메뉴 건너뛰기




Volumn 1102, Issue , 2014, Pages 137-162

Selecting patients for KIT inhibition in melanoma

Author keywords

Acral; Imatinib; KIT; Melanoma; Mucosal

Indexed keywords

DASATINIB; IMATINIB; KIT PROTEIN; NILOTINIB; PROTEIN; SORAFENIB; SUNITINIB; UNCLASSIFIED DRUG;

EID: 84891788190     PISSN: 10643745     EISSN: None     Source Type: Book Series    
DOI: 10.1007/978-1-62703-727-3_9     Document Type: Article
Times cited : (4)

References (82)
  • 1
    • 0032858487 scopus 로고    scopus 로고
    • Phase iii multicenter randomized trial of the dartmouth regimen versus dacarbazine in patients with metastatic melanoma
    • Chapman PB, Einhorn LH, Meyers ML, Saxman S, Destro AN, Panageas KS et al (1999) Phase III multicenter randomized trial of the Dartmouth regimen versus dacarbazine in patients with metastatic melanoma. J Clin Oncol 17(9):2745-2751
    • (1999) J Clin Oncol , vol.17 , Issue.9 , pp. 2745-2751
    • Chapman, P.B.1    Einhorn, L.H.2    Meyers, M.L.3    Saxman, S.4    Destro, A.N.5    Panageas, K.S.6
  • 2
    • 0033024863 scopus 로고    scopus 로고
    • High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993
    • Atkins MB, Lotze MT, Dutcher JP, Fisher RI, Weiss G, Margolin K et al (1999) High-dose recombinant interleukin 2 therapy for patients with metastatic melanoma: Analysis of 270 patients treated between 1985 and 1993. J Clin Oncol 17(7):2105-2116
    • (1999) J Clin Oncol , vol.17 , Issue.7 , pp. 2105-2116
    • Atkins, M.B.1    Lotze, M.T.2    Dutcher, J.P.3    Fisher, R.I.4    Weiss, G.5    Margolin, K.6
  • 5
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, Millward M et al (2012) Dabrafenib in BRAF-mutated metastatic melanoma: A multicentre, open-label, phase 3 randomised controlled trial. Lancet 380(9839): 358-365
    • (2012) Lancet , vol.380 , Issue.9839 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5    Millward, M.6
  • 6
    • 84865092227 scopus 로고    scopus 로고
    • Metric phase iii study: Efficacy of trametinib (t), a potent and selective mek inhibitor (meki), in progression-free survival (pfs) and overall survival (os), compared with chemotherapy C) in patients (pts) with BRAFV600E/K mutant advanced or metastatic melanoma MM
    • suppl):(abstr LBA8509
    • Robert C, Flaherty K, Hersey P, Nathan P, CGarbe C, Milhem M, et al (2012) METRIC phase III study: Efficacy of trametinib (T), a potent and selective MEK inhibitor (MEKi), in progression-free survival (PFS) and overall survival (OS), compared with chemotherapy (C) in patients (pts) with BRAFV600E/K mutant advanced or metastatic melanoma (MM). J Clin Oncol 30(suppl):(abstr LBA8509
    • (2012) J Clin Oncol , vol.30
    • Robert, C.1    Flaherty, K.2    Hersey, P.3    Nathan, P.4    Cgarbe, C.5    Milhem, M.6
  • 9
    • 59049107421 scopus 로고    scopus 로고
    • Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi
    • PMCID 2696133
    • Van Raamsdonk CD, Bezrookove V, Green G, Bauer J, Gaugler L, O'Brien JM et al (2009) Frequent somatic mutations of GNAQ in uveal melanoma and blue naevi. Nature 457(7229): 599-602, PMCID: 2696133
    • (2009) Nature , vol.457 , Issue.7229 , pp. 599-602
    • Van Raamsdonk, C.D.1    Bezrookove, V.2    Green, G.3    Bauer, J.4    Gaugler, L.5    O'Brien, J.M.6
  • 16
    • 33749021085 scopus 로고    scopus 로고
    • Somatic activation of KIT in distinct subtypes of melanoma
    • Curtin JA, Busam K, Pinkel D, Bastian BC (2006) Somatic activation of KIT in distinct subtypes of melanoma. J Clin Oncol 24(26): 4340-4346
    • (2006) J Clin Oncol , vol.24 , Issue.26 , pp. 4340-4346
    • Curtin, J.A.1    Busam, K.2    Pinkel, D.3    Bastian, B.C.4
  • 18
    • 0022626874 scopus 로고
