Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulation

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 387, Issue 1, 2014, Pages 33-45

  Wang, Wei Ting ^a   Chen, Yen Hui ^b   Hsu, Jui Ling ^a   Leu, Wohn Jenn ^a   Yu, Chia Chun ^a   Chan, She Hung ^a   Ho, Yunn Fang ^b   Hsu, Lih Ching ^a   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Bak up regulation; H1 histamine receptor antagonist; Hormone refractory prostate cancer; Mcl 1 cleavage; Terfenadine

Indexed keywords

BETA TUBULIN; CASPASE 3; CASPASE 7; CASPASE 8; CASPASE 9; CHECKPOINT KINASE 1; CHECKPOINT KINASE 2; CYTOCHROME C; DIPHENHYDRAMINE; ETOPOSIDE; FEXOFENADINE; HISTONE H3; LORATADINE; PROTEIN BAD; PROTEIN BAK; PROTEIN BCL 2; PROTEIN MCL 1; TERFENADINE; VORINOSTAT;

ACETYLATION; AMINO TERMINAL SEQUENCE; ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CASTRATION RESISTANT PROSTATE CANCER; CELL PROLIFERATION; COMET ASSAY; CONCENTRATION RESPONSE; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; DNA DAMAGE; DNA FRAGMENTATION; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; IN VITRO STUDY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; PROTEIN CLEAVAGE; REAL TIME POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

APOPTOSIS; BCL-2 HOMOLOGOUS ANTAGONIST-KILLER PROTEIN; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HUMANS; MALE; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; PROSTATIC NEOPLASMS; RECEPTORS, HISTAMINE; TERFENADINE; TUMOR CELLS, CULTURED; UP-REGULATION;

EID: 84891627738     PISSN: 00281298     EISSN: 14321912     Source Type: Journal    
DOI: 10.1007/s00210-013-0912-x     Document Type: Article

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