Host immune status and response to hepatitis E virus infection

Clinical Microbiology Reviews

Volumn 27, Issue 1, 2014, Pages 139-165

  Krain, Lisa J ^a   Nelson, Kenrad E ^a   Labriquea, Alain B ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALANINE AMINOTRANSFERASE; ASPARTATE AMINOTRANSFERASE; CHORIONIC GONADOTROPIN; ESTROGEN; GAMMA INTERFERON; HEPATITIS E VACCINE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 6; INTERLEUKIN 8; PLACEBO; TUMOR NECROSIS FACTOR ALPHA; VIRUS RNA;

ACUTE LYMPHOBLASTIC LEUKEMIA; DISEASE SEVERITY; DNA POLYMORPHISM; ENZYME LINKED IMMUNOSORBENT ASSAY; FOLLOW UP; GENE MUTATION; GENOTYPE; HEPATITIS E; HEPATITIS E 1; HEPATITIS E 2; HEPATITIS E 3; HEPATITIS E 4; HUMAN; IMMUNE RESPONSE; IMMUNOPATHOGENESIS; IMMUNOSUPPRESSIVE TREATMENT; INFECTION; LIVER FAILURE; MIXED INFECTION; MORTALITY; NATURAL KILLER CELL; NUCLEOTIDE SEQUENCE; PATHOGENESIS; PHASE 3 CLINICAL TRIAL (TOPIC); PHYLOGENETIC TREE; PHYLOGENY; PREGNANCY; RANDOMIZED CONTROLLED TRIAL (TOPIC); REVIEW; RISK FACTOR; SENSITIVITY AND SPECIFICITY; SEROPREVALENCE; T LYMPHOCYTE; UNINDEXED SEQUENCE; VACCINATION; VIRAL CLEARANCE; VIREMIA; VIRUS HEPATITIS; VIRUS REPLICATION; VIRUS TRANSMISSION; VIRUS VIRULENCE;

HEPATITIS E; HEPATITIS E VIRUS; HUMANS; IMMUNE SYSTEM; IMMUNITY, CELLULAR;

EID: 84891712487     PISSN: 08938512     EISSN: 10986618     Source Type: Journal    
DOI: 10.1128/CMR.00062-13     Document Type: Review

References (370)

1. Virchow RLK. 1854. Archiv für pathologische Anatomie und Physiologie und für klinische Medizin. Springer, Berlin, Germany.
2. Saint-Vel O, Delahaye VA. 1868. Traité des maladies des régions intertropicales. Adrien Delahaye, Libraire-Éditeur, Paris, France.
3. Teo CG. 2012. Fatal outbreaks of jaundice in pregnancy and the epidemic history of hepatitis E. Epidemiol. Infect. 140:767-787. http://dx.doi.org/10.1017/S0950268811002925.
4. Balayan MS, Andjaparidze AG, Savinskaya SS, Ketiladze ES, Braginsky DM, Savinov AP, Poleschuk VF. 1983. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 20:23-31. http://dx.doi.org/10.1159/000149370.
5. Reyes GR, Purdy MA, Kim JP, Luk KC, Young LM, Fry KE, Bradley DW. 1990. Isolation of a cDNA from the virus responsible for enterically transmitted non-A, non-B hepatitis. Science 247:1335-1339. http://dx.doi.org/10.1126/science.2107574.
6. Tam AW, Smith MM, Guerra ME, Huang CC, Bradley DW, Fry KE, Reyes GR. 1991. Hepatitis E virus (HEV): molecular cloning and sequencing of the full-length viral genome. Virology 185:120-131. http: //dx.doi.org/10.1016/0042-6822(91)90760-9.
7. Bradley DW, Purdy MA, Reyes GR. 1991. Hepatitis E virus genome. Molecular features, expression of immunoreactive proteins and sequence divergence. J. Hepatol. 13(Suppl 4):S152-S154.
8. Ray R, Aggarwal R, Salunke PN, Mehrotra NN, Talwar GP, Naik SR. 1991. Hepatitis E virus genome in stools of hepatitis patients during large epidemic in north India. Lancet 338:783-784. http://dx.doi.org/10.1016 /0140-6736(91)90667-E.
9. Huang CC, Nguyen D, Fernandez J, Yun KY, Fry KE, Bradley DW, Tam AW, Reyes GR. 1992. Molecular cloning and sequencing of the Mexico isolate of hepatitis E virus (HEV). Virology 191:550-558. http: //dx.doi.org/10.1016/0042-6822(92)90230-M.
10. Uchida T, Suzuki K, Hayashi N, Iida F, Hara T, Oo SS, Wang CK, Shikata T, Ichikawa M, Rikihisa T, Mizuno K, Win KM. 1992. Hepatitis E virus: cDNA cloning and expression. Microbiol. Immunol. 36:67-79.
11. Tsarev SA, Emerson SU, Reyes GR, Tsareva TS, Legters LJ, Malik IA, Iqbal M, Purcell RH. 1992. Characterization of a prototype strain of hepatitis E virus. Proc. Natl. Acad. Sci. U. S. A. 89:559-563. http://dx.doi.org/10.1073/pnas.89.2.559.
12. Lu L, Li C, Hagedorn CH. 2006. Phylogenetic analysis of global hepatitis E virus sequences: genetic diversity, subtypes and zoonosis. Rev. Med. Virol. 16:5-36. http://dx.doi.org/10.1002/rmv.482.
13. Kabrane-Lazizi Y, Fine JB, Elm J, Glass GE, Higa H, Diwan A, Gibbs CJ, Jr, Meng XJ, Emerson SU, Purcell RH. 1999. Evidence for widespread infection of wild rats with hepatitis E virus in the United States. Am. J. Trop. Med. Hyg. 61:331-335.
14. Arankalle VA, Joshi MV, Kulkarni AM, Gandhe SS, Chobe LP, Rautmare SS, Mishra AC, Padbidri VS. 2001. Prevalence of anti-hepatitis E virus antibodies in different Indian animal species. J. Viral Hepat. 8:223-227. http://dx.doi.org/10.1046/j.1365-2893.2001.00290.x.
15. Drexler JF, Seelen A, Corman VM, Fumie Tateno A, Cottontail V, Melim Zerbinati R, Gloza-Rausch F, Klose SM, Adu-Sarkodie Y, Oppong SK, Kalko EK, Osterman A, Rasche A, Adam A, Muller MA, Ulrich RG, Leroy EM, Lukashev AN, Drosten C. 2012. Bats worldwide carry hepatitis E-related viruses that form a putative novel genus within the family Hepeviridae. J. Virol. 86:9134-9147. http://dx.doi.org/10.1128/JVI.00800-12.
16. Vitral CL, Pinto MA, Lewis-Ximenez LL, Khudyakov YE, dos Santos DR, Gaspar AM. 2005. Serological evidence of hepatitis E virus infection in different animal species from the Southeast of Brazil. Mem. Inst. Oswaldo Cruz 100:117-122. http://dx.doi.org/10.1590/S0074-02762005000200003.
17. El-Tras WF, Tayel AA, El-Kady NN. 2013. Seroprevalence of hepatitis E virus in humans and geographically matched food animals in Egypt. Zoonoses Public Health 60:244-251. http://dx.doi.org/10.1111/j.1863-2378.2012.01516.x.
18. Okamoto H. 2007. Genetic variability and evolution of hepatitis E virus. Virus Res. 127:216-228. http://dx.doi.org/10.1016/j.virusres.2007.02.002.
19. Altschul SF, Gish W, Miller W, Myers EW, Lipman DJ. 1990. Basic local alignment search tool. J. Mol. Biol. 215:403-410. http://dx.doi.org /10.1016/S0022-2836(05)80360-2.
20. Tamura K, Peterson D, Peterson N, Stecher G, Nei M, Kumar S. 2011. MEGA5: molecular evolutionary genetics analysis using maximum likelihood, evolutionary distance, and maximum parsimony methods. Mol. Biol. Evol. 28:2731-2739. http://dx.doi.org/10.1093/molbev/msr121.
21. Khuroo MS. 1980. Study of an epidemic of non-A, non-B hepatitis. Possibility of another human hepatitis virus distinct from posttransfusion non-A, non-B type. Am. J. Med. 68:818-824.
22. Aggarwal R. 2011. Clinical presentation of hepatitis E. Virus Res. 161: 15-22. http://dx.doi.org/10.1016/j.virusres.2011.03.017.
23. Labrique AB, Zaman K, Hossain Z, Saha P, Yunus M, Hossain A, Ticehurst JR, Nelson KE. 2010. Epidemiology and risk factors of incident hepatitis E virus infections in rural Bangladesh. Am. J. Epidemiol. 172:952-961. http://dx.doi.org/10.1093/aje/kwq225.
24. Dalton HR, Stableforth W, Thurairajah P, Hazeldine S, Remnarace R, Usama W, Farrington L, Hamad N, Sieberhagen C, Ellis V, Mitchell J, Hussaini SH, Banks M, Ijaz S, Bendall RP. 2008. Autochthonous hepatitis E in Southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur. J. Gastroenterol. Hepatol. 20:784-790. http://dx.doi.org/10.1097/MEG.0b013e3282f5195a.
25. Aggarwal RA. 2013. Hepatitis E: clinical presentation in disease-endemic areas and diagnosis. Semin. Liver Dis. 33:30-40. http://dx.doi.org/10.1055/s-0033-1338112.
26. Begum N, Devi SG, Husain SA, Kar P. 2009. Seroprevalence of subclinical HEV infection in pregnant women from north India: a hospital based study. Indian J. Med. Res. 130:709-713.
27. Christensen PB, Engle RE, Hjort C, Homburg KM, Vach W, Georgsen J, Purcell RH. 2008. Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark. Clin. Infect. Dis. 47:1026-1031. http://dx.doi.org/10.1086/591970.
28. Dalton HR, Thurairajah PH, Fellows HJ, Hussaini HS, Mitchell J, Bendall R, Banks M, Ijaz S, Teo CG, Levine DF. 2007. Autochthonous hepatitis E in southwest England. J. Viral Hepat. 14:304-309. http://dx.doi.org/10.1111/j.1365-2893.2006.00800.x.
29. Gad YZ, Mousa N, Shams M, Elewa A. 2011. Seroprevalence of subclinical HEV infection in asymptomatic, apparently healthy, pregnant women in Dakahlya Governorate, Egypt. Asian J. Transfus. Sci. 5:136-139. http://dx.doi.org/10.4103/0973-6247.83238.
30. Guthmann JP, Klovstad H, Boccia D, Hamid N, Pinoges L, Nizou JY, Tatay M, Diaz F, Moren A, Grais RF, Ciglenecki I, Nicand E, Guerin PJ. 2006. A large outbreak of hepatitis E among a displaced population in Darfur, Sudan, 2004: the role of water treatment methods. Clin. Infect. Dis. 42:1685-1691. http://dx.doi.org/10.1086/504321.
31. Khuroo MS, Kamili S, Yattoo GN. 2004. Hepatitis E virus infection may be transmitted through blood transfusions in an endemic area. J. Gastroenterol. Hepatol. 19:778-784. http://dx.doi.org/10.1111/j.1440-1746.2004.03437.x.
32. Nicand E, Grandadam M, Teyssou R, Rey JL, Buisson Y. 2001. Viraemia and faecal shedding of HEV in symptom-free carriers. Lancet 357:68-69. http://dx.doi.org/10.1016/S0140-6736(05)71567-110.1016/S0140-6736(05)71566-X.
33. Renou C, Pariente A, Cadranel JF, Nicand E, Pavio N. 2011. Clinically silent forms may partly explain the rarity of acute cases of autochthonous genotype 3c hepatitis E infection in France. J. Clin. Virol. 51:139-141. http://dx.doi.org/10.1016/j.jcv.2011.02.013.
34. Stoszek SK, Engle RE, Abdel-Hamid M, Mikhail N, Abdel-Aziz F, Medhat A, Fix AD, Emerson SU, Purcell RH, Strickland GT. 2006. Hepatitis E antibody seroconversion without disease in highly endemic rural Egyptian communities. Trans. R. Soc. Trop. Med. Hyg. 100:89-94. http://dx.doi.org/10.1016/j.trstmh.2005.05.019.
35. Kuniholm MH, Purcell RH, McQuillan GM, Engle RE, Wasley A, Nelson KE. 2009. Epidemiology of hepatitis E virus in the United States: results from the Third National Health and Nutrition Examination Survey, 1988-1994. J. Infect. Dis. 200:48-56. http://dx.doi.org/10.1086 /599319.
36. Schlosser B, Stein A, Neuhaus R, Pahl S, Ramez B, Kruger DH, Berg T, Hofmann J. 2012. Liver transplant from a donor with occult HEV infection induced chronic hepatitis and cirrhosis in the recipient. J. Hepatol. 56:500-502. http://dx.doi.org/10.1016/j.jhep.2011.06.021.
37. Despierres LA, Kaphan E, Attarian S, Cohen-Bacrie S, Pelletier J, Pouget J, Motte A, Charrel R, Gérolami R, Colson P. 2011. Neurologic disorders and hepatitis E, France, 2010. Emerg. Infect. Dis. 17:1510-1512. http://dx.doi.org/10.3201/eid1708.102028.
38. Kejariwal D, Roy S, Sarkar N. 2001. Seizure associated with acute hepatitis E. Neurology 57:1935. http://dx.doi.org/10.1212/WNL.57.10.1935.
39. Mandal K, Chopra N. 2006. Acute transverse myelitis following hepatitis E virus infection. Indian Pediatr. 43:365-366.
40. Kamani P, Baijal R, Amarapurkar D, Gupte P, Patel N, Kumar P, Agal S. 2005. Guillain-Barre syndrome associated with acute hepatitis E. Indian J. Gastroenterol. 24:216.
41. Scharn N, Ganzenmueller T, Wenzel JJ, Dengler R, Heim A, Wegner F. 2013. Guillain-Barre syndrome associated with autochthonous infection by hepatitis E virus subgenotype 3c. Infection http://dx.doi.org/10.1007/s15010-013-0448-5.
42. Sharma B, Nagpal K, Bakki Sannegowda R, Prakash S. 2013. Hepatitis E with Gullain-Barre syndrome: still a rare association. J. Neurovirol. 19:186-187. http://dx.doi.org/10.1007/s13365-013-0156-z.
43. Loly JP, Rikir E, Seivert M, Legros E, Defrance P, Belaiche J, Moonen G, Delwaide J. 2009. Guillain-Barre syndrome following hepatitis E. World J. Gastroenterol. 15:1645-1647. http://dx.doi.org/10.3748/wjg.15.1645.
44. Sood A, Midha V, Sood N. 2000. Guillain-Barre syndrome with acute hepatitis E. Am. J. Gastroenterol. 95:3667-3668. http://dx.doi.org/10.1016/S0002-9270(00)02202-4.