    • A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family
    • Besmer P, Murphy JE, George PC, Qiu FH, Bergold PJ, Lederman L et al (1986) A new acute transforming feline retrovirus and relationship of its oncogene v-kit with the protein kinase gene family. Nature 320(6061): 415-421
    • (1986) Nature , vol.320 , Issue.6061 , pp. 415-421
    • Besmer, P.1    Murphy, J.E.2    George, P.C.3    Qiu, F.H.4    Bergold, P.J.5    Lederman, L.6
  • 19
    • 2742529418 scopus 로고
    • Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand
    • PMCID 553789
    • Yarden Y, Kuang WJ, Yang-Feng T, Coussens L, Munemitsu S, Dull TJ et al (1987) Human proto-oncogene c-kit: A new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J 6(11):3341-3351, PMCID: 553789
    • (1987) EMBO J , vol.6 , Issue.11 , pp. 3341-3351
    • Yarden, Y.1    Kuang, W.J.2    Yang-Feng, T.3    Coussens, L.4    Munemitsu, S.5    Dull, T.J.6
  • 20
    • 77954216079 scopus 로고    scopus 로고
    • Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics
    • Woodman SE, Davies MA (2010) Targeting KIT in melanoma: A paradigm of molecular medicine and targeted therapeutics. Biochem Pharmacol 80(5):568-574
    • (2010) Biochem Pharmacol , vol.80 , Issue.5 , pp. 568-574
    • Woodman, S.E.1    Davies, M.A.2
  • 21
    • 0027089718 scopus 로고
    • Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2
    • PMCID 275535
    • Huang EJ, Nocka KH, Buck J, Besmer P (1992) Differential expression and processing of two cell associated forms of the kit-ligand: KL-1 and KL-2. Mol Biol Cell 3(3):349-362, PMCID: 275535
    • (1992) Mol Biol Cell , vol.3 , Issue.3 , pp. 349-362
    • Huang, E.J.1    Nocka, K.H.2    Buck, J.3    Besmer, P.4
  • 22
    • 9744246909 scopus 로고    scopus 로고
    • Signal transduction via the stem cell factor receptor/c-Kit
    • Ronnstrand L (2004) Signal transduction via the stem cell factor receptor/c-Kit. Cell Mol Life Sci 61(19-20):2535-2548
    • (2004) Cell Mol Life Sci , vol.61 , Issue.19-20 , pp. 2535-2548
    • Ronnstrand, L.1
  • 23
    • 0028917884 scopus 로고
    • Membrane-bound steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form
    • Miyazawa K, Williams DA, Gotoh A, Nishimaki J, Broxmeyer HE, Toyama K (1995) Membrane-bound steel factor induces more persistent tyrosine kinase activation and longer life span of c-kit gene-encoded protein than its soluble form. Blood 85(3):641-649
    • (1995) Blood , vol.85 , Issue.3 , pp. 641-649
    • Miyazawa, K.1    Williams, D.A.2    Gotoh, A.3    Nishimaki, J.4    Broxmeyer, H.E.5    Toyama, K.6
  • 24
    • 0018625422 scopus 로고
    • Hereditary anemias of the mouse: A review for geneticists
    • Russell ES (1979) Hereditary anemias of the mouse: A review for geneticists. Adv Genet 20: 357-459
    • (1979) Adv Genet , vol.20 , pp. 357-459
    • Russell, E.S.1
  • 25
    • 0031699406 scopus 로고    scopus 로고
    • Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: A Kit-KL interaction critical for meiosis
    • Vincent S, Segretain D, Nishikawa S, Nishikawa SI, Sage J, Cuzin F et al (1998) Stage-specific expression of the Kit receptor and its ligand (KL) during male gametogenesis in the mouse: A Kit-KL interaction critical for meiosis. Development 125(22):4585-4593
    • (1998) Development , vol.125 , Issue.22 , pp. 4585-4593
    • Vincent, S.1    Segretain, D.2    Nishikawa, S.3    Nishikawa, S.I.4    Sage, J.5    Cuzin, F.6
  • 26
    • 0032983371 scopus 로고    scopus 로고
    • Activating c-kit gene mutations in human germ cell tumors
    • PMCID 1876773
    • Tian Q, Frierson HF Jr, Krystal GW, Moskaluk CA (1999) Activating c-kit gene mutations in human germ cell tumors. Am J Pathol 154(6):1643-1647, PMCID: 1876773
