Molecular mechanism of mast cell-mediated innate defense against endothelin and snake venom sarafotoxin

Journal of Experimental Medicine

Volumn 204, Issue 11, 2007, Pages 2629-2639

  Schneider, Lars A ^a   Schlenner, Susan M ^a   Feyerabend, Thorsten B ^a   Wunderlin, Markus ^a   Rodewald, Hans Reimer ^a  

^a UNIVERSITY OF ULM   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

CARBOXYPEPTIDASE; CARBOXYPEPTIDASE A; ENDOTHELIN; ENDOTHELIN 1; PROTEINASE; SARAFOTOXIN; SNAKE VENOM; TRYPTOPHAN;

ARTICLE; CATALYSIS; CELL FUNCTION; CONTROLLED STUDY; ENZYME ACTIVITY; MASS SPECTROMETRY; MAST CELL; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION;

ANIMALS; CARBOXYPEPTIDASES; CARBOXYPEPTIDASES A; ENDOTHELINS; GENE EXPRESSION REGULATION; MAST CELLS; MICE; MICE, KNOCKOUT; VASOCONSTRICTOR AGENTS; VIPER VENOMS;

EID: 35748944891     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20071262     Document Type: Article

References (46)

1. Echtenacher, B., D.N. Mannel, and L. Hultner. 1996. Critical protective role of mast cells in a model of acute septic peritonitis. Nature. 381:75-77.
2. Malaviya, R., T. Ikeda, E. Ross, and S.N. Abraham. 1996. Mast cell modulation of neutrophil influx and bacterial clearance at sites of infection through TNF-alpha. Nature. 381:77-80.
3. Wort, S.J., and T.W. Evans. 1999. The role of the endothelium in modulating vascular control in sepsis and related conditions. Br. Med. Bull. 55:30-48.
4. Wanecek, M., E. Weitzberg, A. Rudehill, and A. Oldner. 2000. The endothelin system in septic and endotoxin shock. Eur. J. Pharmacol. 407:1-15.
5. Magder, S., and P. Cernacek. 2003. Role of endothelins in septic, cardiogenic, and hemorrhagic shock. Can. J. Physiol. Pharmacol. 81:635-643.
6. Levin, E.R. 1995. Endothelins. N. Engl. J. Med. 333:356-363.
7. Highsmith, R.F. 1998. Endothelin: Molecular Biology, Physiology, and Pathology. Humana Press, Totowa, NJ.
8. Ehrenreich, H., R.W. Anderson, C.H. Fox, P. Rieckmann, G.S. Hoffman, W.D. Travis, J.E. Coligan, J.H. Kehrl, and A.S. Fauci. 1990. Endothelins, peptides with potent vasoactive properties, are produced by human macrophages. J. Exp. Med. 172:1741-1748.
9. McMillen, M.A., and M.E. Cunningham. 1996. Origin of endothelin in sepsis. Crit. Care Med. 24:721-722.
10. Matsushima, H., N. Yamada, H. Matsue, and S. Shimada. 2004. The effects of endothelin-1 on degranulation, cytokine, and growth factor production by skin-derived mast cells. Eur. J. Immunol. 34:1910-1919.
11. Maurer, M., J. Wedemeyer, M. Metz, A.M. Piliponsky, K. Weller, D. Chatterjea, D.E. Clouthier, M.M. Yanagisawa, M. Tsai, and S.J. Galli. 2004. Mast cells promote homeostasis by limiting endothelin-1-induced toxicity. Nature. 432:512-516.
12. Metz, M., A.M. Piliponsky, C.C. Chen, V. Lammel, M. Abrink, G. Pejler, M. Tsai, and S.J. Galli. 2006. Mast cells can enhance resistance to snake and honeybee venoms. Science. 313:526-530.
13. Huang, C., A. Sali, and R.L. Stevens. 1998. Regulation and function of mast cell proteases in inflammation. J. Clin. Immunol. 18:169-183.
14. Caughey, G.H. 2002. New developments in the genetics and activation of mast cell proteases. Mol. Immunol. 38:1353-1357.
