Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis

Liver International

Volumn 27, Issue 9, 2007, Pages 1174-1184

  Itatsu, Keita ^a,b   Zen, Yoh ^c   Ohira, Shusaku ^a,b   Ishikawa, Akira ^a,b   Sato, Yasunori ^a   Harada, Kenichi ^a   Ikeda, Hiroko ^a   Sasaki, Motoko ^a   Nimura, Yuji ^b   Nakanuma, Yasuni ^a  

^a KANAZAWA UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCE   (Japan)

^b NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^c KANAZAWA UNIVERSITY HOSPITAL   (Japan)

Author keywords

Hepatolithiasis; Intraductal papillary neoplasm; Intraepithelial neoplasia; Intrahepatic cholangiocarcinoma; Intrahepatic large bile duct

Indexed keywords

BETA CATENIN; CYCLIN D1; MATRILYSIN; MATRIX METALLOPROTEINASE 14; MYC PROTEIN; UVOMORULIN; WNT PROTEIN;

ADULT; AGED; ARTICLE; BILE DUCT CANCER; BILE DUCT STONE; BILIARY INTRAEPITHELIAL NEOPLASIA; CANCER GROWTH; CANCER INVASION; CONTROLLED STUDY; DISEASE COURSE; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; INTRADUCTAL PAPILLARY NEOPLASM OF THE BILE DUCT; INTRAHEPATIC CHOLANGIOCARCINOMA; LIVER CARCINOGENESIS; LIVER CARCINOMA; MAJOR CLINICAL STUDY; MALE; MALIGNANT TRANSFORMATION; PROTEIN EXPRESSION; PROTEIN LOCALIZATION; SIGNAL TRANSDUCTION;

ADENOCARCINOMA, PAPILLARY; AGED; AGED, 80 AND OVER; BETA CATENIN; BILE DUCT NEOPLASMS; BILE DUCTS, INTRAHEPATIC; CADHERINS; CHOLANGIOCARCINOMA; CHOLELITHIASIS; CYCLINS; DISEASE PROGRESSION; DISEASE-FREE SURVIVAL; FEMALE; HUMANS; IMMUNOENZYME TECHNIQUES; MALE; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 7; MIDDLE AGED; PRECANCEROUS CONDITIONS; PROTO-ONCOGENE PROTEINS C-MYC; TUMOR MARKERS, BIOLOGICAL;

EID: 35148830425     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2007.01577.x     Document Type: Article

References (48)