45. Cronin S, McNicholas R, Kavanagh E, Reid V, O'Rourke K. 2011. Anti-glycolipid GM2-positive Guillain-Barre syndrome due to hepatitis E infection. Ir. J. Med. Sci. 180:255-257. http://dx.doi.org/10.1007 /s11845-010-0635-7.
46. Maurissen I, Jeurissen A, Strauven T, Sprengers D, De Schepper B. 2012. First case of anti-ganglioside GM1-positive Guillain-Barre syndrome due to hepatitis E virus infection. Infection 40:323-326. http://dx.doi.org/10.1007/s15010-011-0185-6.
47. Fong F, Illahi M. 2009. Neuralgic amyotrophy associated with hepatitis E virus. Clin. Neurol. Neurosurg. 111:193-195. http://dx.doi.org/10.1016/j.clineuro.2008.09.005.
48. Kamar N, Bendall RP, Peron JM, Cintas P, Prudhomme L, Mansuy JM, Rostaing L, Keane F, Ijaz S, Izopet J, Dalton HR. 2011. Hepatitis E virus and neurologic disorders. Emerg. Infect. Dis. 17:173-179. http: //dx.doi.org/10.3201/eid1702.100856.
49. Coursaget P, Buisson Y, N, Gawara MN, van Cuyck-Gandre H, Roue R. 1998. Role of hepatitis E virus in sporadic cases of acute and fulminant hepatitis in an endemic area (Chad). Am. J. Trop. Med. Hyg. 58:330-334.
50. Mahtab MA, Rahman S, Khan M, Karim F. 2009. HEV infection as an aetiologic factor for acute hepatitis: experience from a tertiary hospital in Bangladesh. J. Health Popul. Nutr. 27:14-19.
51. Ghoshal UC, Somani S, Chetri K, Akhtar P, Aggarwal R, Naik SR. 2001. Plasmodium falciparum and hepatitis E virus co-infection in fulminant hepatic failure. Indian J. Gastroenterol. 20:111.
52. Kumar A, Aggarwal R, Naik SR, Saraswat V, Ghoshal UC, Naik S. 2004. Hepatitis E virus is responsible for decompensation of chronic liver disease in an endemic region. Indian J. Gastroenterol. 23:59-62.
53. Montalva Villalba MC, Rodriguez Lay LA, Chandra V, Corredor MB, Frometa SS, Moreno AG, Jameel S. 2008. Hepatitis E virus genotype 1, Cuba. Emerg. Infect. Dis. 14:1320-1322. http://dx.doi.org/10.3201 /eid1408.080049.
54. Garcia CG, Sanchez D, Villalba MC, Pujol FH, de Los Angeles Rodriguez Lay L, Pinto B, Chacon EP, Guzman MG. 2012. Molecular characterization of hepatitis E virus in patients with acute hepatitis in Venezuela. J. Med. Virol. 84:1025-1029. http://dx.doi.org/10.1002/jmv.23277.
55. Tavera C, Velazquez O, Avila C, Ornelas G, Alvarez C, Sepulveda J. 1987. Enterically transmitted non-A, non-B hepatitis-Mexico. MMWR Morb. Mortal. Wkly. Rep. 36:597-602.
56. Velazquez O, Stetler HC, Avila C, Ornelas G, Hadler CC, Bradley DW, Sepúlveda J. 1990. Epidemic transmission of enterically transmitted non-A, non-B hepatitis in Mexico, 1986-1987. JAMA 263:3281-3285. http://dx.doi.org/10.1001/jama.263.24.3281.
57. Maila HT, Bowyer SM, Swanepoel R. 2004. Identification of a new strain of hepatitis E virus from an outbreak in Namibia in 1995. J. Gen. Virol. 85:89-95. http://dx.doi.org/10.1099/vir.0.19587-0.
58. Nicand E, Armstrong GL, Enouf V, Guthmann JP, Guerin JP, Caron M, Nizou JY, Andraghetti R. 2005. Genetic heterogeneity of hepatitis E virus in Darfur, Sudan, and neighboring Chad. J. Med. Virol. 77:519-521. http://dx.doi.org/10.1002/jmv.20487.
59. Arankalle VA, Chadha MS, Chitambar SD, Walimbe AM, Chobe LP, Gandhe SS. 2001. Changing epidemiology of hepatitis A and hepatitis E in urban and rural India (1982-98). J. Viral Hepat. 8:293-303. http://dx.doi.org/10.1046/j.1365-2893.2001.00279.x.
60. Arankalle VA, Tsarev SA, Chadha MS, Alling DW, Emerson SU, Banerjee K, Purcell RH. 1995. Age-specific prevalence of antibodies to hepatitis A and E viruses in Pune, India, 1982 and 1992. J. Infect. Dis. 171:447-450. http://dx.doi.org/10.1093/infdis/171.2.447.
61. Arankalle VA, Chadha MS, Mehendale SM, Tungatkar SP. 2000. Epidemic hepatitis E: serological evidence for lack of intrafamilial spread. Indian J. Gastroenterol. 19:24-28.
62. Teshale EH, Grytdal SP, Howard C, Barry V, Kamili S, Drobeniuc J, Hill VR, Okware S, Hu DJ, Holmberg SD. 2010. Evidence of personto-person transmission of hepatitis E virus during a large outbreak in Northern Uganda. Clin. Infect. Dis. 50:1006-1010. http://dx.doi.org/10.1086/651077.
63. Khuroo MS, Dar MY. 1992. Hepatitis E: evidence for person-to-person transmission and inability of low dose immune serum globulin from an Indian source to prevent it. Indian J. Gastroenterol. 11:113-116.
64. Howard CM, Handzel T, Hill VR, Grytdal SP, Blanton C, Kamili S, Drobeniuc J, Hu D, Teshale E. 2010. Novel risk factors associated with hepatitis E virus infection in a large outbreak in northern Uganda: results from a case-control study and environmental analysis. Am. J. Trop. Med. Hyg. 83:1170-1173. http://dx.doi.org/10.4269/ajtmh.2010.10-0384.
65. Khatun F, Rasheed S, Moran AC, Alam AM, Shomik MS, Sultana M, Choudhury N, Iqbal M, Bhuiya A. 2012. Causes of neonatal and maternal deaths in Dhaka slums: implications for service delivery. BMC Public Health 12:84. http://dx.doi.org/10.1186/1471-2458-12-84.
66. Boccia D, Guthmann JP, Klovstad H, Hamid N, Tatay M, Ciglenecki I, Nizou JY, Nicand E, Guerin PJ. 2006. High mortality associated with an outbreak of hepatitis E among displaced persons in Darfur, Sudan. Clin. Infect. Dis. 42:1679-1684. http://dx.doi.org/10.1086/504322.
67. Gove S, Ali-Salad A, Farah MA, Delaney D, Roble MJ, Walter J, Aziz N. 1987. Enterically transmitted non-A, non-B hepatitis-East Africa. MMWR Morb. Mortal. Wkly. Rep. 36:241-244.
68. Isaacson M, Frean J, He J, Seriwatana J, Innis BL. 2000. An outbreak of hepatitis E in Northern Namibia, 1983. Am. J. Trop. Med. Hyg. 62: 619-625.
69. Meng XJ. 2010. Hepatitis E virus: animal reservoirs and zoonotic risk. Vet. Microbiol. 140:256-265. http://dx.doi.org/10.1016/j.vetmic.2009.03.017.
70. Meng XJ. 2011. From barnyard to food table: the omnipresence of hepatitis E virus and risk for zoonotic infection and food safety. Virus Res. 161:23-30. http://dx.doi.org/10.1016/j.virusres.2011.01.016.
71. Adlhoch C, Wolf A, Meisel H, Kaiser M, Ellerbrok H, Pauli G. 2009. High HEV presence in four different wild boar populations in East and West Germany. Vet. Microbiol. 139:270-278. http://dx.doi.org/10.1016 /j.vetmic.2009.06.032.
72. de Deus N, Casas M, Peralta B, Nofrarias M, Pina S, Martin M, Segales J. 2008. Hepatitis E virus infection dynamics and organic distribution in naturally infected pigs in a farrow-to-finish farm. Vet. Microbiol. 132: 19-28. http://dx.doi.org/10.1016/j.vetmic.2008.04.036.
73. de la Caridad Montalvo Villalba M, Owot JC, Corrreia B, Corredor MB, Flaquet PP, Frometa SS, Wong MS, Rodriguez Lay LD. 2013. Hepatitis E virus genotype 3 in humans and swine, Cuba. Infect. Genet. Evol. 14C:335-339. http://dx.doi.org/10.1016/j.meegid.2012.12.022.
74. de Souza AJ, Gomes-Gouvea MS, Soares MD, Pinho JR, Malheiros AP, Carneiro LA, Dos Santos DR, Pereira WL. 2012. HEV infection in swine from Eastern Brazilian Amazon: evidence of co-infection by different subtypes. Comp. Immunol. Microbiol. Infect. Dis. 35:477-485. http://dx.doi.org/10.1016/j.cimid.2012.04.004.
75. Dell'Amico MC, Cavallo A, Gonzales JL, Bonelli SI, Valda Y, Pieri A, Segund H, Ibanez R, Mantella A, Bartalesi F, Tolari F, Bartoloni A. 2011. Hepatitis E virus genotype 3 in humans and Swine, Bolivia. Emerg. Infect. Dis. 17:1488-1490. http://dx.doi.org/10.3201/eid1708.100769.
76. Dong C, Meng J, Dai X, Liang JH, Feagins AR, Meng XJ, Belfiore NM, Bradford C, Corn JL, Cray C, Glass GE, Gordon ML, Hesse RA, Montgomery DL, Nicholson WL, Pilny AA, Ramamoorthy S, Shaver DD, Drobeniuc J, Purdy MA, Fields HA, Kamili S, Teo CG. 2011. Restricted enzooticity of hepatitis E virus genotypes 1 to 4 in the United States. J. Clin. Microbiol. 49:4164-4172. http://dx.doi.org/10.1128/JCM.05481-11.
77. Hosmillo M, Jeong YJ, Kim HJ, Park JG, Nayak MK, Alfajaro MM, Collantes TM, Park SJ, Ikuta K, Yunoki M, Kang MI, Park SI, Cho KO. 2010. Molecular detection of genotype 3 porcine hepatitis E virus in aborted fetuses and their sows. Arch. Virol. 155:1157-1161. http://dx.doi.org/10.1007/s00705-010-0679-z.
78. Ishida S, Yoshizumi S, Ikeda T, Miyoshi M, Goto A, Matsubayashi K, Ikeda H. 2012. Detection and molecular characterization of hepatitis E virus in clinical, environmental and putative animal sources. Arch. Virol. 157:2363-2368. http://dx.doi.org/10.1007/s00705-012-1422-8.
79. Kanai Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K. 2010. Long-term shedding of hepatitis E virus in the feces of pigs infected naturally, born to sows with and without maternal antibodies. J. Med. Virol. 82:69-76. http://dx.doi.org/10.1002/jmv.21647.
80. Keawcharoen J, Thongmee T, Panyathong R, Joiphaeng P, Tuanthap S, Oraveerakul K, Theamboonlers A, Poovorawan Y. 2013. Hepatitis E virus genotype 3f sequences from pigs in Thailand, 2011-2012. Virus Genes 46:369-370. http://dx.doi.org/10.1007/s11262-012-0853-3.
81. Lu YH, Qian HZ, Qin X, Jiang QW, Zheng YJ. 2013. Subtypes of genotype 3 hepatitis E virus in pigs. Vet. J. 197:509-511. http://dx.doi.org/10.1016/j.tvjl.2012.12.023.
82. Norder H, Sundqvist L, Magnusson L, Ostergaard Breum S, Lofdahl M, Larsen LE, Hjulsager CK, Magnius L, Bottiger BE, Widen F. 2009. Endemic hepatitis E in two Nordic countries. Euro Surveill. 14(19): pii_19211. http://www.eurosurveillance.org/ViewArticle.aspx?Article Id_19211.
83. Reuter G, Fodor D, Forgach P, Katai A, Szucs G. 2009. Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. J. Clin. Virol. 44:277-281. http://dx.doi.org/10.1016/j.jcv.2009.01.008.
84. Sato Y, Sato H, Naka K, Furuya S, Tsukiji H, Kitagawa K, Sonoda Y, Usui T, Sakamoto H, Yoshino S, Shimizu Y, Takahashi M, Nagashima S, Jirintai Nishizawa T, Okamoto H. 2011. A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. Arch. Virol. 156: 1345-1358. http://dx.doi.org/10.1007/s00705-011-0988-x.
85. Temmam S, Besnard L, Andriamandimby SF, Foray C, Rasamoelina-Andriamanivo H, Heraud JM, Cardinale E, Dellagi K, Pavio N, Pascalis H, Porphyre V. 2013. High prevalence of hepatitis E in humans and pigs and evidence of genotype-3 virus in swine, Madagascar. Am. J. Trop. Med. Hyg. 88:329-338. http://dx.doi.org/10.4269/ajtmh.2012.12-0615.
86. Zwettler D, Fink M, Revilla-Fernandez S, Steinrigl A, Winter P, Kofer J. 2012. First detection of hepatitis E virus in Austrian pigs by RT-qPCR. Berl. Munch. Tierarztl. Wochenschr. 125:281-289.
87. Cooper K, Huang FF, Batista L, Rayo CD, Bezanilla JC, Toth TE, Meng XJ. 2005. Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 and 2 HEV strains are prevalent in the respective human populations. J. Clin. Microbiol. 43:1684-1688. http://dx.doi.org/10.1128/JCM.43.4.1684-1688.2005.
88. Cossaboom CM, Cordoba L, Cao D, Ni YY, Meng XJ. 2012. Complete genome sequence of hepatitis E virus from rabbits in the United States. J. Virol. 86:13124-13125. http://dx.doi.org/10.1128/JVI.02414-12.
89. Kanai Y, Miyasaka S, Uyama S, Kawami S, Kato-Mori Y, Tsujikawa M, Yunoki M, Nishiyama S, Ikuta K, Hagiwara K. 2012. Hepatitis E virus in Norway rats (Rattus norvegicus) captured around a pig farm. BMC Res. Notes 5:4. http://dx.doi.org/10.1186/1756-0500-5-4.
90. Cossaboom CM, Cordoba L, Dryman BA, Meng XJ. 2011. Hepatitis E virus in rabbits, Virginia, USA. Emerg. Infect. Dis. 17:2047-2049. http: //dx.doi.org/10.3201/eid1711.110428.
91. Geng J, Fu H, Wang L, Bu Q, Liu P, Wang M, Sui Y, Wang X, Zhu Y, Zhuang H. 2011. Phylogenetic analysis of the full genome of rabbit hepatitis E virus (rbHEV) and molecular biologic study on the possibility of cross species transmission of rbHEV. Infect. Genet. Evol. 11:2020-2025. http://dx.doi.org/10.1016/j.meegid.2011.09.006.
