Neuromuscular blockade with rocuronium bromide increases the tolerance of acute normovolemic anemia in anesthetized pigs

European Surgical Research

Volumn 48, Issue 1, 2012, Pages 16-25

  Pape, A ^a   Kertscho, H ^a   Stein, P ^a   Lossen, M ^a   Horn, O ^a   Kutschker, S ^a   Zwissler, B ^c   Habler, O ^b  

^a UNIVERSITY HOSPITAL FRANKFURT   (Germany)

^b KRANKENHAUS NORDWEST   (Germany)

^c LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

Author keywords

Anemia tolerance; Neuromuscular blockade; Pig; Rocuronium bromide

Indexed keywords

DIAZEPAM; ENFLURANE; FENTANYL; HEMOGLOBIN; HETASTARCH; ISOFLURANE; KETAMINE; MIDAZOLAM; MORPHINE; PANCURONIUM; PENTOBARBITAL; PROPOFOL; ROCURONIUM; SUFENTANIL; THIOPENTAL; VECURONIUM;

ACUTE NORMOVOLEMIC ANEMIA; ANEMIA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ARTIFICIAL VENTILATION; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG MEGADOSE; EXCHANGE BLOOD TRANSFUSION; HEART INDEX; HEMATOCRIT; HEMODYNAMICS; HEMOGLOBIN BLOOD LEVEL; LOW DRUG DOSE; NEUROMUSCULAR BLOCKING; NONHUMAN; OXYGEN CONSUMPTION; OXYGEN EXTRACTION FRACTION; OXYGEN TRANSPORT; PRIORITY JOURNAL; SWINE; TISSUE OXYGENATION;

ANDROSTANOLS; ANEMIA; ANESTHESIA; ANIMALS; ENERGY METABOLISM; FEMALE; HEMODILUTION; MALE; MODELS, ANIMAL; NEUROMUSCULAR NONDEPOLARIZING AGENTS; OXYGEN CONSUMPTION; SWINE;

EID: 83755186530     PISSN: 0014312X     EISSN: 14219921     Source Type: Journal    
DOI: 10.1159/000333797     Document Type: Article

References (40)