15. Hallgren, J., and G. Pejler. 2006. Biology of mast cell tryptase. An inflammatory mediator. FEBS J. 273:1871-1895.
16. Feyerabend, T.B., H. Hausser, A. Tietz, C. Blum, L. Hellman, A.H. Straus, H.K. Takahashi, E.S. Morgan, A.M. Dvorak, H.J. Fehling, and H.R. Rodewald. 2005. Loss of histochemical identity in mast cells lacking carboxypeptidase A. Mol. Cell. Biol. 25:6199-6210.
17. Abrink, M., M. Grujic, and G. Pejler. 2004. Serglycin is essential for maturation of mast cell secretory granule. J. Biol. Chem. 279:40897-40905.
18. Stevens, R.L., D. Qui, H.P. McNeil, D.S. Friend, J.E. Hunt, K.F. Austen, and J. Zhang. 1996. Transgenic mice that possess a disrupted mast cell protease 5 (mMCP-5) cannot store carboxypeptidase A in their granules. FASEB J. 10:1307.
19. Serafin, W.E., E.T. Dayton, P.M. Gravallese, K.F. Austen, and R.L. Stevens. 1987. Carboxypeptidase A in mouse mast cells. Identification, characterization, and use as a differentiation marker. J. Immunol. 139:3771-3776.
20. Kolset, S.O., K. Prydz, and G. Pejler. 2004. Intracellular proteoglycans. Biochem. J. 379:217-227.
21. Reynolds, D.S., R.L. Stevens, D.S. Gurley, W.S. Lane, K.F. Austen, and W.E. Serafin. 1989. Isolation and molecular cloning of mast cell carboxypeptidase A. A novel member of the carboxypeptidase gene family. J. Biol. Chem. 264:20094-20099.
22. Karlson, U., G. Pejler, G. Froman, and L. Hellman. 2002. Rat mast cell protease 4 is a beta-chymase with unusually stringent substrate recognition profile. J. Biol. Chem. 277:18579-18585.
23. Reznik, S.E., and L.D. Fricker. 2001. Carboxypeptidases from A to Z: implications in embryonic development and Wnt binding. Cell. Mol. Life Sci. 58:1790-1804.
24. Bukrinsky, J.T., M.J. Bjerrum, and A. Kadziola. 1998. Native carboxypeptidase A in a new crystal environment reveals a different conformation of the important tyrosine 248. Biochemistry. 37:16555-16564.
25. Cho, J.H., D.H. Kim, K.J. Lee, and K.Y. Choi. 2001. The role of Tyr248 probed by mutant bovine carboxypeptidase A: insight into the catalytic mechanism of carboxypeptidase A. Biochemistry. 40:10197-10203.
26. Kitamura, Y., S. Go, and K. Hatanaka. 1978. Decrease in mast cells in W/Wv mice and their increase by bone marrow transplantation. Blood. 52:447-452.
27. Skolovsky, M., R. Galron, Y. Kloog, A. Bdolah, F.E. Indig, S. Blumberg, and G. Fleminger. 1990. Endothelins are more sensitive than sarafotoxins to neutral endopeptidase: possible physiological significance. Proc. Natl. Acad. Sci. USA. 87:4702-4706.
28. Metsarinne, K.P., P. Vehmaan-Kreula, P.T. Kovanen, O. Saijonmaa, M. Baumann, Y. Wang, T. Nyman, F.Y. Fyhrquist, and K.K. Eklund. 2002. Activated mast cells increase the level of endothelin-1 mRNA in cocultured endothelial cells and degrade the secreted Peptide. Arterioscler. Thromb. Vasc. Biol. 22:268-273.
29. Hultner, L., and H. Ehrenreich. 2005. Mast cells and endothelin-1: a life-saving biological liaison? Trends Immunol. 26:235-238.
30. Kloog, Y., I. Ambar, M. Sokolovsky, E. Kochva, Z. Wollberg, and A. Bdolah. 1988. Sarafotoxin, a novel vasoconstrictor peptide: phosphoinositide hydrolysis in rat heart and brain. Science. 242:268-270.
