Maternal obesity and diabetes induces latent metabolic defects and widespread epigenetic changes in isogenic mice

Epigenetics

Volumn 8, Issue 6, 2013, Pages 602-611

  Li, Cheryl C Y ^a   Young, Paul E ^a   Maloney, Christopher A ^a,b   Eaton, Sally A ^a   Cowley, Mark J ^c   Buckland, Michael E ^d   Preiss, Thomas ^a,e   Henstridge, Darren C ^f   Cooney, Gregory J ^b,c   Febbraio, Mark A ^f   Martin, David I K ^g   Cropley, Jennifer E ^a,b   Suter, Catherine M ^a,b  

^a VICTOR CHANG CARDIAC RESEARCH INSTITUTE   (Australia)

^b UNIVERSITY OF NEW SOUTH WALES   (Australia)

^c GARVAN INSTITUTE OF MEDICAL RESEARCH   (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

^e Australian National University   (Australia)

^f BAKER IDI HEART AND DIABETES INSTITUTE   (Australia)

^g CHILDREN S HOSPITAL OAKLAND RESEARCH INSTITUTE   (United States)

Author keywords

Cytosine methylation; Diabetes; Epigenetic programming; Fetal programming; Obesity

Indexed keywords

LEPTIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; COPY NUMBER VARIATION; DIABETES MELLITUS; DNA METHYLATION; FEMALE; GENE EXPRESSION; GLUCOSE TOLERANCE TEST; INSULIN TOLERANCE TEST; LIPID ANALYSIS; LIVER HISTOLOGY; MALE; MATERNAL OBESITY; METABOLIC DISORDER; MICROARRAY ANALYSIS; MOUSE; NONHUMAN; PRINCIPAL COMPONENT ANALYSIS; SEQUENCE ANALYSIS; ANIMAL; DIET; FETUS DEVELOPMENT; GENETIC EPIGENESIS; GENETICS; LIVER; LIVER MITOCHONDRION; METABOLISM; NON INSULIN DEPENDENT DIABETES MELLITUS; OBESITY; PATHOLOGY; PREGNANCY; PREGNANCY COMPLICATION; PREGNANCY DIABETES MELLITUS;

MUS;

ANIMALS; DIABETES MELLITUS, TYPE 2; DIET; EPIGENESIS, GENETIC; FEMALE; FETAL DEVELOPMENT; GENE EXPRESSION; LIVER; MALE; MICE; MITOCHONDRIA, LIVER; OBESITY; PREGNANCY; PREGNANCY COMPLICATIONS; PREGNANCY IN DIABETICS;

EID: 84891686039     PISSN: 15592294     EISSN: 15592308     Source Type: Journal    
DOI: 10.4161/epi.24656     Document Type: Article

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