Norepinephrine increases tolerance to acute anemia

Critical Care Medicine

Volumn 35, Issue 6, 2007, Pages 1484-1492

  Meier, Jens ^a   Pape, Andreas ^a   Loniewska, Daria ^a   Lauscher, Patrick ^a   Kertscho, Harry ^a   Zwissler, Bernhard ^a   Habler, Oliver ^a,b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b KRANKENHAUS NORDWEST   (Germany)

Author keywords

Anemia tolerance; Catecholamines; Mortality; Norepinephrine; Normovolemic anemia; Survival

Indexed keywords

HEMOGLOBIN; HETASTARCH; NORADRENALIN;

ACUTE DISEASE; ANEMIA; ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; AORTA PRESSURE; ARTICLE; BLOOD PRESSURE REGULATION; BLOOD VOLUME; CONTROLLED STUDY; CORONARY ARTERY BLOOD FLOW; DRUG INFUSION; EXCHANGE BLOOD TRANSFUSION; FEMALE; HEMODILUTION; HEMOGLOBIN BLOOD LEVEL; MALE; MEAN ARTERIAL PRESSURE; MORTALITY; NONHUMAN; OUTCOME ASSESSMENT; PRIORITY JOURNAL; PROSPECTIVE STUDY; RANDOMIZATION; SWINE;

EID: 34249335026     PISSN: 00903493     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.CCM.0000265740.62130.1C     Document Type: Article

References (33)

1. Messmer K, Sunder-Plassmann L, Klövekorn W, et al: Circulatory significance of hemodilution: Rheological changes and limitations. Adv Microcirc 1972; 4:1-77
2. Habler O, Messmer K: Hyperoxaemia in extreme haemodilution. Br J Anaesth 1998; 81(Suppl 1):79-82
3. Kemming G, Meisner F, Kleen M, et al: Hyperoxic ventilation at the critical haematocrit. Resuscitation 2003; 56:289-297
4. Meier J, Kemming G, Kisch-Wedel H, et al: Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology 2004; 100:70-76
5. Meier J, Wölkhammer S, Habler O: The DeltaCrit System (DCS): A computer program for standardized bedside detection of critical oxygen delivery using the Deltatrac II metabolic monitor. Comput Biol Med 2003; 33:395-405
6. Lübbers DW: The meaning of the tissue oxygen distribution curve and its measurement by means of Pt electrodes. Progr Respir Res 1968; 3:112-123
7. Bradley E, Barr J: Determination of blood volume using indocyanine green dye. Life Sci 1968; 7:1001-1007
8. Pawlik W, Shepherd A, Jacobson E: Effects of vasoactive agents on intestinal oxygen consumption and blood flow in dogs. J Clin Invest 1975; 56:484-490
9. Richer M, Robert S, Lebel M: Renal hemodynamics during norepinephrine and low-dose dopamine infusions in man. Crit Care Med 1996; 24:1150-1156
10. Schiffer E, Schwieger I, Gosteli P, et al: Systemic and splanchnic oxygen supply-demand relationship with fenoldopam, dopamine and noradrenaline in sheep. Eur J Pharmacol 1995; 286:49-60
11. Setty S, Tune J, Downey H: Nitric oxide modulates right ventricular flow and oxygen consumption during norepinephrine infusion. Am J Physiol 2002; 282:696-703
12. Berk J, Hagen J, Tong R, et al: The role of adrenergic stimulation in the pathogenesis of pulmonary insufficiency. Surgery 1977; 82:366-372
13. Berk J, Hagen J, Tong R, et al: Pulmonary insufficiency produced by norepinephrine: A comparison with epinephrine. Circ Shock 1977; 4:247-251
14. Cannon B, Nedergaard J: Brown adipose tissue: Function and physiological significance. Physiol Rev 2004; 84:277-359
15. Heusch G, Baumgart D, Camici P, et al: α-Adrenergic coronary vasoconstriction and myocardial ischemia in humans. Circulation 2000; 101:689-694
16. Morita K, Mori H, Tsujioka K, et al: α-Adrenergic vasoconstriction reduces systolic retrograde coronary blood flow. Am J Physiol 1997; 273:2746-2755
17. Giantomasso D, May C, Bellomo R: Norepinephrine and vital organ blood flow. Intensive Care Med 2002; 28:1804-1809
18. Sun D, Huang A, Mital S, et al: Norepinephrine elicits β2-receptor-mediated dilation of isolated human coronary arterioles. Circulation 2002; 106:550-555
19. Gorman M, Tune J, Richmond K, et al: Quantitative analysis of feedforward sympathetic coronary vasodilation in exercising dogs. J Appl Physiol 2000; 89:1903-1911
20. Marik PE, Mohedin M: The contrasting effects of dopamine and norepinephrine on systemic and splanchnic oxygen utilization in hyperdynamic sepsis. JAMA 1994; 272:1354-1357
21. Spronk P, Zandstra D, Ince C: Norepinephrine compromises intestinal microvascular perfusion? Int Care Med 2004; 30:173-174
22. Nygren A, Thoren A, Ricksten S: Effects of norepinephrine alone and norepinephrine plus dopamine on human intestinal mucosal perfusion. Int Care Med 2003; 29:1322-1328
23. Treggiari M, Romand J, Burgener D, et al: Effect of increasing norepinephrine dosage on regional blood flow in a porcine model of endotoxin shock. Crit Care Med 2002; 30:1334-1339
24. Morelli A, Tritapepe L, Rocco M, et al: Terlipressin versus norepinephrine to counteract anesthesia-induced hypotension in patients treated with renin-angiotensin system inhibitors: Effects on systemic and regional hemodynamics. Anesthesiology 2005; 102:12-19
25. Sautner T, Wessely C, Riegler M, et al: Early effects of catecholamine therapy on mucosal integrity, intestinal blood flow, and oxygen metabolism in porcine endotoxin shock. Ann Surg 1998; 228:239-248
26. De Backer D, Creteur J, Silva E, et al: Effects of dopamine, norepinephrine, and epinephrine on the splanchnic circulation in septic shock: Which is best? Crit Care Med 2003; 31:1659-1667
27. Cronin R, Erickson A, de Torrente A, et al: Norepinephrine-induced acute renal failure: A reversible ischemic model of acute renal failure. Kidney Int 1978; 14:187-190
28. Anderson WP, Korner PI, Selig SE: Mechanisms involved in the renal responses to intravenous and renal artery infusions of noradrenaline in conscious dogs. J Physiol 1981; 321:21-30
29. Hoogenberg K, Smit A, Girbes A: Effects of low-dose dopamine on renal and systemic hemodynamics during incremental norepinephrine infusion in healthy volunteers. Crit Care Med 1998; 26:260-265
30. Marik PE: Renal dose norepinephrine! Chest 2004; 126:335-336
31. Bellomo R, Giantomasso D: Noradrenaline and the kidney: Friends or foes? Crit Care 2001; 5:294-298
32. Bellomo R, Kellum J, Wisniewski S, et al: Effects of norepinephrine on the renal vasculature in normal and endotoxemic dogs. Am J Respir Crit Care Med 1999; 159:1186-1192
33. Holt J, Rhode E, Kines H: Ventricular volumes and body weight in mammals. Am J Physiol 1968; 215:704-715