P38γ overexpression in gliomas and its role in proliferation and apoptosis

Scientific Reports

Volumn 3, Issue , 2013, Pages

  Yang, Kui ^a   Liu, Yunsheng ^a   Liu, Zhixiong ^a   Liu, Jinfang ^a   Liu, Xin ^b   Chen, Xin ^a   Li, Chuntao ^a   Zeng, Yu ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

^b Hunan Provincial People's Hospital   (China)

Author keywords

[No Author keywords available]

Indexed keywords

MITOGEN ACTIVATED PROTEIN KINASE 12;

APOPTOSIS; BRAIN TUMOR; CELL PROLIFERATION; ENZYMOLOGY; GLIOMA; HUMAN; METABOLISM; PATHOLOGY; REAL TIME POLYMERASE CHAIN REACTION; WESTERN BLOTTING;

APOPTOSIS; BLOTTING, WESTERN; BRAIN NEOPLASMS; CELL PROLIFERATION; GLIOMA; HUMANS; MITOGEN-ACTIVATED PROTEIN KINASE 12; REAL-TIME POLYMERASE CHAIN REACTION;

EID: 84891695628     PISSN: None     EISSN: 20452322     Source Type: Journal    
DOI: 10.1038/srep02089     Document Type: Article

References (33)

1. Risco, A. & Cuenda, A. New Insights into the p38gamma and p38delta MAPK Pathways. Journal of signal transduction 2012, 520289 (2012).
2. Wagner, E. F. & Nebreda, A. R. Signal integration by JNK and p38 MAPK pathways in cancer development. Nature reviews. Cancer 9, 537-549 (2009).
3. Han, J. & Sun, P. The pathways to tumor suppression via route p38. Trends in biochemical sciences 32, 364-371 (2007).
4. Loesch, M. & Chen, G. The p38 MAPK stress pathway as a tumor suppressor or more? Front. Biosci. 13, 3581-3593 (2008).
5. del Barco Barrantes, I. & Nebreda, A. R. Roles of p38 MAPKs in invasion and metastasis. Biochem. Soc. Trans. 40, 79-84 (2012).
6. Lepage, C. et al. Diosgenin induces death receptor-5 through activation of p38 pathway and promotes TRAIL-induced apoptosis in colon cancer cells. Cancer Lett 301, 193-202 (2011).
7. Fujita, M. et al. Cytotoxicity of troglitazone through PPARgamma-independent pathway and p38 MAPK pathway in renal cell carcinoma. Cancer Lett 312, 219-227 (2011).
8. Ho, R. C., Alcazar, O., Fujii, N., Hirshman, M. F. & Goodyear, L. J. p38gamma MAPK regulation of glucose transporter expression and glucose uptake in L6 myotubes and mouse skeletal muscle. American journal of physiology. Regulatory, integrative and comparative physiology 286, R342-349 (2004).
9. Foster, W. H., Tidball, J. G. & Wang, Y. p38gamma activity is required for maintenance of slow skeletal muscle size. Muscle & nerve 45, 266-273 (2012).
10. Kukkonen-Macchi, A. et al. Loss of p38gamma MAPK induces pleiotropic mitotic defects and massive cell death. Journal of cell science 124, 216-227 (2011).
11. Wu, C. C., Wu, X., Han, J. & Sun, P. p38gamma regulates UV-induced checkpoint signaling and repair of UV-induced DNA damage. Protein & cell 1, 573-583 (2010).
12. Meng, F. et al. p38gamma mitogen-activated protein kinase contributes to oncogenic properties maintenance and resistance to poly (ADP-ribose) - polymerase-1 inhibition in breast cancer. Neoplasia 13, 472-482 (2011).
13. Tang, J., Qi, X., Mercola, D., Han, J. & Chen, G. Essential role of p38gamma in K-Ras transformation independent of phosphorylation. The Journal of biological chemistry 280, 23910-23917 (2005).
14. Hou, S. W. et al. PTPH1 dephosphorylates and cooperates with p38gamma MAPK to increase ras oncogenesis through PDZ-mediated interaction. Cancer research 70, 2901-2910 (2010).