92. Geng J, Wang L, Wang X, Fu H, Bu Q, Zhu Y, Zhuang H. 2011. Study on prevalence and genotype of hepatitis E virus isolated from Rex rabbits in Beijing, China. J. Viral Hepat. 18:661-667. http://dx.doi.org/10.1111 /j.1365-2893.2010.01341.x.
93. Geng Y, Zhang H, Li J, Huang W, Harrison TJ, Zhao C, Zhou Y, Lian H, Wang Y. 2013. Comparison of hepatitis E virus genotypes from rabbits and pigs in the same geographic area: no evidence of natural cross-species transmission between the two animals. Infect. Genet. Evol. 13:304-309. http://dx.doi.org/10.1016/j.meegid.2012.11.006.
94. Geng Y, Zhao C, Song A, Wang J, Zhang X, Harrison TJ, Zhou Y, Wang W, Wang Y. 2011. The serological prevalence and genetic diversity of hepatitis E virus in farmed rabbits in China. Infect. Genet. Evol. 11:476-482. http://dx.doi.org/10.1016/j.meegid.2010.12.012.
95. Izopet J, Dubois M, Bertagnoli S, Lhomme S, Marchandeau S, Boucher S, Kamar N, Abravanel F, Guerin JL. 2012. Hepatitis E virus strains in rabbits and evidence of a closely related strain in humans, France. Emerg. Infect. Dis. 18:1274-1281.
96. Jirintai S, Jinshan Tanggis Manglai D, Mulyanto Takahashi M, Nagashima S, Kobayashi T, Nishizawa T, Okamoto H. 2012. Molecular analysis of hepatitis E virus from farm rabbits in Inner Mongolia, China and its successful propagation in A549 and PLC/PRF/5 cells. Virus Res. 170:126-137. http://dx.doi.org/10.1016/j.virusres.2012.09.015.
97. Lhomme S, Dubois M, Abravanel F, Top Bertagnoli SS, Guerin JL, Izopet J. 2013. Risk of zoonotic transmission of HEV from rabbits. J. Clin. Virol. 58:357-362. http://dx.doi.org/10.1016/j.jcv.2013.02.006.
98. Liu P, Li L, Wang L, Bu Q, Fu H, Han J, Zhu Y, Lu F, Zhuang H. 2012. Phylogenetic analysis of 626 hepatitis E virus (HEV) isolates from humans and animals in China (1986-2011) showing genotype diversity and zoonotic transmission. Infect. Genet. Evol. 12:428-434. http://dx.doi.org/10.1016/j.meegid.2012.01.017.
99. Wang S, Cheng X, Dai X, Dong C, Xu M, Liang J, Dong M, Purdy MA, Meng J. 2013. Rabbit and human hepatitis E virus strains belong to a single serotype. Virus Res. 176:101-106. http://dx.doi.org/10.1016/j.virusres.2013.05.013.
100. Wang S, Dong C, Dai X, Cheng X, Liang J, Dong M, Purdy MA, Meng J. 2013. Hepatitis E virus isolated from rabbits is genetically heterogeneous but with very similar antigenicity to human HEV. J. Med. Virol. 85:627-635. http://dx.doi.org/10.1002/jmv.23504.
101. Zhao C, Ma Z, Harrison TJ, Feng R, Zhang C, Qiao Z, Fan J, Ma H, Li M, Song A, Wang Y. 2009. A novel genotype of hepatitis E virus prevalent among farmed rabbits in China. J. Med. Virol. 81:1371-1379. http://dx.doi.org/10.1002/jmv.21536.
102. Hirano M, Ding X, Li TC, Takeda N, Kawabata H, Koizumi N, Kadosaka T, Goto I, Masuzawa T, Nakamura M, Taira K, Kuroki T, Tanikawa T, Watanabe H, Abe K. 2003. Evidence for widespread infection of hepatitis E virus among wild rats in Japan. Hepatol. Res. 27: 1-5. http://dx.doi.org/10.1016/S1386-6346(03)00192-X.
103. Johne R, Heckel G, Plenge-Bonig A, Kindler E, Maresch C, Reetz J, Schielke A, Ulrich RG. 2010. Novel hepatitis E virus genotype in Norway rats, Germany. Emerg. Infect. Dis. 16:1452-1455. http://dx.doi.org/10.3201/eid1609.100444.
104. Koma T, Yoshimatsu K, Yasuda SP, Li T, Amada T, Shimizu K, Isozumi R, Mai LT, Hoa NT, Nguyen V, Yamashiro T, Hasebe F, Arikawa J. 2013. A survey of rodent-borne pathogens carried by wild Rattus spp. in Northern Vietnam. Epidemiol. Infect. 141:1876-1884. http://dx.doi.org/10.1017/S0950268812002385.
105. Purcell RH, Engle RE, Rood MP, Kabrane-Lazizi Y, Nguyen HT, Govindarajan S, St Claire M, Emerson SU. 2011. Hepatitis E virus in rats, Los Angeles, California, USA. Emerg. Infect. Dis. 17:2216-2222. http://dx.doi.org/10.3201/eid1712.110482.
106. Batts W, Yun S, Hedrick R, Winton J. 2011. A novel member of the family Hepeviridae from cutthroat trout (Oncorhynchus clarkii). Virus Res. 158:116-123. http://dx.doi.org/10.1016/j.virusres.2011.03.019.
107. Kulkarni MA, Arankalle VA. 2008. The detection and characterization of hepatitis E virus in pig livers from retail markets of India. J. Med. Virol. 80:1387-1390. http://dx.doi.org/10.1002/jmv.21220.
108. Vivek R, Kang G. 2011. Hepatitis E virus infections in swine and swine handlers in Vellore, Southern India. Am. J. Trop. Med. Hyg. 84:647-649. http://dx.doi.org/10.4269/ajtmh.2011.10-0456.
109. Wang H, He Y, Shen Q, Wang X, Yang S, Cui L, Ren L, Sun G, Hua X, Shao S, Zhang W. 2012. Complete genome sequence of the genotype 4 hepatitis E virus strain prevalent in swine in Jiangsu Province, China, reveals a close relationship with that from the human population in this area. J. Virol. 86:8334-8335. http://dx.doi.org/10.1128/JVI.01060-12.
110. Zhang W, Yang S, Ren L, Shen Q, Cui L, Fan K, Huang F, Kang Y, Shan T, Wei J, Xiu H, Lou Y, Liu J, Yang Z, Zhu J, Hua X. 2009. Hepatitis E virus infection in central China reveals no evidence of crossspecies transmission between human and swine in this area. PLoS One 4:e8156. http://dx.doi.org/10.1371/journal.pone.0008156.
111. Hu GD, Ma X. 2010. Detection and sequences analysis of bovine hepatitis E virus RNA in Xinjiang Autonomous Region. Bing Du Xue Bao 26:27-32.
112. Wang Y, Ma X. 2010. Detection and sequences analysis of sheep hepatitis E virus RNA in Xinjiang Autonomous Region. Wei Sheng Wu Xue Bao 50:937-941.
113. Sanford BJ, Emerson SU, Purcell RH, Engle RE, Dryman BA, Cecere TE, Buechner-Maxwell V, Sponenberg DP, Meng XJ. 22 August 2012. Serological evidence for a hepatitis E virus-related agent in goats in the United States. Transbound. Emerg. Dis. http://dx.doi.org/10.1111/tbed.12001.
114. Shukla P, Chauhan UK, Naik S, Anderson D, Aggarwal R. 2007. Hepatitis E virus infection among animals in northern India: an unlikely source of human disease. J. Viral Hepat. 14:310-317. http://dx.doi.org /10.1111/j.1365-2893.2006.00815.x.
115. Zhang W, He Y, Wang H, Shen Q, Cui L, Wang X, Shao S, Hua X. 2010. Hepatitis E virus genotype diversity in eastern China. Emerg. Infect. Dis. 16:1630-1632. http://dx.doi.org/10.3201/eid1610.100873.
116. Zheng Y, Ge S, Zhang J, Guo Q, Ng MH, Wang F, Xia N, Jiang Q. 2006. Swine as a principal reservoir of hepatitis E virus that infects humans in eastern China. J. Infect. Dis. 193:1643-1649. http://dx.doi.org /10.1086/504293.
117. Geng JB, Wang MR, Wang L, Wang J, Yang ZG, Cheng Y, Qiao F, Wang M. 2012. Genetic characteristics and pathogenicity of human hepatitis E virus in Nanjing, China. World J. Gastroenterol. 18:965-970. http://dx.doi.org/10.3748/wjg.v18.i9.965.
118. Garbuglia AR, Scognamiglio P, Petrosillo N, Mastroianni CM, Sordillo P, Gentile D, La Scala P, Girardi E, Capobianchi MR. 2013. Hepatitis E virus genotype 4 outbreak, Italy, 2011. Emerg. Infect. Dis. 19:110-114. http://dx.doi.org/10.3201/eid1901.120983.
119. Fogeda M, Avellon A, Cilla CG, Echevarria JM. 2009. Imported and autochthonous hepatitis E virus strains in Spain. J. Med. Virol. 81:1743-1749. http://dx.doi.org/10.1002/jmv.21564.
120. Colson P, Romanet P, Moal V, Borentain P, Purgus R, Benezech A, Motte A, Gérolami R. 2012. Autochthonous infections with hepatitis E virus genotype 4, France. Emerg. Infect. Dis. 18:1361-1364. http://dx.doi.org/10.3201/eid1808.111827.
121. Colson P, Swiader L, Motte A, Ferretti A, Borentain P, Gérolami R. 2012. Circulation of almost genetically identical hepatitis E virus of genotype 4 in France. J. Clin. Virol. 55:181-183. http://dx.doi.org/10.1016 /j.jcv.2012.06.014.
122. Hakze-van der Honing RW, van Coillie E, Antonis AF, van der Poel WH. 2011. First isolation of hepatitis E virus genotype 4 in Europe through swine surveillance in the Netherlands and Belgium. PLoS One 6:e22673. http://dx.doi.org/10.1371/journal.pone.0022673.
123. Jeblaoui A, Haim-Boukobza S, Marchadier E, Mokhtari C, Roque-Afonso AM. 2013. Genotype 4 hepatitis E virus in France: an autochthonous infection with a more severe presentation. Clin. Infect. Dis. 57: e122-126. http://dx.doi.org/10.1093/cid/cit291.
124. Tessé S, Lioure B, Fornecker L, Wendling MJ, Stoll-Keller F, Bigaillon C, Nicand E. 2012. Circulation of genotype 4 hepatitis E virus in Europe: first autochthonous hepatitis E infection in France. J. Clin. Virol. 54:197-200. http://dx.doi.org/10.1016/j.jcv.2012.02.007.
125. Takahashi M, Tamura K, Hoshino Y, Nagashima S, Yazaki Y, Mizuo H, Iwamoto S, Okayama M, Nakamura Y, Kajii E, Okamoto H. 2010. A nationwide survey of hepatitis E virus infection in the general population of Japan. J. Med. Virol. 82:271-281. http://dx.doi.org/10.1002/jmv.21678.
126. Takahashi K, Okamoto H, Abe N, Kawakami M, Matsuda H, Mochida S, Sakugawa H, Suginoshita Y, Watanabe S, Yamamoto K, Miyakawa Y, Mishiro S. 2009. Virulent strain of hepatitis E virus genotype 3, Japan. Emerg. Infect. Dis. 15:704-709. http://dx.doi.org/10.3201/eid1505.081100.
127. Inoue J, Takahashi M, Mizuo H, Suzuki K, Aikawa T, Shimosegawa T, Okamoto H. 2009. Nucleotide substitutions of hepatitis E virus genomes associated with fulminant hepatitis and disease severity. Tohoku J. Exp. Med. 218:279-284. http://dx.doi.org/10.1620/tjem.218.279.
128. Kamar N, Abravanel F, Selves J, Garrouste C, Esposito L, Lavayssière L, Cointault O, Ribes D, Cardeau I, Nogier MB, Mansuy JM, Muscari F, Peron JM, Izopet J, Rostaing L. 2010. Influence of immunosuppressive therapy on the natural history of genotype 3 hepatitis-E virus infection after organ transplantation. Transplantation 89:353-360. http://dx.doi.org/10.1097/TP.0b013e3181c4096c.
129. Kamar N, Selves J, Mansuy JM, Ouezzani L, Peron JM, Guitard J, Cointault O, Esposito L, Abravanel F, Danjoux M, Durand D, Vinel JP, Izopet J, Rostaing L. 2008. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N. Engl. J. Med. 358:811-817. http://dx.doi.org/10.1056/NEJMoa0706992.
130. Pischke S, Suneetha PV, Baechlein C, Barg-Hock H, Heim A, Kamar N, Schlue J, Strassburg CP, Lehner F, Raupach R, Bremer B, Magerstedt P, Cornberg M, Seehusen F, Baumgaertner W, Klempnauer J, Izopet J, Manns MP, Grummer B, Wedemeyer H. 2010. Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients. Liver Transpl. 16:74-82. http://dx.doi.org/10.1002/lt.21958.
131. Colson P, Borentain P, Queyriaux B, Kaba M, Moal V, Gallian P, Heyries L, Raoult D, Gérolami R. 2010. Pig liver sausage as a source of hepatitis E virus transmission to humans. J. Infect. Dis. 202:825-834. http://dx.doi.org/10.1086/655898.
132. Meng XJ, Wiseman B, Elvinger F, Guenette DK, Toth TE, Engle RE, Emerson SU, Purcell RH. 2002. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J. Clin. Microbiol. 40:117-122. http://dx.doi.org/10.1128/JCM.40.1.117-122.2002.
133. Perez-Gracia MT, Mateos ML, Galiana C, Fernandez-Barredo S, Garcia A, Gomez MT, Moreira V. 2007. Autochthonous hepatitis E infection in a slaughterhouse worker. Am. J. Trop. Med. Hyg. 77:893-896.
134. Teo CG. 2010. Much meat, much malady: changing perceptions of the epidemiology of hepatitis E. Clin. Microbiol. Infect. 16:24-32. http://dx.doi.org/10.1111/j.1469-0691.2009.03111.x.
135. Matsubayashi K, Kang JH, Sakata H, Takahashi K, Shindo M, Kato M, Sato S, Kato T, Nishimori H, Tsuji K, Maguchi H, Yoshida J, Maekubo H, Mishiro S, Ikeda H. 2008. A case of transfusion-transmitted hepatitis E caused by blood from a donor infected with hepatitis E virus via zoonotic food-borne route. Transfusion 48:1368-1375. http://dx.doi.org/10.1111/j.1537-2995.2008.01722.x.
