Oral Glutamine Prevents Gut Mucosal Injury and Improves Mucosal Recovery Following Lipopolysaccharide Endotoxemia in a Rat

Journal of Surgical Research

Volumn 143, Issue 2, 2007, Pages 379-384

  Sukhotnik, Igor ^a   Agam, Modi ^a   Shamir, Raanan ^b   Shehadeh, Naim ^b   Lurie, Michael ^a   Coran, Arnold G ^c   Shiloni, Eitan ^a   Mogilner, Jorge ^a  

^a TECHNION ISRAEL INSTITUTE OF TECHNOLOGY   (Israel)

^b MEYER CHILDREN S HOSPITAL   (Israel)

^c UNIVERSITY OF MICHIGAN   (United States)

Author keywords

enterocyte apoptosis; enterocyte proliferation; glutamine; intestine; lipopolysaccharide; sepsis

Indexed keywords

DNA; GLUTAMINE; LIPOPOLYSACCHARIDE; PROTEIN;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CELL PROLIFERATION; CONTROLLED STUDY; ENDOTOXEMIA; ILEUM; INTESTINE CELL; INTESTINE INJURY; INTESTINE MUCOSA; INTESTINE VILLUS; JEJUNUM; MALE; NONHUMAN; ORGAN WEIGHT; PRIORITY JOURNAL; RAT;

ADMINISTRATION, ORAL; ANIMALS; APOPTOSIS; BODY WEIGHT; CELL DIVISION; EATING; ENDOTOXEMIA; ENTEROCYTES; GLUTAMINE; INTESTINAL MUCOSA; LIPOPOLYSACCHARIDES; MALE; RATS; RATS, SPRAGUE-DAWLEY; SEPSIS;

EID: 36148989916     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2007.02.002     Document Type: Article

References (22)

1. O'Flaherty L., and Bouchier-Hayes D.J. Immunonutrition and surgical practice. Proc Nutr Soc 58 (1999) 831
2. Beale R.J., Bryg D.J., and Bihari D.J. Immunonutrition in the critically ill: A systematic review of clinical outcome. Crit Care Med 27 (1999) 2799
3. Koretz R.L. Immunonutrition: Can you be what you eat?. Curr Opin Gastroenterol 19 (2003) 134
4. O'Flaherty L., and Bouchier-Hayes D.J. Immunonutrition and surgical practice. Proc Nutr Soc 58 (1999) 831
5. Calder P.C. Immunonutrition. BMJ 327 (2003) 117
6. Deitch E.A. The role of intestinal barrier failure and bacterial translocation in the development of systemic infection and multiple organ failure. Arch Surg 125 (1991) 403
7. Pugin J., and Chevrolet J.C. The intestine-liver-lung axis in septic syndrome. Schweiz Med Wochenschr 121 (1991) 1538
8. Swank G.M., and Deitch E.A. Role of the gut in multiple organ failure: Bacterial translocation and permeability changes. World J Surg 20 (1996) 411
9. Barber A.E., Jones II W.G., Minei J.P., et al. Bacterial overgrowth and intestinal atrophy in the etiology of gut barrier failure in the rat. Am J Surg 161 (1991) 300
10. Chomczynski P. A reagent for the single-step simultaneous isolation of RNA, DNA, and proteins from cell and tissue samples. BioTechniques 15 (1993) 532
11. Park P.O., Haglund U., Bulkley G.B., et al. The sequence of development of intestinal tissue injury after strangulation ischemia and reperfusion. Surgery 107 (1990) 574
12. Sukhotnik I., Mogilner J., Krausz M.M., et al. Oral arginine reduces gut mucosal injury caused by lipopolysaccharide endotoxemia in a rat. J Surg Res 122 (2004) 256
13. Darmaun D., Matthews D.E., and Bier D.M. Glutamine and glutamate kinetic in humans. Am J Physiol 251 (1986) E117
14. Windmuelle H.G., and Spaeth A.E. Uptake and metabolism of plasma glutamine by the small intestine. J Biol Chem 249 (1974) 5070
15. Chapman M.A., Grahn M.F., Giamundo P., et al. New technique to measure mucosal metabolism and its use to map substrate utilization in the healthy human large bowel. Br J Surg 80 (1993) 445
16. Margaritis V.G., Filos K.S., Michalaki M.A., et al. Effect of oral glutamine administration on bacterial translocation, endotoxemia, liver and ileal morphology, and apoptosis in rats with obstructive jaundice. World J Surg 29 (2005) 1329
17. Yao G.X., Xue X.B., Jiang Z.M., et al. Effects of perioperative parenteral glutamine-dipeptide supplementation on plasma endotoxin level, plasma endotoxin inactivation capacity, and clinical outcome. Clin Nutr 24 (2005) 510
18. Uehara K., Takahashi T., Fujii H., et al. The lower intestinal tract-specific induction of heme oxygenase-1 by glutamine protects against endotoxemic intestinal injury. Crit Care Med 33 (2005) 381
19. Wildhaber B.E., Yang H., Spencer A.U., et al. Lack of enteral nutrition-effects on the intestinal immune mucosal system. J Surg Res 123 (2005) 8
20. Sukhotnik I, Khateeb K, Mogilner JG, et al. Dietary glutamine supplementation prevents mucosal injury and modulates intestinal epithelial restitution following ischemia-reperfusion injury in the rat. Dig Dis Sci, in press.
21. Liboni K.C., Li N., Scumpia P.O., et al. Glutamine modulates LPS-induced IL-8 production through IκB/NF-κB in human fetal and adult intestinal epithelium. J Nutr 135 (2005) 245
22. Prabhu R., Thomas S., and Balasubramanian K.A. Oral glutamine attenuates surgical manipulation-induced alterations in the intestinal brush border membrane. J Surg Res 115 (2003) 148