1. Messmer KF: Acceptable hematocrit levels in surgical patients. World J Surg 1987; 11: 41-46.
2. Habler OP, Messmer KF: The physiology of oxygen transport. Transfus Sci 1997; 18: 425-435.
3. Madjdpour C, Spahn DR, Weiskopf RB: Anemia and perioperative red blood cell transfusion: a matter of tolerance. Crit Care Med 2006; 34:S102-S108. (Pubitemid 43670475)
4. Cain SM: Oxygen delivery and uptake in dogs during anemic and hypoxic hypoxia. J Appl Physiol 1977; 42: 228-234.
5. Schumacker PT, Cain SM: The concept of a critical oxygen delivery. Intensive Care Med 1987; 13: 223-229. (Pubitemid 17117827)
6. Pape A, Habler O: Alternatives to allogeneic blood transfusions. Best Pract Res Clin Anaesthesiol 2007; 21: 221-239. (Pubitemid 46888189)
7. Marik PE, Kaufman D: The effects of neuromuscular paralysis on systemic and splanchnic oxygen utilization in mechanically ventilated patients. Chest 1996; 109: 1038-1042. (Pubitemid 26113650)
8. Vernon DD, Witte MK: Effect of neuromuscular blockade on oxygen consumption and energy expenditure in sedated, mechanically ventilated children. Crit Care Med 2000; 28: 1569-1571. (Pubitemid 30324541)
9. Herweling A, Latorre F, Herwig A, Horstick G, Kempski O, Gervais HW: The hemodynamic effects of ephedrine on the onset time of rocuronium in pigs. Anesth Analg 2004; 99: 1703-1707. (Pubitemid 39551907)
10. Meier JM, Wölkhammer S, Habler OP: The DeltaCrit System (DCS): a computer program for standardized bedside detection of critical oxygen delivery using the Deltatrac II metabolic monitor. Comput Biol Med 2003; 33: 395-405. (Pubitemid 36829355)
11. Haller M, Akbulut C, Brechtelsbauer H, Fett W, Briegel J, Finsterer U, Peter K: Determination of plasma volume with indocyanine green in man. Life Sci 1993; 53: 1597-1604.
12. Meier JM, Kemming GI, Kisch-Wedel H, Wolkhammer S, Habler OP: Hyperoxic ventilation reduces 6-hour mortality at the critical hemoglobin concentration. Anesthesiology 2004; 100: 70-76. (Pubitemid 38031656)
13. Meier J, Pape A, Loniewska D, Lauscher P, Kertscho H, Zwissler B, Habler O: Norepinephrine increases tolerance to acute anemia. Crit Care Med 2007; 35: 1484-1492. (Pubitemid 46809311)
14. 2 transport, tissue oxygenation and survival in pigs. Crit Care Med 2005; 33: 1582-1588.
15. Pape A, Kertscho H, Meier J, Horn O, Laout M, Steche M, Lossen M, Theisen A, Zwissler B, Habler O: Improved short-term survival with polyethylene glycol modified hemoglobin liposomes in critical normovolemic anemia. Intensive Care Med 2008; 34: 1534-1543.
16. Perez-de-Sa V, Roscher R, Cunha-Goncalves D, Larsson A, Werner O: Mild hypothermia has minimal effects on the tolerance to severe progressive normovolemic anemia in swine. Anesthesiology 2002; 97: 1189-1197. (Pubitemid 35265574)
17. Pape A, Meier J, Kertscho H, Steche M, Laout M, Schwerdel F, Wedel M, Zwissler B, Habler OP: Hyperoxic ventilation increases the tolerance of acute normovolemic anemia in anesthetized pigs. Crit Care Med 2006; 34: 1475-1482.
18. Kemming GI, Meisner FG, Kleen MS, Meier JM, Tillmanns JH, Hutter JW, Wojtczyk CJ, Packert KB, Bottino DA, Habler OP: Hyperoxic ventilation at the critical haematocrit. Resuscitation 2003; 56: 289-297. (Pubitemid 36288516)
19. Meisner FG, Kemming GI, Habler OP, Kleen MS, Tillmanns JH, Hutter JW, Bottino DA, Thein E, Meier JM, Wojtczyk CJ, Pape A, Messmer KF: Diaspirin crosslinked hemoglobin enables extreme hemodilution beyond the critical hematocrit. Crit Care Med 2001; 29: 829-838. (Pubitemid 32299725)
20. Habler OP, Kleen MS, Hutter JW, Podtschaske AH, Tiede M, Kemming GI, Welte MV, Corso CO, Batra S, Keipert PE, Faithfull NS, Messmer KF: Hemodilution and intravenous perflubron emulsion as an alternative to blood transfusion: effects on tissue oxygenation during profound hemodilution in anesthetized dogs. Transfusion 1998; 38: 145-155. (Pubitemid 28145080)
21. van der Linden P, De Hert S, Mathieu N, Degroote F, Schmartz D, Zhang H, Vincent JL: Tolerance to acute isovolemic hemodilution. Effect of anesthetic depth. Anesthesiology 2003; 99: 97-104. (Pubitemid 36799039)
22. Ickx BE, Rigolet M, van der Linden P: Cardiovascular and metabolic response to acute normovolemic anemia. Effects of anesthesia. Anesthesiology 2000; 93: 1011-1016.
23. Levy PS, Kim SJ, Eckel PK, Chavez R, Ismail EF, Gould SA, Ramez SM, Crystal GJ: Limit to cardiac compensation during acute isovolemic hemodilution: influence of coronary stenosis. Am J Physiol 1993; 265:H340-H349. (Pubitemid 23224729)
24. Kim J, Shen W, Gallagher D, Jones A Jr, Wang Z, Wang J, Heshka S, Heymsfield SB: Totalbody skeletal muscle mass: estimation by dual- energy X-ray absorptiometry in children and adolescents. Am J Clin Nutr 2006; 84: 1014-1020. (Pubitemid 44730370)
25. Eisenberg E, Hill TL: Muscle contraction and free energy transduction in biological systems. Science 1985; 227: 999-1006. (Pubitemid 15142036)
26. Naguib M: Sugammadex: another milestone in clinical neuromuscular pharmacology. Anesth Analg 2007; 104: 575-581.
27. Kampe S, Krombach JW, Diefenbach C: Muscle relaxants. Best Pract Res Clin Anaesthesiol 2003; 17: 137-146. (Pubitemid 38950017)
28. Muldoon SM, Theye RA: The effects of succinylcholine and d-tubocurarine on oxygen consumption. Anesthesiology 1969; 31: 437-442.
29. McCall M, Jeejeebhoy K, Pencharz P, Moulton R: Effect of neuromuscular blockade on energy expenditure in patients with severe head injury. JPEN J Parenter Enteral Nutr 2003; 27: 27-35. (Pubitemid 36105640)
30. Barton RG, Craft WB, Mone MC, Saffle JR: Chemical paralysis reduces energy expenditure in patients with burns and severe respiratory failure treated with mechanical ventilation. J Burn Care Rehabil 1997; 18: 461-468. (Pubitemid 27407553)
31. Russell WC, Greer R, Harper NJ: The effect of neuromuscular blockade on oxygen supply, consumption, and total chest compliance in patients with high oxygen requirements undergoing mechanical ventilation. Anaesth Intensive Care 2002; 30: 192-197. (Pubitemid 34326602)
32. Werlhof V, Sessler DI: Pancuronium does not decrease oxygen consumption during hypothermic or normothermic cardiopulmonary bypass. Anesth Analg 1995; 81: 465-468.
33. Richardson RS: Oxygen transport and utilization: an integration of the muscle systems. Adv Physiol Educ 2003; 27: 183-191.
34. Pittman RN: Oxygen supply to contracting skeletal muscle at the microcirculatory level: diffusion vs convection. Acta Physiol Scand 2000; 168: 593-602.
35. Koskolou MD, Roach RC, Calbet JA, Radegran G, Saltin B: Cardiovascular responses to dynamic exercise with acute anemia in humans. Am J Physiol 1997; 273:H1787-H1793.
36. Holt JP, Rhode EA, Kines H: Ventricular volumes and body weight in mammals. Am J Physiol 1968; 215: 704-715.
37. Fontana JL, Welborn L, Mongan PD, Sturm P, Martin G, Bunger R: Oxygen consumption and cardiovascular function in children during profound intraoperative normovolemic hemodilution. Anesth Analg 1995; 80: 219-225.
38. van Woerkens EC, Trouwborst A, van Lanschot JJ: Profound hemodilution: what is the critical level of hemodilution at which oxygen delivery-dependent oxygen consumption starts in an anesthetized human? Anesth Analg 1992; 75: 818-821.
39. Zollinger A, Hager P, Singer T, Friedl HP, Pasch T, Spahn DR: Extreme hemodilution due to massive blood loss in tumor surgery. Anesthesiology 1997; 87: 985-987. (Pubitemid 27456255)
40. van der Linden P, Schmartz D, De Groote F, Mathieu N, Willaert P, Rausin I, Vincent JL: Critical haemoglobin concentration in anaesthetized dogs: comparison of two plasma substitutes. Br J Anaesth 1998; 81: 556-562. (Pubitemid 28445933)