    • (1999) Am J Pathol , vol.154 , Issue.6 , pp. 1643-1647
    • Tian, Q.1    Frierson Jr., H.F.2    Krystal, G.W.3    Moskaluk, C.A.4
  • 27
    • 33745726073 scopus 로고    scopus 로고
    • Development, migration, and survival of mast cells
    • PMCID 1490026
    • Okayama Y, Kawakami T (2006) Development, migration, and survival of mast cells. Immunol Res 34(2):97-115, PMCID: 1490026
    • (2006) Immunol Res , vol.34 , Issue.2 , pp. 97-115
    • Okayama, Y.1    Kawakami, T.2
  • 28
    • 0028796630 scopus 로고
    • W/kit gene required for interstitial cells of cajal and for intestinal pacemaker activity
    • Huizinga JD, Thuneberg L, Kluppel M, Malysz J, Mikkelsen HB, Bernstein A (1995) W/kit gene required for interstitial cells of Cajal and for intestinal pacemaker activity. Nature 373(6512):347-349
    • (1995) Nature , vol.373 , Issue.6512 , pp. 347-349
    • Huizinga, J.D.1    Thuneberg, L.2    Kluppel, M.3    Malysz, J.4    Mikkelsen, H.B.5    Bernstein, A.6
  • 29
    • 80051981588 scopus 로고    scopus 로고
    • C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation
    • PMCID: 3161112
    • Phung B, Sun J, Schepsky A, Steingrimsson E, Ronnstrand L (2011) C-KIT signaling depends on microphthalmia-associated transcription factor for effects on cell proliferation. PLoS One 6(8):e24064, PMCID: 3161112
    • (2011) PLoS One , vol.6 , Issue.8
    • Phung, B.1    Sun, J.2    Schepsky, A.3    Steingrimsson, E.4    Ronnstrand, L.5
  • 30
    • 57049091596 scopus 로고    scopus 로고
    • Transcriptional and signaling regulation in neural crest stem cellderived melanocyte development: Do all roads lead to Mitf?
    • Hou L, Pavan WJ (2008) Transcriptional and signaling regulation in neural crest stem cellderived melanocyte development: Do all roads lead to Mitf? Cell Res 18(12):1163-1176
    • (2008) Cell Res , vol.18 , Issue.12 , pp. 1163-1176
    • Hou, L.1    Pavan, W.J.2
  • 31
    • 0028957223 scopus 로고
    • Mutations at the W locus affect survival of neural crestderived melanocytes in the mouse
    • Cable J, Jackson IJ, Steel KP (1995) Mutations at the W locus affect survival of neural crestderived melanocytes in the mouse. Mech Dev 50(2-3):139-150
    • (1995) Mech Dev , vol.50 , Issue.2-3 , pp. 139-150
    • Cable, J.1    Jackson, I.J.2    Steel, K.P.3
  • 32
    • 0023694835 scopus 로고
    • The protooncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus
    • Chabot B, Stephenson DA, Chapman VM, Besmer P, Bernstein A (1988) The protooncogene c-kit encoding a transmembrane tyrosine kinase receptor maps to the mouse W locus. Nature 335(6185):88-89
    • (1988) Nature , vol.335 , Issue.6185 , pp. 88-89
    • Chabot, B.1    Stephenson, D.A.2    Chapman, V.M.3    Besmer, P.4    Bernstein, A.5
  • 33
    • 0026541532 scopus 로고
    • Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism
    • PMCID 1682440
    • Spritz RA, Giebel LB, Holmes SA (1992) Dominant negative and loss of function mutations of the c-kit (mast/stem cell growth factor receptor) proto-oncogene in human piebaldism. Am J Hum Genet 50(2):261-269, PMCID: 1682440
    • (1992) Am J Hum Genet , vol.50 , Issue.2 , pp. 261-269
    • Spritz, R.A.1    Giebel, L.B.2    Holmes, S.A.3
  • 34
    • 0024280901 scopus 로고
    • The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene
    • Geissler EN, Ryan MA, Housman DE (1988) The dominant-white spotting (W) locus of the mouse encodes the c-kit proto-oncogene. Cell 55(1):185-192
    • (1988) Cell , vol.55 , Issue.1 , pp. 185-192
    • Geissler, E.N.1    Ryan, M.A.2    Housman, D.E.3
  • 35
    • 33646153073 scopus 로고    scopus 로고
    • Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes
    • Alexeev V, Yoon K (2006) Distinctive role of the cKit receptor tyrosine kinase signaling in mammalian melanocytes. J Invest Dermatol 126(5):1102-1110
    • (2006) J Invest Dermatol , vol.126 , Issue.5 , pp. 1102-1110
    • Alexeev, V.1    Yoon, K.2
  • 36
    • 66749132873 scopus 로고    scopus 로고
    • Stem cell factor-KIT signalling plays a pivotal role in regulating pigmentation in mammalian hair
    • Hachiya A, Sriwiriyanont P, Kobayashi T, Nagasawa A, Yoshida H, Ohuchi A et al (2009) Stem cell factor-KIT signalling plays a pivotal role in regulating pigmentation in mammalian hair. J Pathol 218(1):30-39
    • (2009) J Pathol , vol.218 , Issue.1 , pp. 30-39
    • Hachiya, A.1    Sriwiriyanont, P.2    Kobayashi, T.3    Nagasawa, A.4    Yoshida, H.5    Ohuchi, A.6
  • 37
    • 65149096689 scopus 로고    scopus 로고
    • Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation
    • PMCID 2680999
    • Wang ZQ, Si L, Tang Q, Lin D, Fu Z, Zhang J et al (2009) Gain-of-function mutation of KIT ligand on melanin synthesis causes familial progressive hyperpigmentation. Am J Hum Genet 84(5):672-677, PMCID: 2680999
    • (2009) Am J Hum Genet , vol.84 , Issue.5 , pp. 672-677
    • Wang, Z.Q.1    Si, L.2    Tang, Q.3    Lin, D.4    Fu, Z.5    Zhang, J.6
  • 38
    • 0030459095 scopus 로고    scopus 로고
    • Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential
    • Huang S, Luca M, Gutman M, McConkey DJ, Langley KE, Lyman SD et al (1996) Enforced c-KIT expression renders highly metastatic human melanoma cells susceptible to stem cell factor-induced apoptosis and inhibits their tumorigenic and metastatic potential. Oncogene 13(11):2339-2347
    • (1996) Oncogene , vol.13 , Issue.11 , pp. 2339-2347
    • Huang, S.1    Luca, M.2    Gutman, M.3    McConkey, D.J.4    Langley, K.E.5    Lyman, S.D.6
  • 39
    • 0026793058 scopus 로고
    • Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor
    • Natali PG, Nicotra MR, Winkler AB, Cavaliere R, Bigotti A, Ullrich A (1992) Progression of human cutaneous melanoma is associated with loss of expression of c-kit proto-oncogene receptor. Int J Cancer 52(2):197-201
    • (1992) Int J Cancer , vol.52 , Issue.2 , pp. 197-201
    • Natali, P.G.1    Nicotra, M.R.2    Winkler, A.B.3    Cavaliere, R.4    Bigotti, A.5    Ullrich, A.6
  • 40
    • 0030765407 scopus 로고    scopus 로고
    • Proto-oncogene c-kit expression in malignant melanoma: Protein loss with tumor progression
    • Montone KT, van Belle P, Elenitsas R, Elder DE (1997) Proto-oncogene c-kit expression in malignant melanoma: Protein loss with tumor progression. Mod Pathol 10(9):939-944
    • (1997) Mod Pathol , vol.10 , Issue.9 , pp. 939-944
    • Montone, K.T.1    Van Belle, P.2    Elenitsas, R.3    Elder, D.E.4
  • 41
    • 0026518279 scopus 로고
    • Loss of c-kit expression in cultured melanoma cells
    • Lassam N, Bickford S (1992) Loss of c-kit expression in cultured melanoma cells. Oncogene 7(1):51-56
    • (1992) Oncogene , vol.7 , Issue.1 , pp. 51-56
    • Lassam, N.1    Bickford, S.2
  • 42
    • 0141958794 scopus 로고    scopus 로고
    • Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array
    • Shen SS, Zhang PS, Eton O, Prieto VG (2003) Analysis of protein tyrosine kinase expression in melanocytic lesions by tissue array. J Cutan Pathol 30(9):539-547
    • (2003) J Cutan Pathol , vol.30 , Issue.9 , pp. 539-547
    • Shen, S.S.1    Zhang, P.S.2    Eton, O.3    Prieto, V.G.4
  • 43
    • 21044460131 scopus 로고    scopus 로고
    • Lack of clinical efficacy of imatinib in metastatic melanoma
    • PMCID 2362005
    • Ugurel S, Hildenbrand R, Zimpfer A, La Rosee P, Paschka P, Sucker A et al (2005) Lack of clinical efficacy of imatinib in metastatic melanoma. Br J Cancer 92(8):1398-1405, PMCID: 2362005