136. Feagins AR, Opriessnig T, Guenette DK, Halbur PG, Meng XJ. 2007. Detection and characterization of infectious hepatitis E virus from commercial pig livers sold in local grocery stores in the USA. J. Gen. Virol. 88:912-917. http://dx.doi.org/10.1099/vir.0.82613-0.
137. Berto A, Grierson S, Hakze-van der Honing R, Martelli F, Johne R, Reetz J, Ulrich RG, Pavio N, Van der Poel WH, Banks M. 2013. Hepatitis e virus in pork liver sausage, France. Emerg. Infect. Dis. 19: 264-266. http://dx.doi.org/10.3201/eid1902.121255.
138. Chaussade H, Rigaud E, Allix A, Carpentier A, Touzé A, Delzescaux D, Choutet P, Garcia-Bonnet N, Coursaget P. 2013. Hepatitis E virus seroprevalence and risk factors for individuals in working contact with animals. J. Clin. Virol. 58:504-508. http://dx.doi.org/10.1016/j.jcv.2013.08.030.
139. Crossan C, Baker PJ, Craft J, Takeuchi Y, Dalton HR, Scobie L. 2012. Hepatitis E virus genotype 3 in shellfish, United Kingdom. Emerg. Infect. Dis. 18:2085-2087. http://dx.doi.org/10.3201/eid1812.120924.
140. Diez-Valcarce M, Kokkinos P, Soderberg K, Bouwknegt M, Willems K, de Roda-Husman AM, von Bonsdorff CH, Bellou M, Hernandez M, Maunula L, Vantarakis A, Rodriguez-Lazaro D. 2012. Occurrence of human enteric viruses in commercial mussels at retail level in three European countries. Food Environ. Virol. 4:73-80. http://dx.doi.org/10.1007/s12560-012-9078-9.
141. Donia D, Dell'Amico MC, Petrinca AR, Martinucci I, Mazzei M, Tolari F, Divizia M. 2012. Presence of hepatitis E RNA in mussels used as bio-monitors of viral marine pollution. J. Virol. Methods 186:198-202. http://dx.doi.org/10.1016/j.jviromet.2012.06.007.
142. Renou C, Moreau X, Pariente A, Cadranel JF, Maringe E, Morin T, Causse X, Payen JL, Izopet J, Nicand E, Bourliere M, Penaranda G, Hardwigsen J, Gérolami R, Peron JM, Pavio N, Angh F. 2008. A national survey of acute hepatitis E in France. Aliment. Pharmacol. Ther. 27:1086-1093. http://dx.doi.org/10.1111/j.1365-2036.2008.03679.x.
143. La Rosa G, Muscillo M, Vennarucci VS, Garbuglia AR, La Scala P, Capobianchi MR. 2011. Hepatitis E virus in Italy: molecular analysis of travel-related and autochthonous cases. J. Gen. Virol. 92:1617-1626. http://dx.doi.org/10.1099/vir.0.031278-0.
144. Rolfe KJ, Curran MD, Mangrolia N, Gelson W, Alexander GJ, L'Estrange M, Vivek R, Tedder R, Ijaz S. 2010. First case of genotype 4 human hepatitis E virus infection acquired in India. J. Clin. Virol. 48:58-61. http://dx.doi.org/10.1016/j.jcv.2010.02.004.
145. Adjei AA, Tettey Y, Aviyase JT, Adu-Gyamfi C, Mingle JA, Nartey ET. 2010. Unexpected elevated alanine aminotransferase, aspartate aminotransferase levels and hepatitis E virus infection among persons who work with pigs in Accra, Ghana. Virol. J. 7:336. http://dx.doi.org/10.1186 /1743-422X-7-336.
146. Galiana C, Fernandez-Barredo S, Garcia A, Gomez MT, Perez-Gracia MT. 2008. Occupational exposure to hepatitis E virus (HEV) in swine workers. Am. J. Trop. Med. Hyg. 78:1012-1015.
147. Hinjoy S, Nelson KE, Gibbons RV, Jarman RG, Mongkolsirichaikul D, Smithsuwan P, Fernandez S, Labrique AB, Patchanee P. 27 December 2012. A cross-sectional study of hepatitis E virus infection in healthy people directly exposed and unexposed to pigs in a rural community in northern Thailand. Zoonoses Public Health http://dx.doi.org/10.1111 /zph.12030.
148. Kasorndorkbua C, Opriessnig T, Huang FF, Guenette DK, Thomas PJ, Meng XJ, Halbur PG. 2005. Infectious swine hepatitis E virus is present in pig manure storage facilities on United States farms, but evidence of water contamination is lacking. Appl. Environ. Microbiol. 71:7831-7837. http://dx.doi.org/10.1128/AEM.71.12.7831-7837.2005.
149. McCreary C, Martelli F, Grierson S, Ostanello F, Nevel A, Banks M. 2008. Excretion of hepatitis E virus by pigs of different ages and its presence in slurry stores in the United Kingdom. Vet. Rec. 163:261-265. http: //dx.doi.org/10.1136/vr.163.9.261.
150. Ziemer CJ, Bonner JM, Cole D, Vinje J, Constantini V, Goyal S, Gramer M, Mackie R, Meng XJ, Myers G, Saif LJ. 2010. Fate and transport of zoonotic, bacterial, viral, and parasitic pathogens during swine manure treatment, storage, and land application. J. Anim. Sci. 88:E84-94. http://dx.doi.org/10.2527/jas.2009-2331.
151. Kuno A, Ido K, Isoda N, Satoh Y, Ono K, Satoh S, Inamori H, Sugano K, Kanai N, Nishizawa T, Okamoto H. 2003. Sporadic acute hepatitis E of a 47-year-old man whose pet cat was positive for antibody to hepatitis E virus. Hepatol Res. 26:237-242. http://dx.doi.org/10.1016/S1386-6346(03)00197-9.
152. Okamoto H, Takahashi M, Nishizawa T, Usui R, Kobayashi E. 2004. Presence of antibodies to hepatitis E virus in Japanese pet cats. Infection 32:57-58. http://dx.doi.org/10.1007/s15010-004-3078-0.
153. Anty R, Ollier L, Péron JM, Nicand E, Cannavo I, Bongain A, Giordanengo V, Tran A. 2012. First case report of an acute genotype 3 hepatitis E infected pregnant woman living in South-Eastern France. J. Clin. Virol. 54:76-78. http://dx.doi.org/10.1016/j.jcv.2012.01.016.
154. Mateos Lindemann ML, Morales JG, Fernandez-Barredo S, Dominguez MR, Garcia de la Hoz F, Halfon P, Perez Gracia MT. 2010. Fulminant hepatitis E in a woman taking oral contraceptive medication. Am. J. Trop. Med. Hyg. 82:12-15. http://dx.doi.org/10.4269/ajtmh.2010.09-0436.
155. Dalton HR, Bendall R, Ijaz S, Banks M. 2008. Hepatitis E: an emerging infection in developed countries. Lancet Infect. Dis. 8:698-709. http://dx.doi.org/10.1016/S1473-3099(08)70255-X.
156. Nelson KE, Kmush B, Labrique AB. 2011. The epidemiology of hepatitis E virus infections in developed countries and among immunocompromised patients. Expert Rev. Anti Infect. Ther. 9:1133-1148. http://dx.doi.org/10.1586/eri.11.138.
157. Stoszek SK, Abdel-Hamid M, Saleh DA, El Kafrawy S, Narooz S, Hawash Y, Shebl FM, El Daly M, Said A, Kassem E, Mikhail N, Engle RE, Sayed M, Sharaf S, Fix AD, Emerson SU, Purcell RH, Strickland GT. 2006. High prevalence of hepatitis E antibodies in pregnant Egyptian women. Trans. R. Soc. Trop. Med. Hyg. 100:95-101. http://dx.doi.org/10.1016/j.trstmh.2004.12.005.
158. Navaneethan U, Al Mohajer M, Shata MT. 2008. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Int. 28:1190-1199. http://dx.doi.org/10.1111/j.1478-3231.2008.01840.x.
159. Fix AD, Abdel-Hamid M, Purcell RH, Shehata MH, Abdel-Aziz F, Mikhail N, el Sebai H, Nafeh M, Habib M, Arthur RR, Emerson SU, Strickland GT. 2000. Prevalence of antibodies to hepatitis E in two rural Egyptian communities. Am. J. Trop. Med. Hyg. 62:519-523.
160. Meky FA, Stoszek SK, Abdel-Hamid M, Selim S, Abdel-Wahab A, Mikhail N, El-Kafrawy S, El-Daly M, Abdel-Aziz F, Sharaf S, Mohamed MK, Engle RE, Emerson SU, Purcell RH, Fix AD, Strickland GT. 2006. Active surveillance for acute viral hepatitis in rural villages in the Nile Delta. Clin. Infect. Dis. 42:628-633. http://dx.doi.org/10.1086 /500133.
161. Begum N, Polipalli SK, Husain SA, Kar P. 2010. Molecular analysis of swine hepatitis E virus from north India. Indian J. Med. Res. 132:504-508.
162. Arankalle VA, Chobe LP, Walimbe AM, Yergolkar PN, Jacob GP. 2003. Swine HEV infection in south India and phylogenetic analysis (1985-1999). J. Med. Virol. 69:391-396. http://dx.doi.org/10.1002/jmv.10301.
163. Cordoba L, Huang YW, Opriessnig T, Harral KK, Beach NM, Finkielstein CV, Emerson SU, Meng XJ. 2011. Three amino acid mutations (F51L, T59A, and S390L) in the capsid protein of the hepatitis E virus collectively contribute to virus attenuation. J. Virol. 85:5338-5349. http: //dx.doi.org/10.1128/JVI.02278-10.
164. Shukla P, Nguyen HT, Torian U, Engle RE, Faulk K, Dalton HR, Bendall RP, Keane FE, Purcell RH, Emerson SU. 2011. Cross-species infections of cultured cells by hepatitis E virus and discovery of an infectious virus-host recombinant. Proc. Natl. Acad. Sci. U. S. A. 108:2438-2443. http://dx.doi.org/10.1073/pnas.1018878108.
165. Shukla P, Nguyen HT, Faulk K, Mather K, Torian U, Engle RE, Emerson SU. 2012. Adaptation of a genotype 3 hepatitis E virus to efficient growth in cell culture depends on an inserted human gene segment acquired by recombination. J. Virol. 86:5697-5707. http://dx.doi.org/10.1128/JVI.00146-12.
166. Nguyen HT, Torian U, Faulk K, Mather K, Engle RE, Thompson E, Bonkovsky HL, Emerson S. 2012. A naturally-occurring human/ hepatitis E recombinant virus predominates in serum but not in faeces of a chronic hepatitis E patient and has a growth advantage in cell culture. J. Gen. Virol. 93:526-530. http://dx.doi.org/10.1099/vir.0.037259-0.
167. Chauhan A, Jameel S, Dilawari JB, Chawla YK, Kaur U, Ganguly NK. 1993. Hepatitis E virus transmission to a volunteer. Lancet 341:149-150. http://dx.doi.org/10.1016/0140-6736(93)90008-5.
168. Arankalle VA, Chadha MS, Banerjee K, Srinivasan MA, Chobe LP. 1993. Hepatitis E virus infection in pregnant rhesus monkeys. Indian J. Med. Res. 97:4-8.
169. Bradley DW. 1990. Enterically-transmitted non-A, non-B hepatitis. Br. Med. Bull. 46:442-461.
170. Hoofnagle JH, Nelson KE, Purcell RH. 2012. Hepatitis E. N. Engl. J. Med. 367:1237-1244. http://dx.doi.org/10.1056/NEJMra1204512.
171. Chandra NS, Sharma A, Malhotra B, Rai RR. 2010. Dynamics of HEV viremia, fecal shedding and its relationship with transaminases and antibody response in patients with sporadic acute hepatitis E. Virol. J. 7:213. http://dx.doi.org/10.1186/1743-422X-7-213.
172. Aggarwal R, Kini D, Sofat S, Naik SR, Krawczynski K. 2000. Duration of viraemia and faecal viral excretion in acute hepatitis E. Lancet 356: 1081-1082. http://dx.doi.org/10.1016/S0140-6736(00)02737-9.
173. Blackard JT, Rouster SD, Nady S, Galal G, Marzuuk N, Rafaat MM, Daef E, El Din SS, Purcell RH, Emerson SU, Sherman KE, Shata MT. 2009. Genotypic characterization of symptomatic hepatitis E virus (HEV) infections in Egypt. J. Clin. Virol. 46:140-144. http://dx.doi.org /10.1016/j.jcv.2009.07.007.
174. Zhang JZ, Im SW, Lau SH, Chau TN, Lai ST, Ng SP, Peiris M, Tse C, Ng TK, Ng MH. 2002. Occurrence of hepatitis E virus IgM, low avidity IgG serum antibodies, and viremia in sporadic cases of non-A,-B, and-C acute hepatitis. J. Med. Virol. 66:40-48. http://dx.doi.org/10.1002/jmv.2109.
175. Saravanabalaji S, Tripathy AS, Dhoot RR, Chadha MS, Kakrani AL, Arankalle VA. 2009. Viral load, antibody titers and recombinant open reading frame 2 protein-induced TH1/TH2 cytokines and cellular immune responses in self-limiting and fulminant hepatitis E. Intervirology 52:78-85. http://dx.doi.org/10.1159/000214862.
176. Bose PD, Das BC, Kumar A, Gondal R, Kumar D, Kar P. 2011. High viral load and deregulation of the progesterone receptor signaling pathway: association with hepatitis E-related poor pregnancy outcome. J. Hepatol. 54:1107-1113. http://dx.doi.org/10.1016/j.jhep.2010.08.037.
177. Mishra N, Arankalle VA. 2011. Association of polymorphisms in the promoter regions of TNF-alpha (-308) with susceptibility to hepatitis E virus and TNF-alpha (-1031) and IFN-gamma (+874) genes with clinical outcome of hepatitis E infection in India. J. Hepatol. 55:1227-1234. http://dx.doi.org/10.1016/j.jhep.2011.03.023.
178. Srivastava R, Aggarwal R, Jameel S, Puri P, Gupta VK, Ramesh VS, Bhatia S, Naik S. 2007. Cellular immune responses in acute hepatitis E virus infection to the viral open reading frame 2 protein. Viral Immunol. 20:56-65. http://dx.doi.org/10.1089/vim.2006.0053.
179. Srivastava R, Aggarwal R, Bhagat MR, Chowdhury A, Naik S. 2008. Alterations in natural killer cells and natural killer T cells during acute viral hepatitis E. J. Viral Hepat. 15:910-916. http://dx.doi.org/10.1111/j.1365-2893.2008.01036.x.
180. Majumdar M, Ratho R, Chawla Y, Singh MP. 2013. Evaluation of antigenicity and cell mediated immunity of hepatitis E virus patients: using non radioactive MTT assay. Indian J. Med. Microbiol. 31:64-68. http://dx.doi.org/10.4103/0255-0857.108725.
