Implantable silk composite microneedles for programmable vaccine release kinetics and enhanced immunogenicity in transcutaneous immunization

Advanced Healthcare Materials

Volumn 3, Issue 1, 2014, Pages 47-58

  Demuth, Peter C ^a   Min, Younjin ^a,e   Irvine, Darrell J ^a,b,c,d   Hammond, Paula T ^a,b  

^a Massachusetts Institute of Technology Cambridge   (United States)

^b MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^c MASSACHUSETTS GENERAL HOSPITAL   (United States)

^d HOWARD HUGHES MEDICAL INSTITUTE   (United States)

^e University of Akron   (United States)

Author keywords

Cutaneous delivery; Hydrogels; Microneedles; Vaccines

Indexed keywords

ANTIGENS; HYDROGELS; IMMUNIZATION; KINETICS; NEEDLES; PROTEINS; SILK; T-CELLS; VACCINES;

CUTANEOUS DELIVERIES; HUMORAL IMMUNE RESPONSE; INFLAMMATORY RESPONSE; MICRONEEDLE PATCHES; MICRONEEDLES; RELEASE KINETICS; TRANSCUTANEOUS IMMUNIZATIONS; VACCINE DELIVERY;

IMMUNE SYSTEM;

BREFELDIN A; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; INTERFERON ANTIBODY; OVALBUMIN; POLYACRYLIC ACID; SILK;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIGEN SPECIFICITY; ARTICLE; CD8+ T LYMPHOCYTE; CELLULAR IMMUNITY; CONFOCAL MICROSCOPY; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DENDRITIC CELL; FLUORESCENCE SPECTROSCOPY; HUMORAL IMMUNITY; IMMUNE RESPONSE; IMMUNIZATION; IMMUNOGENICITY; IMMUNOSTIMULATION; IN VIVO STUDY; MICRONEEDLE; MICROSCOPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; PYRAMIDAL NERVE CELL; TRANSCUTANEOUS IMMUNIZATION;

CUTANEOUS DELIVERY; HYDROGELS; MICRONEEDLES; VACCINES;

ACRYLIC RESINS; ADMINISTRATION, CUTANEOUS; ANIMALS; ANTIGEN-PRESENTING CELLS; CD8-POSITIVE T-LYMPHOCYTES; DRUG CARRIERS; IMMUNITY, CELLULAR; IMMUNITY, HUMORAL; KINETICS; MICE; MICE, INBRED C57BL; NEEDLES; SILK; VACCINES;

EID: 84891782974     PISSN: 21922640     EISSN: 21922659     Source Type: Journal    
DOI: 10.1002/adhm.201300139     Document Type: Article

References (36)

