Intraductal papillary neoplasms of the bile duct: Stepwise progression to carcinoma involves common molecular pathways

Modern Pathology

Volumn 27, Issue 1, 2014, Pages 73-86

  Schlitter, Anna Melissa ^a   Born, Diana ^b   Bettstetter, Marcus ^c   Specht, Katja ^a   Kim Fuchs, Corina ^d   Riener, Marc Oliver ^e   Jeliazkova, Petia ^f   Sipos, Bence ^g   Siveke, Jens T ^f   Terris, Benoit ^h   Zen, Yoh ⁱ   Schuster, Tibor ^a   Höfler, Heinz ^a   Perren, Aurel ^b   Klöppel, Günter ^a   Esposito, Irene ^a  

^a TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^b UNIVERSITY OF BERN   (Switzerland)

^c Molecular Pathology South Bavaria   (Germany)

^d UNIVERSITY OF BERN   (Switzerland)

^e UNIVERSITY HOSPITAL ERLANGEN   (Germany)

^f TECHNICAL UNIVERSITY OF MUNICH   (Germany)

^g UNIVERSITY HOSPITAL TÜBINGEN   (Germany)

^h université Paris Cité   (France)

ⁱ KING S COLLEGE HOSPITAL   (United Kingdom)

Author keywords

bile duct tumors; GNAS; intraductal precursor lesion; KRAS

Indexed keywords

BETA CATENIN; EPIDERMAL GROWTH FACTOR RECEPTOR 2; GNAS PROTEIN; MUCIN; PROTEIN; PROTEIN P16; PROTEIN P53; SMAD4 PROTEIN; TRANSCRIPTION FACTOR CDX2; UNCLASSIFIED DRUG; VASCULOTROPIN;

ADULT; AGED; ARTICLE; BILE DUCT CARCINOMA; BILE DUCT TUMOR; BILIARY TRACT TUMOR; CANCER GRADING; CANCER SURVIVAL; CARCINOGENESIS; CLINICAL ARTICLE; COHORT ANALYSIS; CONTROLLED STUDY; FEMALE; GENE LOSS; GENE MUTATION; GENE OVEREXPRESSION; HISTOPATHOLOGY; HUMAN; IMMUNOHISTOCHEMISTRY; INTESTINE TUMOR; INTRADUCTAL CARCINOMA; INTRADUCTAL PAPILLARY NEOPLASM; INVASIVE CARCINOMA; MALE; MIDDLE AGED; MOLECULAR PATHOLOGY; ONCOGENE K RAS; OVERALL SURVIVAL; PANCREAS TUMOR; PRIORITY JOURNAL; STOMACH TUMOR; TUMOR GROWTH; VERY ELDERLY;

ADULT; AGED; AGED, 80 AND OVER; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; BIOPSY; CARCINOMA IN SITU; CARCINOMA, INTRADUCTAL, NONINFILTRATING; CHOLANGIOCARCINOMA; CYCLIN-DEPENDENT KINASE INHIBITOR P16; DISEASE PROGRESSION; DNA MUTATIONAL ANALYSIS; EUROPE; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; KAPLAN-MEIER ESTIMATE; MALE; MIDDLE AGED; MUTATION; NEOPLASM GRADING; NEOPLASM INVASIVENESS; PAPILLOMA; PROGNOSIS; PROPORTIONAL HAZARDS MODELS; PROTO-ONCOGENE PROTEINS; RAS PROTEINS; SIGNAL TRANSDUCTION; TIME FACTORS; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84891745466     PISSN: 08933952     EISSN: 15300285     Source Type: Journal    
DOI: 10.1038/modpathol.2013.112     Document Type: Article

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