181. Prabhu SB, Gupta P, Durgapal H, Rath S, Gupta SD, Acharya SK, Panda SK. 2011. Study of cellular immune response against hepatitis E virus (HEV). J. Viral Hepat. 18:587-594. http://dx.doi.org/10.1111/j.1365-2893.2010.01338.x.
182. Prusty BK, Hedau S, Singh A, Kar P, Das BC. 2007. Selective suppression of NF-kBp65 in hepatitis virus-infected pregnant women manifesting severe liver damage and high mortality. Mol. Med. 13:518-526. http: //dx.doi.org/10.2119/2007-00055.Prusty.
183. Surjit M, Varshney B, Lal SK. 2012. The ORF2 glycoprotein of hepatitis E virus inhibits cellular NF-kappaB activity by blocking ubiquitination mediated proteasomal degradation of IkappaBalpha in human hepatoma cells. BMC Biochem. 13:7. http://dx.doi.org/10.1186/1471-2091-13-7.
184. Bryan JP, Tsarev SA, Iqbal M, Ticehurst J, Emerson S, Ahmed A, Duncan J, Rafiqui AR, Malik IA, Purcell RH, et al. 1994. Epidemic hepatitis E in Pakistan: patterns of serologic response and evidence that antibody to hepatitis E virus protects against disease. J. Infect. Dis. 170: 517-521. http://dx.doi.org/10.1093/infdis/170.3.517.
185. Chadha MS, Walimbe AM, Arankalle VA. 1999. Retrospective serological analysis of hepatitis E patients: a long-term follow-up study. J. Viral Hepat. 6:457-461. http://dx.doi.org/10.1046/j.1365-2893.1999.00190.x.
186. Koshy A, Grover S, Hyams KC, Shabrawy MA, Pacsa A, al-Nakib B, Zaidi SA, al-Anezi AA, al-Mufti S, Burans J, Carl M, Richards AL. 1996. Short-term IgM and IgG antibody responses to hepatitis E virus infection. Scand. J. Infect. Dis. 28:439-441. http://dx.doi.org/10.3109 /00365549609037935.
187. Arankalle VA, Favorov MO, Chadha MS, Phule DM, Banerjee K. 1993. Rhesus monkeys infected with hepatitis E virus (HEV) from the former USSR are immune to subsequent challenge with an Indian strain of HEV. Acta Virol. 37:515-518.
188. Arankalle VA, Chadha MS, Chobe LP, Nair R, Banerjee K. 1995. Cross-challenge studies in rhesus monkeys employing different Indian isolates of hepatitis E virus. J. Med. Virol. 46:358-363. http://dx.doi.org /10.1002/jmv.1890460411.
189. Meng XJ, Purcell RH, Halbur PG, Lehman JR, Webb DM, Tsareva TS, Haynes JS, Thacker BJ, Emerson SU. 1997. A novel virus in swine is closely related to the human hepatitis E virus. Proc. Natl. Acad. Sci. U. S. A. 94:9860-9865. http://dx.doi.org/10.1073/pnas.94.18.9860.
190. Meng J, Pillot J, Dai X, Fields HA, Khudyakov YE. 1998. Neutralization of different geographic strains of the hepatitis E virus with antihepatitis E virus-positive serum samples obtained from different sources. Virology 249:316-324. http://dx.doi.org/10.1006/viro.1998.9346.
191. Arankalle VA, Chadha MS, Chobe LP. 1999. Long-term serological follow up and cross-challenge studies in rhesus monkeys experimentally infected with hepatitis E virus. J. Hepatol. 30:199-204. http://dx.doi.org /10.1016/S0168-8278(99)80062-2.
192. Sanford BJ, Dryman BA, Huang YW, Feagins AR, Leroith T, Meng XJ. 2011. Prior infection of pigs with a genotype 3 swine hepatitis E virus (HEV) protects against subsequent challenges with homologous and heterologous genotypes 3 and 4 human HEV. Virus Res. 159:17-22. http: //dx.doi.org/10.1016/j.virusres.2011.04.010.
193. Drobeniuc J, Meng J, Reuter G, Greene-Montfort T, Khudyakova N, Dimitrova Z, Kamili S, Teo CG. 2010. Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances. Clin. Infect. Dis. 51:e24-27. http://dx.doi.org/10.1086/654801.
194. Baylis SA, Hanschmann KM, Blümel J, Nübling CM, HEV Collaborative Study Group. 2011. Standardization of hepatitis E virus (HEV) nucleic acid amplification technique-based assays: an initial study to evaluate a panel of HEV strains and investigate laboratory performance. J. Clin. Microbiol. 49: 1234-1239. http://dx.doi.org/10.1128/JCM.02578-10.
195. Khudyakov Y, Kamili S. 2011. Serological diagnostics of hepatitis E virus infection. Virus Res. 161:84-92. http://dx.doi.org/10.1016/j.virusres.2011.06.006.
196. Mast EE, Alter MJ, Holland PV, Purcell RH. 1998. Evaluation of assays for antibody to hepatitis E virus by a serum panel. Hepatitis E Virus Antibody Serum Panel Evaluation Group. Hepatology 27:857-861.
197. Seriwatana J, Shrestha MP, Scott RM, Tsarev SA, Vaughn DW, Myint KS, Innis BL. 2002. Clinical and epidemiological relevance of quantitating hepatitis E virus-specific immunoglobulin M. Clin. Diagn. Lab. Immunol. 9:1072-1078.
198. Zhang S, Tian D, Zhang Z, Xiong J, Yuan Q, Ge S, Zhang J, Xia N. 2009. Clinical significance of anti-HEV IgA in diagnosis of acute genotype 4 hepatitis E virus infection negative for anti-HEV IgM. Dig. Dis. Sci. 54:2512-2518. http://dx.doi.org/10.1007/s10620-008-0657-4.
199. Wenzel JJ, Preiss J, Schemmerer M, Huber B, Jilg W. 2013. Test performance characteristics of Anti-HEV IgG assays strongly influence hepatitis E seroprevalence estimates. J. Infect. Dis. 207:497-500. http: //dx.doi.org/10.1093/infdis/jis688.
200. Bendall R, Ellis V, Ijaz S, Ali R, Dalton H. 2010. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J. Med. Virol. 82: 799-805. http://dx.doi.org/10.1002/jmv.21656.
201. Fogeda M, de Ory F, Avellon A, Echevarria JM. 2009. Differential diagnosis of hepatitis E virus, cytomegalovirus and Epstein-Barr virus infection in patients with suspected hepatitis E. J. Clin. Virol. 45:259-261. http://dx.doi.org/10.1016/j.jcv.2009.05.022.
202. Ghinoiu M, Naveau S, Barri-Ova N, Thaury J, Grangeot-Keros L, Perlemuter G. 2009. Acute hepatitis E infection associated with a falsepositive serology against Epstein-Barr virus. Eur. J. Gastroenterol. Hepatol. 21:1433-1435. http://dx.doi.org/10.1097/MEG.0b013e32832f5be4.
203. Arankalle VA, Lole KS, Deshmukh TM, Chobe LP, Gandhe SS. 2007. Evaluation of human (genotype 1) and swine (genotype 4)-ORF2-based ELISAs for anti-HEV IgM and IgG detection in an endemic country and search for type 4 human HEV infections. J. Viral Hepat. 14:435-445. http://dx.doi.org/10.1111/j.1365-2893.2006.00801.x.
204. Bigaillon C, Tesse S, Lagathu G, Nicand E. 2010. Use of hepatitis E IgG avidity for diagnosis of hepatitis E infection. J. Virol. Methods 164:127-130. http://dx.doi.org/10.1016/j.jviromet.2009.11.028.
205. Katano H, Kano M, Nakamura T, Kanno T, Asanuma H, Sata T. 2011. A novel real-time PCR system for simultaneous detection of human viruses in clinical samples from patients with uncertain diagnoses. J. Med. Virol. 83:322-330. http://dx.doi.org/10.1002/jmv.21962.
206. Myint KS, Guan M, Chen HY, Lu Y, Anderson D, Howard T, Noedl H, Mammen MP, Jr. 2005. Evaluation of a new rapid immunochromatographic assay for serodiagnosis of acute hepatitis E infection. Am. J. Trop. Med. Hyg. 73:942-946.
207. Seo DJ, Tahk H, Lee KB, Lee MH, Son NR, Seo S, Cheon DS, Lee BH, Choi C. 2012. Detecting hepatitis E virus with a reverse transcription polymerase chain reaction enzyme-linked immunosorbent assay. Food Environ. Virol. 4:14-20. http://dx.doi.org/10.1007/s12560-011-9073-6.
208. Purcell RH, Engle RE, Govindarajan S, Herbert R, St Claire M, Elkins WR, Cook A, Shaver C, Beauregard M, Swerczek J, Emerson SU. 2013. Pathobiology of hepatitis E: lessons learned from primate models. Emerg. Microbes Infect. 2:e9. http://dx.doi.org/10.1038/emi.2013.9.
209. Huang W, Zhang H, Harrison TJ, Lang S, Huang G, Wang Y. 2008. Cross-protection of hepatitis E virus genotypes 1 and 4 in rhesus macaques. J. Med. Virol. 80:824-832. http://dx.doi.org/10.1002/jmv.21140.
210. Casas M, Cortes R, Pina S, Peralta B, Allepuz A, Cortey M, Casal J, Martin M. 2011. Longitudinal study of hepatitis E virus infection in Spanish farrow-to-finish swine herds. Vet. Microbiol. 148:27-34. http: //dx.doi.org/10.1016/j.vetmic.2010.08.010.
211. Ma H, Zheng L, Liu Y, Zhao C, Harrison TJ, Ma Y, Sun S, Zhang J, Wang Y. 2010. Experimental infection of rabbits with rabbit and genotypes 1 and 4 hepatitis E viruses. PLoS One 5:e9160. http://dx.doi.org/10.1371/journal.pone.0009160.
212. Cheng X, Wang S, Dai X, Shi C, Wen Y, Zhu M, Zhan S, Meng J. 2012. Rabbit as a novel animal model for hepatitis E virus infection and vaccine evaluation. PLoS One 7:e51616. http://dx.doi.org/10.1371/journal.pone.0051616.
213. Cossaboom CM, Cordoba L, Sanford BJ, Pineyro P, Kenney SP, Dryman BA, Wang Y, Meng XJ. 2012. Cross-species infection of pigs with a novel rabbit, but not rat, strain of hepatitis E virus isolated in the United States. J. Gen. Virol. 93:1687-1695. http://dx.doi.org/10.1099/vir.0.041509-0.
214. Liu P, Bu QN, Wang L, Han J, Du RJ, Lei YX, Ouyang YQ, Li J, Zhu YH, Lu FM, Zhuang H. 2013. Transmission of hepatitis E virus from rabbits to cynomolgus macaques. Emerg. Infect. Dis. 19:559-565. http: //dx.doi.org/10.3201/eid1904.120827.
215. Myint KS, Endy TP, Shrestha MP, Shrestha SK, Vaughn DW, Innis BL, Gibbons RV, Kuschner RA, Seriwatana J, Scott RM. 2006. Hepatitis E antibody kinetics in Nepalese patients. Trans. R. Soc. Trop. Med. Hyg. 100:938-941. http://dx.doi.org/10.1016/j.trstmh.2005.12.005.
216. Buti M, Clemente-Casares P, Jardi R, Formiga-Cruz M, Schaper M, Valdes A, Rodriguez-Frias F, Esteban R, Girones R. 2004. Sporadic cases of acute autochthonous hepatitis E in Spain. J. Hepatol. 41:126-131. http://dx.doi.org/10.1016/j.jhep.2004.03.013.
217. Chow WC, Lee AS, Lim GK, Cheong WK, Chong R, Tan CK, Yap CK, Oon CJ, Ng HS. 1997. Acute viral hepatitis E: clinical and serologic studies in Singapore. J. Clin. Gastroenterol. 24:235-238. http://dx.doi.org/10.1097/00004836-199706000-00011.
218. Goldsmith R, Yarbough PO, Reyes GR, Fry KE, Gabor KA, Kamel M, Zakaria S, Amer S, Gaffar Y. 1992. Enzyme-linked immunosorbent assay for diagnosis of acute sporadic hepatitis E in Egyptian children. Lancet 339:328-331. http://dx.doi.org/10.1016/0140-6736(92)91647-Q.
219. Khuroo MS, Kamili S, Dar MY, Moecklii R, Jameel S. 1993. Hepatitis E and long-term antibody status. Lancet 341:1355. http://dx.doi.org/10.1016/0140-6736(93)90873-F.
220. Khuroo MS. 2010. Seroepidemiology of a second epidemic of hepatitis E in a population that had recorded first epidemic 30 years before and has been under surveillance since then. Hepatol. Int. 4:494-499. http://dx.doi.org/10.1007/s12072-009-9159-5.
221. Corwin A, Jarot K, Lubis I, Nasution K, Suparmawo S, Sumardiati A, Widodo S, Nazir S, Orndorff G, Choi Y, et al. 1995. Two years' investigation of epidemic hepatitis E virus transmission in West Kalimantan (Borneo), Indonesia. Trans. R. Soc. Trop. Med. Hyg. 89:262-265. http://dx.doi.org/10.1016/0035-9203(95)90529-4.
222. Liu L, Liu Y. 2011. Analysis of acute to chronic hepatitis E: 6-10 year follow-up. Hepatogastroenterology 58:324-325.
223. Rapicetta M, Kondili LA, Pretolani S, Stroffolini T, Chionne P, Villano U, Madonna E, Casali F, Gasbarrini G. 1999. Seroprevalence and anti-HEV persistence in the general population of the Republic of San Marino. J. Med. Virol. 58:49-53. http://dx.doi.org/10.1002/(SICI)1096-9071(199905)58:1-49::AID-JMV7_3.0.CO;2-C.
224. Ibarra H, Riedemann S, Toledo C. 2006. Hepatitis A and E virus antibodies in Chilean children of low socioeconomic status: a one year follow-up study. Rev. Med. Chil. 134:139-144.
225. Arankalle VA, Lole KS, Deshmukh TM, Srivastava S, Shaligram US. 2009. Challenge studies in rhesus monkeys immunized with candidate hepatitis E vaccines: DNA, DNA-prime-protein-boost and DNA-protein encapsulated in liposomes. Vaccine 27:1032-1039. http://dx.doi.org/10.1016/j.vaccine.2008.11.097.
226. Huang WJ, Zhang HY, Harrison TJ, Lan HY, Huang GY, Wang YC. 2009. Immunogenicity and protective efficacy in rhesus monkeys of a recombinant ORF2 protein from hepatitis E virus genotype 4. Arch. Virol. 154:481-488. http://dx.doi.org/10.1007/s00705-009-0335-7.
