HIV and ageing: What the geriatrician needs to know

Reviews in Clinical Gerontology

Volumn 24, Issue 1, 2014, Pages 10-24

  Levett, T ^a   Wright, J ^a   Fisher, M ^a  

^a ROYAL SUSSEX COUNTY HOSPITAL   (United Kingdom)

Author keywords

ageing; geriatrics; HIV; review

Indexed keywords

ALENDRONIC ACID; ANTIRETROVIRUS AGENT; ANTITHROMBOCYTIC AGENT; NONNUCLEOSIDE REVERSE TRANSCRIPTASE INHIBITOR; PROTEINASE INHIBITOR; RNA DIRECTED DNA POLYMERASE INHIBITOR; TENOFOVIR;

AGING; ARTICLE; BONE DENSITY; BRAIN HEMORRHAGE; CD4 LYMPHOCYTE COUNT; CEREBROVASCULAR ACCIDENT; COGNITION; COMORBIDITY; DRUG EFFICACY; DRUG SAFETY; DUAL ENERGY X RAY ABSORPTIOMETRY; FRAGILITY FRACTURE; GERIATRICIAN; HIV ASSOCIATED DEMENTIA; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; MEDICATION ERROR; OSTEOPENIA; OSTEOPOROSIS; PALLIATIVE THERAPY; POLYPHARMACY; PRACTICE GUIDELINE; SOCIAL NETWORK; SOCIAL STATUS; SOCIAL SUPPORT;

EID: 84891743050     PISSN: 09592598     EISSN: 14699036     Source Type: Journal    
DOI: 10.1017/S0959259813000208     Document Type: Article

References (134)

1. The Antiretroviral Therapy Cohort Collaboration. Life expectancy of individuals on combination antiretroviral therapy in high-income countries: a collaborative analysis of 14 cohort studies. Lancet 2008; 372: 293-99.
2. May M, Gompels M, Delpech V et al. Impact of late diagnosis and treatment on life expectancy in people with HIV-1: UK Collaborative HIV Cohort (UK CHIC) Study. BMJ 2011; 343: d6016 (accessed March 2013).
3. Health Protection Agency. HIV in the United Kingdom: 2012 Report. London: Health Protection Services, Colindale. November 2012. Available at: http://www.hpa.org.uk/webc/HPAwebFile/HPAweb-C/1317137200016 (accessed March 2013).
4. Effros RB, Fletcher CV, Gebo K et al. Aging and infectious disease: workshop on HIV and aging: what is known and future research directions. Clin Infectious Disease 2008; 47: 542-53.
5. O'Keefe KJ, Scheer S, Chen MJ et al. People fifty years or older now account for the majority of AIDS cases in San Francisco, California, 2010. AIDS Care, online edition, 2013; doi: 10.1080/095401212.2012.752565.
6. Negin J, Cumming RG. HIV infection in older adults in sub-Saharan Africa: extrapolating prevalence from existing data. Bull World Health Org 2010; 88: 847-53.
7. Mills EJ, B̈arnighausen T, Negin J. HIV and aging-preparing for the challenges ahead. New Engl J Med 2012; 366: 1270-73.
8. Onen NF, Shacham E, Stamm KE, Overton ET. Comparisons of sexual behaviors and STD prevalence among older and younger individuals with HIV infection. AIDS Care 2010; 22: 711-17.
9. Dolcini MM, Catania JA, Stall RD, Pollack L. The HIV epidemic among older men who have sex with men. J Acquired Immune Deficiency Syndromes 2003; 33: S115-21. (Pubitemid 36801609)
10. Lindau ST, Schumm LP, Laumann EO, Levinson W, O'Muircheartaigh CA, Waite LJ. A study of sexuality and health among older adults in the United States. New Engl J Med 2007; 357, 762-74. (Pubitemid 47295643)
11. Pratt G, Gascoyne K, Cunningham K, Tunbridge A. Human immunodeficiency virus (HIV) in older people. Age Ageing 2010; 39: 289-94.
