Terfenadine-induced apoptosis in human melanoma cells is mediated through Ca2+ homeostasis modulation and tyrosine kinase activity, independently of H1 histamine receptors

Carcinogenesis

Volumn 29, Issue 3, 2008, Pages 500-509

  Jangi, Shawkat Muhialdin ^b   Ruiz Larrea, M Begoña ^a   Nicolau Galmés, Francesca ^a   Andollo, Noelia ^a   Arroyo Berdugo, Yoana ^a   Ortega Martínez, Idoia ^a   Díaz Pérez, José Luís ^c   Boyano, María D ^a  

^a UNIVERSITY OF THE BASQUE COUNTRY UPV EHU   (Spain)

^b HAWLER MEDICAL UNIVERSITY   (Iraq)

^c HOSPITAL DE CRUCES   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

1 [[6 (3 METHOXYESTRA 1,3,5(10) TRIEN 17BETA YL)AMINO]HEXYL] 1H PYRROLE 2,5 DIONE; CALCIUM; CYCLIC AMP; CYCLIC GMP; CYCLIC NUCLEOTIDE; GENISTEIN; HISTAMINE; HISTAMINE H1 RECEPTOR; HISTIDINE; NEOMYCIN; PHOSPHOLIPASE C; PROTEIN TYROSINE KINASE; SMALL INTERFERING RNA; TERFENADINE;

APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CALCIUM HOMEOSTASIS; CELL GROWTH; CELL PROTECTION; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MELANOMA CELL; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; RNA INTERFERENCE; SIGNAL TRANSDUCTION;

APOPTOSIS; BASE SEQUENCE; CALCIUM; CELL LINE, TUMOR; CYCLIC AMP; CYCLIC GMP; DNA PRIMERS; EGTAZIC ACID; ELECTROPHORESIS, POLYACRYLAMIDE GEL; FLUORESCENT ANTIBODY TECHNIQUE; HISTAMINE H1 ANTAGONISTS, NON-SEDATING; HOMEOSTASIS; HUMANS; INOSITOL PHOSPHATES; MELANOMA; PROTEIN-TYROSINE KINASES; RECEPTORS, HISTAMINE H1; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA, SMALL INTERFERING; TERFENADINE; TYPE C PHOSPHOLIPASES;

EID: 40949144006     PISSN: 01433334     EISSN: 14602180     Source Type: Journal    
DOI: 10.1093/carcin/bgm292     Document Type: Article

References (44)

