Tailoring small molecules for an allosteric site on procaspase-6

ChemMedChem

Volumn 9, Issue 1, 2014, Pages 73-77

  Murray, Jeremy ^a   Giannetti, Anthony M ^a   Steffek, Micah ^a   Gibbons, Paul ^a   Hearn, Brian R ^b   Cohen, Frederick ^a   Tam, Christine ^a   Pozniak, Christine ^a   Bravo, Brandon ^a   Lewcock, Joe ^a   Jaishankar, Priyadarshini ^b   Ly, Cuong Q ^a   Zhao, Xianrui ^a   Tang, Yinyan ^b   Chugha, Preeti ^b   Arkin, Michelle R ^b   Flygare, John ^a   Renslo, Adam R ^b  

^a GENENTECH INC   (United States)

^b UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

caspase modulation; caspase 6; drug design; fragment merging; fragment screening

Indexed keywords

CASPASE 6; ENZYME PRECURSOR; PROCASPASE 6; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; BINDING AFFINITY; BINDING SITE; CRYSTAL STRUCTURE; DOSE RESPONSE; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME STABILITY; HYDROGEN BOND; PRIORITY JOURNAL; SURFACE PLASMON RESONANCE; X RAY CRYSTALLOGRAPHY;

CASPASE MODULATION; CASPASE-6; DRUG DESIGN; FRAGMENT MERGING; FRAGMENT SCREENING;

ALLOSTERIC SITE; BINDING SITES; CASPASE 6; CRYSTALLOGRAPHY, X-RAY; DIMERIZATION; DRUG DESIGN; ENZYME PRECURSORS; HYDROGEN-ION CONCENTRATION; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SMALL MOLECULE LIBRARIES; TRANSITION TEMPERATURE;

EID: 84891746290     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300424     Document Type: Article

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