Structural basis for the design of selective phosphodiesterase 4B inhibitors

Cellular Signalling

Volumn 26, Issue 3, 2014, Pages 657-663

  Fox, David ^a   Burgin, Alex B ^a   Gurney, Mark E ^b,c  

^a Emerald BioSystems   (United States)

^b Tetra Discovery Partners   (United States)

^c WEST VIRGINIA UNIVERSITY   (United States)

Author keywords

Anti inflammatory; Control helix; Inhibitor; PDE4B; Phosphodiesterase 4B

Indexed keywords

CYCLIC AMP; PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IV INHIBITOR; PHOSPHODIESTERASE IVB; PHOSPHODIESTERASE IVB INHIBITOR; PHOSPHODIESTERASE IVD; UNCLASSIFIED DRUG;

ARTICLE; BINDING AFFINITY; BINDING SITE; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; CRYSTAL STRUCTURE; DNA SEQUENCE; DRUG DESIGN; DRUG PROTEIN BINDING; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME ASSAY; ENZYME REGULATION; MOLECULAR DYNAMICS; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN DNA BINDING; PROTEIN LOCALIZATION; PROTEIN POLYMORPHISM; SEQUENCE ANALYSIS; SIGNAL TRANSDUCTION; STRUCTURE ANALYSIS;

ANTI-INFLAMMATORY; CONTROL HELIX; CONTROL REGION 3; CR3; INHIBITOR; PDE4B; PHOSPHODIESTERASE-4B;

AMINO ACID SEQUENCE; ANTI-INFLAMMATORY AGENTS; CATALYTIC DOMAIN; CRYSTALLOGRAPHY, X-RAY; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; DRUG DESIGN; MACROPHAGES; MICROGLIA; MODELS, MOLECULAR; MONOCYTES; PHOSPHODIESTERASE 4 INHIBITORS; POLYMORPHISM, GENETIC; TUMOR NECROSIS FACTOR-ALPHA;

EID: 84891758780     PISSN: 08986568     EISSN: 18733913     Source Type: Journal    
DOI: 10.1016/j.cellsig.2013.12.003     Document Type: Article

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