The epidemiology of hepatitis E virus infections in developed countries and among immunocompromised patients

Expert Review of Anti-Infective Therapy

Volumn 9, Issue 12, 2011, Pages 1133-1148

  Nelson, Kenrad E ^a   Kmush, Brittany ^a   Labrique, Alain B ^a  

^a JOHNS HOPKINS BLOOMBERG SCHOOL OF PUBLIC HEALTH   (United States)

Author keywords

developed countries; epidemiology; hepatitis E virus; HIV AIDS; immunosuppression; systematic review; transplant patients

Indexed keywords

ANTIVIRUS AGENT; CYCLOSPORIN A; HEPATITIS E ANTIBODY; HEPATITIS E VACCINE; IMMUNOGLOBULIN M ANTIBODY; PEGINTERFERON ALPHA2B; PEPTIDE VACCINE; RIBAVIRIN; TACROLIMUS; VIRUS RNA;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ASIA; BLOOD TRANSFUSION; CLINICAL FEATURE; DISEASE ASSOCIATION; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; DRUG WITHDRAWAL; EUROPE; FOOD CONTAMINATION; FULMINANT HEPATIC FAILURE; GENOTYPE; GRAFT VERSUS HOST REACTION; HEPATITIS E; HUMAN; IMMUNOGENICITY; INDUSTRIALIZATION; LIVER CIRRHOSIS; NONHUMAN; ORGAN TRANSPLANTATION; PUBLIC HEALTH PROBLEM; REVIEW; SEASONAL VARIATION; SEROLOGY; SEROPREVALENCE; SEROTYPE; VIRAL CONTAMINATION; VIRUS STRAIN; VIRUS TRANSMISSION;

AFRICA; ANIMALS; ANTIBODIES, VIRAL; ASIA, SOUTHEASTERN; BLOOD TRANSFUSION; DISEASE RESERVOIRS; EUROPE; FOODBORNE DISEASES; HEPATITIS E; HEPATITIS E VIRUS; HIV; HIV INFECTIONS; HUMANS; IMMUNOCOMPROMISED HOST; IMMUNOSUPPRESSION; LIVER TRANSPLANTATION; PREVALENCE; RNA, VIRAL; SWINE; UNITED STATES; VACCINATION; VIRAL HEPATITIS VACCINES;

EID: 82455186469     PISSN: 14787210     EISSN: 17448336     Source Type: Journal    
DOI: 10.1586/eri.11.138     Document Type: Review

References (128)

1. Labrique AB, Kuniholm MH, Nelson KE. The global impact of hepatitis E: new horizons for an emerging virus. In:Emerging Infections . Scheld WM, Grayson ML, Hughes JM (Eds).ASM Press, Washington, DC, USA, 53-93 (2010).
2. Purcell RH, Emerson SU. Hepatitis E: an emerging awareness of an old disease. J. Hepatol. 48(3), 494-503 (2008).
3. Teshale EH, Howard CM, Grytdal SP et al. Hepatitis E epidemic, Uganda. Emerg. Infect. Dis. 16(1), 126-129 (2010).
4. Dalton HR, Bendall R, Ijaz S, Banks M. Hepatitis E: an emerging infection in developed countries. Lancet Infect. Dis. 8(11), 698-709 (2008).
5. Chau TN, Lai ST, Tse C et al. Epidemiology and clinical features of sporadic hepatitis E as compared with hepatitis A. Am. J. Gastroenterol. 101(2), 292-296 (2006).
6. Mushahwar IK. Hepatitis E virus: molecular virology, clinical features, diagnosis, transmission, epidemiology, and prevention. J. Med. Virol. 80(4), 646-658 (2008).
7. Navaneethan U, Mohajer MA, Shata MT. Hepatitis E and pregnancy: understanding the pathogenesis. Liver Intl 28(9), 1190-1199 (2008).
