The limit of anemia tolerance during hyperoxic ventilation with pure oxygen in anesthetized domestic pigs

European Surgical Research

Volumn 51, Issue 3-4, 2014, Pages 156-169

  Pape, A ^a   Steche, M ^a   Laout, M ^a   Wedel, M ^a   Schwerdel, F ^a   Weber, C F ^a   Zwissler, B ^c   Habler, O ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b Clinic of Anesthesiology Surgical Intensive Care Medicine and Pain Management   (South Korea)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Acute normovolemic anemia; Critical hemoglobin concentration; Hemodilution; Hyperoxic ventilation; Oxygen transport

Indexed keywords

ANEMIA; ANESTHESIA; ANIMALS; FEMALE; HEMODILUTION; HEMODYNAMICS; HEMOGLOBINS; MALE; MYOCARDIUM; OXYGEN; RESPIRATION, ARTIFICIAL; SWINE;

HEMOGLOBIN; HETASTARCH; OXYGEN;

ANEMIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSISTED VENTILATION; CARDIOVASCULAR PERFORMANCE; FEMALE; HEART FUNCTION; HEMODILUTION; HEMODYNAMICS; HYPEROXIC VENTILATION; MALE; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN SUPPLY; OXYGEN TRANSPORT; PRIORITY JOURNAL; TISSUE OXYGENATION;

EID: 84891687310     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000357171     Document Type: Article

References (33)

