메뉴 건너뛰기




Volumn 185, Issue 2, 2013, Pages 595-604

Pim-3 promotes the growth of human pancreatic cancer in the orthotopic nude mouse model through vascular endothelium growth factor

Author keywords

Nude mice orthotopic model; Pim 3; VEGF

Indexed keywords

CD31 ANTIGEN; CHOLECYSTOKININ OCTAPEPTIDE; PROTEIN BAD; PROTEIN KINASE PIM 3; PROTEIN SERINE THREONINE KINASE; RETROVIRUS VECTOR; UNCLASSIFIED DRUG; VASCULOTROPIN; ONCOPROTEIN; PIM3 PROTEIN, HUMAN; VASCULAR ENDOTHELIAL GROWTH FACTOR A, MOUSE; VASCULOTROPIN A;

EID: 84891669486     PISSN: 00224804     EISSN: 10958673     Source Type: Journal    
DOI: 10.1016/j.jss.2013.06.004     Document Type: Article
Times cited : (15)

References (44)
  • 3
    • 0024396220 scopus 로고
    • Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice
    • Breuer M, Slebos R, Verbeek S, et al. Very high frequency of lymphoma induction by a chemical carcinogen in pim-1 transgenic mice. Nature 1989;340:61.
    • (1989) Nature , vol.340 , pp. 61
    • Breuer, M.1    Slebos, R.2    Verbeek, S.3
  • 4
    • 0033564628 scopus 로고    scopus 로고
    • Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP
    • Konietzko U, Kauselmann G, Scafidi J, et al. Pim kinase expression is induced by LTP stimulation and required for the consolidation of enduring LTP. EMBO J 1999; 18:3359.
    • (1999) EMBO J , vol.18 , pp. 3359
    • Konietzko, U.1    Kauselmann, G.2    Scafidi, J.3
  • 5
    • 0032569028 scopus 로고    scopus 로고
    • KID-1, a protein kinase induced by depolarization in brain
    • Feldman JD, Vician L, Crispino M, et al. KID-1, a protein kinase induced by depolarization in brain. J Biol Chem 1998; 273:16535.
    • (1998) J Biol Chem , vol.273 , pp. 16535
    • Feldman, J.D.1    Vician, L.2    Crispino, M.3
  • 6
    • 2342561104 scopus 로고    scopus 로고
    • Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells
    • Machado HB, Liu W, Vician LJ, et al. Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells. J Neurosci Res 2004;76:334.
    • (2004) J Neurosci Res , vol.76 , pp. 334
    • Machado, H.B.1    Liu, W.2    Vician, L.J.3
  • 7
    • 33746122005 scopus 로고    scopus 로고
    • Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines
    • Li YY, Popivanova BK, Nagai Y, et al. Pim-3, a proto-oncogene with serine/threonine kinase activity, is aberrantly expressed in human pancreatic cancer and phosphorylates bad to block bad-mediated apoptosis in human pancreatic cancer cell lines. Cancer Res 2006;66:6741.
    • (2006) Cancer Res , vol.66 , pp. 6741
    • Li, Y.Y.1    Popivanova, B.K.2    Nagai, Y.3
  • 8
    • 13244284663 scopus 로고    scopus 로고
    • Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines
    • Fujii C, Nakamoto Y, Lu P, et al. Aberrant expression of serine/threonine kinase Pim-3 in hepatocellular carcinoma development and its role in the proliferation of human hepatoma cell lines. Int J Cancer 2005;114:209.
    • (2005) Int J Cancer , vol.114 , pp. 209
    • Fujii, C.1    Nakamoto, Y.2    Lu, P.3
  • 9
    • 33846701190 scopus 로고    scopus 로고
    • Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis
    • Popivanova BK, Li YY, Zheng H, et al. Proto-oncogene, Pim-3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad-mediated apoptosis. Cancer Sci 2007;98:321.
    • (2007) Cancer Sci , vol.98 , pp. 321
    • Popivanova, B.K.1    Li, Y.Y.2    Zheng, H.3
  • 10
    • 40049105999 scopus 로고    scopus 로고
    • Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression
    • Zheng HC, Tsuneyama K, Takahashi H, et al. Aberrant Pim-3 expression is involved in gastric adenoma-adenocarcinoma sequence and cancer progression. J Cancer Res Clin Oncol 2008;134:481.
    • (2008) J Cancer Res Clin Oncol , vol.134 , pp. 481
    • Zheng, H.C.1    Tsuneyama, K.2    Takahashi, H.3
  • 11
    • 3343007095 scopus 로고    scopus 로고
    • Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site
    • Aho TL, Sandholm J, Peltola KJ, et al. Pim-1 kinase promotes inactivation of the pro-apoptotic Bad protein by phosphorylating it on the Ser112 gatekeeper site. FEBS Lett 2004;571:43.
    • (2004) FEBS Lett , vol.571 , pp. 43