8. Chandra NS, Sharma A, Malhotra B, Rai RR. Dynamics of HEV viremia, fecal shedding and its relationship with transaminases and antibody response in patients with sporadic acute hepatitis E. Virol. J. 7, 213 (2010).
9. Hall GF. Hepatitis A, B, C, D, E, G: an update. Ethn. Dis. 17(2 Suppl. 2), S2-40-5 (2007).
10. Meng XJ. Recent advances in hepatitis E virus. J. Viral Hepat. 17(3), 153-161 (2010).
11. Meng XJ. Hepatitis E virus: animal reservoirs and zoonotic risk. Vet. Microbiol. 140(3-4), 256-265 (2010).
12. Dalton HR, Stableforth W, Thurairajah P et al. Autochthonous hepatitis E in southwest England: natural history, complications and seasonal variation, and hepatitis E virus IgG seroprevalence in blood donors, the elderly and patients with chronic liver disease. Eur. J. Gastroenterol. Hepatol. 20(8), 784-790 (2008).
13. Dalton HR, Stableforth W, Hazeldine S et al. Autochthonous hepatitis E in southwest England: a comparison with hepatitis A. Eur. J. Clin. Microbiol. Infect. Dis. 27(7), 579-585 (2008).
14. Pischke S, Wedemeyer H. Chronic hepatitis E in liver transplant recipients: a significant clinical problem? Minerva Gastroenterol. Dietol. 56(2), 121-128 (2010).
15. Purcell RH, Emerson SU. Hidden danger: the raw facts about hepatitis E virus. J. Infect. Dis. 202(6), 819-821 (2010).
16. Lewis HC, Wichmann O, Duizer E. Transmission routes and risk factors for autochthonous hepatitis E virus infection in Europe: a systematic review. Epidemiol. Infect. 138(2), 145-166 (2010).
17. Teshale EH, Hu DJ, Holmberg SD. The two faces of hepatitis E virus. Clin. Infect. Dis. 51(3), 328-334 (2010).
18. Melenhorst WB, Gu YL, Jaspers WJ, Verhage AH. Locally acquired hepatitis E in The Netherlands: associated with the consumption of raw pig meat? Scand. J. Infect. Dis. 39(5), 454-456 (2007).
19. Kuniholm MH, Purcell RH, McQuillan GM, Engle RE, Wasley A, Nelson KE. Epidemiology of hepatitis E virus in the United States: results from the Third national health and nutrition examination survey, 1988-1994. J. Infect. Dis. 200(1), 48-56 (2009).
20. Pischke S, Ho H, Urbanek F et al. Hepatitis E in HIV-positive patients in a low-endemic country. J. Viral Hepat. 17(8), 598-599 (2010).
21. Pischke S, Suneetha PV, Baechlein C et al. Hepatitis E virus infection as a cause of graft hepatitis in liver transplant recipients. Liver Transpl. 16(1), 74-82 (2010).
22. Balayan MS, Andjaparidze AG, Savinskaya SS et al. Evidence for a virus in non-A, non-B hepatitis transmitted via the fecal-oral route. Intervirology 20(1), 23-31 (1983).
23. Usmanov RK, Balaian MS, Dvoinikova OV et al. An experimental infection in lambs by the hepatitis E virus. Vopr. Virusol. 39(4), 165-168 (1994).
24. Kuno A, Ido K, Isoda N et al. Sporadic acute hepatitis E of a 47-year-old man whose pet cat was positive for antibody to hepatitis E virus. Hepatol. Res. 26(3), 237-242 (2003).
25. Kabrane-Lazizi Y, Fine JB, Elm J et al. Evidence for widespread infection of wild rats with hepatitis E virus in the United States. Am. J. Trop. Med. Hyg. 61(2), 331-335 (1999).
26. Johne R, Plenge-Bonig A, Hess M, Ulrich RG, Reetz J, Schielke A. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J. Gen. Virol. 91(Pt 3), 750-758 (2010).