12. Cahill A, Valadez R. Growing older with HIV/AIDS: new public health challenges. Am J Public Health 2013; 103: e7-15.
13. Kearney F, Moore A, Donegan CF, Lambert J. The ageing of HIV: implications for geriatric medicine. Age Ageing 2010; 39: 536-41.
14. Smith RD, Delpech VC, Brown AE, Rice BD. HIV transmission and high rates of late diagnoses among adults aged 50 years and over. AIDS 2010; 24: 2109-15.
15. Iwuji CC, Churchill D, Gilleece Y et al. Older HIV-infected individuals present late and have a higher mortality: Brighton, UK cohort study. BMC Public Health 2013; 13: 397.
16. Vance DE, Mugavero M, Willig J, Raper JL, Saag MS. Aging with HIV: a cross-sectional study of comorbidity prevalence and clinical characteristics across decades of life. J Assoc Nurses AIDS Care 2011; 22: 17-25.
17. CASCADE Collaboration. Determinants of survival following HIV-1 seroconversion after the introduction of HAART. Lancet 2003; 362: 1267-74.
18. Perez JL, Moore RD. Greater effect of highly active antiretroviral therapy on survival in people aged or = 50 years compared with younger people in an urban observational cohort. Clin Infect Dis 2003; 36: 212-18. (Pubitemid 36143421)
19. Deeks SG, Phillips AN. HIV infection, antiretroviral treatment, ageing, and non-AIDS related morbidity. BMJ 2008; 338: 288-92.
20. Reiss P. The art of managing Human Immunodeficiency Virusi: a balancing act. Clin Infectious Dis 2009; 49: 1602-4.
21. Fisher M, Cooper V. HIV and ageing: premature ageing or premature conclusions Current Opin Infectious Dis 2012; 25: 1-3.
22. Obel N, Omland LH, Kronborg G et al. Impact of non-HIV and HIV risk factors on survival in HIV-infected patients on HAART: a populationbased nationwide cohort study. PLoS One 2011; 6: e22698. doi: 10.1371/journal.pone. 0022698.
23. Guaraldi G, Orlando G, Zona S et al. Premature age-related co-morbidities among HIV-infected persons compared to the general population. Clin Infect Dis 2011; 53: 1120-26.
24. Hasse B, Ledergerber B, Furrer H et al. Morbidity and aging in HIV-infected persons: the Swiss HIV cohort study. Clin Infectious Dis 2011; 53: 1130-39.
25. Lewden C, May T, Rosenthal E et al. Changes in causes of death among adults infected by HIV between 2000 and 2005: the 'Mortalite 2000 and 2005' surveys. J Acquir Immune Defic Syndr 2008; 48: 590-98.
26. Rhee MS, Greenblatt DJ. Pharmacologic considerations for the use of antiretroviral agents in the elderly. J Clin Pharmacol 2008; 48: 1212-25.
27. Nogueras M, Navarro G, Anton E et al. Epidemiological and clinical features, response to HAART, and survival in HIV-infected patients diagnosed at the age of 50 or more. BMC Infectious Dis 2006; 4: 46.
28. Gebo KA. Epidemiology of HIV and the response to antiretroviral therapy in the middle aged and elderly. Aging Health 2008; 4: 615-27.
29. Sabin CA, Smith CJ, d'Arminio Monforte A et al. Response to combination antiretroviral therapy: variation by age. AIDS 2008; 22: 1463-73.
30. Branas F, Berenguer J, Sanchez-Conde M et al. The eldest of older adults living with HIV: response and adherence to highly active antiretroviral therapy. Am J Med 2008; 121: 820-24.
31. European Clinical AIDS Society. Guidelines. 2009. Available at: http://www.europeanaids clinicalsociety.org/images/stories/EACSPdf/version-5- november2009-eacsguidelines-cologne.pdf (accessed July 2013).
32. Orlando G, Meraviglia P, Cordier L et al. Antiretroviral treatment and age related co-morbidities in a cohort of older HIV-infected patients. HIV Med 2006; 7: 549-57. (Pubitemid 44742356)
33. Sabin CA, Smith CJ, Delpech V et al. The associations between age and the development of laboratory abnormalities and treatment discontinuation for reasons other than virological failure in the first year of highly active antiretroviral therapy. HIV Med 2009; 10: 35-43.