    • Aho, T.L.1    Sandholm, J.2    Peltola, K.J.3
  • 12
    • 0242580961 scopus 로고    scopus 로고
    • The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death
    • Yan B, Zemskova M, Holder S, et al. The PIM-2 kinase phosphorylates BAD on serine 112 and reverses BAD-induced cell death. J Biol Chem 2003;278:45358.
    • (2003) J Biol Chem , vol.278 , pp. 45358
    • Yan, B.1    Zemskova, M.2    Holder, S.3
  • 13
    • 85013312416 scopus 로고
    • Tumor angiogenesis: Therapeutic implications
    • Folkman J. Tumor angiogenesis: therapeutic implications. N Engl J Med 1971;285:1182.
    • (1971) N Engl J Med , vol.285 , pp. 1182
    • Folkman, J.1
  • 14
    • 33846579129 scopus 로고    scopus 로고
    • Endothelium-microenvironment interactions in the developing embryo and in the adult
    • Red-Horse K, Crawford Y, Shojaei F, et al. Endothelium-microenvironment interactions in the developing embryo and in the adult. Dev Cell 2007;12:181.
    • (2007) Dev Cell , vol.12 , pp. 181
    • Red-Horse, K.1    Crawford, Y.2    Shojaei, F.3
  • 15
    • 30744449235 scopus 로고    scopus 로고
    • Angiogenesis as a therapeutic target
    • Ferrara N, Kerbel RS. Angiogenesis as a therapeutic target. Nature 2005;438:967.
    • (2005) Nature , vol.438 , pp. 967
    • Ferrara, N.1    Kerbel, R.S.2
  • 16
    • 0021111648 scopus 로고
    • Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid
    • Senger DR, Galli SJ, Dvorak AM, et al. Tumor cells secrete a vascular permeability factor that promotes accumulation of ascites fluid. Science 1983;219:983.
    • (1983) Science , vol.219 , pp. 983
    • Senger, D.R.1    Galli, S.J.2    Dvorak, A.M.3
  • 17
    • 72249119811 scopus 로고    scopus 로고
    • VEGF-A: A critical regulator of blood vessel growth
    • Ferrara N. VEGF-A: a critical regulator of blood vessel growth. Eur Cytokine Network 2009;20:158.
    • (2009) Eur Cytokine Network , vol.20 , pp. 158
    • Ferrara, N.1
  • 18
    • 0036842215 scopus 로고    scopus 로고
    • Vascular permeability factor/vascular endothelial growth factor: A critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy
    • Dvorak HF. Vascular permeability factor/vascular endothelial growth factor: a critical cytokine in tumor angiogenesis and a potential target for diagnosis and therapy. J Clin Oncol 2002;20:4368.
    • (2002) J Clin Oncol , vol.20 , pp. 4368
    • Dvorak, H.F.1
  • 19
    • 34247162696 scopus 로고    scopus 로고
    • Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors
    • Zhang J, Jia Z, Li Q, et al. Elevated expression of vascular endothelial growth factor correlates with increased angiogenesis and decreased progression-free survival among patients with low-grade neuroendocrine tumors. Cancer 2007;109:1478.
    • (2007) Cancer , vol.109 , pp. 1478
    • Zhang, J.1    Jia, Z.2    Li, Q.3
  • 20
    • 37549040613 scopus 로고    scopus 로고
    • Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer
    • Miller K, Wang M, Gralow J, et al. Paclitaxel plus bevacizumab versus paclitaxel alone for metastatic breast cancer. N Engl J Med 2007;357:2666.
    • (2007) N Engl J Med , vol.357 , pp. 2666
    • Miller, K.1    Wang, M.2    Gralow, J.3
  • 21
    • 34248173883 scopus 로고    scopus 로고
    • Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: Results from the Eastern Cooperative Oncology Group Study E3200
    • Giantonio BJ, Catalano PJ, Meropol NJ, et al. Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200. J Clin Oncol 2007;25:1539.
    • (2007) J Clin Oncol , vol.25 , pp. 1539
    • Giantonio, B.J.1    Catalano, P.J.2    Meropol, N.J.3
  • 22
    • 0030754056 scopus 로고    scopus 로고
    • Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression
    • Itakura J, Ishiwata T, Friess H, et al. Enhanced expression of vascular endothelial growth factor in human pancreatic cancer correlates with local disease progression. Clin Cancer Res 1997;3:1309.
    • (1997) Clin Cancer Res , vol.3 , pp. 1309
    • Itakura, J.1    Ishiwata, T.2    Friess, H.3
  • 23
    • 0034657029 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma
    • Seo Y, Baba H, Fukuda T, et al. High expression of vascular endothelial growth factor is associated with liver metastasis and a poor prognosis for patients with ductal pancreatic adenocarcinoma. Cancer 2000;88:2239.
    • (2000) Cancer , vol.88 , pp. 2239
    • Seo, Y.1    Baba, H.2    Fukuda, T.3
  • 24
    • 0036311535 scopus 로고    scopus 로고
    • High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas
    • Niedergethmann M, Hildenbrand R, Wostbrock B, et al. High expression of vascular endothelial growth factor predicts early recurrence and poor prognosis after curative resection for ductal adenocarcinoma of the pancreas. Pancreas 2002; 25:122.
    • (2002) Pancreas , vol.25 , pp. 122
    • Niedergethmann, M.1    Hildenbrand, R.2    Wostbrock, B.3
  • 25
    • 0034323062 scopus 로고    scopus 로고
    • De novo expression of vascular endothelial growth factor in human pancreatic cancer: Evidence for an autocrine mitogenic loop
    • von Marschall Z, Cramer T, Hocker M, et al. De novo expression of vascular endothelial growth factor in human pancreatic cancer: evidence for an autocrine mitogenic loop. Gastroenterology 2000;119:1358.
    • (2000) Gastroenterology , vol.119 , pp. 1358
    • Von Marschall, Z.1    Cramer, T.2    Hocker, M.3
  • 26
    • 20344387204 scopus 로고    scopus 로고
    • Prostate-specific antigen modulates the expression of genes involved in prostate tumor growth
    • Bindukumar B, Schwartz SA, Nair MP, et al. Prostate-specific antigen modulates the expression of genes involved in prostate tumor growth. Neoplasia 2005;7:544.
    • (2005) Neoplasia , vol.7 , pp. 544
    • Bindukumar, B.1    Schwartz, S.A.2    Nair, M.P.3
  • 27
    • 2942525073 scopus 로고    scopus 로고
    • Identification of Flk-1 target genes in vasculogenesis: Pim-1 is required for endothelial and mural cell differentiation in vitro
    • Zippo A, De Robertis A, Bardelli M, et al. Identification of Flk-1 target genes in vasculogenesis: pim-1 is required for endothelial and mural cell differentiation in vitro. Blood 2004;103:4536.
    • (2004) Blood , vol.103 , pp. 4536
    • Zippo, A.1    De Robertis, A.2    Bardelli, M.3
  • 28
    • 65549111109 scopus 로고    scopus 로고
    • Pim-3 is expressed in endothelial cells and promotes vascular tube formation
    • Zhang P, Wang H, Min X, et al. Pim-3 is expressed in endothelial cells and promotes vascular tube formation. J Cell Physiol 2009;220:82.
    • (2009) J Cell Physiol , vol.220 , pp. 82
    • Zhang, P.1    Wang, H.2    Min, X.3
  • 29
    • 33748886664 scopus 로고    scopus 로고
    • Noninvasive in vivo imaging in small animal research
    • Koo V, Hamilton PW, Williamson K. Noninvasive in vivo imaging in small animal research. Cell Oncol 2006;28:127.
    • (2006) Cell Oncol , vol.28 , pp. 127
    • Koo, V.1    Hamilton, P.W.2    Williamson, K.3
  • 30
    • 34249032373 scopus 로고    scopus 로고
    • High-resolution whole-body magnetic resonance imaging applications at 1.5 and 3 Tesla: A comparative study
    • Schmidt GP, Wintersperger B, Graser A, et al. High-resolution whole-body magnetic resonance imaging applications at 1.5 and 3 Tesla: a comparative study. Invest Radiol 2007; 42:449.
    • (2007) Invest Radiol , vol.42 , pp. 449
    • Schmidt, G.P.1    Wintersperger, B.2    Graser, A.3
  • 31
    • 0030702123 scopus 로고    scopus 로고
    • Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery
    • Datta SR, Dudek H, Tao X, et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 1997;91:231.
    • (1997) Cell , vol.91 , pp. 231
    • Datta, S.R.1    Dudek, H.2    Tao, X.3
  • 32
    • 0346243679 scopus 로고    scopus 로고
    • Pancreatic cancer growth is inhibited by blockade of VEGF-RII
    • Büchler P, Reber HA, Ullrich A, et al. Pancreatic cancer growth is inhibited by blockade of VEGF-RII. Surgery 2003; 134: 772.
    • (2003) Surgery , vol.134 , pp. 772
    • Büchler, P.1    Reber, H.A.2    Ullrich, A.3
  • 33
    • 79953756112 scopus 로고    scopus 로고
    • Stat3/Socs3 activation by IL-6 trans-signaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer
    • Lesina M, Kurkowski MU, Ludes K, et al. Stat3/Socs3 activation by IL-6 trans-signaling promotes progression of pancreatic intraepithelial neoplasia and development of pancreatic cancer. Cancer Cell 2011;19:456.