1. Y.-C. Kim, J.-H. Park, M. R. Prausnitz, Adv. Drug Delivery Rev. 2012, 64, 1547.
2. M. del Pilar Martin, W. C. Weldon, V. G. Zarnitsyn, D. G. Koutsonanos, H. Akbari, I. Skountzou, J. Jacob, M. R. Prausnitz, R. W. Compans, mBio 2012, 3, e00012.
3. P. C. DeMuth, J. J. Moon, H. Suh, P. T. Hammond, D. J. Irvine, ACS Nano 2012, 6, 8041.
4. C. M. Jewell, L. S. C. Bustamante, D. J. Irvine, Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 15745.
5. P. Johansen, T. Storni, L. Rettig, Z. Qiu, A. Der-Sarkissian, K. A. Smith, V. Manolova, K. S. Lang, G. Senti, B. Mullhaupt, T. Gerlach, R. F. Speck, A. Bot, T. M. Kundig, Proc. Natl. Acad. Sci. U.S.A. 2008, 105, 5189.
6. M. F. Bachmann, R. R. Beerli, P. Agnellini, P. Wolint, K. Schwarz, A. Oxenius, Eur. J. Immunol. 2006, 36, 842.
7. A. Shaulov, K. Murali-Krishna, J. Immunol. 2008, 180, 1131.
8. P. C. DeMuth, W. F. Garcia-Beltran, M. L. Ai-Ling, P. T. Hammond, D. J. Irvine, Adv. Funct. Mater. 2012, 23, 161.
9. E. M. Pritchard, D. L. Kaplan, Expert Opin. Drug Delivery 2011, 8, 797.
10. E. Wenk, H. P. Merkle, L. Meinel, J. Controlled Release 2011, 150, 128.
11. K. Tsioris, W. K. Raja, E. M. Pritchard, B. Panilaitis, D. L. Kaplan, F. G. Omenetto, Adv. Funct. Mater. 2012, 22, 330.
12. X. You, J.-H. Chang, B.-K. Ju, J. J. Pak, Mater. Sci. Eng., C 2011, 31, 1632.
13. J. Zhang, E. Pritchard, X. Hu, T. Valentin, B. Panilaitis, F. G. Omenetto, D. L. Kaplan, Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 11981.
14. D. N. Rockwood, R. C. Preda, T. Yucel, X.-Q. Wang, M. L. Lovett, D. L. Kaplan, Nat. Protoc. 2011, 6, 1612.
15. Y. Yue, W. Xu, L. Hu, Z. Jiang, S. Xiong, Virology 2009, 386, 438.
16. P. C. DeMuth, X. Su, R. E. Samuel, P. T. Hammond, D. J. Irvine, Adv. Mater. 2010, 22, 4851.
17. C. Stahl-Hennig, M. Eisenblaetter, E. Jasny, T. Rzehak, K. Tenner-Racz, C. Trumpfheller, A. M. Salazar, K. Ueberla, K. Nieto, J. Kleinschmidt, R. Schulte, L. Gissmann, M. Mueller, A. Sacher, P. Racz, R. M. Steinman, M. Uguccioni, R. Ignatius, PLoS Pathogens 2009, 5, e1000373.
18. P. C. DeMuth, Y. Min, B. Huang, J. A. Kramer, A. D. Miller, D. H. Barouch, P. T. Hammond, D. J. Irvine, Nat. Mater. 2013, 12, 367.
19. W.-H. W. Lin, R. D. Kouyos, R. J. Adams, B. T. Grenfell, D. E. Griffin, Proc. Natl. Acad. Sci. U.S.A. 2012, 109, 14989.
20. D. L. Turner, L. S. Cauley, K. M. Khanna, L. Lefrancois, J. Virol. 2007, 81, 2039.
21. D. J. Zammit, D. L. Turner, K. D. Klonowski, L. Lefrancois, L. S. Cauley, Immunity 2006, 24, 439.
22. T. S. Kim, M. M. Hufford, J. Sun, Y.-X. Fu, T. J. Braciale, J. Exp. Med. 2010, 207, 1161.
23. K. N. Reetoo, S. A. Osman, S. J. Illavia, C. L. Cameron-Wilson, J. E. Banatvala, P. Muir, J. Gen. Virol. 2000, 81, 2755.
24. F. Sallusto, J. Geginat, A. Lanzavecchia, Annu. Rev. Immunol. 2004, 22, 745.
25. S. Gross, S. T. Gammon, B. L. Moss, D. Rauch, J. Harding, J. W. Heinecke, L. Ratner, D. Piwnica-Worms, Nat. Med. 2009, 15, 455.
26. J.-C. Tseng, A. L. Kung, Chem. Biol. 2012, 19, 1199.
27. X. Chen, H. J. Corbett, S. R. Yukiko, A. P. Raphael, E. J. Fairmaid, T. W. Prow, L. E. Brown, G. J. P. Fernando, M. A. F. Kendall, Adv. Funct. Mater. 2011, 21, 464.
28. D. G. Koutsonanos, E. V. Vassilieva, A. Stavropoulou, V. G. Zarnitsyn, E. S. Esser, M. T. Taherbhai, M. R. Prausnitz, R. W. Compans, I. Skountzou, Sci. Rep. 2012, 2, 357.
29. K. Numata, D. L. Kaplan, Adv. Drug Delivery Rev. 2010, 62, 1497.
30. M.-C. Chen, S.-F. Huang, K.-Y. Lai, M.-H. Ling, Biomaterials 2013, 34, 3077.
31. F. O. Nestle, M. P. Di, J.-Z. Qin, B. J. Nickoloff, Nat. Rev. Immunol. 2009, 9, 679.
32. R. E. Lanford, Z. Feng, D. Chavez, B. Guerra, K. M. Brasky, Y. Zhou, D. Yamane, A. S. Perelson, C. M. Walker, S. M. Lemon, Proc. Natl. Acad. Sci. U.S.A. 2011, 108, 11223.
33. B. Levine, J. M. Hardwick, B. D. Trapp, T. O. Crawford, R. C. Bollinger, D. E. Griffin, Science 1991, 254, 856.
34. D. L. Woodland, J. E. Kohlmeier, Nat. Rev. Immunol. 2009, 9, 153.
35. D. Gray, Nat. Rev. Immunol. 2002, 2, 60.
36. S. N. Mueller, R. Ahmed, Proc. Natl. Acad. Sci. U.S.A. 2009, 106, 8623.