227. Kamili S, Spelbring J, Carson D, Krawczynski K. 2004. Protective efficacy of hepatitis E virusDNAvaccine administered by gene gun in the cynomolgus macaque model of infection. J. Infect. Dis. 189:258-264. http://dx.doi.org/10.1086/380801.
228. Purcell RH, Nguyen H, Shapiro M, Engle RE, Govindarajan S, Blackwelder WC, Wong DC, Prieels JP, Emerson SU. 2003. Pre-clinical immunogenicity and efficacy trial of a recombinant hepatitis E vaccine. Vaccine 21:2607-2615. http://dx.doi.org/10.1016/S0264-410X(03)00100-2.
229. Tsarev SA, Tsareva TS, Emerson SU, Govindarajan S, Shapiro M, Gerin JL, Purcell RH. 1997. Recombinant vaccine against hepatitis E: dose response and protection against heterologous challenge. Vaccine 15:1834-1838. http://dx.doi.org/10.1016/S0264-410X(97)00145-X.
230. Zhang M, Emerson SU, Nguyen H, Engle RE, Govindarajan S, Gerin JL, Purcell RH. 2001. Immunogenicity and protective efficacy of a vaccine prepared from 53 kDa truncated hepatitis E virus capsid protein expressed in insect cells. Vaccine 20:853-857. http://dx.doi.org/10.1016 /S0264-410X(01)00399-1.
231. Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Yao X, Liang ZL, Wu T, Li JX, Yan Q, Yang CL, Jiang HM, Huang HJ, Xian YL, Shih JWK, Ng MH, Li YM, Wang JZ, Zhu FC, Xia NS. 5 October 2013. Protection against hepatitis E virus infection by naturally acquired and vaccine induced immunity. Clin. Microbiol. Infect. http://dx.doi.org/10.1111/1469-0691.12419.
232. Zhu FC, Zhang J, Zhang XF, Zhou C, Wang ZZ, Huang SJ, Wang H, Yang CL, Jiang HM, Cai JP, Wang YJ, Ai X, Hu YM, Tang Q, Yao X, Yan Q, Xian YL, Wu T, Li YM, Miao J, Ng MH, Shih JW, Xia NS. 2010. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, phase 3 trial. Lancet 376:895-902. http://dx.doi.org/10.1016/S0140-6736(10)61030-6.
233. Li SW, Zhang J, Li YM, Ou SH, Huang GY, He ZQ, Ge SX, Xian YL, Pang SQ, Ng MH, Xia NS. 2005. A bacterially expressed particulate hepatitis E vaccine: antigenicity, immunogenicity and protectivity on primates. Vaccine 23:2893-2901. http://dx.doi.org/10.1016/j.vaccine.2004.11.064.
234. Wu T, Huang SJ, Zhu FC, Zhang XF, Ai X, Yan Q, Wang ZZ, Yang CL, Jiang HM, Liu XH, Guo M, Du HL, Ng MH, Zhang J, Xia NS. 25 July 2013. Immunogenicity and safety of hepatitis E vaccine in healthy hepatitis B surface antigen positive adults. Hum. Vaccin Immunother. doi: http://dx.doi.org/10.4161/hv.25814.
235. Zhang J, Shih JW, Wu T, Li SW, Xia NS. 2013. Development of the hepatitis E vaccine: from bench to field. Semin. Liver Dis. 33:79-88. http://dx.doi.org/10.1055/s-0033-1338116.
236. Proffitt A. 2012. First HEV vaccine approved. Nat. Biotechnol. 30:300. http://dx.doi.org/10.1038/nbt0412-300a.
237. Labrique AB, Sikder SS, Krain LJ, West KP, Jr, Christian P, Rashid M, Nelson KE. 2012. Hepatitis E, a vaccine-preventable cause of maternal death. Emerg. Infect. Dis. 18:1401-1404. http://dx.doi.org/10.3201 /eid1809.120241.
238. Sarin SK, Kumar MA. 2011. Vaccine for hepatitis E: has it finally arrived? Gastroenterology 140:1349-1352. (Discussion 140:1352-1353.) http: //dx.doi.org/10.1053/j.gastro.2011.02.040.
239. Kamili S. 2011. Toward the development of a hepatitis E vaccine. Virus Res. 161:93-100. http://dx.doi.org/10.1016/j.virusres.2011.05.008.
240. Basnyat B. 2010. Neglected hepatitis E and typhoid vaccines. Lancet 376:869. http://dx.doi.org/10.1016/S0140-6736(10)61403-1.
241. Holmberg SD. 2010. Hepatitis E vaccine: not a moment too soon. Lancet 376:849-851. http://dx.doi.org/10.1016/S0140-6736(10)61260-3.
242. Myint KS, Gibbons RV. 2008. Hepatitis E: a neglected threat. Trans. R. Soc. Trop. Med. Hyg. 102:211-212. http://dx.doi.org/10.1016/j.trstmh.2007.03.014.
243. Krawczynski K. 2007. Hepatitis E vaccine-ready for prime time? N. Engl. J. Med. 356:949-951. http://dx.doi.org/10.1056/NEJMe068311.
244. Basu S, Lurie P. 2007. Hepatitis E vaccine. N. Engl. J. Med. 356:2421-2422. http://dx.doi.org/10.1056/NEJMc070884.
245. Bhattarai A. 2007. Hepatitis E vaccine. N. Engl. J. Med. 356:2421-2422. http://dx.doi.org/10.1056/NEJMc070884.
246. Basu S, Andrews J, Smith-Rohrberg D. 2006. Populations who test drugs should benefit from them. Nature 440:605. http://dx.doi.org/10.1038/440605d.
247. Shrestha MP, Scott RM, Joshi DM, Mammen MP, Jr, Thapa GB, Thapa N, Myint KS, Fourneau M, Kuschner RA, Shrestha SK, David MP, Seriwatana J, Vaughn DW, Safary A, Endy TP, Innis BL. 2007. Safety and efficacy of a recombinant hepatitis E vaccine. N. Engl. J. Med. 356:895-903. http://dx.doi.org/10.1056/NEJMoa061847.
248. Robinson RA, Burgess WH, Emerson SU, Leibowitz RS, Sosnovtseva SA, Tsarev S, Purcell RH. 1998. Structural characterization of recombinant hepatitis E virus ORF2 proteins in baculovirus-infected insect cells. Protein Expr. Purif. 12:75-84. http://dx.doi.org/10.1006/prep.1997.0817.
249. Shata MT, Barrett A, Shire NJ, Abdelwahab SF, Sobhy M, Daef E, El-Kamary SS, Hashem M, Engle RE, Purcell RH, Emerson SU, Strickland GT, Sherman KE. 2007. Characterization of hepatitis E-specific cell-mediated immune response using IFN-gamma ELISPOT assay. J. Immunol. Methods 328:152-161. http://dx.doi.org/10.1016/j.jim.2007.08.014.
250. Husain MM, Srivastava R, Akondy R, Aggarwal R, Jameel S, Naik S. 2011. Evidence of hepatitis E virus exposure among seronegative healthy residents of an endemic area. Intervirology 54:139-143. http://dx.doi.org/10.1159/000319840.
251. Satoh S, Ido K-i, Isoda N, Hirasawa T, Iino S, Hozumi M, Ono K, Nagamine N, Sugano K, Okamoto H, Mayumi M. 2002. A case of domestically infected acute hepatitis E. Kanzo. 43:332-335. http://dx.doi.org/10.2957/kanzo.43.332.
252. Takahashi M, Nishizawa T, Yoshikawa A, Sato S, Isoda N, Ido K, Sugano K, Okamoto H. 2002. Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad. J. Gen. Virol. 83:1931-1940.
253. Moal V, Gérolami R, Colson P. 2012. First human case of coinfection with two different subtypes of hepatitis E virus. Intervirology 55:484-487. http://dx.doi.org/10.1159/000335664.
254. Smith DB, Vanek J, Wellington L, Johannessen I, Ramalingam S, Simmonds P. 2013. Hepatitis E virus mixed infection in immunocompetent patient. Emerg. Infect. Dis. 19:468-470. http://dx.doi.org/10.3201/eid1903.121510.
255. Shrestha SM, Shrestha S, Tsuda F, Nishizawa T, Gotanda Y, Takeda N, Okamoto H. 2003. Molecular investigation of hepatitis E virus infection in patients with acute hepatitis in Kathmandu, Nepal. J. Med. Virol. 69:207-214. http://dx.doi.org/10.1002/jmv.10276.
256. Shrestha SM, Shrestha S, Tsuda F, Nishizawa T, Takahashi M, Gotanda Y, Okamoto H. 2004. Genetic changes in hepatitis E virus of subtype 1a in patients with sporadic acute hepatitis E in Kathmandu, Nepal, from 1997 to 2002. J. Gen. Virol. 85:97-104. http://dx.doi.org/10.1099/vir.0.19571-0.
257. Arankalle VA, Chobe LP, Joshi MV, Chadha MS, Kundu B, Walimbe AM. 2002. Human and swine hepatitis E viruses from Western India belong to different genotypes. J. Hepatol. 36:417-425. http://dx.doi.org /10.1016/S0168-8278(01)00297-5.
258. Ma Z, Feng R, Zhao C, Harrison TJ, Li M, Qiao Z, Feng Y, Wang Y. 2010. Seroprevalence and distribution of hepatitis E virus in various ethnic groups in Gansu province, China. Infect. Genet. Evol. 10:614-619. http://dx.doi.org/10.1016/j.meegid.2010.04.003.
259. Arankalle VA, Chobe LP, Chadha MS. 2006. Type-IV Indian swine HEV infects rhesus monkeys. J. Viral Hepat. 13:742-745. http://dx.doi.org/10.1111/j.1365-2893.2006.00759.x.
260. Matsubayashi K, Nagaoka Y, Sakata H, Sato S, Fukai K, Kato T, Takahashi K, Mishiro S, Imai M, Takeda N, Ikeda H. 2004. Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan. Transfusion 44:934-940. http://dx.doi.org/10.1111/j.1537-2995.2004.03300.x.
261. Mitsui T, Tsukamoto Y, Yamazaki C, Masuko K, Tsuda F, Takahashi M, Nishizawa T, Okamoto H. 2004. Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. J. Med. Virol. 74:563-572. http://dx.doi.org/10.1002/jmv.20215.
262. Boxall E, Herborn A, Kochethu G, Pratt G, Adams D, Ijaz S, Teo CG. 2006. Transfusion-transmitted hepatitis E in a 'nonhyperendemic' country. Transfus. Med. 16:79-83. http://dx.doi.org/10.1111/j.1365-3148.2006.00652.x.
263. Tamura A, Shimizu YK, Tanaka T, Kuroda K, Arakawa Y, Takahashi K, Mishiro S, Shimizu K, Moriyama M. 2007. Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma. Hepatol. Res. 37:113-120. http://dx.doi.org/10.1111/j.1872-034X.2007.00024.x.
264. Colson P, Coze C, Gallian P, Henry M, De Micco P, Tamalet C. 2007. Transfusion-associated hepatitis E, France. Emerg. Infect. Dis. 13:648-649. http://dx.doi.org/10.3201/eid1304.061387.
265. Mansuy JM, Huynh A, Abravanel F, Recher C, Peron JM, Izopet J. 2009. Molecular evidence of patient-to-patient transmission of hepatitis E virus in a hematology ward. Clin. Infect. Dis. 48:373-374. http://dx.doi.org/10.1086/595893.
266. Colson P, Dhiver C, Poizot-Martin I, Tamalet C, Gérolami R. 2011. Acute and chronic hepatitis E in patients infected with human immunodeficiency virus. J. Viral Hepat. 18:227-228. http://dx.doi.org/10.1111/j.1365-2893.2010.01311.x.
267. Colson P, Kaba M, Moreau J, Brouqui P. 2009. Hepatitis E in an HIV-infected patient. J. Clin. Virol. 45:269-271. http://dx.doi.org/10.1016/j.jcv.2009.06.002.
268. Dalton HR, Bendall RP, Keane FE, Tedder RS, Ijaz S. 2009. Persistent carriage of hepatitis E virus in patients with HIV infection. N. Engl. J. Med. 361:1025-1027. http://dx.doi.org/10.1056/NEJMc0903778.
269. Dalton HR, Keane FE, Bendall R, Mathew J, Ijaz S. 2011. Treatment of chronic hepatitis E in a patient with HIV infection. Ann. Intern. Med. 155: 479-480. http://dx.doi.org/10.7326/0003-4819-155-7-201110040-00017.
270. Jagjit Singh GK, Ijaz S, Rockwood N, Farnworth SP, Devitt E, Atkins M, Tedder R, Nelson M. 2013. Chronic hepatitis E as a cause for cryptogenic cirrhosis in HIV. J. Infect. 66:103-106. http://dx.doi.org/10.1016 /j.jinf.2011.11.027.
271. Jardi R, Crespo M, Homs M, Van den Eyden E, Girones R, Rodriguez J, Caballero A, Buti M, Esteban R, Rodriguez-Frias F. 2012. HIV, HEV and cirrhosis: evidence of a possible link from eastern Spain. HIV Med. 13:379-383. http://dx.doi.org/10.1111/j.1468-1293.2011.00985.x.
272. Kaba M, Richet H, Ravaux I, Moreau J, Poizot-Martin I, Motte A, Nicolino-Brunet C, Dignat-George F, Ménard A, Dhiver C, Brouqui P, Colson P. 2011. Hepatitis E virus infection in patients infected with the human immunodeficiency virus. J. Med. Virol. 83:1704-1716. http://dx.doi.org/10.1002/jmv.22177.
273. Kenfak-Foguena A, Schoni-Affolter F, Burgisser P, Witteck A, Darling KE, Kovari H, Kaiser L, Evison JM, Elzi L, Gurter-De La Fuente V, Jost J, Moradpour D, Abravanel F, Izpopet J, Cavassini M, Data Center of the Swiss Hiv Cohort Study LS. 2011. Hepatitis E virus seroprevalence and chronic infections in patients with HIV, Switzerland. Emerg. Infect. Dis. 17:1074-1078. http://dx.doi.org/10.3201/eid/1706.101067.
274. Neukam K, Barreiro P, Macias J, Avellon A, Cifuentes C, Martin-Carbonero L, Echevarria JM, Vargas J, Soriano V, Pineda JA. 2013. Chronic hepatitis E in HIV patients: rapid progression to cirrhosis and response to oral ribavirin. Clin. Infect. Dis. 57:465-468. http://dx.doi.org/10.1093/cid/cit224.
275. Kamar N, Garrouste C, Haagsma EB, Garrigue V, Pischke S, Chauvet C, Dumortier J, Cannesson A, Cassuto-Viguier E, Thervet E, Conti F, Lebray P, Dalton HR, Santella R, Kanaan N, Essig M, Mousson C, Radenne S, Roque-Afonso AM, Izopet J, Rostaing L. 2011. Factors associated with chronic hepatitis in patients with hepatitis E virus infection who have received solid organ transplants. Gastroenterology 140: 1481-1489. http://dx.doi.org/10.1053/j.gastro.2011.02.050.
