Effects of exercise and low-fat diet on adipose tissue inflammation and metabolic complications in obese mice

American Journal of Physiology - Endocrinology and Metabolism

Volumn 296, Issue 5, 2009, Pages

  Vieira, Victoria J ^a   Valentine, Rudy J ^a   Wilund, Kenneth R ^a   Antao, Nirav ^a   Baynard, Tracy ^a   Woods, Jeffrey A ^a  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

Hepatic steatosis; Insulin resistance; Macrophage; Obesity

Indexed keywords

LEPTIN; MONOCYTE CHEMOTACTIC PROTEIN 1; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADIPOSE TISSUE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; EXERCISE; FATTY LIVER; INFLAMMATION; INSULIN RESISTANCE; LIFESTYLE MODIFICATION; LIPID DIET; LOW FAT DIET; MALE; MOUSE; NONHUMAN; OBESITY; PRIORITY JOURNAL; PROTEIN EXPRESSION; TREADMILL EXERCISE;

ADIPOKINES; ADIPONECTIN; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIETARY FATS; FATTY LIVER; INFLAMMATION; INSULIN RESISTANCE; INTRA-ABDOMINAL FAT; MICE; MICE, INBRED C57BL; OBESITY; PHYSICAL CONDITIONING, ANIMAL; RANDOM ALLOCATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, MESSENGER; TRIGLYCERIDES;

EID: 66149118127     PISSN: 01931849     EISSN: 15221555     Source Type: Journal    
DOI: 10.1152/ajpendo.00054.2009     Document Type: Article

References (40)

