N-Acetylcysteine-and mk-801-induced changes in glutamate levels do not affect in vivo binding of metabotropic glutamate 5 receptor radioligand 11C-ABP688 in rat brain

Journal of Nuclear Medicine

Volumn 54, Issue 11, 2013, Pages 1954-1961

  Wyckhuys, Tine ^a   Verhaeghe, Jeroen ^a   Wyffels, Leonie ^b   Langlois, Xavier ^c   Schmidt, Mark ^c   Stroobants, Sigrid ^a,b   Staelens, Steven ^a  

^a UNIVERSITY OF ANTWERP   (Belgium)

^b ANTWERP UNIVERSITY HOSPITAL   (Belgium)

^c Department of Neuroscience Janssen Pharmaceutica NV ^*  (Belgium)

Author keywords

Binding potential; Glutamate; Mglur5; Microprobes; Small animal PET;

Indexed keywords

ACETYLCYSTEINE; CARBON 3 (6 METHYLPYRIDIN 2 YLETHYNYL)CYCLOHEX 2 ENONE O METHYLOXIME C 11; DIZOCILPINE; GLUTAMIC ACID; TRACER; UNCLASSIFIED DRUG; 3 (6 METHYLPYRIDIN 2 YLETHYNYL)CYCLOHEX 2 ENONE O METHYLOXIME; 3-(6-METHYLPYRIDIN-2-YLETHYNYL)CYCLOHEX-2-ENONE-O-METHYLOXIME; CARBON; DIAGNOSTIC AGENT; DIZOCILPINE MALEATE; LIGAND; METABOTROPIC RECEPTOR 5; OXIME; PYRIDINE DERIVATIVE; PROTEIN BINDING;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN REGION; CEREBELLUM; CHEMICAL BINDING; CONTROLLED STUDY; FRONTAL CORTEX; HIPPOCAMPUS; IN VIVO STUDY; ISOTOPE LABELING; LIGAND BINDING; MICROANALYSIS; NONHUMAN; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; PUTAMEN; RADIOASSAY; RAT; THALAMUS; Β-MICROPROBES; ANIMAL; BINDING POTENTIAL; BRAIN; DRUG EFFECT; METABOLISM; MGLUR5; PROTEIN BINDING; SCINTISCANNING; SMALL-ANIMAL PET; SPRAGUE DAWLEY RAT; DIAGNOSTIC USE; DRUG EFFECTS;

Β-MICROPROBES; BINDING POTENTIAL; GLUTAMATE; MGLUR5; SMALL-ANIMAL PET;

ACETYLCYSTEINE; ANIMALS; BRAIN; CARBON RADIOISOTOPES; DIZOCILPINE MALEATE; GLUTAMIC ACID; LIGANDS; OXIMES; POSITRON-EMISSION TOMOGRAPHY; PROTEIN BINDING; PYRIDINES; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, METABOTROPIC GLUTAMATE 5;

EID: 84891691648     PISSN: 01615505     EISSN: None     Source Type: Journal    
DOI: 10.2967/jnumed.113.121608     Document Type: Article

References (34)