34. Marzolini C, Back D, Weber R et al. Ageing with HIV: medication use and risk for potential drug-drug interactions. J Antimicrobial Chemotherapy 2011; 66: 2107-11.
35. Sherr L, Harding R, Lampe F et al. Clinical and behavioural aspects of aging with HIV infection. Psychol Health Med. 2009; 14: 273-79.
36. McLennon SM, Smith R and Orrick JJ. Recognizing and preventing drug interactions in older adults with HIV. J Gerontol Nursing 2003; 29: 5-12.
37. Marzolini C, Elzi L, Gibbons S et al. Prevalence of comedications and the effect of potential drug-drug interactions in the Swiss HIV Cohort Study. Antiviral Therapy 2010; 15: 413-23.
38. Waters L, Patterson B, Scourfield A et al. A dedicated clinic for HIV-positive individuals over 50 years of age: a multidisciplinary experience. Int J STI AIDS 2012; 23: 546-52.
39. Rastegar DA, Knight AM, Monolakis JS. Antiretroviral medication errors among hospitalized patients with HIV infection. Clin Infect Dis 2006; 43: 933-38. (Pubitemid 44435525)
40. Mok S, Minson Q. Drug-related problems in hospitalized patients with HIV. Am J Health Syst Pharm 2008; 65: 55-59.
41. Evans-Jones J, Cottle LE, Back DJ et al. Recognition of risk for clinically significant drug interactions among HIV-infected patients receiving antiretroviral therapy. Clin Infect Dis 2010; 50: 1419-21.
42. Hinkin CH, Hardy DJ, Mason KI et al. Medication adherence in HIV-infected adults: effect of patient age, cognitive status and substance abuse. AIDS 2004; 18 (suppl 1): S19-25. (Pubitemid 38365902)
43. Lee S, Shafe ACE, Cowie MR. UK stroke incidence, mortality and cardiovascular risk management 1999-2008: time-trend analysis from the General Practice Research Database. BMJ Open 2011; 1:e000269. Available at: http://bmjopen.bmj.com/content/1/2/e000269. long (accessed 29 March 2013)
44. Ovbiagele B, Nath A. Increasing incidence of ischemic stroke in patients with HIV infection. Neurology 2011; 76: 444-50.
45. Benjamin LA, Bryer A, Emsley HCA, Khoo S, Solomon T, Connor MD. HIV infection and stroke: current perspectives and future directions. Lancet Neurology 2012; 11: 878-90.
46. Corral I, Quereda C, Moreno A et al. Cerebrovascular ischemic events in HIV-1-infected patients receiving highly active antiretroviral therapy: incidence and risk factors. Cerebrovasc Dis 2009; 27: 559-63.
47. Pinto AN. AIDS and cerebrovascular disease. Stroke 1996; 27: 538-43. (Pubitemid 26081455)
48. Cole JW, Pinto AN, Hebel JR et al. Acquired immunodeficiency syndrome and the risk of stroke. Stroke 2004; 35: 51-56. (Pubitemid 38057589)
49. Modi G, Modi M, Mochan A. Is stroke a HIV-related neurological manifestation Expert Rev Neurotherapeutics 2008; 8: 1247-53.
50. Rasmussen LD, Engsig FN, Christensen H et al. Risk of cerebrovascular events in persons with and without HIV: a Danish nationwide population-based cohort study. AIDS 2011; 25: 1637-46.
51. Chow FC, Regan S, Feske S, Meigs J, Grinspoon SK, Triant VA. Comparison of ischaemic stroke incidence in HIV-Infected and non-HIV-infected patients in a US health care system. J Acquir Immune Defic Syndrome 2012; 60: 351-58.