276. Halac U, Beland K, Lapierre P, Patey N, Ward P, Brassard J, Houde A, Alvarez F. 2012. Chronic hepatitis E infection in children with liver transplantation. Gut 61:597-603. http://dx.doi.org/10.1136/gutjnl-2011-300708.
277. Buffet C, Laurent-Puig P, Chandot S, Laurian Y, Charpentier B, Briantais MJ, Dussaix E. 1996. A high hepatitis E virus seroprevalence among renal transplantation and haemophilia patient populations. J. Hepatol. 24:122-125. http://dx.doi.org/10.1016/S0168-8278(96)80196-6.
278. Agarwal SK, Irshad M, Dash SC. 1999. Prevalence of antibodies against hepatitis E virus in haemodialysis patients in India. Nephron 81:448. http://dx.doi.org/10.1159/000045334.
279. Arinsoy T, Yilmaz M, Derici Üsindel S, Tekin I, Hasanoglu E. 1998. Prevalence of hepatitis E virus antibody in hemodialysis patients. Nephron 80:85. http://dx.doi.org/10.1159/000045133.
280. Ayoola EA, Want MA, Gadour MO, Al-Hazmi MH, Hamza MK. 2002. Hepatitis E virus infection in haemodialysis patients: a case-control study in Saudi Arabia. J. Med. Virol. 66:329-334. http://dx.doi.org/10.1002 /jmv.2149.
281. Taremi M, Khoshbaten M, Gachkar L, EhsaniArdakani M, Zali M. 2005. Hepatitis E virus infection in hemodialysis patients: a seroepidemiological survey in Iran. BMC Infect. Dis. 5:36. http://dx.doi.org/10.1186/1471-2334-5-36.
282. Khameneh ZR, Sepehrvand N, Masudi S. 2011. Seroprevalence of hepatitis E among Iranian renal transplant recipients. Hepat Mon. 11: 646-651. http://dx.doi.org/10.5812/kowsar.1735143X.709.
283. Psichogiou M, Vaindirli E, Tzala E, Voudiclari S, Boletis J, Vosnidis G, Moutafis S, Skoutelis G, Hadjiconstantinou V, Troonen H, Hatzakis A. 1996. Hepatitis E virus (HEV) infection in haemodialysis patients. The Multicentre Haemodialysis Cohort Study on Viral Hepatitis. Nephrol. Dial. Transplant. 11:1093-1095.
284. Dalekos GN, Zervou E, Elisaf M, Germanos N, Galanakis E, Bourantas K, Siamopoulos KC, Tsianos EV. 1998. Antibodies to hepatitis E virus among several populations in Greece: increased prevalence in an hemodialysis unit. Transfusion 38:589-595. http://dx.doi.org/10.1046/j.1537-2995.1998.38698326339.x.
285. Fabrizi F, Lunghi G, Bacchini G, Corti M, Pagano A, Locatelli F. 1997. Hepatitis E virus infection in haemodialysis patients: a seroepidemiological survey. Nephrol. Dial. Transplant. 12:133-136. http://dx.doi.org/10.1093/ndt/12.1.133.
286. Sylvan SP, Jacobson SH, Christenson B. 1998. Prevalence of antibodies to hepatitis E virus among hemodialysis patients in Sweden. J. Med. Virol. 54:38-43. http://dx.doi.org/10.1002/(SICI)1096-9071(199801)54:1-38::AID-JMV6_3.0.CO;2-Q.
287. Takahashi M, Tanaka T, Azuma M, Kusano E, Aikawa T, Shibayama T, Yazaki Y, Mizuo H, Inoue J, Okamoto H. 2007. Prolonged fecal shedding of hepatitis E virus (HEV) during sporadic acute hepatitis E: evaluation of infectivity of HEV in fecal specimens in a cell culture system. J. Clin. Microbiol. 45:3671-3679. http://dx.doi.org/10.1128/JCM.01086-07.
288. Abravanel F, Mansuy JM, Huynh A, Kamar N, Alric L, Peron JM, Récher C, Izopet J. 2012. Low risk of hepatitis E virus reactivation after haematopoietic stem cell transplantation. J. Clin. Virol. 54:152-155. http://dx.doi.org/10.1016/j.jcv.2012.02.015.
289. Alric L, Bonnet D, Beynes-Rauzy O, Izopet J, Kamar N. 2011. Definitive clearance of a chronic hepatitis E virus infection with ribavirin treatment. Am. J. Gastroenterol. 106:1562-1563. http://dx.doi.org/10.1038 /ajg.2011.158.
290. Koenecke C, Pischke S, Heim A, Raggub L, Bremer B, Raupach R, Buchholz S, Schulz T, Manns MP, Ganser A, Wedemeyer H. 2011. Chronic hepatitis E in hematopoietic stem cell transplant patients in a low-endemic country? Transpl. Infect. Dis. 14:103-106. http://dx.doi.org/10.1111/j.1399-3062.2011.00702.x.
291. le Coutre P, Meisel H, Hofmann J, Röcken C, Vuong GL, Neuburger S, Hemmati PG, Dörken B, Arnold R. 2009. Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukaemia after allogeneic stem cell transplantation. Gut 58:699-702. http://dx.doi.org/10.1136 /gut.2008.165571.
292. Motte A, Roquelaure B, Galambrun C, Bernard F, Zandotti C, Colson P. 2012. Hepatitis E in three immunocompromised children in southeastern France. J. Clin. Virol. 53:162-166. http://dx.doi.org/10.1016/j.jcv.2011.11.012.
293. Ollier L, Tieulie N, Sanderson F, Heudier P, Giordanengo V, Fuzibet JG, Nicand E. 2009. Chronic hepatitis after hepatitis E virus infection in a patient with non-Hodgkin lymphoma taking rituximab. Ann. Intern. Med. 150:430-431. http://dx.doi.org/10.7326/0003-4819-150-6-200903170-00025.
294. Pfefferle S, Frickmann H, Gabriel M, Schmitz N, Gunther S, Schmidt-Chanasit J. 2011. Fatal course of an autochthonous hepatitis E virus infection in a patient with leukemia in Germany. Infection 40:451-454. http://dx.doi.org/10.1007/s15010-011-0220-7.
295. Balayan MS, Fedorova OE, Mikhailov MI, Rytick PG, Eremin VF, Danilova TI, Shevelev BI, Gorbacheva EC, Pankova GY. 1997. Antibody to hepatitis E virus in HIV-infected individuals and AIDS patients. J. Viral Hepat. 4:279-283. http://dx.doi.org/10.1046/j.1365-2893.1997.00050.x.
296. Fainboim H, Gonzalez J, Fassio E, Martinez A, Otegui L, Eposto M, Cahn P, Marino R, Landeira G, Suaya G, Gancedo E, Castro R, Brajterman L, Laplume H. 1999. Prevalence of hepatitis viruses in an anti-human immunodeficiency virus-positive population from Argentina. A multicentre study. J. Viral Hepat. 6:53-57. http://dx.doi.org/10.1046/j.1365-2893.1999.t01-1-6120135.x.
297. Montella F, Rezza G, Di Sora F, Pezzotti P, Recchia O. 1994. Association between hepatitis E virus and HIV infection in homosexual men. Lancet 344:1433. http://dx.doi.org/10.1016/S0140-6736(94)90598-3.
298. Nandwani R, Medrano FJ, Sanchez-Quijano A, Torronteras R, Leal M, Lissen E. 1995. Hepatitis E virus and HIV infection in homosexual men. Lancet 345:126-127. http://dx.doi.org/10.1016/S0140-6736(95)90091-8.
299. Medrano FJ, Sanchez-Quijano A, Torronteras R, Leal M, Lissen E. 1995. Hepatitis E virus and HIV infection in homosexual men. Lancet 345:127.
300. Christensen PB, Engle RE, Jacobsen SE, Krarup HB, Georgsen J, Purcell RH. 2002. High prevalence of hepatitis E antibodies among Danish prisoners and drug users. J. Med. Virol. 66:49-55. http://dx.doi.org /10.1002/jmv.2110.
301. Bissuel F, Houhou N, Leport C, Brun-Vezinet F, Vilde JL. 1996. Hepatitis E antibodies and HIV status. Lancet 347:1494. http://dx.doi.org/10.1016/S0140-6736(96)91734-1.
302. Pawlotsky JM, Belec L, Gresenguet G, Deforges L, Bouvier M, Duval J, Dhumeaux D. 1995. High prevalence of hepatitis B, C, and E markers in young sexually active adults from the Central African Republic. J. Med. Virol. 46:269-272. http://dx.doi.org/10.1002/jmv.1890460318.
303. Crum-Cianflone NF, Curry J, Drobeniuc J, Weintrob A, Landrum M, Ganesan A, Bradley W, Agan BK, Kamili S, Infectious Disease Clinical Research Program HIV Working Group. 2012. Hepatitis E virus infection in HIV-infected persons. Emerg. Infect. Dis. 18:502-506. http://dx.doi.org/10.3201/eid1803.111278.
304. Curry JA, Adams N, Crum-Cianflone NF. 2009. Acute hepatitis E virus infection in an HIV-infected person in the United States. Ann. Intern. Med. 150:226-227. http://dx.doi.org/10.7326/0003-4819-150-3-200902030-00028.
305. Achwan WA, Muttaqin Z, Zakaria E, Depamede SA, Mulyanto Sumoharjo S, Tsuda F, Takahashi K, Abe N, Mishiro S. 2007. Epidemiology of hepatitis B, C, and E viruses and human immunodeficiency virus infections in Tahuna, Sangihe-Talaud Archipelago, Indonesia. Intervirology 50:408-411. http://dx.doi.org/10.1159/000112915.
306. Caron M, Bouscaillou J, Kazanji M. 2012. Acute risk for hepatitis E virus infection among HIV-1-positive pregnant women in central Africa. Virol. J. 9:254. http://dx.doi.org/10.1186/1743-422X-9-254.
307. Colson P, Dhiver C, Gérolami R. 2008. Hepatitis E virus as a newly identified cause of acute viral hepatitis during human immunodeficiency virus infection. Clin. Microbiol. Infect. 14:1176-1180. http://dx.doi.org /10.1111/j.1469-0691.2008.02102.x.
308. Colson P, Gérolami R, Moreau J, Borentain P, Brouqui P. 2010. Concurrent autochthonous acute hepatitis E and hepatitis B reverse seroconversion in an HIV-1-infected patient: one virus may hide another. Int. J. Infect. Dis. 14:e357. http://dx.doi.org/10.1016/j.ijid.2009.04.007.
309. Renou C, Lafeuillade A, Cadranel JF, Pavio N, Pariente A, Allègre T, Poggi C, Pénaranda G, Cordier F, Nicand E, Angh. 2010. Hepatitis E virus in HIV-infected patients. AIDS 24:1493-1499. http://dx.doi.org/10.1097/QAD.0b013e32833a29ab.
310. Renou C, Lafeuillade A, Pavio N, Nicand E. 2010. Response to Madejon et al.: are HIV-infected patients at risk of HEV infection? J. Viral Hepat. 17:380. http://dx.doi.org/10.1111/j.1365-2893.2009.01203.x.
311. Sellier P, Mazeron MC, Tessé S, Badsi E, Evans J, Magnier JD, Sanson-Le-Pors MJ, Bergmann JF, Nicand E. 2011. Hepatitis E virus infection in HIV-infected patients with elevated serum transaminases levels. Virol. J. 8:171. http://dx.doi.org/10.1186/1743-422X-8-171.
312. Thoden J, Venhoff N, Miehle N, Klar M, Huzly D, Panther E, Jilg N, Kunze M, Warnatz K. 2008. Hepatitis E and jaundice in an HIV-positive pregnant woman. AIDS 22:909-910. http://dx.doi.org/10.1097/QAD.0b013e3282f7cb9a.
313. van Welzen BJ, Lunel FM, Meindertsma F, Hoepelman AI, Arends JE. 2012. Hepatitis E virus as a causative agent of unexplained liver enzyme elevations in HIV-infected patients. J. Acquir. Immune Defic. Syndr. 60:e65-67. http://dx.doi.org/10.1097/QAI.0b013e318251b01f.
314. Keane F, Gompels M, Bendall R, Drayton R, Jennings L, Black J, Baragwanath G, Lin N, Henley W, Ngui SL, Ijaz S, Dalton H. 2012. Hepatitis E virus coinfection in patients with HIV infection. HIV Med. 13:83-88. http://dx.doi.org/10.1111/j.1468-1293.2011.00942.x.
315. Madejón A, Vispo E, Bottecchia M, Sánchez-Carrillo M, García-Samaniego J, Soriano V. 2009. Lack of hepatitis E virus infection in HIV patients with advanced immunodeficiency or idiopathic liver enzyme elevations. J. Viral Hepat. 16:895-896. http://dx.doi.org/10.1111/j.1365-2893.2009.01138.x.
316. Mateos-Lindemann ML, Gonzalez-Galdámez A, Bordallo-Cardona M, Pérez-Gracia MT. 2012. Are HIV-infected patients a high-risk population for hepatitis E virus infection in Spain? Enferm. Infecc. Microbiol. Clin. 30:582-583. http://dx.doi.org/10.1016/j.eimc.2012.03.010.
317. Maylin S, Stephan R, Molina JM, Peraldi MN, Scieux C, Nicand E, Simon F, Delaugerre C. 2012. Prevalence of antibodies and RNA genome of hepatitis E virus in a cohort of French immunocompromised. J. Clin. Virol. 53:346-349. http://dx.doi.org/10.1016/j.jcv.2012.01.001.
318. Ng KP, He J, Saw TL, Lyles CM. 2000. A seroprevalence study of viral hepatitis E infection in human immunodeficiency virus type 1 infected subjects in Malaysia. Med. J. Malaysia 55:58-64.
319. Kuniholm MH, Labrique AB, Nelson KE. 2010. Should HIV-infected patients with unexplained chronic liver enzyme elevations be tested for hepatitis E virus? Clin. Infect. Dis. 50:1545-1546. http://dx.doi.org/10.1086/652716.
320. Dalton HR, Hunter JG, Bendall R. 2013. Autochthonous hepatitis E in developed countries and HEV/HIV coinfection. Semin. Liver Dis. 33:50-61. http://dx.doi.org/10.1055/s-0033-1338114.
321. Pischke S, Ho H, Urbanek F, Meyer-Olsen D, Suneetha PV, Manns MP, Stoll M, Wedemeyer H. 2010. Hepatitis E in HIV-positive patients in a low-endemic country. J. Viral Hepat. 17:598-599. http://dx.doi.org /10.1111/j.1365-2893.2009.01219.x.