27. Okamoto H. Hepatitis E virus cell culture models. Virus Res. 161(1), 65-77 (2011).
28. Ijaz S, Arnold E, Banks M et al. Non-travel-associated hepatitis E in England and Wales: demographic, clinical, and molecular epidemiological characteristics. J. Infect. Dis. 192(7), 1166-1172 (2005).
29. Mansuy JM, Peron JM, Abravanel F et al. Hepatitis E in the south west of France in individuals who have never visited an endemic area. J. Med. Virol. 74(3), 419-424 (2004).
30. Renou C, Moreau X, Pariente A et al. A national survey of acute hepatitis E in France. Aliment. Pharmacol. Ther. 27(11), 1086-1093 (2008).
31. Wichmann O, Schimanski S, Koch J et al. Phylogenetic and case-control study on hepatitis E virus infection in Germany. J. Infect. Dis. 198(12), 1732-1741 (2008).
32. Zaaijer HL, Kok M, Lelie PN, Timmerman RJ, Chau K, van der Pal HJ. Hepatitis E in The Netherlands: imported and endemic. Lancet 341(8848), 826 (1993).
33. Widdowson MA, Jaspers WJ, van der Poel WH et al. Cluster of cases of acute hepatitis associated with hepatitis E virus infection acquired in The Netherlands. Clin. Infect. Dis. 36(1), 29-33 (2003).
34. Waar K, Herremans MM, Vennema H, Koopmans MP, Benne CA. Hepatitis E is a cause of unexplained hepatitis in The Netherlands. J. Clin. Virol. 33(2), 145-149 (2005).
35. van der Poel WH, Verschoor F, van der Heide R et al. Hepatitis E virus sequences in swine related to sequences in humans, The Netherlands. Emerg. Infect. Dis. 7(6), 970-976 (2001).
36. Borgen K, Herremans T, Duizer E et al. Non-travel related hepatitis E virus genotype 3 infections in The Netherlands; a case series 2004-2006. BMC Infect. Dis. 8, 61 (2008).
37. Reuter G, Fodor D, Forgach P, Katai A, Szucs G. Characterization and zoonotic potential of endemic hepatitis E virus (HEV) strains in humans and animals in Hungary. J. Clin. Virol. 44(4), 277-281 (2009).
38. Lindemann ML, Gabilondo G, Romero B, de la Maza OM, Perez-Gracia MT. Low prevalence of hepatitis E infection among pregnant women in Madrid, Spain. J. Med. Virol. 82(10), 1666-1668 (2010).
39. Voiculescu M, Iliescu L, Ionescu C et al. A cross-sectional epidemiological study of HBV, HCV, HDV and HEV prevalence in the SubCarpathian and south-eastern regions of Romania. J. Gastrointestin. Liver Dis. 19(1), 43-48 (2010).
40. Baylis SA, Nick S, Blumel J, Micha Nubling C. Hepatitis E virus and blood donors in Germany. Vox Sang. 98(3 Pt 2), 479 (2010).
41. Bouwknegt M, Engel B, Herremans MM et al. Bayesian estimation of hepatitis E virus seroprevalence for populations with different exposure levels to swine in The Netherlands. Epidemiol. Infect. 136(4), 567-576 (2008).
42. Christensen PB, Engle RE, Hjort C et al. Time trend of the prevalence of hepatitis E antibodies among farmers and blood donors: a potential zoonosis in Denmark. Clin. Infect. Dis. 47(8), 1026-1031 (2008).
43. Withers MR, Correa MT, Morrow M et al. Antibody levels to hepatitis E virus in north Carolina swine workers, non-swine workers, swine, and murids. Am. J. Trop. Med. Hyg. 66(4), 384-388 (2002).
44. Meng XJ, Wiseman B, Elvinger F et al. Prevalence of antibodies to hepatitis E virus in veterinarians working with swine and in normal blood donors in the United States and other countries. J. Clin. Microbiol. 40(1), 117-122 (2002).