1. No authors listed. Physical activity guidelines for Americans. Okla Nurse 53: 25, 2008.
2. Adams LA, Lymp JF, St Sauver J, Sanderson SO, Lindor KD, Feldstein A, Angulo P. The natural history of nonalcoholic fatty liver disease: a population-based cohort study. Gastroenterology 129: 113-121, 2005. (Pubitemid 41002048)
3. Bradley RL, Jeon JY, Liu FF, Maratos-Flier E. Voluntary exercise improves insulin sensitivity and adipose tissue inflammation in dietinduced obese mice. Am J Physiol Endocrinol Metab 295: E586-E594, 2008.
4. Browning LM, Jebb SA, Mishra GD, Cooke JH, O'Connell MA, Crook MA, Krebs JD. Elevated sialic acid, but not CRP, predicts features of the metabolic syndrome independently of BMI in women. Int J Obes Relat Metab Disord 28: 1004-1010, 2004.
5. Bruun JM, Helge JW, Richelsen B, Stallknecht B. Diet and exercise reduce low-grade inflammation and macrophage infiltration in adipose tissue but not in skeletal muscle in severely obese subjects. Am J Physiol Endocrinol Metab 290: E961-E967, 2006.
6. de Ferranti S, Mozaffarian D. The perfect storm: obesity, adipocyte dysfunction, and metabolic consequences. Clin Chem 54: 945-955, 2008.
7. Eriksson M, Johnson O, Boman K, Hallmans G, Hellsten G, Nilsson TK, Soderberg S. Improved fibrinolytic activity during exercise may be an effect of the adipocyte-derived hormones leptin and adiponectin. Thromb Res 122: 701-708, 2008.
8. Gauthier MS, Couturier K, Latour JG, Lavoie JM. Concurrent exercise prevents high-fat-diet-induced macrovesicular hepatic steatosis. J Appl Physiol 94: 2127-2134, 2003. (Pubitemid 36605269)
9. Gomez-Merino D, Drogou C, Guezennec CY, Chennaoui M. Effects of chronic exercise on cytokine production in white adipose tissue and skeletal muscle of rats. Cytokine 40: 23-29, 2007. (Pubitemid 350088496)
10. Hamdy O, Porramatikul S, Al-Ozairi E. Metabolic obesity: the paradox between visceral and subcutaneous fat. Curr Diabetes Rev 2: 367-373, 2006.
11. Hotamisligil GS, Budavari A, Murray D, Spiegelman BM. Reduced tyrosine kinase activity of the insulin receptor in obesity-diabetes. Central role of tumor necrosis factor-alpha. J Clin Invest 94: 1543-1549, 1994.
12. Huang W, Dedousis N, O'Doherty RM. Hepatic steatosis and plasma dyslipidemia induced by a high-sucrose diet are corrected by an acute leptin infusion. J Appl Physiol 102: 2260-2265, 2007. (Pubitemid 47080758)
13. Jacobs DR Jr, Sluik D, Rokling-Andersen MH, Anderssen SA, Drevon CA. Association of 1-y changes in diet pattern with cardiovascular disease risk factors and adipokines: results from the 1-y randomized Oslo Diet and Exercise Study. Am J Clin Nutr 89: 509-517, 2009.
14. Kamiñski KA, Oledzka E, Bialobrzewska K, Kozuch M, Musial WJ, Winnicka MM. The effects of moderate physical exercise on cardiac hypertrophy in interleukin 6 deficient mice. Adv Med Sci 52: 164-168, 2007.
15. Kanda H, Tateya S, Tamori Y, Kotani K, Hiasa K, Kitazawa R, Kitazawa S, Miyachi H, Maeda S, Egashira K, Kasuga M. MCP-1 contributes to macrophage infiltration into adipose tissue, insulin resistance, and hepatic steatosis in obesity. J Clin Invest 116: 1494-1505, 2006. (Pubitemid 43911004)
16. Le Floch JP, Escuyer P, Baudin E, Baudon D, Perlemuter L. Blood glucose area under the curve. Methodological aspects. Diabetes Care 13: 172-175, 1990.
17. Lumeng CN, Bodzin JL, Saltiel AR. Obesity induces a phenotypic switch in adipose tissue macrophage polarization. J Clin Invest 117: 175-184, 2007.
18. Maachi M, Pieroni L, Bruckert E, Jardel C, Fellahi S, Hainque B, Capeau J, Bastard JP. Systemic low-grade inflammation is related to both circulating and adipose tissue TNFalpha, leptin and IL-6 levels in obese women. Int J Obes Relat Metab Disord 28: 993-997, 2004. (Pubitemid 38998704)
19. Matthews DR, Hosker JP, Rudenski AS, Naylor BA, Treacher DF, Turner RC. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 28: 412-419, 1985.
20. Moschen AR, Tilg H. Nutrition in pathophysiology and treatment of nonalcoholic fatty liver disease. Curr Opin Clin Nutr Metab Care 11: 620-625, 2008.
21. Palomer X, Pérez A, Blanco-Vaca F. [Adiponectin: a new link between obesity, insulin resistance and cardiovascular disease]. Med Clin (Barc) 124: 388-395, 2005.
22. Patsouris D, Li PP, Thapar D, Chapman J, Olefsky JM, Neels JG. Ablation of CD11c-positive cells normalizes insulin sensitivity in obese insulin resistant animals. Cell Metab 8: 301-309, 2008.
23. Pedersen BK. The anti-inflammatory effect of exercise: its role in diabetes and cardiovascular disease control. Essays Biochem 42: 105-117, 2006.
24. Puglisi MJ, Fernandez ML. Modulation of C-reactive protein, tumor necrosis factor-alpha, and adiponectin by diet, exercise, and weight loss. J Nutr 138: 2293-2296, 2008.
25. Rubin DA, McMurray RG, Harrell JS, Thorpe DE, Hackney AC. Vigorous physical activity and cytokines in adolescents. Eur J Appl Physiol 103: 495-500, 2008.
26. Sakurai T, Izawa T, Kizaki T, Ogasawara JE, Shirato K, Imaizumi K, Takahashi K, Ishida H, Ohno H. Exercise training decreases expression of inflammation-related adipokines through reduction of oxidative stress in rat white adipose tissue. Biochem Biophys Res Commun 379: 605-609, 2009.
27. Schefer V, Talan MI. Oxygen consumption in adult and AGED C57BL/6J mice during acute treadmill exercise of different intensity. Exp Gerontol 31: 387-392, 1996. (Pubitemid 26170725)
28. Stienstra R, Mandard S, Patsouris D, Maass C, Kersten S, Muller M. Peroxisome proliferator-activated receptor alpha protects against obesity-induced hepatic inflammation. Endocrinology 148: 2753-2763, 2007. (Pubitemid 46984788)
29. Todoric J, Loffler M, Huber J, Bilban M, Reimers M, Kadl A, Zeyda M, Waldhausl W, Stulnig TM. Adipose tissue inflammation induced by high-fat diet in obese diabetic mice is prevented by n-3 polyunsaturated fatty acids. Diabetologia 49: 2109-2119, 2006. (Pubitemid 44168479)
30. Tsai AC, Sandretto A, Chung YC. Dieting is more effective in reducing weight but exercise is more effective in reducing fat during the early phase of a weight-reducing program in healthy humans. J Nutr Biochem 14: 541-549, 2003. (Pubitemid 37162653)
31. US Department of Agriculture. Dietary Guidelines for Americans, 2005. Washington, DC: USDA, 2005.
32. Vaccaro O, Masulli M, Cuomo V, Rivellese AA, Uusitupa M, Vessby B, Hermansen K, Tapsell L, Riccardi G. Comparative evaluation of simple indices of insulin resistance. Metabolism 53: 1522-1526, 2004. (Pubitemid 39556363)
33. van der Poorten D, Milner KL, Hui J, Hodge A, Trenell MI, Kench JG, London R, Peduto T, Chisholm DJ, George J. Visceral fat: a key mediator of steatohepatitis in metabolic liver disease. Hepatology 48: 449-457, 2008.
34. Van Dorsten B, Lindley EM. Cognitive and behavioral approaches in the treatment of obesity. Endocrinol Metab Clin North Am 37: 905-922, 2008.
35. Vieira V, Hu L, Valentine RJ, McAuley E, Evans EM, Baynard T, Woods JA. Reduction in trunk fat predicts cardiovascular exercise training- related reductions in C-Reactive protein. Brain Behav Immun. In press.
36. Vitseva OI, Tanriverdi K, Tchkonia TT, Kirkland JL, McDonnell ME, Apovian CM, Freedman J, Gokce N. Inducible Toll-like receptor and NF-kappaB regulatory pathway expression in human adipose tissue. Obesity (Silver Spring) 16: 932-937, 2008.
37. Williams EA, Perkins SN, Smith NC, Hursting SD, Lane MA. Carbohydrate versus energy restriction: effects on weight loss, body composition and metabolism. Ann Nutr Metab 51: 232-243, 2007.
38. Woods JA, Vieira VJ, Keylock KT. Exercise, inflammation, and innate immunity. Neurol Clin 24: 585-599, 2006.
39. Yang RZ, Lee MJ, Hu H, Pollin TI, Ryan AS, Nicklas BJ, Snitker S, Horenstein RB, Hull K, Goldberg NH, Goldberg AP, Shuldiner AR, Fried SK, Gong DW. Acute-phase serum amyloid A: an inflammatory adipokine and potential link between obesity and its metabolic complications. PLoS Med 3: e287, 2006. (Pubitemid 43987831)
40. Ye J. Emerging role of adipose tissue hypoxia in obesity and insulin resistance. Int J Obes (Lond) 33: 54-66, 2009.