322. Aubry P, Niel L, Niyongabo T, Kerguelen S, Larouze B. 1997. Seroprevalence of hepatitis E virus in an adult urban population from Burundi. Am. J. Trop. Med. Hyg. 57:272-273.
323. Richard-Lenoble D, Traore O, Kombila M, Roingeard P, Dubois F, Goudeau A. 1995. Hepatitis B, C, D, and E markers in rural equatorial African villages (Gabon). Am. J. Trop. Med. Hyg. 53:338-341.
324. Feldt T, Sarfo FS, Zoufaly A, Phillips RO, Burchard G, van Lunzen J, Jochum J, Chadwick D, Awasom C, Claussen L, Drosten C, Drexler JF, Eis-Hubinger AM. 2013. Hepatitis E virus infections in HIV-infected patients in Ghana and Cameroon. J. Clin. Virol. 58:18-23. http://dx.doi.org/10.1016/j.jcv.2013.05.004.
325. Andersson MI, Preiser W, Maponga TG, Heys I, Taljaard JJ, van Rensburg C, Tedder RS, Ijaz S. 2013. Immune reconstitution hepatitis E: a neglected complication of antiretroviral therapy in Africa? AIDS 27:487-489. http://dx.doi.org/10.1097/QAD.0b013e32835b1074.
326. Kumar A, Beniwal M, Kar P, Sharma JB, Murthy NS. 2004. Hepatitis E in pregnancy. Int. J. Gynaecol. Obstet. 85:240-244. http://dx.doi.org /10.1016/j.ijgo.2003.11.018.
327. Rein DB, Stevens G, Theaker J, Wittenborn JS, Wiersma ST. 2012. The global burden of hepatitis E virus genotypes 1 and 2 in 2005. Hepatology 55:988-997. http://dx.doi.org/10.1002/hep.25505.
328. Gurley ES, Halder AK, Streatfield PK, Sazzad HM, Nurul Huda TM, Hossain MJ, Luby SP. 2012. Estimating the burden of maternal and neonatal deaths associated with jaundice in Bangladesh: possible role of hepatitis E infection. Am. J. Public Health 102:2248-2254. http://dx.doi.org/10.2105/AJPH.2012.300749.
329. Ahmed RE, Karsany MS, Adam I. 2008. Acute viral hepatitis and poor maternal and perinatal outcomes in pregnant Sudanese women. J. Med. Virol. 80:1747-1748. http://dx.doi.org/10.1002/jmv.21284.
330. Patra S, Kumar A, Trivedi SS, Puri M, Sarin SK. 2007. Maternal and fetal outcomes in pregnant women with acute hepatitis E virus infection. Ann. Intern. Med. 147:28-33. http://dx.doi.org/10.7326/0003-4819-147-1-200707030-00005.
331. Rasheeda CA, Navaneethan U, Jayanthi V. 2008. Liver disease in pregnancy and its influence on maternal and fetal mortality: a prospective study from Chennai, Southern India. Eur. J. Gastroenterol. Hepatol. 20: 362-364. http://dx.doi.org/10.1097/MEG.0b013e3282f246d6.
332. Rathi U, Bapat M, Rathi P, Abraham P. 2007. Effect of liver disease on maternal and fetal outcome-a prospective study. Indian J. Gastroenterol. 26:59-63.
333. Tsega E, Hansson BG, Krawczynski K, Nordenfelt E. 1992. Acute sporadic viral hepatitis in Ethiopia: causes, risk factors, and effects on pregnancy. Clin. Infect. Dis. 14:961-965. http://dx.doi.org/10.1093 /clinids/14.4.961.
334. Khuroo MS, Kamili S. 2009. Clinical course and duration of viremia in vertically transmitted hepatitis E virus (HEV) infection in babies born to HEV-infected mothers. J. Viral Hepat. 16:519-523. http://dx.doi.org/10.1111/j.1365-2893.2009.01101.x.
335. Naidu SS, Viswanathan R. 1957. Infectious hepatitis in pregnancy during Delhi epidemic. Indian J. Med. Res. 45:71-76.
336. Khuroo MS, Kamili S, Jameel S. 1995. Vertical transmission of hepatitis E virus. Lancet 345:1025-1026. http://dx.doi.org/10.1016/S0140-6736(95) 90761-0.
337. Dahiya M, Kumar A, Kar P, Gupta RK. 2005. Acute viral hepatitis in third trimester of pregnancy. Indian J. Gastroenterol. 24:128-129.
338. Jamieson DJ, Theiler RN, Rasmussen SA. 2006. Emerging infections and pregnancy. Emerg. Infect. Dis. 12:1638-1643. http://dx.doi.org/10.3201/eid1211.060152.
339. Doria A, Iaccarino L, Arienti S, Ghirardello A, Zampieri S, Rampudda ME, Cutolo M, Tincani A, Todesco S. 2006. Th2 immune deviation induced by pregnancy: the two faces of autoimmune rheumatic diseases. Reprod. Toxicol. 22:234-241. http://dx.doi.org/10.1016/j.reprotox.2006.04.001.
340. Romagnani S. 1997. The Th1/Th2 paradigm. Immunol. Today 18:263-266. http://dx.doi.org/10.1016/S0167-5699(97)01070-0.
341. Klein SL. 2004. Hormonal and immunological mechanisms mediating sex differences in parasite infection. Parasite Immunol. 26:247-264. http: //dx.doi.org/10.1111/j.0141-9838.2004.00710.x.
342. Robinson DP, Klein SL. 2012. Pregnancy and pregnancy-associated hormones alter immune responses and disease pathogenesis. Horm. Behav. 62:262-271. http://dx.doi.org/10.1016/j.yhbeh.2012.02.023.
343. Vargas-Villavicencio JA, De Leon-Nava MA, Morales-Montor J. 2009. Immunoendocrine mechanisms associated with resistance or susceptibility to parasitic diseases during pregnancy. Neuroimmunomodulation 16:114-121. http://dx.doi.org/10.1159/000180266.
344. Aris A, Lambert F, Bessette P, Moutquin JM. 2008. Maternal circulating interferon-gamma and interleukin-6 as biomarkers of Th1/Th2 immune status throughout pregnancy. J. Obstet. Gynaecol. Res. 34:7-11. http://dx.doi.org/10.1111/j.1447-0756.2007.00676.x.
345. Kraus TA, Sperling RS, Engel SM, Lo Y, Kellerman L, Singh T, Loubeau M, Ge Y, Garrido JL, Rodriguez-Garcia M, Moran TM. 2010. Peripheral blood cytokine profiling during pregnancy and post-partum periods. Am. J. Reprod. Immunol. 64:411-426. http://dx.doi.org/10.1111/j.1600-0897.2010.00889.x.
346. Kraus TA, Engel SM, Sperling RS, Kellerman L, Lo Y, Wallenstein S, Escribese MM, Garrido JL, Singh T, Loubeau M, Moran TM. 2012. Characterizing the pregnancy immune phenotype: results of the Viral Immunity and Pregnancy (VIP) study. J. Clin. Immunol. 32:300-311. http://dx.doi.org/10.1007/s10875-011-9627-2.
347. Hidaka Y, Amino N, Iwatani Y, Kaneda T, Mitsuda N, Morimoto Y, Tanizawa O, Miyai K. 1991. Changes in natural killer cell activity in normal pregnant and postpartum women: increases in the first trimester and postpartum period and decrease in late pregnancy. J. Reprod. Immunol. 20:73-83. http://dx.doi.org/10.1016/0165-0378(91)90024-K.
348. Klein SL, Jedlicka A, Pekosz A. 2010. The Xs and Y of immune responses to viral vaccines. Lancet Infect. Dis. 10:338-349. http://dx.doi.org/10.1016/S1473-3099(10)70049-9.
349. Pal R, Aggarwal R, Naik SR, Das V, Das S, Naik S. 2005. Immunological alterations in pregnant women with acute hepatitis E. J. Gastroenterol. Hepatol. 20:1094-1101. http://dx.doi.org/10.1111/j.1440-1746.2005.03875.x.
350. Jilani N, Das BC, Husain SA, Baweja UK, Chattopadhya D, Gupta RK, Sardana S, Kar P. 2007. Hepatitis E virus infection and fulminant hepatic failure during pregnancy. J. Gastroenterol. Hepatol. 22:676-682. http://dx.doi.org/10.1111/j.1440-1746.2007.04913.x.
351. Kar P, Jilani N, Husain SA, Pasha ST, Anand R, Rai A, Das BC. 2008. Does hepatitis E viral load and genotypes influence the final outcome of acute liver failure during pregnancy? Am. J. Gastroenterol. 103:2495-2501. http://dx.doi.org/10.1111/j.1572-0241.2008.02032.x.
352. Labrique AB, Klein S, Kmush B, Ali H, Engle R, Schulze K, West KP, Jr, Purcell RH, Nelson KE. 2012. Immunologic dysregulation and micronutrient deficiencies associated with risk of intrapartum hepatitis E infections in pregnant Bangladeshi women. FASEB J. 26:127.4.
353. Jiang T, Christian P, Khatry SK, Wu L, West KP, Jr. 2005. Micronutrient deficiencies in early pregnancy are common, concurrent, and vary by season among rural Nepali pregnant women. J. Nutr. 135:1106-1112.
354. Scholl PF, Cole RN, Ruczinski I, Gucek M, Diez R, Rennie A, Nathasingh C, Schulze K, Christian P, Yager JD, Groopman JD, West KP, Jr. 2012. Maternal serum proteome changes between the first and third trimester of pregnancy in rural southern Nepal. Placenta 33:424-432. http: //dx.doi.org/10.1016/j.placenta.2012.02.009.
355. Lozano R, Naghavi M, Foreman K, Lim S, Shibuya K, Aboyans V, Abraham J, Adair T, Aggarwal R, Ahn SY, Alvarado M, Anderson HR, Anderson LM, Andrews KG, Atkinson C, Baddour LM, Barker-Collo S, Bartels DH, Bell ML, Benjamin EJ, Bennett D, Bhalla K, Bikbov B, Bin Abdulhak A, Birbeck G, Blyth F, Bolliger I, Boufous S, Bucello C, Burch M, Burney P, Carapetis J, Chen H, Chou D, Chugh SS, Coffeng LE, Colan SD, Colquhoun S, Colson KE, Condon J, Connor MD, Cooper LT, Corriere M, Cortinovis M, de Vaccaro KC, Couser W, Cowie BC, Criqui MH, Cross M, Dabhadkar KC, Dahodwala N, De Leo D, Degenhardt L, Delossantos A, Denenberg J, et al. 2012. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010. Lancet 380:2095-2128. http://dx.doi.org/10.1016/S0140-6736(12)61728-0.
356. Khan KS, Wojdyla D, Say L, Gulmezoglu AM, Van Look PF. 2006. WHO analysis of causes of maternal death: a systematic review. Lancet 367:1066-1074. http://dx.doi.org/10.1016/S0140-6736(06)68397-9.
357. Puri M, Patra S, Singh P, Malhotra N, Trivedi SS, Sharma S, Kumar A, Sarin SK. 2011. Factors influencing occurrence of postpartum haemorrhage in pregnant women with hepatitis E infection and deranged coagulation profile. Obstet. Med. 4:108-112. http://dx.doi.org/10.1258 /om.2011.110031.
358. Geng Y, Yang J, Huang W, Harrison TJ, Zhou Y, Wen Z, Wang Y. 2013. Virus host protein interaction network analysis reveals that the HEV ORF3 protein may interrupt the blood coagulation process. PLoS One 8:e56320. http://dx.doi.org/10.1371/journal.pone.0056320.
359. Poliakova AM, Novozhenina EB, Danil'iants IL. 1994. The hemostatic system of patients with a severe course of viral hepatitis E. Ter Arkh 66:19-21.
360. Wu T, Zhu FC, Huang SJ, Zhang XF, Wang ZZ, Zhang J, Xia NS. 2012. Safety of the hepatitis E vaccine for pregnant women: a preliminary analysis. Hepatology 55:2038. http://dx.doi.org/10.1002/hep.25522.
361. Amer AF, Zaki SA, Nagati AM, Darwish MA. 1996. Hepatitis E antibodies in Egyptian adolescent females: their prevalence and possible relevance. J. Egypt Public Health Assoc. 71:273-284.
362. Surya IG, Kornia K, Suwardewa TG, Mulyanto Tsuda F, Mishiro S. 2005. Serological markers of hepatitis B, C, and E viruses and human immunodeficiency virus type-1 infections in pregnant women in Bali, Indonesia. J. Med. Virol. 75:499-503. http://dx.doi.org/10.1002/jmv.20314.
363. Mizuo H, Suzuki K, Takikawa Y, Sugai Y, Tokita H, Akahane Y, Itoh K, Gotanda Y, Takahashi M, Nishizawa T, Okamoto H. 2002. Polyphyletic strains of hepatitis E virus are responsible for sporadic cases of acute hepatitis in Japan. J. Clin. Microbiol. 40:3209-3218. http://dx.doi.org/10.1128/JCM.40.9.3209-3218.2002.
364. Caron M, Kazanji M. 2008. Hepatitis E virus is highly prevalent among pregnant women in Gabon, central Africa, with different patterns between rural and urban areas. Virol. J. 5:158. http://dx.doi.org/10.1186 /1743-422X-5-158.
365. Cevrioglu AS, Altindis M, Tanir HM, Aksoy F. 2004. Investigation of the incidence of hepatitis E virus among pregnant women in Turkey. J. Obstet. Gynaecol Res. 30:48-52. http://dx.doi.org/10.1111/j.1341-8076.2004.00155.x.
366. Hannachi N, Hidar S, Harrabi I, Mhalla S, Marzouk M, Ghzel H, Ghannem H, Khairi H, Boukadida J. 2011. Seroprevalence and risk factors of hepatitis E among pregnant women in central Tunisia. Pathol. Biol. (Paris) 59:e115-118. http://dx.doi.org/10.1016/j.patbio.2009.06.004.
367. Traore KA, Rouamba H, Nebie Y, Sanou M, Traore AS, Barro N, Roques P. 2012. Seroprevalence of fecal-oral transmitted hepatitis A and E virus antibodies in Burkina Faso. PLoS One 7:e48125. http://dx.doi.org /10.1371/journal.pone.0048125.
368. Huang F, Ma T, Li L, Zeng W, Jing S. 18 September 2013. Low seroprevalence of hepatitis E virus infection in pregnant women in Yunnan, China. Braz. J. Infect. Dis. http://dx.doi.org/10.1016/j.bjid.2013.02.006.
369. Oncu S, Oncu S, Okyay P, Ertug S, Sakarya S. 2006. Prevalence and risk factors for HEV infection in pregnant women. Med. Sci. Monit. 12: CR36-CR39.
370. Krain LJ, Nelson KE, Atwell JA, Labrique AB. Fetal and neonatal health consequences of vertically-transmitted hepatitis E virus infection. Am. J. Trop. Med. Hyg., in press.