45. Bendall R, Ellis V, Ijaz S, Ali R, Dalton H. A comparison of two commercially available anti-HEV IgG kits and a re-evaluation of anti-HEV IgG seroprevalence data in developed countries. J. Med. Virol. 82(5), 799-805 (2010).
46. Mast EE, Alter MJ, Holland PV, Purcell RH. Evaluation of assays for antibody to hepatitis E virus by a serum panel. Hepatitis E virus antibody serum panel evaluation group. Hepatology 27(3), 857-861 (1998).
47. Drobeniuc J, Meng J, Reuter G et al. Serologic assays specific to immunoglobulin M antibodies against hepatitis E virus: pangenotypic evaluation of performances. Clin. Infect. Dis. 51(3), e24-e27 (2010).
48. Legrand-Abravanel F, Thevenet I, Mansuy JM et al. Good performance of immunoglobulin M assays in diagnosing genotype 3 hepatitis E virus infections. Clin. Vaccine Immunol. 16(5), 772-774 (2009).
49. Yazaki Y, Mizuo H, Takahashi M et al. Sporadic acute or fulminant hepatitis E in Hokkaido, Japan, may be food-borne, as suggested by the presence of hepatitis E virus in pig liver as food. J. Gen. Virol. 84(Pt 9), 2351-2357 (2003).
50. Takahashi K, Kitajima N, Abe N, Mishiro S. Complete or near-complete nucleotide sequences of hepatitis E virus genome recovered from a wild boar, a deer, and four patients who ate the deer. Virology 330(2), 501-505 (2004).
51. Tei S, Kitajima N, Takahashi K, Mishiro S. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet 362(9381), 371-373 (2003).
52. Emerson SU, Arankalle VA, Purcell RH. Thermal stability of hepatitis E virus. J. Infect. Dis. 192(5), 930-933 (2005).
53. Williams TP, Kasorndorkbua C, Halbur PG et al. Evidence of extrahepatic sites of replication of the hepatitis E virus in a swine model. J. Clin. Microbiol. 39(9), 3040-3046 (2001).
54. Said B, Ijaz S, Kafatos G et al. Hepatitis E outbreak on cruise ship. Emerg. Infect. Dis. 15(11), 1738-1744 (2009).
55. Colson P, Borentain P, Queyriaux B et al. Pig liver sausage as a source of hepatitis E virus transmission to humans. J. Infect. Dis. 202(6), 825-834 (2010).
56. Feagins AR, Opriessnig T, Guenette DK, Halbur PG, Meng XJ. Detection and characterization of infectious Hepatitis E virus from commercial pig livers sold in local grocery stores in the USA. J. Gen. Virol. 88(Pt 3), 912-917 (2007).
57. Drobeniuc J, Favorov MO, Shapiro CN et al. Hepatitis E virus antibody prevalence among persons who work with swine. J. Infect. Dis. 184(12), 1594-1597 (2001).
58. Teshale EH, Grytdal SP, Howard C et al. Evidence of person-to-person transmission of hepatitis E virus during a large outbreak in northern Uganda. Clin. Infect. Dis. 50(7), 1006-1010 (2010).
59. Tamura A, Shimizu YK, Tanaka T et al. Persistent infection of hepatitis E virus transmitted by blood transfusion in a patient with T-cell lymphoma. Hepatol. Res. 37(2), 113-120 (2007).
60. Matsubayashi K, Nagaoka Y, Sakata H et al. Transfusion-transmitted hepatitis E caused by apparently indigenous hepatitis E virus strain in Hokkaido, Japan. Transfusion 44(6), 934-940 (2004).
61. Mitsui T, Tsukamoto Y, Yamazaki C et al. Prevalence of hepatitis E virus infection among hemodialysis patients in Japan: evidence for infection with a genotype 3 HEV by blood transfusion. J. Med. Virol. 74(4), 563-572 (2004).