1. Malhi H, Gores GJ. Cholangiocarcinoma: Modern advances in understanding a deadly old disease. J Hepatol 2006; 45: 856-67.
2. Okuda K, Nakanuma Y, Miyazaki M. Cholangiocarcinoma: Recent progress. Part 1: Epidermiology and etiology. J Gastroenterol Hepatol 2002; 17: 1049-55.
3. Nakanuma Y, Terada T, Tanaka Y, et al. Are hepatolithiasis and cholangiocarcinoma aetiologically related? A morphological study of 12 cases of hepatolithiasis associated with cholangiocarcinoma. Virchows Arch A Pathol Anat Histopathol 1985; 406: 45-58.
4. Shimonishi T, Zen Y, Chen TC, et al. Increasing expression of gastrointestinal phenotypes and p53 along with histologic progression of intraductal papillary neoplasia of the liver. Hum Pathol 2002; 33: 503-11.
5. Zen Y, Sasaki M, Fujii T, et al. Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct-an immunohistochemical study of 110 cases of hepatolithiasis. J Hepatol 2006; 44: 350-8.
6. Chen TC, Nakanuma Y, Zen Y, et al. Intraductal papillary neoplasia of the liver associated with hepatolithiasis. Hepatology 2001; 34: 651-8.
7. Adsay NV, Merati K, Andea A, et al. The dichotomy in the preinvasive neoplasia to invasive carcinoma sequence in the pancreas: Differential expression of MUC1 and MUC2 supports the existence of two separate pathways of carcinogenesis. Mod Pathol 2002; 15: 1087-95.
8. Hruban RH, Takaori K, Klimstra DS, et al. An illustrated consensus on the classification of pancreatic intraepithelial neoplasia and intraductal papillary mucinous neoplasms. Am J Surg Pathol 2004; 28: 977-87.
9. Zen Y, Fujii T, Itatsu K, et al. Biliary papillary tumors share pathological features with intraductal papillary mucinous neoplasm of the pancreas. Hepatology 2006; 44: 1333-43.
10. Ishikawa A, Sasaki M, Ohira S, et al. Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis. Lab Invest 2004; 84: 629-38.
11. Giles RH, van Es JH, Clevers H. Caught up in a Wnt storm: Wnt signaling in cancer. Biochim Biophys Acta 2003; 1653: 1-24.
12. Tokumoto N, Ikeda S, Ishizaki Y, et al. Immunohistochemical and mutational analyses of Wnt signaling components and target genes in intrahepatic cholangiocarcinomas. Int J Oncol 2005; 27: 973-80.
13. Nakanuma Y, Hoso M, Sanzen T, et al. Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply. Microsc Res Tech 1997; 38: 552-70.
14. Nakanuma Y, Yamaguchi K, Ohta G, et al. Pathologic features of hepatolithiasis in Japan. Hum Pathol 1988; 19: 1181-6.
15. Portmann BC, Nakanuma Y. Disease of the bile ducts. In: Burt AD, Portmann BC, Ferrell LD, eds. Mac Sween's Pathology of the Liver, 5th edn. Philadelphia: Churchill Livingstone, Elsevier, 2007; 517-81.
16. Nakanuma Y, Sripa B, Vatanasapt V, et al. Intrahepatic cholangiocarcinoma. In: Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours, Pathology and Genetics: Tumours of the Digestive Systems. Lyon, France: IARC Press, 2000; 173-80.
17. Zen Y, Aishima S, Ajioka Y, et al. Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement. Pathol Int 2005; 55: 180-8.
18. Longnecker DS, Hruban RH, Adler G, et al. Intraductal papillary-mucinous neoplasms of the pancreas. In: Hamilton SR, Aaltonen LA, eds. World Health Organization Classification of Tumours, Pathology and Genetics: Tumours of the Digestive Systems. Lyon, France: IARC Press, 2000; 237-40.
19. Adsay NV, Conlon KC, Zee SY, et al. Intraductal papillary-mucinous neoplasms of the pancreas: An analysis of in situ and invasive carcinomas in 28 patients. Cancer 2002; 94: 62-77.
20. Sudo Y, Harada K, Tsuneyama K, et al. Oncocytic biliary cystadenocarcinoma is a form of intraductal oncocytic papillary neoplasm of the liver. Mod Pathol 2001; 14: 1304-9.
21. Spector SA, Bejarano PA, Amortegui JD, et al. Intraductal oncocytic papillary neoplasm of the extrahepatic biliary tree: First report. Am Surg 2004; 70: 55-8.
22. Ashida K, Terada T, Kitayama Y, et al. Expression of E-cadherin, α-catenin, β-catenin, and CD44 (standard and variant isoforms) in human cholangiocarcinoma: An immunohistochemical study. Hepatology 1998; 27: 974-82.
23. Sugimachi K, Taguchi K, Aishima A, et al. Altered expression of β-catenin without genetic mutation in intrahepatic cholangiocarcinoma. Mod Pathol 2001; 14: 900-5.