    • (2005) Br J Cancer , vol.92 , Issue.8 , pp. 1398-1405
    • Ugurel, S.1    Hildenbrand, R.2    Zimpfer, A.3    La Rosee, P.4    Paschka, P.5    Sucker, A.6
  • 44
    • 33646268037 scopus 로고    scopus 로고
    • Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Signifi cant toxicity with no clinical efficacy
    • Wyman K, Atkins MB, Prieto V, Eton O, McDermott DF, Hubbard F et al (2006) Multicenter phase II trial of high-dose imatinib mesylate in metastatic melanoma: Signifi cant toxicity with no clinical efficacy. Cancer 106(9): 2005-2011
    • (2006) Cancer , vol.106 , Issue.9 , pp. 2005-2011
    • Wyman, K.1    Atkins, M.B.2    Prieto, V.3    Eton, O.4    McDermott, D.F.5    Hubbard, F.6
  • 45
    • 50249141632 scopus 로고    scopus 로고
    • Phase II trial of imatinib mesylate in patients with metastatic melanoma
    • PMCID 2528157
    • Kim KB, Eton O, Davis DW, Frazier ML, McConkey DJ, Diwan AH et al (2008) Phase II trial of imatinib mesylate in patients with metastatic melanoma. Br J Cancer 99(5):734-740, PMCID: 2528157
    • (2008) Br J Cancer , vol.99 , Issue.5 , pp. 734-740
    • Kim, K.B.1    Eton, O.2    Davis, D.W.3    Frazier, M.L.4    McConkey, D.J.5    Diwan, A.H.6
  • 46
    • 34249018869 scopus 로고    scopus 로고
    • Gastrointestinal stromal tumour
    • Rubin BP, Heinrich MC, Corless CL (2007) Gastrointestinal stromal tumour. Lancet 369(9574):1731-1741
    • (2007) Lancet , vol.369 , Issue.9574 , pp. 1731-1741
    • Rubin, B.P.1    Heinrich, M.C.2    Corless, C.L.3
  • 47
    • 20844433223 scopus 로고    scopus 로고
    • Progressionfree survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial
    • Verweij J, Casali PG, Zalcberg J, LeCesne A, Reichardt P, Blay JY et al (2004) Progressionfree survival in gastrointestinal stromal tumours with high-dose imatinib: Randomised trial. Lancet 364(9440):1127-1134
    • (2004) Lancet , vol.364 , Issue.9440 , pp. 1127-1134
    • Verweij, J.1    Casali, P.G.2    Zalcberg, J.3    LeCesne, A.4    Reichardt, P.5    Blay, J.Y.6
  • 48
    • 0032523833 scopus 로고    scopus 로고
    • Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization
    • Bastian BC, LeBoit PE, Hamm H, Brocker EB, Pinkel D (1998) Chromosomal gains and losses in primary cutaneous melanomas detected by comparative genomic hybridization. Cancer Res 58(10):2170-2175
    • (1998) Cancer Res , vol.58 , Issue.10 , pp. 2170-2175
    • Bastian, B.C.1    LeBoit, P.E.2    Hamm, H.3    Brocker, E.B.4    Pinkel, D.5
  • 50
    • 3242794909 scopus 로고    scopus 로고
    • Detection of c-kit-activating mutations in gastrointestinal stromal tumors by high-resolution amplicon melting analysis
    • Willmore C, Holden JA, Zhou L, Tripp S, Wittwer CT, Layfield LJ (2004) Detection of c-kit-activating mutations in gastrointestinal stromal tumors by high-resolution amplicon melting analysis. Am J Clin Pathol 122(2): 206-216
    • (2004) Am J Clin Pathol , vol.122 , Issue.2 , pp. 206-216
    • Willmore, C.1    Holden, J.A.2    Zhou, L.3    Tripp, S.4    Wittwer, C.T.5    Layfield, L.J.6
  • 51
    • 33646145930 scopus 로고    scopus 로고
    • BRAF and c-kit gene copy number in mutation-positive malignant melanoma
    • Willmore-Payne C, Holden JA, Hirschowitz S, Layfield LJ (2006) BRAF and c-kit gene copy number in mutation-positive malignant melanoma. Hum Pathol 37(5):520-527
    • (2006) Hum Pathol , vol.37 , Issue.5 , pp. 520-527
    • Willmore-Payne, C.1    Holden, J.A.2    Hirschowitz, S.3    Layfield, L.J.4
  • 52
    • 34250335270 scopus 로고    scopus 로고
    • L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition
    • Antonescu CR, Busam KJ, Francone TD, Wong GC, Guo T, Agaram NP et al (2007) L576P KIT mutation in anal melanomas correlates with KIT protein expression and is sensitive to specific kinase inhibition. Int J Cancer 121(2):257-264
    • (2007) Int J Cancer , vol.121 , Issue.2 , pp. 257-264
    • Antonescu, C.R.1    Busam, K.J.2    Francone, T.D.3    Wong, G.C.4    Guo, T.5    Agaram, N.P.6
  • 53
    • 37549021543 scopus 로고    scopus 로고
    • C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma
    • Rivera RS, Nagatsuka H, Gunduz M, Cengiz B, Gunduz E, Siar CH et al (2008) C-kit protein expression correlated with activating mutations in KIT gene in oral mucosal melanoma. Virchows Arch 452(1):27-32
    • (2008) Virchows Arch , vol.452 , Issue.1 , pp. 27-32
    • Rivera, R.S.1    Nagatsuka, H.2    Gunduz, M.3    Cengiz, B.4    Gunduz, E.5    Siar, C.H.6
  • 54
    • 57449093330 scopus 로고    scopus 로고
    • Analysis of c-KIT expression and KIT gene mutation in human mucosal melanomas
    • PMCID 2607233
    • Satzger I, Schaefer T, Kuettler U, Broecker V, Voelker B, Ostertag H et al (2008) Analysis of c-KIT expression and KIT gene mutation in human mucosal melanomas. Br J Cancer 99(12):2065-2069, PMCID: 2607233
    • (2008) Br J Cancer , vol.99 , Issue.12 , pp. 2065-2069
    • Satzger, I.1    Schaefer, T.2    Kuettler, U.3    Broecker, V.4    Voelker, B.5    Ostertag, H.6
  • 55
    • 58149461573 scopus 로고    scopus 로고
    • Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas
    • Ashida A, Takata M, Murata H, Kido K, Saida T (2009) Pathological activation of KIT in metastatic tumors of acral and mucosal melanomas. Int J Cancer 124(4):862-868
    • (2009) Int J Cancer , vol.124 , Issue.4 , pp. 862-868
    • Ashida, A.1    Takata, M.2    Murata, H.3    Kido, K.4    Saida, T.5
  • 56
    • 70350668375 scopus 로고    scopus 로고
    • Correlation between KIT expression and KIT mutation in melanoma: A study of 173 cases with emphasis on the acral-lentiginous/mucosal type
    • Torres-Cabala CA, Wang WL, Trent J, Yang D, Chen S, Galbincea J et al (2009) Correlation between KIT expression and KIT mutation in melanoma: A study of 173 cases with emphasis on the acral-lentiginous/mucosal type. Mod Pathol 22(11):1446-1456
    • (2009) Mod Pathol , vol.22 , Issue.11 , pp. 1446-1456
    • Torres-Cabala, C.A.1    Wang, W.L.2    Trent, J.3    Yang, D.4    Chen, S.5    Galbincea, J.6
  • 58
    • 0033619142 scopus 로고    scopus 로고
    • Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/ MAP kinase pathway and c-fos induction
    • Lennartsson J, Blume-Jensen P, Hermanson M, Ponten E, Carlberg M, Ronnstrand L (1999) Phosphorylation of Shc by Src family kinases is necessary for stem cell factor receptor/c-kit mediated activation of the Ras/ MAP kinase pathway and c-fos induction. Oncogene 18(40):5546-5553
    • (1999) Oncogene , vol.18 , Issue.40 , pp. 5546-5553
    • Lennartsson, J.1    Blume-Jensen, P.2    Hermanson, M.3    Ponten, E.4    Carlberg, M.5    Ronnstrand, L.6
  • 59
    • 41749118496 scopus 로고    scopus 로고
    • Molecular pathobiology of gastrointestinal stromal sarcomas
    • Corless CL, Heinrich MC (2008) Molecular pathobiology of gastrointestinal stromal sarcomas. Annu Rev Pathol 3:557-586
    • (2008) Annu Rev Pathol , vol.3 , pp. 557-586
    • Corless, C.L.1    Heinrich, M.C.2
  • 60
    • 79953324920 scopus 로고    scopus 로고
    • Large-scale analysis of kit aberrations in chinese patients with melanoma
    • Kong Y, Si L, Zhu Y, Xu X, Corless CL, Flaherty KT et al (2011) Large-scale analysis of KIT aberrations in Chinese patients with melanoma. Clin Cancer Res 17(7):1684-1691
    • (2011) Clin Cancer Res , vol.17 , Issue.7 , pp. 1684-1691
    • Kong, Y.1    Si, L.2    Zhu, Y.3    Xu, X.4    Corless, C.L.5    Flaherty, K.T.6