62. Adlhoch C, Kaiser M, Pauli G, Koch J, Meisel H. Indigenous hepatitis E virus infection of a plasma donor in Germany. Vox Sang. 97(4), 303-308 (2009).
63. Fukuda S, Sunaga J, Saito N et al. Prevalence of antibodies to hepatitis E virus among Japanese blood donors: identification of three blood donors infected with a genotype 3 hepatitis E virus. J. Med. Virol. 73(4), 554-561 (2004).
64. Colson P, Coze C, Gallian P, Henry M, De Micco P, Tamalet C. Transfusion-associated hepatitis E, France. Emerg. Infect. Dis. 13(4), 648-649 (2007).
65. Boxall E, Herborn A, Kochethu G et al. Transfusion-transmitted hepatitis E in a 'nonhyperendemic' country. Transfus. Med. 16(2), 79-83 (2006).
66. Beale MA, Tettmar K, Szypulska R, Tedder RS, Ijaz S. Is there evidence of recent hepatitis E virus infection in English and north Welsh blood donors? Vox Sang. 100(3), 340-342 (2011).
67. Sakata H, Matsubayashi K, Takeda H et al. A nationwide survey for hepatitis E virus prevalence in Japanese blood donors with elevated alanine aminotransferase. Transfusion 48(12), 2568-2576 (2008).
68. Li TC, Chijiwa K, Sera N et al. Hepatitis E virus transmission from wild boar meat. Emerg. Infect. Dis. 11(12), 1958-1960 (2005).
69. Tei S, Kitajima N, Ohara S et al. Consumption of uncooked deer meat as a risk factor for hepatitis E virus infection: an age- and sex-matched case-control study. J. Med. Virol. 74(1), 67-70 (2004).
70. Fu H, Li L, Zhu Y et al. Hepatitis E virus infection among animals and humans in Xinjiang, China: possibility of swine to human transmission of sporadic hepatitis E in an endemic area. Am. J. Trop. Med. Hyg. 82(5), 961-966 (2010).
71. Nishizawa T, Takahashi M, Mizuo H, Miyajima H, Gotanda Y, Okamoto H. Characterization of Japanese swine and human hepatitis E virus isolates of genotype IV with 99% identity over the entire genome. J. Gen. Virol. 84(Pt 5), 1245-1251 (2003).
72. Takahashi K, Kang JH, Ohnishi S, Hino K, Mishiro S. Genetic heterogeneity of hepatitis E virus recovered from Japanese patients with acute sporadic hepatitis. J. Infect. Dis. 185(9), 1342-1345 (2002).
73. Takahashi M, Nishizawa T, Yoshikawa A et al. Identification of two distinct genotypes of hepatitis E virus in a Japanese patient with acute hepatitis who had not travelled abroad. J. Gen. Virol. 83(Pt 8), 1931-1940 (2002).
74. Li RC, Ge SX, Li YP et al. Seroprevalence of hepatitis E virus infection, rural southern People's Republic of China. Emerg. Infect. Dis. 12(11), 1682-1688 (2006).
75. Zhang W, Yang S, Ren L et al. Hepatitis E virus infection in central China reveals no evidence of cross-species transmission between human and swine in this area. PLoS One 4(12), e8156 (2009).
76. Hsieh SY, Meng XJ, Wu YH et al. Identity of a novel swine hepatitis E virus in Taiwan forming a monophyletic group with Taiwan isolates of human hepatitis E virus. J. Clin. Microbiol. 37(12), 3828-3834 (1999).
77. Hsieh SY, Yang PY, Ho YP, Chu CM, Liaw YF. Identification of a novel strain of hepatitis E virus responsible for sporadic acute hepatitis in Taiwan. J. Med. Virol. 55(4), 300-304 (1998).