1. Bradford HF. Glutamate, GABA and epilepsy. Prog Neurobiol. 1995;47:477-511.
2. Olney JW, Farber NB. Glutamate receptor dysfunction and schizophrenia. Arch Gen Psychiatry. 1995;52:998-1007.
3. Chase TN, Oh JD. Striatal dopamine-and glutamate-mediated dysregulation in experimental parkinsonism. Trends Neurosci. 2000;23(suppl):S86-S91.
4. 11C] ABP688 and N-acetylcysteine challenge. Biol Psychiatry. 2011;69:822-824.
5. 11C-ABP688 as a probe for imaging the metabotropic glutamate receptor subtype 5. J Nucl Med. 2006;47:698-705.
6. Dean O, Giorlando F, Berk M. N-acetylcysteine in psychiatry: current therapeutic evidence and potential mechanisms of action. J Psychiatry Neurosci. 2011;36:78-86.
7. Dean OM, Bush AI, Berk M. Translating the Rosetta Stone of N-acetylcysteine. Biol Psychiatry. 2012;71:935-936.
8. 11C]ABP688. J Cereb Blood Flow Metab. 2010;30:1538-1549.
9. 11C]ABP688 and positron emission tomography in rats. Synapse. 2012;66:552-560.
10. Daghighian F, Mazziotta JC, Hoffman EJ, et al. Intraoperative beta probe: a device for detecting tissue labeled with positron or electron emitting isotopes during surgery. Med Phys. 1994;21:153-157.
11. Léna I, Chessel A, Le Pen G, Krebs M-O, Garcia R. Alterations in prefrontal glutamatergic and noradrenergic systems following MK-801 administration in rats prenatally exposed to methylazoxymethanol at gestational day 17. Psychopharmacology (Berl). 2007;192:373-383.
12. 11CABP688 as PET ligand for the measurement of the metabotropic glutamate receptor subtype 5 using autoradiographic studies and a beta-scintillator. Neuroimage. 2007;35:1086-1092.
13. Visser EP, Disselhorst JA, Brom M, et al. Spatial resolution and sensitivity of the Inveon small-animal PET scanner. J Nucl Med. 2009;50:139-147.
14. Bao Q, Newport D, Chen M, Stout DB, Chatziioannou AF. Performance evaluation of the Inveon dedicated PET preclinical tomograph based on the NEMA NU-4 standards. J Nucl Med. 2009;50:401-408.
15. Constantinescu CC, Mukherjee J. Performance evaluation of an Inveon PET preclinical scanner. Phys Med Biol. 2009;54:2885-2899.
16. Hudson HM, Larkin R. Accelerated image reconstruction using ordered subsets of projection data. IEEE Trans Med Imaging. 1994;13:601-609.
17. Defrise M, Kinahan P, Townsend D, Michel C, Sibomana M, Newport D. Exact and approximate rebinning algorithms for 3-D PET data. IEEE Trans Med Imaging. 1997;16:145-158.
18. Watson CC. New, faster, image-based scatter correction for 3D PET. IEEE Trans Nucl Sci. 2000;47:1587-1594.
19. Lammertsma AA, Hume SP. Simplified reference tissue model for PET receptor studies. Neuroimage. 1996;4:153-158.
20. Pain F, Dhenain M, Gurden H, et al. A method based on Monte Carlo simulations and voxelized anatomical atlases to evaluate and correct uncertainties on radiotracer accumulation quantitation in beta microprobe studies in the rat brain. Phys Med Biol. 2008;53:5385-5404.
21. Paxinos G, Watson C. The Rat Brain in Stereotaxic Coordinates. San Diego, CA: Academic Press; 2007.
22. Weber B, Späth N, Wyss M, et al. Quantitative cerebral blood flow measurements in the rat using a beta-probe and H2 15O. J Cereb Blood Flow Metab. 2003;23: 1455-1460.
23. 11C]raclopride in rats. Synapse. 2004;52:89-99.
24. 11C]ABP688. J Cereb Blood Flow Metab. 2011;31:2169-2180.
25. 11C]ABP688: binding variability and specificity for the metabotropic glutamate receptor subtype 5 in baboons. Eur J Nucl Med Mol Imaging. 2011;38:1083-1094.
26. 11C]ABP688 with N-acetylcysteine challenge in rhesus monkeys. Synapse. 2013;67:489-501.
27. Kovacic P, Somanathan R. Clinical physiology and mechanism of dizocilpine (MK-801): electron transfer, radicals, redox metabolites and bioactivity. Oxid Med Cell Longev. 2010;3:13-22.
28. Baker DA, McFarland K, Lake RW, Shen H, Toda S, Kalivas PW. N-acetylcysteine-induced blockade of cocaine-induced reinstatement. Ann N Y Acad Sci. 2003;1003:349-351.
29. Andiné P, Widermark N, Axelsson R, et al. Characterization of MK-801-induced behavior as a putative rat model of psychosis. J Pharmacol Exp Ther. 1999;290: 1393-1408.
30. Alagarsamy S, Marino MJ, Rouse ST, Gereau RW, Heinemann SF, Conn PJ. Activation of NMDA receptors reverses desensitization of mGluR5 in native and recombinant systems. Nat Neurosci. 1999;2:234-240.
31. Homayoun H, Moghaddam B. Bursting of prefrontal cortex neurons in awake rats is regulated by metabotropic glutamate 5 (mGlu5) receptors: rate-dependent influence and interaction with NMDA receptors. Cereb Cortex. 2006;16:93-105.
32. Myers RD, Adell A, Lankford MF. Simultaneous comparison of cerebral dialysis and push-pull perfusion in the brain of rats: a critical review. Neurosci Biobehav Rev. 1998;22:371-387.
33. Hume SP, Gunn RN, Jones T. Pharmacological constraints associated with positron emission tomographic scanning of small laboratory animals. Eur J Nucl Med. 1998;25:173-176.
34. Schiffer WK, Mirrione MM, Biegon A, Alexoff DL, Patel V, Dewey SL. Serial microPET measures of the metabolic reaction to a microdialysis probe implant. J Neurosci Methods. 2006;155:272-284.