Rotigotine protects against glutamate toxicity in primary dopaminergic cell culture

European Journal of Pharmacology

Volumn 724, Issue 1, 2014, Pages 31-42

  Oster, Sandra ^a   Radad, Khaled ^b   Scheller, Dieter ^c   Hesse, Marlen ^a   Balanzew, Wladimir ^a   Reichmann, Heinz ^a   Gille, Gabriele ^a  

^a DRESDEN UNIVERSITY OF TECHNOLOGY   (Germany)

^b Assiut University   (Egypt)

^c UCB PHARMA   (Belgium)

Author keywords

Glutamate excitotoxicity; Neuroprotection; Parkinson disease; PI3K Akt pathway; Rotigotine

Indexed keywords

CALCIUM CHANNEL L TYPE; CALCIUM ION; DOPAMINE 3 RECEPTOR; GLUTAMIC ACID; GLYCOGEN SYNTHASE KINASE 3BETA; N METHYL DEXTRO ASPARTIC ACID RECEPTOR; NITRIC OXIDE; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN KINASE B; ROTIGOTINE; SUPEROXIDE;

ANIMAL CELL; ANTIOXIDANT ACTIVITY; ARTICLE; CALCIUM TRANSPORT; CELL SURVIVAL; CONTROLLED STUDY; DOPAMINERGIC NERVE CELL; DRUG MECHANISM; EMBRYO; ENZYME ACTIVATION; ENZYME INACTIVATION; ENZYME PHOSPHORYLATION; EXCITOTOXICITY; FEMALE; IN VITRO STUDY; MESENCEPHALON; MOUSE; NERVE CELL CULTURE; NEUROPROTECTION; NONHUMAN; PRIORITY JOURNAL;

GLUTAMATE EXCITOTOXICITY; NEUROPROTECTION; PARKINSON DISEASE; PI3K/AKT PATHWAY; ROTIGOTINE;

ANIMALS; CALCIUM; CALCIUM CHANNELS, L-TYPE; CELLS, CULTURED; DOPAMINE AGONISTS; DOPAMINERGIC NEURONS; GLUTAMIC ACID; GLUTATHIONE; MICE; MICE, INBRED C57BL; NEUROPROTECTIVE AGENTS; PHOSPHATIDYLINOSITOL 3-KINASES; PRIMARY CELL CULTURE; PROTO-ONCOGENE PROTEINS C-AKT; RECEPTORS, DOPAMINE D2; SUPEROXIDES; TETRAHYDRONAPHTHALENES; THIOPHENES;

EID: 84891785950     PISSN: 00142999     EISSN: 18790712     Source Type: Journal    
DOI: 10.1016/j.ejphar.2013.12.014     Document Type: Article

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