78. Lin DB, Lin JB, Chen SC, Yang CC, Chen WK, Chen CJ. Seroepidemiology of hepatitis E virus infection among preschool children in Taiwan. J. Med. Virol. 74(3), 414-418 (2004).
79. Cooper K, Huang FF, Batista L et al. Identification of genotype 3 hepatitis E virus (HEV) in serum and fecal samples from pigs in Thailand and Mexico, where genotype 1 and 2 HEV strains are prevalent in the respective human populations. J. Clin. Microbiol. 43(4), 1684-1688 (2005).
80. Siripanyaphinyo U, Laohasinnarong D, Siripanee J et al. Full-length sequence of genotype 3 hepatitis E virus derived from a pig in Thailand. J. Med. Virol. 81(4), 657-664 (2009).
81. Caron M, Enouf V, Than SC, Dellamonica L, Buisson Y, Nicand E. Identification of genotype 1 hepatitis E virus in samples from swine in Cambodia. J. Clin. Microbiol. 44(9), 3440-3442 (2006).
82. Koizumi Y, Isoda N, Sato Y et al. Infection of a Japanese patient by genotype 4 hepatitis e virus while traveling in Vietnam. J. Clin. Microbiol. 42(8), 3883-3885 (2004).
83. Li TC, Miyamura T, Takeda N. Detection of hepatitis E virus RNA from the bivalve Yamato-Shijimi (Corbicula japonica) in Japan. Am. J. Trop. Med. Hyg. 76(1), 170-172 (2007).
84. Li TC, Saito M, Ogura G, Ishibashi O, Miyamura T, Takeda N. Serologic evidence for hepatitis E virus infection in mongoose. Am. J. Trop. Med. Hyg. 74(5), 932-936 (2006).
85. La Fauci V, Sindoni D, Grillo OC, Calimeri S, Lo Giudice D, Squeri R. Hepatitis E virus (HEV) in sewage from treatment plants of Messina University Hospital and of Messina city council. J. Prev. Med. Hyg. 51(1), 28-30 (2010).
86. La Rosa G, Pourshaban M, Iaconelli M, Vennarucci VS, Muscillo M. Molecular detection of hepatitis E virus in sewage samples. Appl. Environ. Microbiol. 76(17), 5870-5873 (2010).
87. Clemente-Casares P, Rodriguez-Manzano J, Girones R. Hepatitis E virus genotype 3 and sporadically also genotype 1 circulate in the population of Catalonia, Spain. J. Water Health 7(4), 664-673 (2009).
88. Albinana-Gimenez N, Clemente-Casares P, Bofill-Mas S, Hundesa A, Ribas F, Girones R. Distribution of human polyomaviruses, adenoviruses, and hepatitis E virus in the environment and in a drinking-water treatment plant. Environ. Sci. Technol. 40(23), 7416-7422 (2006).
89. Buffet C, Laurent-Puig P, Chandot S et al. A high hepatitis E virus seroprevalence among renal transplantation and haemophilia patient populations. J. Hepatol. 24(1), 122-125 (1996).
90. Ibarra H, Riedemann S, Reinhardt G, Ardiles L, Calvo M, Siegel F. Anti-HEV in dialysis and renal transplant patients in an endemic region in Chile. Clin. Nephrol. 50(4), 267-268 (1998).
91. Gerolami R, Moal V, Picard C, Colson P. Hepatitis E virus as an emerging cause of chronic liver disease in organ transplant recipients. J. Hepatol. 50(3), 622-624 (2009).
92. Kamar N, Selves J, Mansuy JM et al. Hepatitis E virus and chronic hepatitis in organ-transplant recipients. N. Engl. J. Med. 358(8), 811-817 (2008).
93. Kamar N, Mansuy JM, Cointault O et al. Hepatitis E virus-related cirrhosis in kidney- and kidney-pancreas-transplant recipients. Am. J. Transpl. 8(8), 1744-1748 (2008).