24. Ishikawa A, Sasaki M, Sato Y, et al. Frequent p16 ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis. Hum Pathol 2004; 35: 1505-14.
25. Kang YK, Kim WH, Jang JJ. Expression of G1-S modulators (p53, p16, p27, cyclin D1, Rb) and Smad4/Dpc4 in intrahepatic cholangiocarcinoma. Hum Pathol 2002; 33: 877-83.
26. Settakorn J, Kaewpila N, Burns GF, et al. FAT, E-cadherin, beta catenin, HER 2/neu, Ki67 immuno-expression, and histological grade in intrahepatic cholangiocarcinoma. J Clin Pathol 2005; 58: 1249-54.
27. Kolligs FT, Bommer G, Göke B. Wnt/beta-catenin/Tcf signaling: A critical pathway in gastrointestinal tumorigenesis. Digestion 2002; 66: 131-44.
28. Mikami T, Saegusa M, Mitomi H, et al. Significant correlations of E-cadherin, catenin, and CD44 variant form expression with carcinoma cell differentiation and prognosis of extrahepatic bile duct carcinoma. Am J Clin Pathol 2001; 116: 369-76.
29. Siitonen SM, Kononen JT, Helin HJ, et al. Reduced E-cadherin expression is associated with invasiveness and unfavorable prognosis in breast cancer. Am J Clin Pathol 1996; 105: 394-402.
30. Tajima Y, Kuroki T, Fukuda K, et al. An intraductal papillary component is associated with prolonged survival after hepatic resection for intrahepatic cholangiocarcinoma. Br J Surg 2004; 91: 99-104.
31. Yeh TS, Tseng JH, Chen TC, et al. Characterization of intrahepatic cholangiocarcinoma of the intraductal growth-type and its precursor lesions. Hepatology 2005; 42: 657-64.
32. Westermarck J, Kahari VM. Regulation of matrix metalloproteinase expression in tumor invasion. FASEB J 1999; 13: 781-92.
33. Adachi Y, Yamamoto H, Itoh F, et al. Contribution of matrilysin (MMP-7) to the metastatic pathway of human colorectal cancers. Gut 1999; 45: 252-8.
34. Ishikawa T, Ichikawa Y, Mitsuhashi M, et al. Matrilysin is associated with progression of colorectal tumor. Cancer Lett 1996; 107: 5-10.
35. Sato H, Takino T, Okada Y, et al. A matrix metalloproteinase expressed on the surface of invasive tumour cells. Nature 1994; 370: 61-5.
36. Seiki M. Membrane-type 1 matrix metalloproteinase: A key enzyme for tumor invasion. Cancer Lett 2003; 194: 1-11.
37. Shirabe K, Shimada M, Kajiyama K, et al. Expression of matrix metalloproteinase-9 in surgically resected intrahepatic cholangiocarcinoma. Surgery 1999; 126: 842-6.
38. Terada T, Okada Y, Nakanuma Y. Expression of immunoreactive matrix metalloproteinases in human normal livers and primary liver tumors. Hepatology 1996; 23: 1341-4.
39. Miwa S, Miyagawa S, Soeda J, et al. Matrix metalloproteinase-7 expression and biologic aggressiveness of cholangiocellular carcinoma. Cancer 2002; 94: 428-34.
40. Sugimachi K, Aishima S, Taguchi K, et al. The role of overexpression and gene amplification of cyclin D1 in intrahepatic cholangiocarcinoma. J Hepatol 2001; 35: 74-9.
41. Sherr CJ. Cancer cell cycles. Science 1996; 274: 1672-7.
42. He T-C, Sparks AB, Rago C, et al. Identification of c-MYC as a target of the APC pathway. Science 1998; 281: 1509-12.
43. Doucas H, Garcea G, Neal CP, et al. Change in the Wnt signaling pathway in gastrointestinal cancers and their prognostic significance. Eur J Cancer 2005; 41: 365-79.
44. Li YJ, Wei ZM, Meng YX, et al. Beta-catenin up-regulates the expression of cyclinD1, c-myc, and MMP-7 in human pancreatic cancer: Relationships with carcinogenesis and metastasis. World J Gastroenterol 2005; 11: 2117-23.
45. Kikuchi A. Regulation of β-catenin signaling in the Wnt pathway. Biochem Biophys Res Commun 2000; 268: 243-8.
46. Abraham SC, Lee JH, Hruban RH, et al. Molecular and immunohistochemical analysis of intraductal papillary neoplasms of the biliary tract. Hum Pathol 2003; 34: 902-10.
47. Takahashi M, Tsunoda T, Seiki M, et al. Identification of membrane-type matrix metalloproteinase-1 as a target of the beta-catenin/Tcf4 complex in human colorectal cancers. Oncogene 2002; 21: 5861-7.
48. Shibahara H, Tamada S, Goto M, et al. Pathologic features of mucin-producing bile duct tumors: Two histopathologic categories as counterparts of pancreatic intraductal papillary-mucinous neoplasms. Am J Surg Pathol 2004; 28: 327-38.