1. Pape A, Habler O: Alternatives to allogeneic blood transfusions. Best Pract Res Clin Anaesthesiol 2007; 21: 221-239.
2. Messmer KF: Acceptable hematocrit levels in surgical patients. World J Surg 1987; 11: 41-46.
3. Habler OP, Messmer KF: The physiology of oxygen transport. Transfus Sci 1997; 18: 425-435.
4. Madjdpour C, Spahn DR, Weiskopf RB: Anemia and perioperative red blood cell transfusion: a matter of tolerance. Crit Care Med 2006; 34:S102-S108.
5. Cain SM: Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia. J Appl Physiol 1977; 42: 228-234.
6. Schumacker PT, Cain SM: The concept of a critical oxygen delivery. Intensive Care Med 1987; 13: 223-229.
7. Pape A, Meier J, Kertscho H, Steche M, Laout M, Schwerdel F, Wedel M, Zwissler B, Habler OP: Hyperoxic ventilation increases the tolerance of acute normovolemic anemia in anesthetized pigs. Crit Care Med 2006; 34: 1475-1482.
8. Meier JM, Woelkhammer S, Habler OP: The Deltacrit-System (DCS)-a new method for online-determination of critical VO 2-decline. Comput Biol Med 2003; 33: 395-405.
9. Haller M, Akbulut C, Brechtelsbauer H, Fett W, Briegel J, Finsterer U, Peter K: Determination of plasma volume with indocyanine green in man. Life Sci 1993; 53: 1597-1604.
10. Kessler M, Hoper J, Krumme BA: Monitoring of tissue perfusion and cellular function. Anesthesiology 1976; 45: 184-197.
11. Pittman RN: Oxygen supply to contracting skeletal muscle at the microcirculatory level: diffusion vs convection. Acta Physiol Scand 2000; 168: 593-602.
12. Wettstein R, Tsai AG, Erni D, Lukyanov AN, Torchilin VP, Intaglietta M: Improving microcirculation is more effective than substitution of red blood cells to correct metabolic disorder in experimental hemorrhagic shock. Shock 2004; 21: 235-240.
13. De Backer D: VO2/DO2 relationship: how to get rid of methodological pitfalls? Intensive Care Med 2000; 26: 1719-1722.
14. Meier JM, Kemming GI, Kisch-Wedel H, Wolkhammer S, Habler OP: Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology 2004; 100: 70-76.
15. Meier JM, Pape A, Lauscher P, Zwissler B, Habler OP: Hyperoxia in lethal methemoglobinemia-effects on O 2 transport, tissue oxygenation and survival in pigs. Crit Care Med 2005; 33: 1582-1588.
16. Pape A, Kertscho H, Meier J, Horn O, Laout M, Steche M, Lossen M, Theisen A, Zwissler B, Habler O: Improved short-term survival with polyethylene glycol modified hemoglobin liposomes in critical normovolemic anemia. Intensive Care Med 2008; 34: 1534-1543.
17. Lauscher P, Kertscho H, Schmidt O, Zimmermann R, Rosenberger P, Zacharowski K, Meier J: Determination of organ-specific anemia tolerance. Crit Care Med 2013; 41: 1037-1045.
18. Perez-de-Sa V, Roscher R, Cunha-Goncalves D, Larsson A, Werner O: Mild hypothermia has minimal effects on the tolerance to severe progressive normovolemic anemia in Swine. Anesthesiology 2002; 97: 1189-1197.
19. Meier J, Pape A, Loniewska D, Lauscher P, Kertscho H, Zwissler B, Habler O: Norepinephrine increases tolerance to acute anemia. Crit Care Med 2007; 35: 1484-1492.
20. Habler OP, Kleen MS, Hutter JW, Podtschaske AH, Tiede M, Kemming GI, Welte MV, Corso CO, Batra S, Keipert PE, Faithfull NS, Messmer KF: Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs. Transfusion 1998; 38: 145-155.
21. Meisner FG, Kemming GI, Habler OP, Kleen MS, Tillmanns JH, Hutter JW, Bottino DA, Thein E, Meier JM, Wojtczyk CJ, Pape A, Messmer KF: Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit. Crit Care Med 2001; 29: 829-838.
22. Pape A, Kertscho H, Stein P, Lossen M, Horn O, Kutschker S, Zwissler B, Habler O: Neuromuscular blockade with rocuronium bromide increases the tolerance of acute normovolemic anemia in anesthetized pigs. Eur Surg Res 2011; 48: 16-25.
23. Pape A, Kutschker S, Kertscho H, Stein P, Horn O, Lossen M, Zwissler B, Habler O: The choice of the intravenous fluid influences the tolerance of acute normovolemic anemia in anesthetized domestic pigs. Crit Care 2012; 16:R69.
24. Dimmeler S, Fleming I, Fisslthaler B, Hermann C, Busse R, Zeiher AM: Activation of nitric oxide synthase in endothelial cells by Akt-dependent phosphorylation. Nature 1999; 399: 601-605.
25. Doss DN, Estafanous FG, Ferrario CM, Brum JM, Murray PA: Mechanism of systemic vasodilation during normovolemic hemodilution. Anesth Analg 1995; 81: 30-34.
26. Habler OP, Kleen MS, Kemming GI, Zwissler B: Hyperoxia in extreme hemodilution. Eur Surg Res 2002; 34: 181-187.
27. Habler OP, Messmer KF: Hyperoxaemia in extreme haemodilution. Br J Anaesth 1998; 81(suppl 1):79-82.
28. Mazzoni MC, Tsai AG, Intaglietta M: Blood and plasma viscosity and microvascular function in hemodilution. A perspective from La Jolla, California. Eur Surg Res 2002; 34: 101-105.
29. Cabrales P, Intaglietta M, Tsai AG: Transfusion restores blood viscosity and reinstates microvascular conditions from hemorrhagic shock independent of oxygen carrying capacity. Resuscitation 2007; 75: 124-134.
30. Merilainen PT: Metabolic monitor. Int J Clin Monit Comput 1987; 4: 167-177.
31. Carter J, Jeukendrup AE: Validity and reliability of three commercially available breath-by-breath respiratory systems. Eur J Appl Physiol 2002; 86: 435-441.
32. Lauscher P, Lauscher S, Kertscho H, Habler O, Meier J: Hyperoxia reversibly alters oxygen consumption and metabolism. ScientificWorldJournal 2012; 2012: 410321.
33. Holt JP, Rhode EA, Kines H: Ventricular volumes and body weight in mammals. Am J Physiol 1968; 215: 704-715.