94. Ollier L, Tieulie N, Sanderson F et al. Chronic hepatitis after hepatitis E virus infection in a patient with non-Hodgkin lymphoma taking rituximab. Ann. Intern. Med. 150(6), 430-431 (2009).
95. le Coutre P, Meisel H, Hofmann J et al. Reactivation of hepatitis E infection in a patient with acute lymphoblastic leukaemia after allogeneic stem cell transplantation. Gut 58(5), 699-702 (2009).
96. Legrand-Abravanel F, Kamar N, Sandres- Saune K et al. Hepatitis E virus infection without reactivation in solid-organ transplant recipients, France. Emerg. Infect. Dis. 17(1), 30-37 (2011).
97. Legrand-Abravanel F, Kamar N, Sandres- Saune K et al. Characteristics of autochthonous hepatitis E virus infection in solid-organ transplant recipients in France. J. Infect. Dis. 202(6), 835-844 (2010).
98. Haagsma EB, Niesters HGM, van den Berg AP et al. Prevalence of hepatitis E virus infection in liver transplant recipients. Liver Transpl. 15(10), 1225-1228 (2009).
99. Haagsma EB, van den Berg AP, Porte RJ et al. Chronic hepatitis E virus infection in liver transplant recipients. Liver Transpl. 14(4), 547-553 (2008).
100. Curry JA, Adams N, Crum-Cianflone NF. Acute hepatitis E virus infection in an HIV-infected person in the United States. Ann. Intern. Med. 150(3), 226-227 (2009).
101. Dalton HR, Bendall RP, Keane FE, Tedder RS, Ijaz S. Persistent carriage of hepatitis E virus in patients with HIV infection. N. Engl. J. Med. 361(10), 1025-1027 (2009).
102. Colson P, Kaba M, Moreau J, Brouqui P. Hepatitis E in an HIV-infected patient. J. Clin. Virol. 45(4), 269-271 (2009).
103. Madejon A, Vispo E, Bottecchia M, Sanchez-Carrillo M, Garcia-Samaniego J, Soriano V. Lack of hepatitis E virus infection in HIV patients with advanced immunodeficiency or idiopathic liver enzyme elevations. J. Viral Hepat. 16(12), 895-896 (2009).
104. Kaba M, Brouqui P, Richet H et al. Chronic hepatitis E in human immunodeficiency virus-infected patients living in south eastern France. Program and Abstracts of the 19th European Congress of Clinical Microbiology and Infectious Diseases. Helsinki, Finland (2009) (Abstract P1996).
105. Keane F, Gompels M, Benadall R. Hepatitis E virus coninfection in patients with HIV infection. HIV Med. doi:10.1111/j.1468-1293.2011.00942.x (2011) (Epub ahead of print).
106. Kovari H, Ledergerber B, Battegay M et al. Incidence and risk factors for chronic elevation of alanine aminotransferase levels in HIV-infected persons without hepatitis B or C virus co-infection. Clin. Infect. Dis. 50(4), 502-511 (2010).
107. Maida I, Nunez M, Rios MJ et al. Severe liver disease associated with prolonged exposure to antiretroviral drugs. J. Acquir. Immune Defic. Syndr. 42(2), 177-182 (2006).
108. Kuniholm MH, Labrique AB, Nelson KE. Should HIV-infected patients with unexplained chronic liver enzyme elevations be tested for hepatitis E virus? Clin. Infect. Dis. 50(11), 1545-1546; author reply 1546 (2010).
109. Colson P, Payraudeau E, Leonnet C et al. Severe thrombocytopenia associated with acute hepatitis E virus infection. J. Clin. Microbiol. 46(7), 2450-2452 (2008).
110. Peron JM, Bureau C, Poirson H et al. Fulminant liver failure from acute autochthonous hepatitis E in France: description of seven patients with acute hepatitis E and encephalopathy. J. Viral Hepat. 14(5), 298-303 (2007).