  • 61
    • 79955965083 scopus 로고    scopus 로고
    • Kit amplifi cation and gene mutations in acral/mucosal melanoma in korea
    • Yun J, Lee J, Jang J, Lee EJ, Jang KT, Kim JH et al (2011) KIT amplifi cation and gene mutations in acral/mucosal melanoma in Korea. APMIS 119(6):330-335
    • (2011) APMIS , vol.119 , Issue.6 , pp. 330-335
    • Yun, J.1    Lee, J.2    Jang, J.3    Lee, E.J.4    Jang, K.T.5    Kim, J.H.6
  • 62
    • 77949406203 scopus 로고    scopus 로고
    • Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure
    • Handolias D, Salemi R, Murray W, Tan A, Liu W, Viros A et al (2010) Mutations in KIT occur at low frequency in melanomas arising from anatomical sites associated with chronic and intermittent sun exposure. Pigment Cell Melanoma Res 23(2):210-215
    • (2010) Pigment Cell Melanoma Res , vol.23 , Issue.2 , pp. 210-215
    • Handolias, D.1    Salemi, R.2    Murray, W.3    Tan, A.4    Liu, W.5    Viros, A.6
  • 63
    • 74449089861 scopus 로고    scopus 로고
    • C-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes
    • Monsel G, Ortonne N, Bagot M, Bensussan A, Dumaz N (2010) c-Kit mutants require hypoxia-inducible factor 1alpha to transform melanocytes. Oncogene 29(2):227-236
    • (2010) Oncogene , vol.29 , Issue.2 , pp. 227-236
    • Monsel, G.1    Ortonne, N.2    Bagot, M.3    Bensussan, A.4    Dumaz, N.5
  • 65
    • 68849093078 scopus 로고    scopus 로고
    • Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates
    • Woodman SE, Trent JC, Stemke-Hale K, Lazar AJ, Pricl S, Pavan GM et al (2009) Activity of dasatinib against L576P KIT mutant melanoma: Molecular, cellular, and clinical correlates. Mol Cancer Ther 8(8):2079-2085
    • (2009) Mol Cancer Ther , vol.8 , Issue.8 , pp. 2079-2085
    • Woodman, S.E.1    Trent, J.C.2    Stemke-Hale, K.3    Lazar, A.J.4    Pricl, S.5    Pavan, G.M.6
  • 67
    • 76649108873 scopus 로고    scopus 로고
    • Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy-case report and review of the literature
    • Satzger I, Kuttler U, Volker B, Schenck F, Kapp A, Gutzmer R (2010) Anal mucosal melanoma with KIT-activating mutation and response to imatinib therapy-case report and review of the literature. Dermatology 220(1):77-81
    • (2010) Dermatology , vol.220 , Issue.1 , pp. 77-81
    • Satzger, I.1    Kuttler, U.2    Volker, B.3    Schenck, F.4    Kapp, A.5    Gutzmer, R.6
  • 68
    • 47249099056 scopus 로고    scopus 로고
    • Dosedependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation
    • Lutzky J, Bauer J, Bastian BC (2008) Dosedependent, complete response to imatinib of a metastatic mucosal melanoma with a K642E KIT mutation. Pigment Cell Melanoma Res 21(4):492-493
    • (2008) Pigment Cell Melanoma Res , vol.21 , Issue.4 , pp. 492-493
    • Lutzky, J.1    Bauer, J.2    Bastian, B.C.3
  • 70
    • 57049109807 scopus 로고    scopus 로고
    • Complete response of stage IV anal mucosal melanoma expressing kit val560asp to the multikinase inhibitor sorafenib
    • Quintas-Cardama A, Lazar AJ, Woodman SE, Kim K, Ross M, Hwu P (2008) Complete response of stage IV anal mucosal melanoma expressing KIT Val560Asp to the multikinase inhibitor sorafenib. Nat Clin Pract Oncol 5(12):737-740
    • (2008) Nat Clin Pract Oncol , vol.5 , Issue.12 , pp. 737-740
    • Quintas-Cardama, A.1    Lazar, A.J.2    Woodman, S.E.3    Kim, K.4    Ross, M.5    Hwu, P.6
  • 71
    • 76649118476 scopus 로고    scopus 로고
    • Response to sunitinib in Chinese KIT -mutated metastatic mucosal melanoma
    • abstract
    • Zhu Y, Si L, Kong Y, Chi Z, Yuan X, Cui C, et al. (2009) Response to sunitinib in Chinese KIT -mutated metastatic mucosal melanoma. J Clin Oncol 27(abstract):e20017
