ulceration
    • Menguy R (1981) Role of gastric mucosal energy metabolism in the etiology of stress ulceration. World J Surg 5, 175-180.
    • (1981) World J Surg , vol.5 , pp. 175-180
    • Menguy, R.1
  • 45
    • 0023180925 scopus 로고
    • The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants
    • Sugino K, Dohi K, Yamada K, et al. (1987) The role of lipid peroxidation in endotoxin-induced hepatic damage and the protective effect of antioxidants. Surgery 101, 746-752.
    • (1987) Surgery , vol.101 , pp. 746-752
    • Sugino, K.1    Dohi, K.2    Yamada, K.3
  • 46
    • 0024542475 scopus 로고
    • Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor
    • Lancaster JR Jr, Laster SM & Gooding LR (1989) Inhibition of target cell mitochondrial electron transfer by tumor necrosis factor. FEBS Lett 248, 169-174.
    • (1989) FEBS Lett , vol.248 , pp. 169-174
    • Lancaster Jr., J.R.1    Laster, S.M.2    Gooding, L.R.3
  • 47
    • 0024996681 scopus 로고
    • The oxidative inactivation of mitochondrial electron transport chain components and ATPase
    • Zhang Y, Marcillat O, Giulivi C, et al. (1990) The oxidative inactivation of mitochondrial electron transport chain components and ATPase. J Biol Chem 265, 16330-16336.
    • (1990) J Biol Chem , vol.265 , pp. 16330-16336
    • Zhang, Y.1    Marcillat, O.2    Giulivi, C.3


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