52. Tipping B, de Villiers L, Wainwright H, Candy S, Bryer A. Stroke in patients with human immunodeficiency virus. J Neurol Neurosurg Psychiatry 2007; 78: 1320-24. (Pubitemid 350221410)
53. Roquer J, Palomeras E, Knobel H, Pou A. Intracerebral haemorrhage and AIDS. Cerebrovasc Dis 1998; 8: 222-27.
54. Ortiz G, Koch S, Romano JG, Forteza AM, Rabinstein AA. Mechanisms of ischemic stroke in HIV-infected patients. Neurology 2007; 68: 1257-61. (Pubitemid 46625970)
55. Kumwenda JJ, Mateyu G, Kampondeni S, van Dam AP, van Lieshout L, Zijlstra EE. Differential diagnosis of stroke in a setting of high HIV prevalence in Blantyre, Malawi. Stroke 2005; 36: 960-64. (Pubitemid 40629284)
56. Lindsberg PJ, Grau AJ. Inflammation and infections as risk factors for ischemic stroke. Stroke 2003; 34: 2518-32. (Pubitemid 37221976)
57. Sen S, Rabinstein AA, Elkind MS, Powers WJ. Recent developments regarding human immunodeficiency virus infection and stroke. Cerebrovasc Dis 2012; 33: 209-18.
58. Boccara F, Cohen A. Coronary artery disease and stroke in HIV-infected patients: prevention and pharmacological therapy. Adv Cardiol 2003; 40: 163-84.
59. Dobbs MR, Berger JR. Stroke in HIV infection and AIDS. Expert Rev Cardiovasc Therapy 2009; 7: 1263-71.
60. Heaton RK, Franklin DR, Ellis RJ et al. HIV-associated neurocognitive disorders before and during the era of combination antiretroviral therapy: differences in rates, nature, and predictors. J Neurovirol 2011; 17: 3-16.
61. Garvey L, Surendrakumar V, Winston A. Low rates of neurocognitive impairment are observed in neuroasymptomatic HIV-infected subjects on effective antiretroviral therapy. HIV Clin Trials 2011; 12: 333-38.
62. Antinori A, Arendt G, Becker JT et al. Updated research nosology for HIV associated neurocognitive disorders. Neurology 2007; 69: 1789-99. (Pubitemid 350059308)
63. Gonźalez-Scarano F, Mart́n-Garća J. The neuropathogenesis of AIDS. Nat Rev Immunol 2005; 5: 69-81. (Pubitemid 40070332)
64. Robertson KR, Smurzynski M, Parsons TD et al. The prevalence and incidence of neurocognitive impairment in the HAART era. AIDS 2007; 21: 1915-21. (Pubitemid 47329768)
65. Mateen FJ, Mills EJ. Aging and HIV-related cognitive loss. JAMA 2012; 308: 349-50.
66. Department of Health. Living well with dementia: A National Dementia Strategy.
67. February 2009. Available at: http://www.dh.gov.uk/prod-consum-dh/groups/ dh-digitalassets/@dh/@en/documents/digitalasset/dh-094051.pdf (accessed 14 April 2013).
68. Asboe D, Aitken C, Boffito M et al. on behalf of the BHIVA Guidelines Subcommittee. British HIV Association guidelines for the routine investigation and monitoring of adult HIV-1-infected individuals 2011. HIV Med 2012; 13: 1-44.
69. British Psychological Society (BPS), British HIV Association (BHIVA) and Medical Foundation for AIDS & Sexual Health (MedFASH) Standards for psychological support for adults living with HIV.
70. November 2011. Available at: http://www.bhiva.org/ StandardsForPsychological Support.aspx (accessed 14 April 2013).
71. British HIV Association. Standards of Care for People Living with HIV, 2013. Available at: http://www.bhiva.org/documents/Standards-ofcare/ BHIVAStandardsA4.pdf (accessed 14 April 2013).
72. Smurzynski M, Wu K, Letendre S et al. Effects of central nervous system antiretroviral penetration on cognitive functioning in the ALLRT cohort. AIDS 2011; 25: 357-65.
73. Erlandson KM, Allshouse AA, Jankowski CM et al. Risk factors for falls in HIV-infected persons. J Acquired Immune Deficiency Syndrome 2012; 61: 484-89.
74. Tinetti ME. Preventing falls in elderly persons. New Engl J Med 2003; 348: 42-49. (Pubitemid 36026346)
75. Brown TT, Qaqish RB. Antiretroviral therapy and the prevalence of osteoporosis and osteopenia: A meta-analytical review. AIDS 2006; 20: 2164-74.