    • (2009) J Clin Oncol , vol.27
    • Zhu, Y.1    Si, L.2    Kong, Y.3    Chi, Z.4    Yuan, X.5    Cui, C.6
  • 74
    • 84867867288 scopus 로고    scopus 로고
    • Nilotinib in patients with metastatic melanoma harboring KIT gene aberration
    • Cho JH, Kim KM, Kwon M, Kim JH, Lee J (2011) Nilotinib in patients with metastatic melanoma harboring KIT gene aberration. Invest New Drugs 30(5):2008-2014
    • (2011) Invest New Drugs , vol.30 , Issue.5 , pp. 2008-2014
    • Cho, J.H.1    Kim, K.M.2    Kwon, M.3    Kim, J.H.4    Lee, J.5
  • 75
    • 84978034236 scopus 로고    scopus 로고
    • Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    • Long GV, Menzies AM, Nagrial AM, Haydu LE, Hamilton AL, Mann GJ et al (2011) Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol 29(10):1239-1246
    • (2011) J Clin Oncol , vol.29 , Issue.10 , pp. 1239-1246
    • Long, G.V.1    Menzies, A.M.2    Nagrial, A.M.3    Haydu, L.E.4    Hamilton, A.L.5    Mann, G.J.6
  • 76
    • 72549086618 scopus 로고    scopus 로고
    • Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: An in vitro mutagenesis screen for drug resistance
    • PMCID 2783687
    • Guo T, Hajdu M, Agaram NP, Shinoda H, Veach D, Clarkson BD et al (2009) Mechanisms of sunitinib resistance in gastrointestinal stromal tumors harboring KITAY502-3ins mutation: An in vitro mutagenesis screen for drug resistance. Clin Cancer Res 15(22):6862-6870, PMCID: 2783687
    • (2009) Clin Cancer Res , vol.15 , Issue.22 , pp. 6862-6870
    • Guo, T.1    Hajdu, M.2    Agaram, N.P.3    Shinoda, H.4    Veach, D.5    Clarkson, B.D.6
  • 78
    • 0642368571 scopus 로고    scopus 로고
    • Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor
    • Heinrich MC, Corless CL, Demetri GD, Blanke CD, von Mehren M, Joensuu H et al (2003) Kinase mutations and imatinib response in patients with metastatic gastrointestinal stromal tumor. J Clin Oncol 21(23): 4342-4349
    • (2003) J Clin Oncol , vol.21 , Issue.23 , pp. 4342-4349
    • Heinrich, M.C.1    Corless, C.L.2    Demetri, G.D.3    Blanke, C.D.4    Von Mehren, M.5    Joensuu, H.6
  • 79
    • 41149170835 scopus 로고    scopus 로고
    • Clinicopathologic profi le of gastrointestinal stromal tumors (gists) with primary kit exon 13 or exon 17 mutations: A multicenter study on 54 cases
    • Lasota J, Corless CL, Heinrich MC, Debiec-Rychter M, Sciot R, Wardelmann E et al (2008) Clinicopathologic profi le of gastrointestinal stromal tumors (GISTs) with primary KIT exon 13 or exon 17 mutations: A multicenter study on 54 cases. Mod Pathol 21(4):476-484
    • (2008) Mod Pathol , vol.21 , Issue.4 , pp. 476-484
    • Lasota, J.1    Corless, C.L.2    Heinrich, M.C.3    Debiec-Rychter, M.4    Sciot, R.5    Wardelmann, E.6
  • 81
    • 84863072006 scopus 로고    scopus 로고
    • Major response to everolimus in melanoma with acquired imatinib resistance
    • Si L, Xu X, Kong Y, Flaherty KT, Chi Z, Cui C et al (2012) Major response to everolimus in melanoma with acquired imatinib resistance. J Clin Oncol 30(4):e37-e40
    • (2012) J Clin Oncol , vol.30 , Issue.4
    • Si, L.1    Xu, X.2    Kong, Y.3    Flaherty, K.T.4    Chi, Z.5    Cui, C.6
  • 82
    • 77950866918 scopus 로고    scopus 로고
    • Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in kit
    • PMCID 2856012
    • Handolias D, Hamilton AL, Salemi R, Tan A, Moodie K, Kerr L et al (2010) Clinical responses observed with imatinib or sorafenib in melanoma patients expressing mutations in KIT. Br J Cancer 102(8):1219-1223, PMCID: 2856012
    • (2010) Br J Cancer , vol.102 , Issue.8 , pp. 1219-1223
    • Handolias, D.1    Hamilton, A.L.2    Salemi, R.3    Tan, A.4    Moodie, K.5    Kerr, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.