1. Mitsuhashi,M. et al. (1992) Functional diversity of histamine and histamine receptors. J. Invest. Dermatol., 98 (suppl. 6), 8S-11S.
2. Rivera,E.S. et al. (2000) Histamine as an autocrine growth factor: an unusual role for a widespread mediator. Semin. Cancer Biol., 10, 15-23.
3. Bartholeyns,J. et al. (1994) Involvement of histamine in growth of mouse and rat tumors: Antitumoral properties of monofluoromethylhistidine, an enzyme-activated irreversible inhibitor of histidine decarboxylase. Cancer Res., 44, 639-645.
4. Pearsons,M.E. et al. (2006) Histamine and its receptors. Br. J. Pharmacol., 147, S127-S135.
5. Haak-Frendscho,M. et al. (2000) Histidine decarboxylase expression in human melanoma. J. Invest. Dermatol., 15, 345-352.
6. Hill,S.J. et al. (1997) International Union of Pharmacology. XIII. Classification of histamine receptors. Pharmacol. Rev., 49, 253-278.
7. Liu,C. et al. (2001) Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. Mol. Pharmacol., 296, 1058-1066.
8. Tilly,B.C. et al. (1990) Histamine as a growth factor and chemoattractant for human carcinoma and melanoma cells: Action through Ca2(+)-mobilizing H1 receptors. J. Cell Biol., 110, 1211-1215.
9. Pós,Z. et al. (2005) Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and Rho-C as histamine-regulated melanoma progression markers. Cancer Res., 65, 4458-4466.
10. Hegyesi,H. et al. (2005) Histamine elevates the expression of Ets-1, a protooncogen in human melanoma cell lines through H2 receptor. FEBS Lett., 579, 2475-2479.
11. Megson,A.C. et al. (2001) Role of protein kinase Calpha in signaling from the histamine H(1) receptor to the nucleus. Mol. Pharmacol., 59, 1012-1021.
12. Simons,F.E. (2004) Advances in H1-antihistamines. N. Engl. J. Med. 351, 2203-2217.
13. Diaz-Trelles,R. et al. (2000) Antihistamine terfenadine potentiates NMDA receptor-mediated calcium influx, oxygen radical formation, and neuronal death. Brain Res., 880, 17-27.
14. Viktorsson,K. et al. (2005) Apoptotic pathways and therapy resistance in human malignancies. Adv. Cancer Res., 94, 143-196.
15. Hajra,K.M. et al. (2004) Apoptosome dysfunction in human cancer. Apoptosis, 9, 691-704.
16. Rello,S. et al. (2005) Morphological criteria to distinguish cell death induced by apoptotic and necrotic treatments. Apoptosis, 10, 201-208.
17. Hengartner,M.O. (2000) The biochemistry of apoptosis. Nature, 407, 770-776.
18. Rizzuto,R. et al. (2003) Calcium and apoptosis: Facts and hypotheses. Oncogene, 22, 8619-8627.
19. Yu,S.P. et al. (2001) Ion homeostasis and apoptosis. Curr. Opin. Cell Biol., 4, 405-411.
20. Jangi,S.M. et al. (2004) Apoptosis of human T-cell acute lymphoblastic leukemia cells by diphenhydramine, an H1 histamine receptor antagonist. Oncol. Res., 14, 363-372.
21. Jangi,S.M. et al. (2006) H1 histamine receptor antagonists induce genotoxic and caspase-2-dependent apoptosis in human melanoma cells. Carcinogenesis, 27, 1787-1796.
22. Vandesompele,J. et al. (2002) Accurate normalization of real-time quantitative RT-PCR data by geometric averaging of multiple internal control genes. Genome Biol., 3, 1-12.
23. Asumendi,A. et al. (2002) Implication of mitochondria-derived ROS and cardiolipin peroxidation in N-(4-hydroxyphenyl) retinamide-induced apoptosis. Br J. Cancer, 86, 1951-1956.
24. Grynkiewicz,G. et al. (1985) A new generation of Ca2+ indicators with greatly improved fluorescence properties. J. Biol. Chem., 260, 3440-3450.
25. Darvas,Z. et al. (2003) Autonomous histamine metabolism in human melanoma cells. Melanoma Res., 3, 239-246.
26. Asemissen,A.M. et al. (2005) Addition of histamine to interleukin 2 treatment augments type 1 T-cell responses in patients with melanoma in vivo: Immunologic results from a randomized clinical trial of interleukin 2 with or without bistamine (MP 104). Clin. Cancer Res. 11, 290-297.
27. Tomita,K. et al. (2005) Histamine regulates growth of malignant melanoma implants via H2 receptors in mice. Inflammopharmacology, 13, 281-289.
28. Liu,J.D. et al. (2003) Molecular mechanisms of G0/G1 cell-cycle arrest and apoptosis induced by terfenadine in human cancer cells. Mol. Carcinog., 37, 39-50.
29. Wang,Y.J. et al. (2002) Ketoconazole potentiates terfenadine-induced ap- optosis in human Hep G2 cells through inhibition of cytochrome p450 3A4 activity. J. Cell. Biochem., 87, 147-159.
30. Enomoto,R. et al. (2004) Terfenadine induces thymocyte apoptosis via. mitochondrial pathway. Eur. J. Pharmacol., 496, 11-21.
31. Lee,K.C. et al. (2001) Mechanism of histamine-induced intracellular Ca2+ release and extracellular Ca2+ entry in MG63 human osteosarcoma cells. Biochem. Pharmacol., 61, 1537-1541.
32. 2+ levels and leukotriene release: Novel mechanisms of action independent of the anti-histamine activity. Eur. J. Pharmacol., 266, 219-227.
33. 2+ entry: Dynamic interplay between endoplasmic reticulum, mitochondria and plasma membrane. J. Physiol., 547, 333-348.
34. 2+ channels with different activation modes and molecular origin in LNCaP human prostate cancer epithelial cells. J. Biol. Chem., 279, 30326-30337.
35. Allen,D.H. et al. (1997) Ion channel phenotype of melanoma cell lines. J. Membr. Biol., 155, 27-34.
36. Berridge,M.J. (1993) Inositol trisphosphate and calcium signalling. Nature, 361, 315-325.
37. Aguilar-Maldonado,B. et al. (2003) Histamine potentiates IP(3)-mediated Ca(2+) release via thapsigargin-sensitive Ca(2+) pumps. Cell. Signal., 15, 689-697.
38. 2+ depletion triggers apoptotic signals for endoplasmic reticulum (ER) overload response induced by overexpressed reticulon 3 (RTN3/HAP). J. Cell, Physiol., 204 549-559.
39. Salas,V.M. et al. (1997) Calcium-dependent DNA damage and adenosine 3′,5′-cyclic monophosphate-independent glycogen phosphorylase activation in an in vitro model of acetaminophen-induced liver injury. Hepatology, 25, 1432-1438.
40. Johnson,G.L. et al. (1994) Sequential protein kinase reactions controlling cell growth and differentiation. Curr. Opin. Cell Biol. 6, 230-238.
41. Wan,Y. et al. (1996) Tyrosine kinases in activation of the MAP kinase cascade by G-protem-coupled receptors. Nature, 380, 541-544.
42. Akiyama,T. et al. (1987) Genistein, a specific inhibitor of tyrosine-specific tyrosine protein kinases. J. Biol. Chem., 262 5592-5595.
43. Iwata,K. et al. (2005) Bimodal regulation of the human H1 histamine receptor by G protein-coupled receptor kinase 2. J. Biol. Chem., 280, 2197-2204.
44. Waters,C. et al. (2004) The role of G-protein coupled receptors and associated proteins in receptor tyrosine kinase signal transduction. Semin. Cell Dev. Biol., 15, 309-323.