Methylphenylpyridium ion (MPP+) enhances glutamate-induced cytotoxicity against dopaminergic neurons in cultured rat mesencephalon

Journal of Neuroscience Research

Volumn 43, Issue 1, 1996, Pages 55-62

  Sawada, H ^a   Shimohama, S ^a   Tamura, Y ^b   Kawamura, T ^a   Akaike, A ^a   Kimura, J ^a  

^a KYOTO UNIVERSITY   (Japan)

^b FUKUYAMA UNIVERSITY   (Japan)

Author keywords

dopaminergic neuron; glutamate; MPP+; neuronal death; Parkinson's disease

Indexed keywords

1 METHYL 4 PHENYLPYRIDINIUM; DIZOCILPINE; GLUTAMATE RECEPTOR ANTAGONIST; GLUTAMIC ACID;

ANIMAL CELL; ARTICLE; CONTROLLED STUDY; CYTOTOXICITY; DOPAMINERGIC NERVE CELL; DRUG DESIGN; MESENCEPHALON; NERVE CELL DEGENERATION; NERVE CELL NECROSIS; NONHUMAN; PARKINSON DISEASE; PATHOGENESIS; PRIORITY JOURNAL; RAT;

1-METHYL-4-PHENYLPYRIDINIUM; ANIMALS; CELL DEATH; DIZOCILPINE MALEATE; DOPAMINE; DRUG SYNERGISM; EXCITATORY AMINO ACID ANTAGONISTS; GLUTAMIC ACID; MESENCEPHALON; NAD(P)H DEHYDROGENASE (QUINONE); NEURONS; NEUROPROTECTIVE AGENTS; NEUROTOXINS; PARKINSON DISEASE; RATS; RECEPTORS, N-METHYL-D-ASPARTATE;

EID: 0030065222     PISSN: 03604012     EISSN: None     Source Type: Journal    
DOI: 10.1002/jnr.490430107     Document Type: Article

References (30)

1. Beal MF, Ferrante RJ, Swartz KJ, Kowall NW (1991): Chronic quinolinic acid lesions in rats closely resemble Huntington's disease. J Neurosci 11:1649-1659.
2. +). Neurosci Let 117:129-133.
3. Choi DW (1987): Ionic dependence of glutamate neurotoxicity. J Neurosci 7:369-379.
4. Collins MA, Neafsey EJ, Matsubara K, Cobuzzi RJ Jr, Rollema H (1992): Indole-N-methylated beta-carbonium ions as potential brain-bioactivated neurotoxins. Brain Res 570:154-160.
5. Coyle JT, Puttfarcken P (1993): Oxidative stress, glutamate, and neurodegenerative disorders. Science 262:689-695.
6. Davis GC, Williams AC, Markey SP, Ebert MH, Caine ED, Reichert CM, Kopin IJ (1979): Chronic parkinsonism secondary to intravenous injection of meperidine analogues. Psychiatry Res 1:249-254.
7. Difazio MC, Hollingsworth Z, Young AB, Penney JB Jr (1992): Glutamate receptors in the substantia nigra of Parkinson's disease brains. Neurology 42:402-406.
8. Fonnum F (1984): Glutamate: a neurotransmitter in mammalian brain. J Neurochem 42:1-11.
9. Javitch JA, D'Amato RJ, Strittmatter SM, Snyder SH (1985): Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity. Proc Natl Acad Sci USA 82:2173-2177.
10. Kato K, Puttfarcken PS, Lyons WE, Coyle JT (1991): Developmental time course and ionic dependence of kainate-mediated toxicity in rat cerebellar granule cell cultures. J Pharmacol Exp Ther 256:402-411.
11. Kikuchi S, Kim SU (1993): Glutamate neurotoxicity in mesencephalic dopaminergic neurons in culture. J Neurosci Res 36:558-569.
12. +) involves binding at the same site as the respiratory inhibitor, rotenone. Biochem Biophys Res Commun 169:123-128.
13. Langston JW, Ballard P, Tetrud JW, Irwin I (1983): Chronic parkinsonism in humans due to a product of meperdine-analog synthesis. Science 219:979-980.
14. McDonald JW, Johnston MV (1990): Physiological and pathophysiological roles of excitatory amino acids during central nervous system development. Brain Res Rev 15:41-70.
15. Michel PP, Dandapani BK, Efange SMN, Hefti F (1990): Potential environmental neurotoxins related to 1-methyl-4-phenylpyridinium: selective toxicity of 1-methyl-4-(4′-acetamidophenyl)-pyridinium and 1-methyl-4-cyclohexylpyridinium for dopaminergic neurons in culture. Exp. Neurol 108.141-150.
16. +) in rat dissociated mesencephalic cultures. Brain Res 597:233-240.
17. Mizuno Y, Suzuki K, Sone N, Saitoh T (1988): Inhibition of mitochondrial respiration by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in mouse brain in vivo. Neurosci Lett 91:349-353.
18. +) in ventral mesencephalic-striatal coculture in rat. Neurosci Lett 170:191-194.
19. Nicklas WJ, Vyas I, Heikkila RE (1985): Inhibition of NADH-linked oxidation in brain mitochondria by 1-methyl-4-phenyl-pyridine, a metabolite of the neurotoxin, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine. Life Sci 36:2503-2508.
20. Parker WD Jr, Boyson SJ, Parks JK (1989): Abnormalities of the electron transport chain in idiopathic Parkinson's disease. Ann Neurol 26:719-723.
21. Ramsay RR, Dadger J, Trevor A, Singer TP (1986): Energy-driven uptake of N-methyl-4-phenylpyridine by brain mitochondria mediates the neurotoxicity of MPTP. Life Sci 39:581-588.
22. +) and it analogs with the rotenone/piericidin binding site of NADH dehydrogenase. J Neurochem 56:1184-1190.
23. Rothstein JD, Martin LJ, Kuncl RW (1992): Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. N Engl J Med 326:1464-1468.
24. Saporito MS, Heikkila RE, Youngster SK, Nicklas WJ (1992): Dopaminergic neurotoxicity of 1-methyl-4-phenylpyridinium analogs in cultured neurons: relationship to the dopamine uptake system and inhibition of mitochondrial respiration. J Pharmacol Exp Ther 260:1400-1409.
25. Schapira AH, Cooper JM, Dexter D, Clark JB, Jenner P, Marsden CD (1990); Mitochondrial complex I deficiency in Parkinson's disease. J Neurochem 54:823-827.
26. Schapira AH, Mann VM, Cooper JM, Krige D, Jenner PJ (1992): Mitochondrial function in Parkinson's disease. Ann Neurol 32: S116-S124.
27. Smith CC, Bowen DM, Francis PT, Snowden JS, Neary D (1985): Putative amino acid transmitters in lumbar cerebrospinal fluid of patients with histologically verified Alzheimer's dementia. J Neurol Neurosurg Psychiatry 48:469-471.
28. Suzuki K, Mizuno Y, Yoshida M (1990): Inhibition of mitochondrial respiration by 1,2,3,4-tetrahydroisoquinoline-like endogenous alkaloids in mouse brain. Nerurochem Res 15:705-710.
29. + neurotoxicity by N-methyl-D-asparatate antagonists. Nature 349:414-418.
30. Zuddas A, Oberto G, Vaglini F, Fascetti F, Fornai F, Corsini GU (1992): MK-801 prevents 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-induced parkinsonism in primates. J Neurochem 59:733-739.