    • (2011) Cancer Cell , vol.19 , pp. 456
    • Lesina, M.1    Kurkowski, M.U.2    Ludes, K.3
  • 34
    • 79953761842 scopus 로고    scopus 로고
    • Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression
    • Fukuda A, Wang SC, Morris JT, et al. Stat3 and MMP7 contribute to pancreatic ductal adenocarcinoma initiation and progression. Cancer Cell 2011;19:441.
    • (2011) Cancer Cell , vol.19 , pp. 441
    • Fukuda, A.1    Wang, S.C.2    Morris, J.T.3
  • 35
    • 85047695527 scopus 로고    scopus 로고
    • Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis
    • Niu G, Wright KL, Huang M, et al. Constitutive Stat3 activity up-regulates VEGF expression and tumor angiogenesis. Oncogene 2002;21:2000.
    • (2002) Oncogene , vol.21 , pp. 2000
    • Niu, G.1    Wright, K.L.2    Huang, M.3
  • 36
    • 0037461934 scopus 로고    scopus 로고
    • Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis
    • Wei D, Le X, Zheng L, et al. Stat3 activation regulates the expression of vascular endothelial growth factor and human pancreatic cancer angiogenesis and metastasis. Oncogene 2003;22:319.
    • (2003) Oncogene , vol.22 , pp. 319
    • Wei, D.1    Le Zheng X, L.2
  • 37
    • 24644457736 scopus 로고    scopus 로고
    • Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways
    • Xu Q, Briggs J, Park S, et al. Targeting Stat3 blocks both HIF-1 and VEGF expression induced by multiple oncogenic growth signaling pathways. Oncogene 2005;24:5552.
    • (2005) Oncogene , vol.24 , pp. 5552
    • Xu, Q.1    Briggs, J.2    Park, S.3
  • 38
    • 77956585637 scopus 로고    scopus 로고
    • PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation
    • Chang M, Kanwar N, Feng E, et al. PIM kinase inhibitors downregulate STAT3(Tyr705) phosphorylation. Mol Cancer Ther 2010;9:2478.
    • (2010) Mol Cancer Ther , vol.9 , pp. 2478
    • Chang, M.1    Kanwar, N.2    Feng, E.3
  • 39
    • 65549150854 scopus 로고    scopus 로고
    • Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer
    • Van Cutsem E, Vervenne WL, Bennouna J, et al. Phase III trial of bevacizumab in combination with gemcitabine and erlotinib in patients with metastatic pancreatic cancer. J Clin Oncol 2009;27:2231.
    • (2009) J Clin Oncol , vol.27 , pp. 2231
    • Van Cutsem, E.1    Vervenne, W.L.2    Bennouna, J.3
  • 40
    • 82455171860 scopus 로고    scopus 로고
    • Bevacizumab plus gemcitabine and oxaliplatin as first-line therapy for metastatic or locally advanced pancreatic cancer: A phase II trial
    • Fogelman D, Jafari M, Varadhachary GR, et al. Bevacizumab plus gemcitabine and oxaliplatin as first-line therapy for metastatic or locally advanced pancreatic cancer: a phase II trial. Cancer Chemother Pharmacol 2011;68:1431.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 1431
    • Fogelman, D.1    Jafari, M.2    Varadhachary, G.R.3
  • 41
    • 47949099628 scopus 로고    scopus 로고
    • Modes of resistance to anti-angiogenic therapy
    • Bergers G, Hanahan D. Modes of resistance to anti-angiogenic therapy. Nat Rev Cancer 2008;8:592.
    • (2008) Nat Rev Cancer , vol.8 , pp. 592
    • Bergers, G.1    Hanahan, D.2
  • 42
    • 15344342455 scopus 로고    scopus 로고
    • Genentech discloses safety concerns over Avastin
    • Ratner M. Genentech discloses safety concerns over Avastin. Nat Biotechnol 2004;22:1198.
    • (2004) Nat Biotechnol , vol.22 , pp. 1198
    • Ratner, M.1
  • 43
    • 0037370325 scopus 로고    scopus 로고
    • Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    • Eremina V, Sood M, Haigh J, et al. Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases. J Clin Invest 2003;111:707.
    • (2003) J Clin Invest , vol.111 , pp. 707
    • Eremina, V.1    Sood, M.2    Haigh, J.3
  • 44
    • 26444448463 scopus 로고    scopus 로고
    • The survival kinases Akt and Pim as potential pharmacological targets
    • Amaravadi R, Thompson CB. The survival kinases Akt and Pim as potential pharmacological targets. J Clin Invest 2005; 115:2618.
    • (2005) J Clin Invest , vol.115 , pp. 2618
    • Amaravadi, R.1    Thompson, C.B.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.