31. Klein, J. 1997. Allergies and other hypersensitivities. In Immunology. J. Klein and V. Hoerjsi, editors. Blackwell Science, Oxford. pp. 608-634.
32. Knight, P.A., S.H. Wright, C.E. Lawrence, Y.Y. Paterson, and H.R. Miller. 2000. Delayed expulsion of the nematode Trichinella spiralis in mice lacking the mucosal mast cell-specific granule chymase, mouse mast cell protease-1. J. Exp. Med. 192:1849-1856.
33. Rivera, J. 2006. Snake bites and bee stings: the mast cell strikes back. Nat. Med. 12:999-1000.
34. Kimura, S., Y. Kasuya, T. Sawamura, O. Shinmi, Y. Sugita, M. Yanagisawa, K. Goto, and T. Masaki. 1988. Structure-activity rela tionships of endothelin: importance of the C-terminal moiety. Biochem. Biophys. Res. Commun. 156:1182-1186.
35. Orry, A.J., and B.A. Wallace. 2000. Modeling and docking the endothelin G-protein-coupled receptor. Biophys. J. 79:3083-3094.
36. Lundblad, R., and K.E. Giercksky. 1995. Endothelin concentrations in experimental sepsis: profiles of big endothelin and endothelin 1-21 in lethal peritonitis in rats. Eur. J. Surg. 161:9-16.
37. Ornan, D.A., I.H. Chaudry, and P. Wang. 2000. The dissociation between upregulated endothelins and hemodynamic responses during polymicrobial sepsis. Biochim. Biophys. Acta. 1501:211-218.
38. Baveja, R., N. Kresge, J.H. Ashburn, S. Keller, Y. Yokoyama, N. Sonin, J.X. Zhang, T. Huynh, and M.G. Clemens. 2002. Potentiated hepatic microcirculatory response to endothelin-1 during polymicrobial sepsis. Shock. 18:415-422.
39. Figueras-Aloy, J., L. Gomez-Lopez, J.M. Rodriguez-Miguelez, Y. Jordan-Garcia, M.D. Salvia-Roiges, W. Jimenez, and X. Carbonell-Estrany. 2004. Plasma endothelin-1 and clinical manifestations of neonatal sepsis. J. Perinat. Med. 32:522-526.
40. Siren, A.L., and G. Feuerstein. 1989. Hemodynamic effects of endothelin after systemic and central nervous system administration in the conscious rat. Neuropeptides. 14:231-236.
41. Oldner, A., M. Wanecek, M. Goiny, E. Weitzberg, A. Rudehill, K. Alving, and A. Sollevi. 1998. The endothelin receptor antagonist bosentan restores gut oxygen delivery and reverses intestinal mucosal acidosis in porcine endotoxin shock. Gut. 42:696-702.
42. Szalay, L., J. Kaszaki, S. Nagy, and M. Boros. 2000. Endothelin-1 induces mucosal mast cell degranulation in the rat small intestine. Life Sci. 67:1947-1958.
43. Waskow, C., G. Terszowski, C. Costa, M. Gassmann, and H.R. Rodewald. 2004. Rescue of lethal c-KitW/W mice by erythropoietin. Blood. 104:1688-1695.
44. Sawano, A., and A. Miyawaki. 2000. Directed evolution of green fluorescent protein by a new versatile PCR strategy for site-directed and semi-random mutagenesis. Nucleic Acids Res. 28:E78.
45. Henningsson, F., J. Ledin, C. Lunderius, M. Wilen, L. Hellman, and G. Pejler. 2002. Altered storage of proteases in mast cells from mice lacking heparin: a possible role for heparin in carboxypeptidase A processing. Biol. Chem. 383:793-801.
46. Janes, R.W., D.H. Peapus, and B.A. Wallace. 1994. The crystal structure of human endothelin. Nat. Struct. Biol. 1:311-319.