76. Arnsten JH, Freeman R, Howard AA, Floris-Moore M, Lo Y, Klein RS. Decreased bone mineral density and increased fracture risk in aging men with or at risk of HIV infection. AIDS 2007; 21: 617-23.
77. Pepe J, Isidori AM, Falciano M et al. The combination of FRAX and Ageing Male Symptoms scale better identifies treated HIV in males at risk for major fracture. Clin Endocrinol 2012; 77: 672-78.
78. Mary-Krause M, Viard JP, Ename-Mkoumazok B et al. Prevalence of low bone mineral density in men and women infected with human immunodeficiency virus 1 and a proposal for screening strategy. J Clin Densitometry 2012; 15: 422-33.
79. Prior J, Burdge D, Maan E et al. Fragility fractures and bone mineral density in HIV positive women: a case-control population-based study. Osteoporosis Int 2007; 18: 1345-53. (Pubitemid 47389474)
80. Arnsten JH, Freeman R, Howard AA, Floris-Moore M, Santoro N, Schoenbaum EE. HIV infection and bone mineral density in middle-aged women. Clin Infect Dis 2006; 42: 1014-20.
81. YinMT, McMahon DJ, Ferris DC et al. Low bone mass and high bone turnover in postmenopausal human immunodeficiency virus-infected women. J Clin Endocrinol Metab 2010; 95: 620-29.
82. Bonjoch A, Figueras M, Estany C et al. High prevalence of and progression to low bone mineral density in HIV-infected patients: a longitudinal cohort study. AIDS 2010; 24: 2827-33.
83. Jones S, Restrepo D, Kasowitz A et al. Risk factors for decreased bone density and effects of HIV on bone in the elderly. Osteoporosis Int 2008; 19: 913-18.
84. Ofotukun I, Weitzmann MN. HIV-1 infection and antiretroviral therapies: risk factors for osteoporosis and bone fracture. Curr Opin Endocrinol Diabetes Obesity 2010; 17: 523-29.
85. Cummings SR, Melton LJ. Epidemiology and outcomes of osteoporotic fractures. Lancet 2002; 359:1761-67.
86. Klotzbeucher CM, Ross PD, Landsman PB, Abbott TA, Berger M. Patients with prior fractures have an increased risk of future fractures: a summary of the literature and statistical synthesis. J Bone Mineral Res 2000; 15: 721-39. (Pubitemid 30174026)
87. Van Staa TP, Leufkens HGM, Cooper C. Does a fracture at one site predict later fractures at other sites A British cohort study. Osteoporosis Int 2002; 13: 624-29.
88. Triant VA, Brown TT, Lee H, Grinspoon SK. Fracture prevalence among human immunodeficiency virus (HIV)-infected versus non-HIV-infected patients in a large U.S. healthcare system. J Clinical Endocrinol Metab 2008; 93: 3499-504.
89. Womack JA, Goulet JL, Gibert C et al. for the Veterans Aging Cohort Study Team. Increased risk of fragility fracture among HIV infected compared to uninfected make veterans. PLoS ONE 2011; 6: e17217.
90. Young B, Dao CN, Buchacz K et al. Increased rates of bone fracture among HIV-infected Persons in the HIV Outpatient Study (HOPS) compared with the US general population, 2000-2006. Clin Infect Dis 2010; 52: 1061-68.
91. McComsey GA, Huang JS, Woolley IJ et al. Fragility fractures in HIV-infected patients: Need to better understanding of diagnosis and management. J Int Assoc Physicians AIDS Care 2004; 3: 86-91.
92. Kanis JA, Johnell O, Oden A, Johansson H, McCloskey E. FRAXTM and the assessment of fracture probability in men and women from the UK. Osteoporosis Int 2008; 19: 385-97.
93. Gazzola L, Comi L, Savoldi A et al. Use of the FRAX equation as first-line screening of bone metabolism alteration in the HIV-infected population. J Infect Dis 2010; 202: 330-31.