15. Demuth, T. et al. MAP-ing glioma invasion: mitogen-activated protein kinase kinase 3 and p38 drive glioma invasion and progression and predict patient survival. Molecular cancer therapeutics 6, 1212-1222 (2007).
16. Yao, Y. Q. et al. Anti-tumor effect of beta-elemene in glioblastoma cells depends on p38 MAPK activation. Cancer Lett 264, 127-134 (2008).
17. Mrugala, M. M. Advances and challenges in the treatment of glioblastoma: a clinician's perspective. Discovery medicine 15, 221-230 (2013).
18. Patel, M., Vogelbaum, M. A., Barnett, G. H., Jalali, R. & Ahluwalia, M. S. Molecular targeted therapy in recurrent glioblastoma: current challenges and future directions. Expert opinion on investigational drugs 21, 1247-1266 (2012).
19. Marumoto, T. & Saya, H. Molecular biology of glioma. Adv. Exp. Med. Biol. 746, 2-11 (2012).
20. Wang, Y. & Jiang, T. Understanding high grade glioma: molecular mechanism, therapy and comprehensive management. Cancer Lett 331, 139-146 (2013).
21. Uehara, N., Kanematsu, S., Miki, H., Yoshizawa, K. & Tsubura, A. Requirement of p38 MAPK for a cell-death pathway triggered by vorinostat in MDA-MB-231 human breast cancer cells. Cancer Lett 315, 112-121 (2012).
22. de la Cruz-Morcillo, M. A. et al. Abrogation of the p38 MAPK alpha signaling pathway does not promote radioresistance but its activity is required for 5-Fluorouracil-associated radiosensitivity. Cancer Lett 335, 66-74 (2013).
23. Lou, X., Zhou, Q., Yin, Y., Zhou, C. & Shen, Y. Inhibition of the met receptor tyrosine kinase signaling enhances the chemosensitivity of glioma cell lines to CDDP through activation of p38 MAPK pathway. Molecular cancer therapeutics 8, 1126-1136 (2009).
24. Yeung, Y. T. et al. p38 MAPK inhibitors attenuate pro-inflammatory cytokine production and the invasiveness of human U251 glioblastoma cells. J. Neurooncol. 109, 35-44 (2012).
25. Chiacchiera, F. et al. Blocking p38/ERK crosstalk affects colorectal cancer growth by inducing apoptosis in vitro and in preclinical mouse models. Cancer Lett 324, 98-108 (2012).
26. Qi, X. et al. p38alpha antagonizes p38gamma activity through c-Jun-dependent ubiquitin-proteasome pathways in regulating Ras transformation and stress response. The Journal of biological chemistry 282, 31398-31408 (2007).
27. Hou, S. et al. p38gamma Mitogen-activated protein kinase signals through phosphorylating its phosphatase PTPH1 in regulating ras protein oncogenesis and stress response. The Journal of biological chemistry 287, 27895-27905 (2012).
28. Boldrini, L. et al. Telomerase activity and hTERT mRNA expression in glial tumors. International journal of oncology 28, 1555-1560 (2006).
29. Matsuo, T. et al. Correlation between p38 mitogen-activated protein kinase and human telomerase reverse transcriptase in sarcomas. Journal of experimental & clinical cancer research: CR 31, 5 (2012).
30. Dwyer, J., Li, H., Xu, D. & Liu, J. P. Transcriptional regulation of telomerase activity: roles of the the Ets transcription factor family. Ann. N. Y. Acad. Sci. 1114, 36-47 (2007).
31. Goueli, B. S. & Janknecht, R. Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. Oncogene 22, 8042-8047 (2003).
32. Cerezo-Guisado, M. I. et al. Evidence of p38gamma and p38delta involvement in cell transformation processes. Carcinogenesis 32, 1093-1099 (2011).
33. Beyne-Rauzy, O. et al. Tumor necrosis factor-alpha inhibits hTERT gene expression in human myeloid normal and leukemic cells. Blood 106, 3200-3205 (2005).