111. Jaroszewicz J, Flisiak R, Kalinowska A, Wierzbicka I, Prokopowicz D. Acute hepatitis E complicated by acute pancreatitis: a case report and literature review. Pancreas 30(4), 382-384 (2005).
112. Kamar N, Izopet J, Cintas P et al. Hepatitis E virus-induced neurological symptoms in a kidney-transplant patient with chronic hepatitis. Am. J. Transpl. 10(5), 1321-1324 (2010).
113. Kamar N, Bendall RP, Peron JM et al. Hepatitis E virus and neurologic disorders. Emerg. Infect. Dis. 17(2), 173-179 (2011).
114. Dalton HR, Fellows HJ, Stableforth W et al. The role of hepatitis E virus testing in drug-induced liver injury. Aliment Pharmacol. Ther. 26(10), 1429-1435 (2007).
115. Davern TJ, Chalasani N, Fontana RJ et al. Acute hepatitis E infection accounts for some cases of suspected drug-induced liver injury. Gastroenterology doi:10.1053/j. gastro.2011.07.051 (2011) (Epub ahead of print).
116. Thoden J, Venhoff N, Miehle N et al. Hepatitis E and jaundice in an HIV-positive pregnant woman. AIDS 22(7), 909-910 (2008).
117. Mateos Lindemann ML, Morales JG, Fernandez-Barredo S et al. Fulminant hepatitis E in a woman taking oral contraceptive medication. Am. J. Trop. Med. Hyg. 82(1), 12-15 (2010).
118. Zijlstra JG, Haagsma EB, Tulleken JE, van der Werf TS. Hepatitis-E-associated fulminant hepatic failure in non-pregnant young women. Lancet 350(9073), 289-290 (1997).
119. Mallet V, Nicand E, Sultanik P et al. Brief communication: case reports of ribavirin treatment for chronic hepatitis E. Ann. Intern. Med. 153(2), 85-89 (2010).
120. Kamar N, Rostaing L, Abravanel F et al. Ribavirin therapy inhibits viral replication on patients with chronic hepatitis e virus infection. Gastroenterology 139(5), 1612-1618 (2010).
121. Kamar N, Rostaing L, Abravanel F et al. Pegylated interferon-a for treating chronic hepatitis E virus infection after liver transplantation. Clin. Infect. Dis. 50(5), e30-e33 (2010).
122. Haagsma EB, Riezebos-Brilman A, van den Berg AP, Porte RJ, Niesters HG. Treatment of chronic hepatitis E in liver transplant recipients with pegylated interferon α-2b. Liver Transpl. 16(4), 474-477 (2010).
123. Kamar N, Abravanel F, Selves J et al. Influence of immunosuppressive therapy on the natural history of genotype 3 hepatitis-E virus infection after organ transplantation. Transplantation 89(3), 353-360 (2010).
124. Shrestha MP, Scott RM, Joshi DM et al. Safety and efficacy of a recombinant hepatitis E vaccine. N. Engl. J. Med. 356(9), 895-903 (2007).
125. Zhu FC, Zhang J, Zhang XF et al. Efficacy and safety of a recombinant hepatitis E vaccine in healthy adults: a large-scale, randomised, double-blind placebo-controlled, Phase 3 trial. Lancet 376(9744), 895-902 (2010).
126. Zhang J, Liu CB, Li RC et al. Randomized-controlled Phase 2 clinical trial of a bacterially expressed recombinant hepatitis E vaccine. Vaccine 27(12), 1869-1874 (2009).
127. Dalton HR, Thurairajah PH, Fellows HJ et al. Autochthonous hepatitis E in southwest England. J. Viral Hepat. 14(5), 304-309 (2007).
128. Terzic D, Dupanovic B, Mugosa B, Draskovic N, Svirtlih N. Acute hepatitis E in Montenegro: epidemiology, clinical and laboratory features. Ann. Hepatol. 8(3), 203-206 (2009).