94. McComsey GA, Kendall MA, Tebas P et al. Alendronate with calcium and vitamin D supplementation is safe and effective for the treatment of decreased bone mineral density. AIDS 2007; 21: 2473-82. (Pubitemid 350145179)
95. Guaraldi G, Orlando G, Madeddu G et al. Alendronate reduces bone resorption in HIV associated osteopenia/osteoporosis. HIV Clin Trials 2004; 5: 269-77. (Pubitemid 39545399)
96. Mondy K, Powderly WG, Claxton SA et al. Alendronate, vitamin D and calcium for the treatment of osteopenia/osteoporosis associated with HIV infection. J Acquired Immune Deficiency Syndrome 2005; 38: 426-31. (Pubitemid 40381552)
97. Negredo E, Martnez-Lopez E, Paredes R et al. Reversal of HIV-1-associated osteoporosis with once-weekly alendronate. AIDS 2005; 19: 343-45. (Pubitemid 40396568)
98. Markle-Reid M, Browne G. Conceptualizations of frailty in relation to older adults. J Advanced Nursing 2003; 44: 48-58.
99. Fried LP, Tangen CM, Walston J et al. Frailty in older adults: evidence for a phenotype. J Gerontol A Bio Sci Med Sci 2001; 56: 146-56.
100. Rockwood R, Mitnitski A. Frailty defined by deficit accumulation and geriatric medicine defined by Frailty. Clinical Geriatric Med 2001; 27: 17-26.
101. Desquilbet L, Jacobson LP, Fried LP et al. HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty. J Gerontol 2007; 62A: 12791286.
102. Desquilbet L, Margolick JB, Fried LP et al. Relationship between a frailty-related phenotype and progressive deterioration of the immune system in HIV-infected men. J Acquir Immune Defic Syndr 2009; 50: 299-306.
103. Onen NF, Agbebi A, Shacham E, Stamm KE, Onen AR, Overton ET. Frailty among HIV-infected persons in an urban outpatient care setting. J Infection 2009; 59: 346-52.
104. Terzian AS, Holman S, Nathwani N et al. Factors associated with preclinical disability and frailty among HIV-infected and HIV-uninfected women in the era of cART. J Womens Health (Larchmt) 2009; 18: 1965-74.
105. Ianas V, Berg E, Mohler MJ, Wendel C, Klotz SA. Antiretroviral therapy protects against frailty in HIV-1 infection. J Int Assoc Providers AIDS Care (JIAPAC) 2013; 12: 62-66.
106. Pathi S, Gilbert C, Weiss HA et al. Frailty in HIV-infected adults in South Africa. J Acquir Immune Defic Syndr 2013; 62: 43-51.
107. Desquilbet L, Jacobson LP, Fried LP et al. A frailty-related phenotype before HAART initiation as an independent risk factor for AIDS or death after HAART among HIV-infected men. J Gerontol A Biol Sci Med Sci 2011; 66A: 1030-38.
108. Ruiz M, Cefalu C. Palliative care program for human immunodeficiency virus-infected patients: rebuilding of an academic urban program. Am J Hospice Palliative Med 2011; 28: 16-21.
109. Karus D, Raveis VH, Alexander C et al. Patient reports of symptoms and their treatment at three palliative care projects servicing individuals with HIV/AIDS. J Pain Symptom Management 2005; 30: 408-17. (Pubitemid 41718961)
110. Simms V, Higginson IJ and Harding R. What palliative care-related problems do patients experience at HIV diagnosis A systematic review of the evidence. J Pain Symptom Management 2011; 42: 734-53.
111. Lorenz KA, Cunningham WE, Spritzer KL, Hays RD. Changes in symptoms and health-related quality of life in a nationally representative sample of adults in treatment for HIV. Qual Life Res 2006; 15: 951-58. (Pubitemid 44221449)
112. Corless IB, Nicholas PK, Davis SM, Dolan SA, McGibbon CA. Symptom status, medication adherence, and quality of life in HIV disease. J Hospice Palliative Care Nursing 2005; 7: 129-38.
113. Harding R, Easterbrook P, Higginson IJ, Karus D, Raveis VH, Marconi K. Access and equity in HIV/AIDS palliative care: a review of the evidence and responses. Palliative Med 2005; 19: 251-58. (Pubitemid 40668084)
114. Green K, Tuan T, Vu Hoang T, Thi Trang NN, Thanh Ha NT, Hung ND. Integrating palliative care into HIV outpatient clinical settings: preliminary findings from an intervention study in Vietnam. J Pain Symptom Management 2010; 40: 31-34.
