HDAC9 knockout mice are protected from adipose tissue dysfunction and systemic metabolic disease during high-fat feeding

Diabetes

Volumn 63, Issue 1, 2014, Pages 176-187

  Chatterjee, Tapan K ^a,c   Basford, Joshua E ^a   Knoll, Ellen ^a   Tong, Wilson S ^a   Blanco, Victor ^a   Blomkalns, Andra L ^a   Rudich, Steven ^b   Lentsch, Alex B ^b   Hui, David Y ^a   Weintraub, Neal L ^a,c  

^a UNIVERSITY OF CINCINNATI COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF CINCINNATI   (United States)

^c MEDICAL COLLEGE OF GEORGIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; CCAAT ENHANCER BINDING PROTEIN ALPHA; CHOLESTEROL; GLUCOSE; HISTONE DEACETYLASE; HISTONE DEACETYLASE 9; INSULIN; LEPTIN; LIPID; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA; RESISTIN; UNCLASSIFIED DRUG;

ADIPOCYTE; ADIPOGENESIS; ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BROWN ADIPOSE TISSUE; CALORIMETRY; CELL DIFFERENTIATION; CHOLESTEROL BLOOD LEVEL; CONTROLLED STUDY; ENERGY EXPENDITURE; EPIDIDYMIS FAT; FAT MASS; FATTY LIVER; GENE DELETION; GENE EXPRESSION; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; IN VITRO STUDY; INSULIN BLOOD LEVEL; INSULIN RELEASE; INSULIN SENSITIVITY; LIPID DIET; LIPID LIVER LEVEL; LIPID STORAGE; MALE; MARKER GENE; METABOLIC DISORDER; MOUSE; NONHUMAN; OBESITY; OXYGEN CONSUMPTION; PRIORITY JOURNAL; PROADIPOCYTE; PROTEIN EXPRESSION; SUBCUTANEOUS FAT; SUBCUTANEOUS FAT DISORDER; SYSTEMIC DISEASE; THERMOGENESIS; UPREGULATION; WEIGHT GAIN; WHITE ADIPOSE TISSUE; WILD TYPE;

EID: 84891751641     PISSN: 00121797     EISSN: 1939327X     Source Type: Journal    
DOI: 10.2337/db13-1148     Document Type: Article

References (22)

1. Hauner H. Secretory factors from human adipose tissue and their functional role. Proc Nutr Soc 2005;64:163-169
2. Rigamonti A, Brennand K, Lau F, Cowan CA. Rapid cellular turnover in adipose tissue. PLoS One 2011;6:e17637
3. Joe AW, Yi L, Even Y, Vogl AW, Rossi FM. Depot-specific differences in adipogenic progenitor abundance and proliferative response to high-fat diet. Stem Cells 2009;27:2563-2570
4. Pinnick KE, Karpe F. DNA methylation of genes in adipose tissue. Proc Nutr Soc 2011;70:57-63
5. Chatterjee TK, Idelman G, Blanco V, et al. Histone deacetylase 9 is a negative regulator of adipogenic differentiation. J Biol Chem 2011;286: 27836-27847
6. Fisher FM, Kleiner S, Douris N, et al. FGF21 regulates PGC-1α and browning of white adipose tissues in adaptive thermogenesis. Genes Dev 2012;26:271-281
7. Zhang CL, McKinsey TA, Chang S, Antos CL, Hill JA, Olson EN. Class II histone deacetylases act as signal-responsive repressors of cardiac hypertrophy. Cell 2002;110:479-488
8. Chatterjee TK, Stoll LL, Denning GM, et al. Proinflammatory phenotype of perivascular adipocytes: influence of high-fat feeding. Circ Res 2009;104: 541-549
9. Romero MdelM, Grasa MdelM, Esteve M, Fernández-López JA, Alemany M. Semiquantitative RT-PCR measurement of gene expression in rat tissues including a correction for varying cell size and number. Nutr Metab (Lond) 2007;4:26
10. Hofmann SM, Zhou L, Perez-Tilve D, et al. Adipocyte LDL receptor-related protein-1 expression modulates postprandial lipid transport and glucose homeostasis in mice. J Clin Invest 2007;117:3271-3282
11. Seale P, Conroe HM, Estall J, et al. Prdm16 determines the thermogenic program of subcutaneous white adipose tissue in mice. J Clin Invest 2011; 121:96-105
12. Fitzgibbons TP, Kogan S, Aouadi M, Hendricks GM, Straubhaar J, Czech MP. Similarity of mouse perivascular and brown adipose tissues and their resistance to diet-induced inflammation. Am J Physiol Heart Circ Physiol 2011;301:H1425-H1437
13. Wu J, Boström P, Sparks LM, et al. Beige adipocytes are a distinct type of thermogenic fat cell in mouse and human. Cell 2012;150:366-376
14. Wu J, Cohen P, Spiegelman BM. Adaptive thermogenesis in adipocytes: is beige the new brown? Genes Dev 2013;27:234-250
15. Schulz TJ, Huang P, Huang TL, et al. Brown-fat paucity due to impaired BMP signalling induces compensatory browning of white fat. Nature 2013; 495:379-383
16. Auffret J, Viengchareun S, Carré N, et al. Beige differentiation of adipose depots in mice lacking prolactin receptor protects against high-fat-dietinduced obesity. FASEB J 2012;26:3728-3737
17. Qian SW, Tang Y, Li X, et al. BMP4-mediated brown fat-like changes in white adipose tissue alter glucose and energy homeostasis. Proc Natl Acad Sci USA 2013;110:E798-E807
18. Ye L, Wu J, Cohen P, et al. Fat cells directly sense temperature to activate thermogenesis. Proc Natl Acad Sci U S A 2013;110:12480-12485
19. Lenoir O, Flosseau K, Ma FX, et al. Specific control of pancreatic endocrine β- and δ-cell mass by class IIa histone deacetylases HDAC4, HDAC5, and HDAC9. Diabetes 2011;60:2861-2871
20. Lee P, Werner CD, Kebebew E, Celi FS. Functional thermogenic beige adipogenesis is inducible in human neck fat. Int J Obes (Lond). 21 May 2013. [Epub ahead of print]
21. Cypess AM, Lehman S, Williams G, et al. Identification and importance of brown adipose tissue in adult humans. Genes Dev 2013;27:234-250
22. Sharp LZ, Shinoda K, Ohno H, et al. Human BAT possesses molecular signatures that resemble beige/brite cells. PLoS One 2012;7:e49452