Gamma ray sterilization of delta inulin adjuvant particles (Advax™) makes minor, partly reversible structural changes without affecting adjuvant activity

Vaccine

Volumn 32, Issue 5, 2014, Pages 552-557

  Cooper, P D ^a,b,c   Barclay, T G ^d   Ginic Markovic, M ^d   Petrovsky, N ^a,e  

^a VAXINE PTY LTD   (Australia)

^b The Australian National University   (Australia)

^c Biology and Environment   (Australia)

^d UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^e FLINDERS MEDICAL CENTRE   (Australia)

Author keywords

Adjuvant; Immunity; Inulin; Polymorph; Sterilization; Vaccine

Indexed keywords

DELTA INULIN; IMMUNOLOGICAL ADJUVANT; INULIN; TETRAZOLIUM; UNCLASSIFIED DRUG;

ARTICLE; COLORIMETRY; CONTROLLED STUDY; DISSOLUTION; GAMMA RADIATION; HEATING; OXIDATION; PRIORITY JOURNAL; RADIATION DOSE; RADIATION STERILIZATION; SUSPENSION; TEMPERATURE;

ADJUVANT; AI-2; ALPHA-2 INULIN; BP; BRITISH PHARMACOPOEIA; CRITICAL TEMPERATURE OF AN ISOFORM/POLYMORPHIC VARIANT; DEGREE OF POLYMERIZATION; DELTA INULIN; DI; DP; DPN; EDTA; EI; EPSILON INULIN; ETHYLENE DIAMINE TETRA ACETATE; GAMMA INULIN; GAMMA RADIATION; GI; GR; IMMUNITY; INULIN; KGY; KILOGRAY; NUMBER AVERAGE DEGREE OF POLYMERIZATION; PBS; PHOSPHATE BUFFERED SALINE; POLYMORPH; REFRACTIVE INDEX; RI; ROOM TEMPERATURE (20-21°C); RT; SD; STANDARD DEVIATION; STERILIZATION; TC; UNITED STATES PHARMACOPOEIA; USP; VACCINE;

ADJUVANTS, IMMUNOLOGIC; ANIMALS; FEMALE; GAMMA RAYS; INULIN; MICE; MICE, INBRED BALB C; PROTEIN ISOFORMS; STERILIZATION;

EID: 84891659052     PISSN: 0264410X     EISSN: 18732518     Source Type: Journal    
DOI: 10.1016/j.vaccine.2013.11.105     Document Type: Article

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