115. Cochrane J. The experience of uncertainty for individuals with HIV/AIDS and the palliative care paradigm. Int J Palliative Nursing 2003; 9: 382-88.
116. Karasz A, Dyche L, Selwyn P. Physicians' experiences of caring for late-stage HIV patients in the post-HAART era: challenges and adaptations. Social Sci Med 2003; 57: 1609-20. (Pubitemid 37028315)
117. Corless IB, Nicholas PK. Long-term continuum of care for people living with HIV/AIDS. J Urban Health 2000; 77: 176-86. (Pubitemid 30337301)
118. Harding R, Karus D, Easterbrook P, Raveis VH, Higginson IJ, Marconi K. Does palliative care improve outcomes for patients with HIV/AIDS A systematic review of the evidence. Sex Transm Infect 2005; 81: 5-14. (Pubitemid 40222859)
119. Kell ME, Walley JD. Palliative care for HIV in the era of antiretroviral therapy availability: perspectives of nurses in Lesotho. BMC Palliative Care 2009; 8: 11.
120. Simms V, Higginson IJ, Harding R. Integration of palliative care throughout HIV disease. Lancet Infect Dis 2012; 12: 571-75.
121. Harding R, Simms V, Krakauer E et al. Quality HIV care to the end of life. Clin Infect Dis 2011; 52: 553-54.
122. Erlandson KM, Allshouse AA, Jankowski CM et al. Comparison of functional status instruments in HIV infected adults on effective antiviral therapy. HIV Clin Trials 2012; 13: 324-34.
123. Oursler KK, Goulet JL, Leaf DA et al. Association of comorbidity with physical disability in older HIV-infected adults. AIDS Patient Care STDs 2006; 20: 782-91. (Pubitemid 44904666)
124. Emlet CA. An examination of the social networks and social isolation in older and younger adults living with HIV/AIDS. Health Social Work 2006; 31: 299-308.
125. Shippy RA, Karpiak SE. The aging HIV/AIDS population: fragile social networks. Aging Mental Health 2005; 9: 246-54. (Pubitemid 40789953)
126. Nokes KN, Holzember WL, Corless IB et al. Health-related quality of life in persons younger and older than 50 living with HIV/AIDS. Res Aging 2000; 22: 290-310. (Pubitemid 30246608)
127. Poindexter C, Shippy RA. Networks of older New Yorkers with HIV: fragility, resilience, and transformation. AIDS Patient Care STDs 2008; 22: 723-33.
128. Fritsch T. HIV/AIDS and the older adult: an exploratory study of the age-related differences in access to medical and social services. J Appl Gerontol 2005; 24: 35-54. (Pubitemid 40096889)
129. Pitts M, Grierson J, Misson S. Growing older with HIV: a study of health, social and economic circumstances for people living with HIV in Australia over the age of 50 years. AIDS Patient Care STDs 2005; 19: 460-65. (Pubitemid 41105526)
130. Owen G, Catalan J 'We never expected this to happen': narratives of ageing with HIV among gay men living in London, UK. Culture, Health & Sexuality. 2011. doi: 10.1080/13691058. 2011.621449.
131. McMahon J, Wanke C, Terrin N, Skinner S, Knox T. Poverty, hunger, education, and residential status impact survival in HIV. AIDS Behaviour 2011; 15: 1503-11.
132. Power L, Bell M, Freemantle I. Joseph Rowntree Foundation. A National Study of Ageing and HIV (50 Plus). 2010. Available at: http://www.jrf. org.uk. ISBN: 978-1-85935-754-5.
133. High KP, Brennan-Ing M, Clifford DB et al. HIV and aging: state of the knowledge and areas of critical need for research. A report of the NIH offices of AIDS research by the HIV and aging working group. J Acquir Immune Defic Syndrome 2012; 60 (suppl 1): S1-18.
134. Hughes AK. HIV knowledge and attitudes among providers in aging: results from a national survey. AIDS Patient Care STDs 2011; 25: 539-45.